Stanislaw Rajmund Burzynski, Stanislaw R. Burzynski, Stanislaw Burzynski, Stan R. Burzynski, Stan Burzynski, S. R. BURZYNSKI, S. Burzynski, Arthur Burzynski, Hippocrates Hypocrite Hypocrites Critic Critics Critical HipoCritical
—————————————————————– “Orac” and David H. Gorski, M.D., Ph.D., FACS,
collectively, “GOrac” a/k/a GorskGeek thinks that signs of “Getting Worse is Getting Better” [1]😛
That’s right ! 🙂
I almost couldn’t believe my eyes, but GorskGeek seems to have come around to Burzynski’s way of thinking (according to “Dr.” Bob🙂)
GorskGeek describes it thusly:
—————————————————————– “Conventional cancer treatment can also cause tumors to swell temporarily, due to inflammation”
“A patient who isn’t familiar with this phenomenon may assume her tumor is growing”
“When that swelling subsides, patients may assume it’s because of Burzynski, Adamson says”
“In reality, the tumor was just returning to its previous size”
“Pseudoprogression can be a real confounder in assessing the response of brain tumors to therapy, being observed up to 28% of the time”
—————————————————————–
Here’s how GorskGeek’s“brother” in blatherskite; I’m NOT a doctor, 😷 (but I play one on The Other Burzynski Patient Group), Robert J. (don’t call me “Bobby”) “Bob” Blaskiewicz Blatherskitewicz, describes it [2] 😝:
—————————————————————– 8/27/2012, Monday[2]
“On the 27th, we hear:”
“Firstly, Amelia hasn’t quite been herself unfortunately”
“She has been very reluctant to walk, a lot more tired, slow and pretty lethargic”
“She was sick on Saturday night also”(8/25/2012)
“We are reasonably confident we have probably gone too far with the steroid reduction so we have actually increased these slightly again today”
“We decided we would rather have a happy and more alert Amelia than one who doesn’t want to do too much – so we made this decision today in coordination with the Burzynski clinic“
“We’ll see how she does”
“There is a small chance it is the tumour growing, but much more likely given the scans we have that this is due to swelling of the tumour caused by the treatment”
“Time will tell. […]”
“The symptoms we are seeing right now are a direct result of the tumour, hopefully due to it swelling, and the steroids will fix this”
“They are also what we would see if it has grown”
—————————————————————–
(Below comments by: I’m NOT a doctor, 😷 (but I play one on The Other Burzynski Patient Group), Bob Blaskiewicz 😜)
And here’s another example of something that is…desperately, desperately wrong at the Clinic 😦
The patient is being told that the tumor is swelling because of the treatment 😳
How is it that only at the Burzynski Clinic that getting worse is indistinguishable from getting better?😡
Second point:
this is a tumor on the brainstem
If a possible side effect were swelling of the thing pressing against the brainstem, you’d expect that to be on the informed consent form, right? 😐
The type of thing that would be among the “serious side effects,” right? 😮
—————————————————————–
So, to recap 😄:
—————————————————————— David H. Gorski
• ( “Getting Worse is Getting Better”) 😃
•“Conventional cancer treatment can also cause tumors to swell temporarily, due to inflammation“
—————————————————————– Amelia Saunders
•“ . . . but much more likely given the scans we have that this is due to swelling of the tumour caused by the treatment”
•“The symptoms we are seeing right now are a direct result of the tumour, hopefully due to it swelling . . . ”
—————————————————————– “Dr.” Bob Blaskiewicz (I’m NOT a doctor, 😷 but I play one on The Other Burzynski Patient Group)
• The patient is being told that the tumor is swelling because of the treatment
• How is it that only at the Burzynski Clinic that getting worse is indistinguishable from getting better?
