Burzynski: LOW-GRADE ASTROCYTOMA

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# and % of Patients Resolving or Stabilizing Disease = Complete Response + Partial Response + Stable Disease
——————————————————————
10 /100% – 2006 Antineoplastons (ANP) Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)

10 / 100% – 2006 Antineoplastons: Progressive Low-Grade ASTROCYTOMA in Children

10 / 100% – 10/2003 Antineoplastons: Alive and Well (2 to 13 years Post Diagnosis): Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13)

44 / 96% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

73 / 93% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006

104 / 92% – 2004 Chemotherapy / Targeted Therapy – Protocol: Gnekow AK, Kortmann RD, Pietsch T, et al. Low-grade chiasmatic-hypothalamic glioma-carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy : report from the multicenter treatment study for children and adolescents with a low grade glioma: HIT-LGG 1996. Society of Pediatric Oncology and Hematology (GPOH). Klin Pediatr 2004; 216: 331-42 Treatments for Astrocytic Tumors – Optical Pathway Glioma (OPG) LOW-GRADE GLIOMA IN CHILDREN (Pgs. 171 + 176) Vincristine /Carboplatin 2006

11 / 91% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

11 / 85% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006

12 / 80% – 6/2010 Antineoplastons – Protocol – CHILDREN WITH Recurrent and / or Progressive LOW-GRADE ASTROCYTOMA (LGA)

15 / 75% – 1992 Chemotherapy: Pons MA, Finlay JL, Walker RW, et al. Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J Neurooncol 1992; 14: 151-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Vincristine / Etoposide 2006

11 / 73% – 1991 Chemotherapy: Petronio J, Edwards MS, Prados M, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74: 701-8 (Pgs. 170 + 176) LOW-GRADE GLIOMA IN CHILDREN – Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006

7 / 70% – 2006 Antineoplastons (ANP): Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pg. 169)

/ 70% – 2006 small group of patients with Low-Grade ASTROCYTOMA (LGA) Targeted Therapy (Pg. 176)

9 / 69% – 2003 Chemotherapy: Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2003; 25: 372-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

7 / 64% – 7/1994 (1986–1992) – Protocol – MULTICENTRIC GLIOMA: Mamelak et al

/ 61% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

9 / 60% – 1991 Chemotherapy: Petronio J, Edwards MS, Prados M, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74: 701-8 (Pgs. 170 + 176) LOW-GRADE GLIOMA IN CHILDREN – Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006

/ 33% – 2006 Chemotherapy: Carboplatin / vincristine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

/ 20% – 2006 Chemotherapy: vinblastine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

/ 15% – Chemotherapy: Tamoxifen / carboplatin – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

3 / 10% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

/ 5% – 2006 Chemotherapy: vincristine / etoposide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)
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# and % of Patients Showing Objective Response = Complete Response + Partial Response
——————————————————————
7 / 70% – 2006 Antineoplastons: Progressive Low-Grade ASTROCYTOMA in Children

7 / 70% – 2006 Antineoplastons (ANP) Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)

/ 70% – 2006 small group of patients with Low-Grade ASTROCYTOMA (LGA) Targeted Therapy (Pg. 176)

/ 61% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

28 / 61% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

7 / 58% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

6 / 58% – 10/2003 Antineoplastons – Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13)

7 / 47% – 6/2010 Antineoplastons – Protocol – CHILDREN WITH Recurrent and / or Progressive LOW-GRADE ASTROCYTOMA (LGA)

/ 33% – 2006 Chemotherapy: Carboplatin / vincristine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

26 / 33% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006

3 / 30% – 2006 Antineoplastons (ANP): Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pg. 169)

3 / 23% – 2003 Chemotherapy: Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2003; 25: 372-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

/ 20% – 2006 Chemotherapy: vinblastine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

2 / 18% – 7/1994 (1986–1992) – Protocol – MULTICENTRIC GLIOMA: Mamelak et al

/ 15% – Chemotherapy: Tamoxifen / carboplatin – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

2 / 15% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006

3 / 10% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

3 / 10% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

/ 5% – 2006 Chemotherapy: vincristine / etoposide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

