Burzynski and China / Taiwan, ROC

http://www.china-burzynski.com

http://www.china-burzynski.com/lczl/bingrengushi_135135.html

http://www.china-burzynski.com/lxwm
Below is information I have located re CDA-2 research in Taiwan, ROC and China

The history of CDA-2 (CDA-H or CDA-II) in Taiwan, ROC and China:

(Please note the numerous references to Liau & Burzynski)

1999 – Liao MC – A clever anticancer drug CDA-H
Taipei: ShiMao publisher
1999; 149–161

2000 – China – Antitumor effect of CDA-2 … (6. Publications Reference 8.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

2000 – China – HUMAN URINE extracts (CDA-II) as a novel anticancer agent … – NHRI Conf. New Drug Dev. Chin. Med (Abstract), p. 12, 2000 (listed as Reference on pg. 9 of PDF)
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X

2000 – Taiwan, ROC – HUMAN URINE extracts (CDA-II) as a novel anticancer agent …
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

2001 – Effect of CDA-II, urinary preparation, on lipofuscin, lipid peroxidation and antioxidant systems in young and middle-aged rat brain
http://www.ncbi.nlm.nih.gov/m/pubmed/11321484
– …, LIAU MC, …
Department of Pharmacology, China Medical College, Taichung, Taiwan, ROC
Am J Chin Med. 2001;29(1):91-9
References:
1988 – 3. BURZYNSKI, S.R. – … antineoplastons
1992 – 29. SAMID, D., S. … – Phenylacetate: …
http://www.worldscientific.com/doi/abs/10.1142/S0192415X01000101
PDF
http://www.worldscientific.com/doi/pdf/10.1142/S0192415X01000101
PDF+
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X01000101
Cited by:
1/2009 – China – 1. CDA-II, a URINARY …
2008 – China – 2. HUMAN URINE extract CDA-2 …
10/2005 – Taiwan, ROC – 3. … HUMAN URINE Extract
6/2005 – China – 4. Anti-tumor effect of CDA-II …
2003 – China / Taiwan, ROC – 5. …, Ming-Cheng LIAU, … Effect of CDA-II …
2002 – CHEN CH, … – CDA-Ⅱ … The 7th Taiwan Joint Cancer Conference ([ Conference Abstracts] Reference 5.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2002 – … HUMAN URINE extract CDA-Ⅱ … The 7th Taiwan Joint Cancer Conference ([Conference Abstracts] Reference 6. and 7.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – … , CHEN CH, … – CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] Reference 4.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – HUMAN URINE Extract CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] References 2. and 3.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – CHEN CH, – … CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] Reference 1.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

1/2003 – Effect of CDA-II on Cell Viability, Lipid Peroxidation, Glutathione Concentration and Its Related Enzyme Activities in Primary Rat Hepatocytes
The American Journal of Chinese Medicine, January 2003, Vol. 31, No. 03 : pp. 415-423
doi: 10.1142/S0192415X0300103X
CDA-II (cell differentiation agent: a preparation of HUMAN URINE)
China / Taiwan, ROC
References (pg. 9 of PDF):
1988 – LIAU, M.C., … and S.R. BURZYNSKI – … antineoplaston A5
1990 – LIAU, M.C. and S.R. BURZYNSKI – … anticancer components of antineoplaston A2, A3 and A5
Cited by (pg. 10 of PDF):
2012 – 2. Zirong CHEN, … – … CDA- II …
2006 – 3. … , M.C. LIAU, … – Inhibitory effect of CDA-II, a urinary preparation, …
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X

1/2003 – Synergistic effect of cell differential agent-II and arsenic trioxide on induction of cell cycle arrest and apoptosis in hepatoma cells
http://www.ncbi.nlm.nih.gov/m/pubmed/12508353
Department of General Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong Province, China
public.guangzhou.gd.cn
World J Gastroenterol. 2003 Jan;9(1):65-8
http://www.wjgnet.com/1007-9327/full/v9/i1/65.htm
PDF
http://www.wjgnet.com/1007-9327/9/65.pdf
1/2003
http://www.wjgnet.com/1007-9327/full/v9/i1/65.htm
PDF
http://www.wjgnet.com/1007-9327/9/65.pdf