• If a possible side effect were swelling of the thing pressing against the brainstem, you’d expect that to be on the informed consent form, right? “O”
——————————————————————
The problem with this is:
In support of this “phenomenon”, the article provides a link to a Canadian web-site [3] 😶
——————————————————————
The site posits:
—————————————————————— “RT/TMZ is now widely practiced and the standard of care for appropriately selected patients, we are learning more about the consequences of RT/TMZ”
“One phenomena, termed Pseudo-Progression (psPD)…”
——————————————————————
The problem is that this only applies to “Glioblastoma Multiforme (GBM)”, and the article provides NO proof whatsoever, that any of Burzynski’s “Glioblastoma Multiforme (GBM)” patients have taken “RT/TMZ” 😐
——————————————————————
Additionally, the site cites the reference as:
Sanghera, Perry, Sahgal, et al., “Sunnybrook Health Sciences Odette Cancer Centre” (in press, Canadian Journal of Neuroscience)
(“In press” refers to journal articles which have been accepted for publication, but have not yet been published)
However, the journal article in question was published 1/2010, so it has NOT been “in press” for over 3 years and 7 months [4] 😁
Get your act together, aye, CAN-A-DUH! 😇
——————————————————————
☺
😉
—————————————————————–
“He also stated quite frankly during the Google Hangout that nothing will ever change his mind”
—————————————————————— Woo, Bob did NOT provide enough evidence that would cause me to “change my mind”
—————————————————————— “So what’s the point of any further discourse?”
—————————————————————— Woo, the point is, it gives you the opportunity to explain why you lied to The Guardian [2]
—————————————————————— “His idea of “debate” is having critics post comments on his blog; whether that is to drive up page views or merely to seek attention we’ll never know”
—————————————————————— Woo, who suggested leaving comments on my blog ?
Bob ? [3]
9/28/2013 Google+ Hangout
—————————————————————— 1:13:00
—————————————————————— “Okay, I’ll look at that, and I will respond to it once I’ve taken a look at that, okay ?“
“Um, and I’ll respond on your web-site“
“Um, seems only fair“
—————————————————————— 1:14:00
—————————————————————— 2:09:00
—————————————————————— “… and don’t worry I will go to your site and I will comment on on on what you’ve run“
—————————————————————— 2:10:15
—————————————————————— 2:18:00
—————————————————————— “Um, I will look at your web-site, and we will, uh, we, uh, you, oh make sure that I I go to your blog and and I talk there“
—————————————————————— 2:19:00
—————————————————————— “What none of us understands is his motivation”
“I have discussed this privately in e-mails with Bob B. and you, Guy”
“When asked about this during the session on Saturday all he said was that he wanted to correct what he perceives as misinformation from Burzynski critics on social media”
—————————————————————— Woo, you’re obviously NOT from Texas
It’s like a whole ‘notherCountry
My motivation ?
I am a Texan and an American and I do NOT have any respect for individuals who lie about cancer treatment on social media
Verstehen ?
There’s a saying:
“Don’t mess with Texas”
—————————————————————— “It has to go deeper than that”
“He didn’t wake up one day and out of the blue decide he was going to champion Burzynski”
“He has to have some connection, either personal or commercial”
—————————————————————— Woo, you’re still wrong
Prove it
—————————————————————— “The sheer amount of time and effort he’s pored into writing hundreds, if not thousands of comments on science blogs, his rabid attempts to edit Wikipedia and his own blog posts indicates he something invested”
—————————————————————— Woo, why don’t you count the amount of comments I posted on “Orac’s” Respectful Insolence science blog and let everyone know the results ?
—————————————————————— “He denied he works for Burzynski as he stated he doesn’t even live in Texas anymore, but that is irrelevant”
“I don’t believe Marc Stephens lived in Texas for the duration of time he represented the clinic”
—————————————————————— Woo, who cares what you think about Marc Stephens ?
Prove it
—————————————————————— “I wish he would just be honest and tell us why he has spent devoted so much of his time over the past year (almost) promoting and supporting Burzynski (and Merola, for that matter)”
—————————————————————— Woo, where have I been “promoting and supporting” them ?
Everything on my blog is devoted to showing how “The Skeptics™” lie
—————————————————————— “I was going to say it would be hard to go back to calling him an idiot after hearing him speak on Saturday, as he became humanized”
—————————————————————— Woo, I have no problem calling you an “idiot” after you lied about me [2]
—————————————————————— “His folksy “y’all” and his laughter made him a real person”
“He was no longer just words on a screen, but a living, breathing human being”
“However after seeing the Tweets he posted immediately following the Hangout, where he reverted to his juvenile insults, his name-calling, his inability to write a coherent sentence and his out-and-out lack of respect for people like you and Dr. Gorksi has made me reevaluate my stance”
—————————————————————— Woo, please cite one of these “supposed”Tweetsyou have a problem with
Surely you did NOT think I was giving Bobcarte blanche to continue on Twitter without proving his case ?