1 / 5% – 1992 Chemotherapy: Pons MA, Finlay JL, Walker RW, et al. Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J Neurooncol 1992; 14: 151-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Vincristine / Etoposide 2006
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# and % of Patients Showing Complete Response
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6 / 60% – 2006 Antineoplastons (ANP) Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)

6 / 60% – 2006 Antineoplastons: Progressive Low-Grade ASTROCYTOMA in Children

/ 60% – 2006 small group of patients with Low-Grade ASTROCYTOMA (LGA) Targeted Therapy (Pg. 176)

6 / 40% – 6/2010 Antineoplastons – Protocol – CHILDREN WITH Recurrent and / or Progressive LOW-GRADE ASTROCYTOMA (LGA)

4 / 33% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

4 / 33% – 10/2003 Antineoplastons: Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13)

3 / 30% – 2006 Antineoplastons (ANP): Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pg. 169)

8 / 27% = next best standard treatment study: 2006 – Protocol – LOW-GRADE GLIOMA IN CHILDREN

11 / 24% – 2006 next closest standard treatment study

/ 24% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

11 / 24% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided): 7/1994 (1986–1992) – Protocol – MULTICENTRIC GLIOMA: Mamelak et al

/ 5% – 2006 Chemotherapy: Carboplatin / vincristine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

4 / 5% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006

0 / 0% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

0 / 0% – 2003 Chemotherapy: Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2003; 25: 372-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

0 / 0% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006

0 / 0% – 1992 Chemotherapy: Pons MA, Finlay JL, Walker RW, et al. Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J Neurooncol 1992; 14: 151-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Vincristine / Etoposide 2006

0 / 0% – 1991 Chemotherapy: Petronio J, Edwards MS, Prados M, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74: 701-8 (Pgs. 170 + 176) Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006 Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006
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# and % of Patients Showing Partial Response
——————————————————————
9 / 60% – 2006 best next standard treatment study

9 / 60% – 1991 Chemotherapy: Petronio J, Edwards MS, Prados M, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74: 701-8 (Pgs. 170 + 176) LOW-GRADE GLIOMA IN CHILDREN – Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006

1 / 56% = next best standard treatment study: 2006 – Protocol – LOW-GRADE GLIOMA IN CHILDREN

/ 37% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

17 / 37% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

/ 28% – 2006 Chemotherapy: Carboplatin / vincristine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

22 / 28% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006

3 / 25% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

2 / 25% – 10/2003 Antineoplastons: Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13)

3 / 23% – 2003 Chemotherapy: Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2003; 25: 372-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

/ 20% – 2006 Chemotherapy: vinblastine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided): 7/1994 (1986–1992) – Protocol – MULTICENTRIC GLIOMA: Mamelak et al

/ 15% – Chemotherapy: Tamoxifen / carboplatin – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

2 / 15% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006

1 / 10% – 2006 Antineoplastons (ANP) Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)

1 / 10% – 2006 Antineoplastons: Progressive Low-Grade ASTROCYTOMA in Children

/ 10% – 2006 small group of patients with Low-Grade ASTROCYTOMA (LGA) Targeted Therapy (Pg. 176)

3 / 10% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

3 / 10% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

1 / 7% – 6/2010 Antineoplastons – Protocol – CHILDREN WITH Recurrent and / or Progressive LOW-GRADE ASTROCYTOMA (LGA)

/ 5% – 2006 Chemotherapy: vincristine / etoposide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)

1 / 5% – 1992 Chemotherapy: Pons MA, Finlay JL, Walker RW, et al. Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J Neurooncol 1992; 14: 151-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Vincristine / Etoposide 2006

0 / 0% – 2006 Antineoplastons (ANP): Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pg. 169)
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# and % of Patients Showing Stable Disease
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14 / 70% – 2006 next closest standard treatment study: Stable Disease + Minor Response

# and % of Patients Showing Stable Disease + Minor Response
9 / 70% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006

# and % of Patients Showing Stable Disease + Minor Response
14 / 70% – 1992 Chemotherapy: Pons MA, Finlay JL, Walker RW, et al. Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J Neurooncol 1992; 14: 151-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Vincristine / Etoposide 2006

# and % of Patients Showing Stable Disease + Minor Response
47 / 60% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006

