Wikipedia or Wikipediantic ? – wants your 3 pounds of flesh (WikiPEEdia, UR all INe)

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[WP:SOP] Statement of principles from Wikipedia founder Jimbo Wales, as updated by the community since then. 7.”)

Due & undue weight: [3]

“The relative prominence of each viewpoint among Wikipedia editors or the general public is not relevant & should not be considered,”

[WP:NPOV] “History of NPOV:” (Content # 6, Note 3)

(Neutral Point of View)
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TRANSLATION: Wikipedia editors, YOUR OPINION IS NOT RELEVANT
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MEANING: It is meaningless to attempt to slather your biased OPINION all over Wikipedia like butter on Texas toast, since supposedly, we only care about verifiable FACTS
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Wikipedia, what the problem is ?

Jimmy Donal Wales

Who ?

No, “The Who” is actually really British !

(as opposed to some “furreigner” who plops across the pond, wants to pound one of your pelts after a celebrity hunt, pops it in his bonnet, pip-pips about, and mounts it up on his rented wall along with what’s left of his balls)

I’m writing, of course, about “Jimbo,” the one who got away . . . Thankfully

The recipient of the write-up earlier this year in The New York Times [1] (Oh, pithy !!)
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Wales, who no longer runs the day-to-day operations of Wikipedia

“He applies his libertarian worldview to the Internet and has taken on institutions like the United States government
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You must be bloody well right joking me

(joking me ? Quit jokin’ me !)

JimCrow’s ’bout as “libertarian” as Fidel Castro with a gun in his hand and (f)lies between his teeth; from traveling with the windows down

Stephen Colbert shoulda seen that comin’ from a 8 mile away

Hey Stephen, Report’ THAT !!!
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“He grew up in Huntsville, Ala., the son of a teacher and a retail man
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And obviously, he didn’t “learnt” well

I think a refund’s in order

And here’s your free school Insolence to go with it

Happy eat in’

It is claimed that “HE” spends time:
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“traveling the world giving talks on free speech and Internet freedom
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seriously ?

Seriously ??

SERIOUSLY ???

Welcome to MizFitTV

What would “Jymboree” know about “free speech” and “Internet freedom,“ anyway ?

How many days did you serve your country in the United States military ?

Oh, you did NOT realize that while you were in San Diego, you could have signed that contract ?

After all, he’s no Vincent Kennedy McMahon”
(“HE” knows where “HIS” GRAPEFRUITS are)
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“B.D.F.L., or the Benevolent Dictator for Life”
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How ’bout:

Big
Disappointing
Fascist
Loser ?
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Argumentum ad Jimbonem” means dutifully following what Wales says, but there are even arguments about that”
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WP:NICETRY, but that’s “SHEEPLE”
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“One Wikipedia editor said, for instance, that Wales was no longer comfortable with the B.D.F.L. description”
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Jiminy Cricket !

Whazzamatta Jiminy?

Did “FASCIST” hit a bit too close to home ?
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“(There is, among some, a debate over what to call him)”

“Some users have also disputed the Latinized version of “Jimbo.”

“(Should it be “Jimboni” or “Jimbini”?)”
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Can you smell what “The Rock” is cookin’ ?

La-La-La-La-Laaaaaaawwww, JIMBRONI !!!!!!!

Get ready, and bend over, ’cause I’m gonna shine this thing up, turn it sideways, and shove it straight up your Candy AstroTurf hatch
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Introduction (statement of principles) [WP:SOP]

“This is a statement of principles from Wikipedia founder Jimbo Wales, as updated by the community since then”
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(Or if you go by The New York Times article, [1] Jimbroni is the co-founder” who tries to re-write history to make it appear that “HE” is the one-and-only Fascist Founder ?)
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“I should point out that these are my principles, such that I am the final judge of them”

This does not mean that I will not listen to you, but it does mean that at some ultimate, fundamental level, this is how Wikipedia will be run”
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No, actually, it DOES mean that he will NOT listen to you, as was the case when he ignored my 2/7/2013 appeal