—————————————————————— “He simply deserves to be ignored”
“He has a serious personality disorder and doesn’t merit any of our attention ever again”
—————————————————————— Woo, my personality is serious enough NOT to lie about people to The Guardian
Do you have a serious “compulsive liar” personality disorder ?
====================================== Guy Chapman – 10/2/2013 – 12:26 am
“He kind of admitted it when he said that he’d be persuaded by the FDA not having granted phase 3 approval; defining your rejection criteria according to some test whose outcome is already know is one of the techniques used by homeopaths”
—————————————————————— Guy, which homeopathic “remedy” has received Orphan Drug Designation (ODD) and FDA Phase 3 approval ?
—————————————————————— “You do not interpret this thing as I would like, therefore you are denying this thing happened, therefore you lie, is another,”
—————————————————————— Guy, what massive cognitive dissonance dreamworld are you living in ?
====================================== Guy Chapman – 10/2/2013 – 12:28 am
“Actually, we know what he is”
“A troll”
“Why did we let ourselves get sucked in?”
—————————————————————— “Troll” is an excusecowards use to try and label someone in order to claim that they should NOT be put in a position to do something they agreed to
====================================== IamBreastCancer – 10/2/2013 – 12:27 am
“Excellent summary, Guy”
“I agree with WooFighter that his motivation is suspect, but there are some desperately lonely attention-seeking people out there who will grasp onto any controversial issue just to get “in the game.””
“As a cancer patient myself, I was struck by the fact that he could yammer on for almost 2-1/2 hours without showing a shred of concern or compassion for cancer patients or legitimate cancer treatment questions”
“His behavior before, during and since the debate clearly shows he absolutely has no regard for real facts or evidence”
“I’m thankful that he’s unable to write coherently, as it cripples his capacity for causing harm to cancer patients”
“Unlike so many other charlatans out there, I don’t think he represents much of a threat to patient safety, just a lot of noise and bandwidth waste”
“His 15 minutes of fame needs to end”
—————————————————————— Quidama, I’m sorry you have cancer, but it sounds to me like you seriously need a “reality check”: [4]
—————————————————————— A. Tried to “control the conversation” 1. Bob Blaskiewicz
2.
—————————————————————— B.Interrupted the other individual the most: 1. 30+ – Bob Blaskiewicz interrupted DJT
2. (20+ back at ya) – DJT interrupted BB
—————————————————————— C.Asked the most questions: 1. Bob Blaskiewicz
2.
—————————————————————— D.Most speaking time: 1. Bob Blaskiewicz
2.
—————————————————————— E.Most words: 1. 13,933 – Bob Blaskiewicz
2. 8,847 – DJT
—————————————————————— F.Most characters: 1. 66,123 – Bob Blaskiewicz
2. 43,245 – DJT
—————————————————————— G.Acted as if they were teaching a class, and dictating what your possible responses were, implying that they did NOT consider this to be a “debate” where the participants were free to choose their own responses: 1. Bob Blaskiewicz
2.
—————————————————————— H.Proved they do NOT know how to debate 1. Bob Blaskiewicz
2.
—————————————————————— I.Proved they do NOT have manners 1. Bob Blaskiewicz
2.
—————————————————————— J.Must have thought they were on the Morton Downey Jr. talk show (or do you prefer Jerry Springer ?) 1. Bob Blaskiewicz
2.
—————————————————————— K.Controlled themself best:
1. 2. DJT
—————————————————————— L.Did NOT need help from any pro-position pundits
1. 2. DJT
—————————————————————— “Thanks for all you do!”