Critics ignore CDA-2 (CDA-H or CDA-II) Phase III Clinical Trials list Burzynski as References: 7., 23., 32, and 35.
http://file.lw23.com/f/f0/f07/f074852c-64a4-4b03-8595-47a5e6609a3f.pdf
Critics should study the history of CDA-II (CDA-2 or CDA-H):
6/2005 – Burzynski References 7. and 9.
http://www.springerlink.com/content/vq43t88675366262
2003 – Burzynski References 12. and; 13.
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X
2001 – Burzynski Reference 3.
Samid Reference 29. (who learned from Burzynski)
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X01000101
Connection between Burzynski and China under the section titled “Evaluating Antineoplaston Therapy,” there is a paragraph about 1/2 way through the article which describes this:
http://www.commonweal.org/pubs/choices/21.html
Phase I/II/III clinical trials of CDA-2 were completed in China in 2003
In August 2004, the State Drug Administration (SDA) of China approved the use of CDA-2 as an anticancer drug in solid tumors
CDA-2 had been approved as a 1st class new anti-cancer drug by the SFDA of mainland China in 2004 through the effort of both sides of the Taiwan Strait

2005 – Phase III Clinical Trials of the Cell Differentiation Agent-2(CDA2): Therapeutic Eficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma
Cell Differentiation Agent-2 (CDA-2) … – a URINARY preparation, …
CDA-2 & its main component PHENYLACETYLGLUTAMINE (PG) {Antineoplaston AS2-5} …
China / Taiwan, ROC
Chinese Journal of Clinical Oncology
2005/Volume2/Number4 PGA. 706-716
(PDF – 11 pgs.)
Burzynski / Liau References
1989 – 7. Liau MC, … , BURZYNSKI SR
(PDF-pg. 9 of 11)
1986 – 23. Liau MC, BURZYNSKI SR
(PDF-pg. 10 of 11)
1990 – Antineoplaston A5 – 32. Liau MC, … , BURZYNSKI SR
1987 – 35. Liau MC, … , BURZINSKY SR
http://file.lw23.com/f/f0/f07/f074852c-64a4-4b03-8595-47a5e6609a3f.pdf

6/2005 – Anti-tumor effect of CDA-II on a human glioma cell
China
Chinese Journal of Clinical Oncology
June 2005, Volume 2, Issue 3, pp 679-684
DOI
10.1007/BF02739731
http://link.springer.com/article/10.1007%2FBF02739731
References:
1999 – 2. Taiwan, ROC – Liao MC – A clever anticancer drug CDA-II
1986 – 7. BURZYNSKI SR – Antineoplastons: …
2002 – 8. China – … CDA-H …
2003 – 9. BURZYNSKI SR, … Phase II … antineoplaston A10 & AS2-1 …
2003 – 11. … CDA-II
2003 – 12. … cell differentiation agent II …
2001 – 13. … CDA-II, URINARY preparation, …

10/2005 – Differentiation of pheochromocytoma PC12 cells induced by human urine extract and the involvement of the extracellular signal-regulated kinase signaling pathway
http://www.ncbi.nlm.nih.gov/m/pubmed/16296925
… HUMAN URINE extract …
Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC
J Altern Complement Med. 2005 Oct;11(5):903-8
http://online.liebertpub.com/doi/abs/10.1089/acm.2005.11.903

4/2006 (10/17/2005) – Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B(1)-induced oxidative stress and DNA damage in primary cultured rat hepatocytes
http://www.ncbi.nlm.nih.gov/m/pubmed/16229933
The effects of CDA-II (cell differentiation agent II; a URINARY preparation) …
Department of Pharmacology, China Medical University, Taichung 404, Taiwan, ROC
Inhibitory effect of CDA-II, a URINARY preparation, …
… LIAU MC, …
Food Chem Toxicol. 2006 Apr;44(4):546-51. Epub 2005 Oct 17
http://www.sciencedirect.com/science/article/pii/S0278691505002875

8/1/2008 – Human urine extract CDA-2 induces apoptosis of myelodysplastic syndrome-derived MUTZ-1 cells through the PI3K/Akt signaling pathway in a caspase-3-dependent manner
http://www.ncbi.nlm.nih.gov/m/pubmed/18664328
HUMAN URINE extract CDA-2 …
Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Acta Pharmacol Sin. 2008 Aug;29(8):951-64. doi: 10.1111/j.1745-7254.2008.00826.x
References (pg. 13 of PDF):
1986 – 5. BURZYNSKI SR – Antineoplastons: …
2000 – 6. Egypt – Potential utility of antineoplaston A-10 levels in breast cancer
2001 – 7. …, LIAU MC – Effect of CDA-II, URINARY preparation, …
2006 – 8. …, LIAU MC, … – Inhibitory effect of CDA-II, a URINARY preparation, …
2005 – 9. … HUMAN URINE extract …
http://www.nature.com/aps/journal/v29/n8/full/aps2008115a.html
PDF
http://www.nature.com/aps/journal/v29/n8/pdf/aps2008115a.pdf