5 / 46% – 7/1994 (1986–1992) – Protocol – MULTICENTRIC GLIOMA: Mamelak et al

6 / 46% – 2003 Chemotherapy: Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2003; 25: 372-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

25 / 44% = best standard treatment study: 2006 – Protocol – LOW-GRADE GLIOMA IN CHILDREN

13 / 43% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

4 / 40% – 2006 Antineoplastons (ANP): Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pg. 169)

# and % of Patients Showing Stable Disease + Minor Response
16 / 35% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

5 / 33% – 6/2010 Antineoplastons – Protocol – CHILDREN WITH Recurrent and / or Progressive LOW-GRADE ASTROCYTOMA (LGA) (47 – 85 days / 60 – Median days of Antineoplastons (ANP))

4 / 33% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

4 / 33% – 10/2003 Antineoplastons – Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13)

# and % of Patients Showing Stable Disease + Minor Response
3 / 30% – 2006 Antineoplastons (ANP) Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)

3 / 30% – 2006 Antineoplastons: Progressive Low-Grade ASTROCYTOMA in Children
Stable Disease + Minor Response

# and % of Patients Showing Stable Disease + Minor Response
2 / 13% – 1991 Chemotherapy: Petronio J, Edwards MS, Prados M, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74: 701-8 (Pgs. 170 + 176) LOW-GRADE GLIOMA IN CHILDREN – Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006
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# and % of Patients Showing Progressive Disease
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0 / 0% – 2006 Antineoplastons (ANP) Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)

0 / 0% – 2006 Antineoplastons: Progressive Low-Grade ASTROCYTOMA in Children

0 / 0% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

0 / 0% – 10/2003 Antineoplastons – Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13)

2 / 4% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

5 / 7% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006

2 / 15% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006

3 / 20% – 6/2010 Antineoplastons – Protocol – CHILDREN WITH Recurrent and / or Progressive LOW-GRADE ASTROCYTOMA (LGA) (47 – 85 days / 60 – Median days of Antineoplastons (ANP))

13 / 23% = best standard treatment study: 2006 – Protocol – LOW-GRADE GLIOMA IN CHILDREN

5 / 25% – 1992 Chemotherapy: Pons MA, Finlay JL, Walker RW, et al. Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J Neurooncol 1992; 14: 151-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Vincristine / Etoposide 2006

4 / 27% – 1991 Chemotherapy: Petronio J, Edwards MS, Prados M, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74: 701-8 (Pgs. 170 + 176) LOW-GRADE GLIOMA IN CHILDREN – Tioguanine / Procarbazine / Mitolactol / Lomustine / Vincristine 2006

3 / 30% – 2006 Antineoplastons (ANP): Protocol – LOW-GRADE GLIOMA IN CHILDREN (Pg. 169)

4 / 31% – 2003 Chemotherapy: Kuo DJ, Weiner HL, Wisoff J, et al. Temozolomide is active in childhood progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2003; 25: 372-8 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006

4 / 36% – # and % of Patients Died: 7/1994 (1986–1992) – Protocol – MULTICENTRIC GLIOMA: 3 – from disease progression / 1 – from chemotherapy-induced toxicity: Mamelak et al

14 / 47% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pgs. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006
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# and % of Patients Non-evaluable
——————————————————————
1 / 9% – 2004 Antineoplastons (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG): LOW-GRADE ASTROCYTOMA (BT-13)

1 / 9% – 10/2003 Antineoplastons: Protocol – MULTICENTRIC GLIOMA (LOW-GRADE ASTROCYTOMA) (BT-13) due to only 4 weeks of treatment / lack of follow-up scans. Patient died while on treatment due to brain infarct / counted as treatment failure