—————————————————————— You’re welcome
[1] – 9/19/2013 – “Americans love to fight, traditionally”
“All real Americans love the sting and clash of battle…When you, here, everyone of you, were kids, you all admired the champion marble player, the fastest runner, the toughest boxer, the big league ball players, and the All-American football players”
“Americans love a winner”
“Americans will not tolerate a loser”
– General George S. Patton, Jr., June.5, 1944
The above might as well be Greek to Dr. David H. Gorski a/k/a “Orac”
He’s the epitome of the word “loser”
Indeed, “Orac” described his work-place nemesis as “user hostile”
After 5 years, he still didn’t fully understand much of it, and he claims he’s not exactly computer illiterate
Gorski is that “guy” who couldn’t even find Burzynski’s publication:
[2] – 1997 – Burzynski. S.R. Antineoplastons. oncogenes and cancer
[3] – “Orac” batted the big “O” when he tried to find “the scientific rationale to expect that” antineoplastons “might have antitumor activity”
[4] – Gorski was geniusless when it came to finding “which genes are targeted by antineoplastons,“proving that he really does NOT know Burzynski’s personalized gene-targeted therapy
In fairness, I will point out that he hasn’t put the time in to learn all the ins and outs of the system …
He pontidefecates about phase II clinical trials when his name isn’t even on a phase 2 trial, too
[5] – 9/19/2013 – He’s the “guy” who’s “mystified” as to how Stanislaw Burzynski “has managed to keep practicing for 36 years after he first began treating patients with an unapproved (not ordinary) chemotherapeutic drug (the concoction of peptides purportedly isolated from blood and urine that Burzynski dubbed “antineoplastons” because of their alleged ability to inhibit the growth of cancer)”
This is not an issue unique to Gorski; I’ve discussed other cases like this, such as Bobby Blaskiewicz, who used his man-crush relationship with Gorski to appear on the Skeptic Canary Show; Davey James, who was only recently stripped of his license to practice in several states of mind; Adam Jacobs, who went so far as to use his business influence to alter his Dianthus Mediclueless web-site in London to be more hack friendly, and an interventist who administered twerkpidity to posers who didn’t have common sense and defrauded minions for tens of millions of minutia
It’s a general problem
However, as far as doctors who should have been shut down a long time ago, “Orac” takes the cake
[6] – He has NOT yet figured out that Burzynski learned from the best
[7] – Who could do it better than someone like Dr. Michael A. Friedman, Associate Director, Cancer Therapy Evaluation Program (CTEP), Division of Cancer Treatment (DCT), National Cancer Institute (NCI), Department of Health & Human Services (HHS), Public Health Service, National Institutes of Health (NIH) who Burzynski had to deal with:
“This is, as you point out, a most serious matter, and I was hoping that you could allay my concerns by showing me where they are unfounded“
“However, your letter conspicuously fails to address them“
“You also make reference to “numerous factual misstatements” but fail to identify any of them, much less provide documentation to show they are false”
Pg. 2
“I am glad that you plan to “thoroughly examine the accusations” I have made”
“I also eagerly await a substantiative response to the points raised in my letter of 4/20/1995”
After all, can we really take a person seriously, who claimed:
—————————————————————— [8] – 11/2/2012 – “Personally, having pored over Burzynski’s publications … “
—————————————————————— [9] – 5/8/2013 – “I’ve searched Burzynski’s publications … “
—————————————————————— [10] – 6/5/2013 – “ … I do know cancer science”
—————————————————————— Uhhhhhhh … yeah
But do you really know Burzynski’s cancer science when you did NOT even know:
“which genes are targeted by antineoplastons“?
Has “GOraCON” (“Orac” + @Gorskon) even read these ?
—————————————————————— [11] – 10/2003 – Waldbillig R, Burzynski SR. Mechanism of action, uptake, and gene array studies on the antineoplastic agent phenylacetylglutamine (PG) in human glioma cells U-87. Neuro-Oncology. 2003; 5: 309
Volume 5 Issue 4 October 2003
(genes CD38, OASL, and TCF8)
—————————————————————— [12] – 10/2007 – Patil, S., Burzynski, S.R., Mrowczynski, E., Grela, K. Phenylacetylglutamine (PG) and phenylacetate (PN) interact additively to produce detachment-induced apoptosis/anoikis in glioblastoma cells. Neuro-Oncology 2007; 9:482
Volume 9 Issue 4 October 2007