In his defense, perhaps Kate Garvey has his balls
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Principles

1. “Wikipedia’s success to date is entirely a function of our open community”

“This community will continue to live and breathe and grow only so long as those of us who participate in it continue to Do The Right Thing

Doing The Right Thing takes many forms, but perhaps most central is the preservation of our shared vision for the neutral point of view policy and for a culture of thoughtful, diplomatic honesty
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The problem with this Wacky Tobacky “We are the (Wiki) World” WikiWhOReD Wonderland Jimbroni’s living in, is that “HE” has NOT been Doing The Right Thing since “HE” abdicated “his” “neutral point of view policy” and “culture of thoughtful, diplomatic honesty,” to “The Skeptics”

“The Skeptics,” who serve as gatekeepers of the Burzynski Clinic article, and who cite Dr. David H. Gorski a/k/a “Orac” aka GorskGeek as if he were a “reliable source”

“The Skeptics,” who bring new meaning to the term “Wikipedia Zero”

“The Skeptics,” who are Intellectual Cowards like their false god Gorski, the Closet Communist of Science-Based Medicine a/k/a Science-Basted Medicine aka Science-Based Mudicine (Spinning Bowel Movement), Wiki Wordsmith Wannabes, nut-jobbers, stale from their failure at the National Peanut Festival in Dothan, Alabama
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3. ““You can edit this page right now” is a core guiding check on everything that we do”

“We must respect this principle as sacred”
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Do the lies just dribble off your chin like phlegm?

You canNOT just go in and “edit” the Burzynski Clinic article “page right now”

That statement is pure, unadulterated Alabama B.S.

That’s NOT a “sacred principle,” it’s sacré “bull”
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7. “Anyone with a complaint should be treated with the utmost respect and dignity”
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Unfortunately, you do NOT practice what you preach, do you, HYPOCRITE ?
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“They should be encouraged constantly to present their problems in a constructive way”
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So that you can ignore the problem(s), right, Jimbroni ?
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“Anyone who just complains without foundation, refusing to join the discussion, should simply be rejected and ignored”
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THAT would automatically exclude all of “The Skeptics” now, wouldn’t it ?
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“We must not let the “squeaky wheel” be greased just for being a jerk
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Jimbroni, why have you allowed “The Skeptics” to choose from their “squeaky” wheel-house bag o’ tricks, get all “greased” up and jerk” so many people around in such a big CIRCLE-JERK, for so long?
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8. “Diplomacy consists of combining honesty and politeness

“Both are objectively valuable moral principles”

“Be honest with me, but don’t be mean to me”

“Don’t misrepresent my views for your own political ends, and I’ll treat you the same way”
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“Honesty” and “politeness” are really great buzzwords,” Jimbroni, but they are as foreign to your “Skeptics,” as “moral principles”
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A great example of the questionable “honesty” and “moral principles” of one of your apparatchiks, was demonstrated 2/3/2013, 6:56, when I sent an arbitration appeal e-mail to Wikipedia, advising, in part, that the e-mail listed on Wikipedia; as the one that blocked users should use, did NOT work, because there was NO “@” sign in it

There was a . (period) where the “@” sign belonged
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2/3/2013, 8:11 AM, Anthony (AGK) BASC
wikiagk@gmail.com
advised:

“Everything you have said in that e-mail demonstrates a misunderstanding or misreading of Wikipedia policy”
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Check the “time” and “place” where you are, so that you, too, can advise, that according to Wikipedia, pointing out to them that the e-mail they advise people to use, DOES NOT WORK; because there is no “@” sign in it (instead, there’s a . (period)), translates into meaning:
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“Everything you have said in that e-mail demonstrates a misunderstanding or misreading of Wikipedia policy”
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Core principles

Wikipedia:Simplified ruleset [WP:SR]