9/2008 – [In vitro study of the effects of CDA-II combined with cAMP on apoptosis induction in retinoic acid resistant acute promyelocytic leukemia cells]
http://www.ncbi.nlm.nih.gov/m/pubmed/19175987
Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
2008 Sep;29(9):603-6. Article in Chinese

1/2009 (8/9/2008) – CDA-II, a urinary preparation, induces growth arrest and apoptosis of human leukemia cells through inactivation of nuclear factor-kappaB in a caspase-dependent manner
http://www.ncbi.nlm.nih.gov/m/pubmed/18761050
CDA-II, a URINARY preparation, …
CDA-II (cell differentiation agent II) was a URINARY preparation, isolated from HEALTHY HUMAN URINE
We determined the anticancer activity of CDA-II …
Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Food Chem Toxicol. 2009 Jan;47(1):40-9. doi: 10.1016/j.fct.2008.08.001. Epub 2008 Aug 9
http://www.sciencedirect.com/science/article/pii/S0278691508004249

4/2009 (10/14/2008) – Comparative proteomics and molecular mechanical analysis in CDA-II induced therapy of LCI-D20 hepatocellular carcinoma model
http://www.ncbi.nlm.nih.gov/m/pubmed/18853186
… CDA-II … – (cell differentiation agent-II)
Chemistry Department of Fudan University, Shanghai, China
fudan.edu.cn
J Cancer Res Clin Oncol. 2009 Apr;135(4):591-602. doi: 10.1007/s00432-008-0493-0. Epub 2008 Oct 14
References
1987 – 18. LIAU MC, … BURZYNSKI SR – … urinary … antineoplaston therapy
2006 – 19. …, LIAU MC, … – Inhibitory effect of CDA-II, a URINARY preparation, …
http://link.springer.com/article/10.1007%2Fs00432-008-0493-0

http://www.springerlink.com/content/47t5872g67727285

6/8/2012 (5/22/2012) – DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation
http://www.ncbi.nlm.nih.gov/m/pubmed/22627135
CDA-II (cell differentiation agent II), isolated from HEALTHY HUMAN URINE
CDA-2, a URINARY Preparation
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China
Biochem Biophys Res Commun. 2012 Jun 8;422(3):522-6. doi: 10.1016/j.bbrc.2012.05.068. Epub 2012 May 22
http://www.sciencedirect.com/science/article/pii/S0006291X1200945X

http://services.elsevier.com/SDWebExport/export/figure/S0006291X1200945X/1-s2.0-S0006291X1200945X-gr1.jpg/ppt

11/2012 – CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma
Cell differentiation agent-2 (CDA-2) is an extraction from HEALTHY HUMAN URINE …
China
Journal of Neuro-Oncology
November 2012, Volume 110, Issue 2, pp 179-186
10.1007/s11060-012-0961-x
References:
2005 – 1. … HUMAN URINE extract …
2001 – 2. … (CDA-II) injection
2011 – 3. … CDA-2 …
2006 – 4. Effect of CDA-II …
2009 – 6. … CDA-2 …
2008 – 7. HUMAN URINE extract CDA-2 …
http://link.springer.com/article/10.1007%2Fs11060-012-0961-x

http://www.springerlink.com/content/w40102w0qm212g44

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117

12/17/2012 – CDA-2, a urinary preparation, inhibits lung cancer development through the suppression of NF-kappaB activation in myeloid cell.
http://www.ncbi.nlm.nih.gov/m/pubmed/23284890
CDA-2, a URINARY preparation, …
– … (cell differentiation agent 2) …
Department of Pharmacy, Putuo People’s Hospital, Shanghai, China
PLoS One. 2012;7(12):e52117. doi: 10.1371/journal.pone.0052117. Epub 2012 Dec 17
References (pg. 10 of PDF):
2009 – 3. CDA-II, a URINARY preparation, …
2006 – 4. …, LIAU MC, … – Inhibitory effect of CDA-II, a URINARY preparation, …
2005 – 5. … HUMAN URINE extract …
2008 – 6. HUMAN URINE extract CDA-2 …
2009 – 7. … CDA-2 …
(pg. 11 of PDF)
1995 – 22. …, Burzynski SR – …
antineoplaston AS21 …
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524164
PDF
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524164/pdf/pone.0052117.pdf

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117

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