Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate

Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate
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http://www.ncbi.nlm.nih.gov/pubmed/12241121/
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J Neurooncol. 2002 Sep;59(3):239-42
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http://www.ncbi.nlm.nih.gov/m/pubmed/12241121/
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Journal of Neuro-Oncology
Volume 59, Issue 3 , pp 239-242
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http://link.springer.com/article/10.1023%2FA%3A1019905127442
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DOI
10.1023/A:1019905127442
Journal of Neuro-Oncology 59: 239–242, 2002
2002 Kluwer Academic Publishers. Printed in the Netherlands
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Click to access Baker_Complete_response_of_GBM_with_Phenylbutyrate_2002.pdf

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Neuro-Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
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REFERENCES:
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6. Gore SD, SAMID D, Weng LJ: Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells. Clin Cancer Res 3(10): 1755–1762, 1997
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7. Ram Z, SAMID D, Walbridge S, Oshiro EM, Viola JJ, Tao-Cheng JH, Shack S, Thibault A, Myers CE, Oldfield EH: Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate. Cancer Res 54: 2923–2927, 1994
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8. Thibault A, SAMID D, Cooper MR, Figg WD, Tompkins AC, Patronas N, Headlee DJ, Kohler DR, Venzon DJ, Myers CE: Phase I study of phenylacetate administration twice daily to patients with cancer. Cancer 75: 2932–2938, 1995
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9. SAMID D, Hudgins WR, Shack S, Liu L, Prasanna P, Myers CE: Phenylacetate and phenylbutyrate as novel, non-toxic differentiation inducers. Adv Exp Med Biol 400A: 501–505, 1997
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10. Chang SM, Kuhn JG, Robins HI, Schold SC, Spence AM, Berger MS, Mehta MP, Bozik ME, Pollack I, Schiff D, Gilbert M, Rankin C, Prados MD: Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report. J Clin Oncol 17(3): 984–990, 1999

Click to access 984.full.pdf

SAMID D References
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11. Buckner JC, Malkin MG, Reed E, Cascino TL, Reid JM, Ames MM, Tong WP, Lim S, Figg WD: Phase II study of antineoplastons A10 (NSC 648539) and AS2-1 (NSC 620261) in patients with recurrent glioma. Mayo Clin Proc 74(6): 641–642, 1999
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12. SAMID D, Ram Z, Hudgins WR, Shack S, Liu L, Walbridge S, Oldfield EH, Myers CE: Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. Cancer Res 54: 891–895, 1994
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Antineoplastons: Phenylacetylglutaminate (PG or PAG), Phenylacetate (PN), and Phenylbutyrate (PB):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/17/phenylacetylglutaminate-pg-or-pag-phenylacetate-pn-and-phenylbutyrate-pb/
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Phenylbutyrate (PB):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/18/phenylbutyrate-pb/
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Phenylacetate (PN):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/18/phenylacetate-pn/
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Phenylacetylglutamine (PG or PAG):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/18/phenylacetylglutamine-pg-or-pag/
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Burzynski, China, and Dvorit D. Samid:
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https://stanislawrajmundburzynski.wordpress.com/2013/02/21/burzynski-china-dvorit-d-samid/
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Critiquing: Dr. David H. “Orac” Gorski and The Skeptics™ http://www.scienceblogs.com/Insolence
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https://stanislawrajmundburzynski.wordpress.com/2013/08/08/critiquing-dr-david-h-orac-gorski-and-the-skeptics/
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