2 / 4% – 2006 next closest standard treatment study
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Follow-up for some:
——————————————————————
17 years – Antineoplastons (ANP) Targeted Therapy: ASTROCYTOMAS (Pgs. 174 + 177) Treatments for Astrocytic Tumors 2006
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follow-up period for some patients:
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>17 years – 2006 Antineoplastons (ANP) Long-term follow-up of children with ASTROCYTOMAS (Pg. 174)
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Maximum Survival:
——————————————————————
15+ years – 2006 Antineoplastons (ANP)
small group of Patients with progressive Low-Grade ASTROCYTOMA (LGA)
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Maximum Survival:
——————————————————————
15+ years – 2006 Antineoplastons (ANP) small group of patients with Low-Grade ASTROCYTOMA (LGA) Targeted Therapy
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Alive and Well from 2 to >14 years Post-Diagnosis:
——————————————————————
10 – 2004 Antineoplastons: children with recurrent and progressive MULTICENTRIC GLIOMA (Pgs. 315-317 and 320-321)
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Alive and Well from 2 to >14 years Post-Diagnosis:
——————————————————————
10 / 100% – 10/2003 Antineoplastons: Protocol – MULTICENTRIC GLIOMA
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# and % of Patients Alive and Well (2 to 13 years Post Diagnosis):
——————————————————————
10 / 100% – 10/2003 Antineoplastons: Protocol – MULTICENTRIC GLIOMA
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Long-Term Disease Free-Survival:
——————————————————————
8 / 80%+ – 2006 Antineoplastons (ANP) Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)
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10 year Tumor control:
——————————————————————
60+% – 2006 Radiation Therapy: Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)
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Median Survival:
——————————————————————