Wikipedia does not have its own views, or determine what is “correct”
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I wish I could LIE like that, but I have a conscience
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12/24/2012, Monday – 3:52 pm – 21:52 (UTC) –
“We are told that 2013 will be a big year, but apparently his plan is to release another bullshit movie not to publish useful research”

[User Talk:JzG|Guy] ([User JzG/help|Help!]) [2]

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“Bullshit movie” ?
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Does anyone other than me NOT think it a “coinkydink” that some “Guy” on Wikipedia, going by the name “Guy”, using the same 2 words (“Bullshit movie”) as a “Guy” on Twitter ?
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2. Founding principles:

“Neutrality is mandatory . . . “
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I call B.S.

Neutrality is mandatory,” EXCEPT on the Burzynski Clinic article, controlled by “The Skeptics”
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4. “Ignore all rules (IAR):”

“Rules on Wikipedia are not fixed in stone”
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Especially when Jimbroni allows “The Skeptics”
to “dictator” the “rules”
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“The spirit of the rule trumps the letter of the rule

“The common purpose of building an encyclopedia trumps both”

“This means that any rule can be broken for a very good reason, if it ultimately helps to improve the encyclopedia”
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And “The Skeptics” are NOT required to provide ANY reason for having broken “any rule”
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“It doesn’t mean that anything can be done just by claiming IAR, or that discussion is not necessary to explain one’s decision”
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But do NOT expect Wikipedia to require anything from The Skeptics”
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Founding principles

1. “Neutral point of view (NPOV) as a mandatory editorial principle”
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EXCEPT when it comes to the Burzynski Clinic article
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12/26/2012 – I attempted to get Wikipedia to reference the interview which Burzynski’s attorney, Richard (Rick) A. Jaffe, and Lola Quinlan’s attorney; who posted it on his web-site, had given: [4]

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Please add re WP:NPOV that Burzynski’s attorney, Richard Jaffe has disputed Lola Quinlan’s claims:

“On February 1, 2012, Dr. Burzynski’s attorney, Richard Jaffe, disputed Lola Quinlan’s allegations on Houston’s KPRC News.”

Thank you very much.[[User: Didymus Judas Thomas 15:03, 12/26/2012 (UTC)
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So? [OR] Disputing it in the media probably means he doesn’t have a case. [/OR] In any case, a lawyer disputing the allegations against his client is not even news. — [[User: Arthur Rubin 15:24, 12/26/2012 (UTC)

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Arthur Rubin, I’m not sure what relevance your above post has re WP:NPOV since the article includes statements from attorneys representing both sides

17:51, 12/27/2012 (UTC) Didymus Judas Thomas

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12/24/2012, Monday – 3:54 pm (21:54.UTC) – “What they mean is that nobody else is doing any meaningful work on it, which necessarily means that it’s not considered in the least promising.”

[[User Talk:JzG|Guy]] ([User JzG/help|Help!])

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“Nobody else is doing meaningful work on it” ?

Ignores independent research done in Poland, Russia, Korea, Egypt, Japan, & China which specifically reference SRB’s publications in their publications re antineoplastons & phenylacetylglutamine (PG); which is AS2-5, & includes phase III trials published in China & continued research being published in China 12/17/2012?

FACTS:

1. I pointed out to Wikipedia, a 12/17/2012 scientific publication re antineoplastons, which referenced Burzynski @ 22. (antineoplaston AS21)

2. 7 days after this scientific journal was published, Wikipedia’a “Guy (Help!’s) ”response, Monday, 12/24/2012 @ 3:54 pm, is to advise me:

“What they mean is that nobody else is doing any meaningful work on it, which necessarily means that it’s not considered in the least promising.”