We have conducted a total human gene array screen using the Affymetrix Human Genome plus 2.0 oligonucleotide arrays, for genes regulated by PG and a combination of PG and PN
gene TXNIP was up-regulated almost 5-fold with PG, and almost 120-fold using a combination of PG and PN
genes that are significantly up-regulated are CLDND1, ATF3, CASP5, TP53, TRIB3, and UNC5B
Genes that were down-regulated include AKT2, ASPM, CDCA8
(caspase 5, p53, netrin receptor) and AKT pathway (AKT2, TRB3)
—————————————————————— [13] – 10/2008 – Patil, S., Burzynski, S., Chittur, S., Mrowczynski, E., Grela, K. Antineoplaston AS2-1 affects cell cycle checkpoints, leading to apoptosis in human glioblastoma cells. Neuro-Oncology 2008; 10:786
Volume 10 Issue 5 October 2008
Affymetrix Human Genome
CDCs 25A and 25B, cyclins D3 and E, and CDKs 3, 4, and 6
ORC1L and CDC6
MCMs 2, 3, 4, 5, 6, and 7, and CDC7
cyclins A, B1, and B2, polykinase 1, and CDKs 1 and 2
MAD2L1, BUB1 and CDC20
p21, p53, and GADD45A
p21/CDKN1A, and PPM1A
Based on pathway analysis, it was observed that anti-neoplastons affected the expression of more than 40 genes instrumental in the cell cycle in GBM cells
—————————————————————— [14] – 12/2008 – Patil, S., Burzynski, S., Chittur, S., Mrowczynski, E., Grela, K. The ingredients of antineoplaston AS2-1 down-regulate glycolysis pathways in glioblastoma cells. Neuro-Oncology 2008; 10:1148
Volume 10 Issue 6 December 2008
In 2004 the FDA granted orphan drug designation for antineoplastons A10 and AS2-1 for the treatment of brainstem glioma
12 FDA-supervised phase II clinical trials have confirmed anti-tumor efficacy in several types of brain tumors
A total human gene array screen using the Affymetrix Human Genome
The expression of mRNA for vitamin D3 up-regulated protein 1 (VDUP1) was found to be over 100 fold higher for cells treated with PG and PN
succinate dehydrogenase C (SDHC), fumarate hydrogenase (FH), succinate-CoA ligase 1 and 2 (SUCLG1and 2), and aconitase 2 (ACO2)
—————————————————————— [15] – 11/2010 – Patil S, Burzynski SR, Mrowczynski E, Grela K. Targeting MicroRNAs in Glioma Cells with Antineoplastons. Neuro-Oncology 2010; 12, iv10
Volume 12 Supplement 4 November 2010
This study was done using the Dharmacon mRNA profiling array (Thermo Fisher Scientific)
mRNAs 125a-5p and 125a-3p
mRNAs 125a-5p has recently been shown to be regulated by the epidermal growth factor receptor and to function as a tumor suppressor in lung cancer
It has also been shown that the over-expression of mRNA 125a or mRNA 125b caused reduced migration and invasion of SKBR3 breast cancer cells
Using the total human microarray screen (Affymetrix)
AKT2
—————————————————————— [16] – 6/2012 – Sonali, S. Patil, Stanislaw R. Burzynski, Emilia Mrowczynski, Krzysztof Grela, Sridar V. Chittur. Phenylacetylglutaminate and Phenylacetate in combination Upregulate VDUP1, cause cell cycle blockade and Apoptosis in U87 Glioblastoma cells. Journal of Cancer Therapy 2012;3:192-200
—————————————————————— [17] – 9/2012 – Patil, S., Burzynski S.R., Mrowczynski, E., Grela, K. P.003. Phenylacetylglutaminate in combination with Phenylbutyrate effectively inhibits growth of brain tumor cell In Vitro. Neuro-Oncology 2012;14(Suppl. 3):iii16
Volume 14 Supplement 3 September 2012
The FDA granted Orphan Drug designation for Antineoplastons A10 and AS2-1 for the treatment of gliomas, in 2009
12 FDA-supervised Phase II clinical trials have confirmed anti-tumor efficacy in several types of brain tumor
AKT2
PG is not toxic to normal cells whereas PB has dose-limiting neuro-cortical toxicity
—————————————————————— Cancer care: Is the system “in crisis” ?
The Institute of Medicine, just in case you’re like “Orac” and have NOT yet figured it out, “the system” has been “in crisis” since the Gubment“forgot”who they are here to serve
[18] – Gorsi, maybe you can explain to The Institute of Medicine why the Cancer care system is “in crisis” because M.D.’s with Ph.D’s who hold positions “at an NCI-designated comprehensive cancer center,”are responsible for massive fact-checking #FAILS
——————————————————————
Journal of Cancer Therapy, 2012, 3, 192-200
doi:10.4236/jct.2012.33028 Published Online June 2012
5. Acknowledgements
This study was supported by and carried out at the Burzynski research Institute (BRI), Houston TX, USA. The Microarray assay was supported by BRI and carried out at Center for Functional Genomics, University of Albany, NY, USA
====================================== [17] – 9/2012
——————————————————————
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