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Median Survival Time (MST):
——————————————————————
93 months (7 year 9 months – 2006 Antineoplastons (ANP): small group of Patients with progressive tumor – Low-Grade ASTROCYTOMA (LGA) in children (Pg. 170)
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Median Survival:
——————————————————————
7 years 9 months – 2006 small group of patients with Low-Grade ASTROCYTOMA (LGA) Targeted Therapy
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Median Survival Time (MST)
——————————————————————
93 months (7 years 9 months)
– 2006 Antineoplastons (ANP) Protocol LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)
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Median Survival Post Diagnosis:
——————————————————————
7 years approximately – Antineoplastons: (7/31/1996–4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG) (Pgs. 317 and 320-321) 3 – treated under Special Exception (SE) granted by the US FDA (Pg. 320) (Pgs. 315 and 320-321)
======================================
Median Overall Survival from Diagnosis (OSD):
——————————————————————
6.3 years – 6/1/2003 Antineoplastons: Protocols – LOW-GRADE GLIOMA IN CHILDREN 2004 (Pg. 50)
======================================
substantial # Tumor Free:
——————————————————————
5+ years – Antineoplastons (ANP) Targeted Therapy: ASTROCYTOMAS (Pgs. 174 + 177) Treatments for Astrocytic Tumors 3/2006
======================================
substantial number of patients tumor free:
——————————————————————
>5 years – 2006 Antineoplastons (ANP) Long-term follow-up of children with ASTROCYTOMAS (Pg. 174)
======================================
Median Overall Survival Post Diagnosis from initiation of Antineoplastons (ANP) with studies still ongoing:
——————————————————————
5 years – Antineoplastons: (7/31/1996–4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG) (Pgs. 317 and 320-321) 3 – treated under Special Exception (SE) granted by the US FDA (Pg. 320) (Pgs. 315 and 320-321)
======================================
Median Progression-Free Survival (PFS):
——————————————————————
5 years – Antineoplastons: (7/31/1996–4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG) (Pgs. 317 and 320-321) 3 – treated under Special Exception (SE) granted by the US FDA (Pg. 320) (Pgs. 315 and 320-321)
======================================
3 year Progression-Free Survival (PFS) (%):
——————————————————————
9 / 90% – 2006 Antineoplastons (ANP): progressive tumor – Low-Grade ASTROCYTOMA (LGA) in children (Pg. 170)
======================================
3 year Progression-Free Survival (PFS) (%):
——————————————————————
9 / 90% – 2006 Antineoplastons (ANP): progressive tumor – Low-Grade ASTROCYTOMA (LGA) in children (Pg. 170)
======================================
3 year Progression-Free Survival (PFS):
——————————————————————
9 / 90% – 2006 Antineoplastons (ANP) Protocol LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)
======================================
3 year Progression-Free Survival (PFS):
——————————————————————
9 / 68% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006
======================================
3 year Progression-Free Survival (PFS):
——————————————————————
6 / 47% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006
======================================
3 year Progression-Free Survival (PFS):
——————————————————————
47% – 2006 Chemotherapy: vinblastine – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)
======================================
3 years Overall Survival (OS):
——————————————————————
9 / 90% – 2006 Antineoplastons (ANP) Protocol LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)
======================================
3 year Overall Survival (OS):
——————————————————————
9 / 69% – 2000 Chemotherapy: Walter AW, Gajjar A, Reardon DA, et al. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol 2000; 22: 247-51 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Tamoxifen / Carboplatin 2006
======================================
3 year Overall Survival (OS) [%] – Efficacy:
——————————————————————
68% – best other standard treatment study (Pg. 170)
======================================
Tumor Stable after resection:
——————————————————————
27 months (2 years 3 months) – 2006 Surgery and Radiation Therapy (Pg. 171) LOW-GRADE GLIOMA IN CHILDREN
======================================
1 year Overall Survival (OS) [%] – Efficacy:
——————————————————————
10 / 100% – 2006 Antineoplastons (ANP): progressive tumor – Low-Grade ASTROCYTOMA (LGA) in children (Pg. 170)
======================================
1 year Progression-Free Survival (PFS) (%):
——————————————————————
10 / 100% – 2006 best other standard treatment study (Pg. 170)
======================================
1 year Overall Survival (OS):
——————————————————————
10 / 100% – 2006 Antineoplastons (ANP) Protocol LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)
======================================
1 year Overall Survival (OS) [%] – Efficacy:
——————————————————————
96% – 2006 next closest standard treatment (Pg. 170)
======================================
1 year Overall Survival (OS):
——————————————————————
19 / 96% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006
======================================
1 year Progression-Free Survival (PFS) (%):
——————————————————————
9 / 90% – 2006 Antineoplastons (ANP): progressive tumor – Low-Grade ASTROCYTOMA (LGA) in children (Pg. 170)
======================================
1 year Progression-Free Survival (PFS):
——————————————————————
11 / 86% – 1997 Chemotherapy: Packer RJ, Ater J, Allen J, et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997; 86: 747-54 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Carboplatin / Vincristine 2006
======================================
1 year Progression-Free Survival (PFS):
——————————————————————
10 / 51% – 2004 Chemotherapy: Gururangan S, Allen JC, Phillips PC, et al. Phase II study of oral temozolomide (TMZ) in children with progressive low grade gliomas (LGG) [abstract]. Neuro-oncol 2004; 6: 457 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006
======================================
1 year Progression-Free Survival (PFS):
——————————————————————
50+% – 2006 Chemotherapy: temozolomide – Low-Grade ASTROCYTOMA (LGA) (grade 1-2 tumors)
===================================
1 year Progression-Free Survival (PFS):
——————————————————————
9 / 90% – 2006 Antineoplastons (ANP) Protocol LOW-GRADE GLIOMA IN CHILDREN (Pgs. 170 + 176)
======================================
1 year Progression-Free Survival (PFS):
——————————————————————
35 / 76% – 2003 Chemotherapy: Quinn JA, Reardon DA, Friedman AH, et al. Phase II trial of temozolomide in patients with progressive low grade gliomas. J Clin Oncol 2003; 21: 646-51 (Pg. 170 + 175) LOW-GRADE GLIOMA IN CHILDREN – Temozolomide 2006
======================================
# and % of Patients Showing Progressive Disease:
——————————————————————
0 / 0% – Antineoplastons: (7/31/1996–4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG) (Pgs. 317 and 320-321) 3 – treated under Special Exception (SE) granted by the US FDA (Pg. 320) (Pgs. 315 and 320-321)
======================================
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Burzynski: Complete Response, Partial Response, Stable Disease, Progressive Disease, Objective Response, and Response:
https://stanislawrajmundburzynski.wordpress.com/2013/07/04/burzynski-complete-response-partial-response-stable-disease-progressive-disease-objective-response-and-response/
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Burzynski: Progression-Free Survival:
https://stanislawrajmundburzynski.wordpress.com/2013/07/04/burzynski-progression-free-survival/
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