Guy (Help!) 3:54 pm, 12/24/2012, Monday

3. So, Wikipedia’s, Guy (Help!), defines an event having been published 7 days ago (12/17/2012 to 12/24/2012) as:

“…nobody else is doing any meaningful work on it…”

12/17/2012
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524164
CDA-2 (cell differentiation agent 2), a URINARY preparation
http://po.st/g71N8P
CDA-2 and its main component PHENYLACETYLGLUTAMINE (PG or PAG)
Antineoplaston AS2-5 is PHENYLACETYLGLUTAMINE (PAG or PG)
http://redd.it/1dk974
Antineoplaston AS2-1 is a 4:1 mixture of phenylacetic acid (PA) and PHENYLACETYLGLUTAMINE (PAG or PG)
Antineoplastons AS2-5 and AS2-1 are derived from Antineoplaston A10
BURZYNSKI Reference: 22.
antineoplaston AS21
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117
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12/26/2012, Wednesday – 12:43 – “There is unlikely to be any dispassionate debate over ANPs while Burzynski continues with his unethical practices.”

JzG|Guy User:JzG/help|Help!

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Wikipedia: Judge, Jury, Executioner
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“The world, right now, considers Burzynski to be at best unethical and at worst a quack…”?

Since when did Wikipedia conduct a world-wide “opinion poll” re Burzynski ?

And if Wikipedia is correct, how did this happen ?

Burzynski referenced by other Cancer researchers:

2011 – Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas
http://neuro-oncology.oxfordjournals.org/content/13/3/298.full
University of California—San Francisco

Children’s Hospital Boston, Massachusetts

St Jude Children’s Research Hospital, Memphis, Tennessee

Seattle Children’s Hospital, Seattle, Washington

Children’s Hospital of Philadelphia, Pennsylvania

Children’s Hospital of Pittsburgh, Pennsylvania

Children’s National Medical Center, Washington, DC

Cincinnati Children’s Hospital Medical Center, Ohio

Neuro Oncol (2011) 13 (3): 298-306
doi: 10.1093/neuonc/noq202

5.723 Impact Factor

25. ↵ Burzynski SR
Treatments for astrocytic tumors in children: current and emerging strategies
Paediatr Drugs. 2006;8:167-178
http://link.springer.com/article/10.2165%2F00148581-200608030-00003
Pediatric Drugs
May 2006, Volume 8, Issue 3, pp 167-178
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Rhode Island Red attempts to get away with misquoting me:
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“The other argument is that the secondary sources (i.e., respected cancer organizations, FDA, etc.) are not reliable because they are Burzynski’s “competitors”

[[User: Rhode Island Red]] 4:18 pm, Yesterday (UTC−6)
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What a Wipocrite (Wiki + Hypocrite)

Steve Pereira (SilkTork) is such a “WIPOCRITE,” that he claims:
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“the community were united that your contributions were biased”
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He conveniently; like a good little mini-Jimbroni would, ignores ALL of his fellow WIPOCRITES comments, which completely ignored:
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([WP:SOP] Statement of principles from Wikipedia founder Jimbo Wales, as updated by the community since then. 7.”)

Due & undue weight: [3]

“The relative prominence of each viewpoint among Wikipedia editors or the general public is not relevant & should not be considered,”

[WP:NPOV] “History of NPOV:” (Content # 6, Note 3)

(Neutral Point of View)
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1. 12/24/2012, Monday – 3:52 pm – 21:52 (UTC) – “We are told that 2013 will be a big year, but apparently his plan is to release another bullshit movie not to publish useful research”
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2. 12/24/2012, Monday – 3:54 pm (21:54.UTC) – “What they mean is that nobody else is doing any meaningful work on it, which necessarily means that it’s not considered in the least promising.”
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3. 12/26/2012, Wednesday – 12:43 – “There is unlikely to be any dispassionate debate over ANPs while Burzynski continues with his unethical practices.”
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4. 12/30/2012 8:58 “The world, right now, considers Burzynski to be at best unethical and at worst a quack…”?
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Am I NOT the only one convinced that “the community” was also “united” in something more than just their “goose-stepping ?
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Pereira, the imperfect ‘pedia Pimp tries to Wow his readers by waxing WikiWhOReD, by ignoring that ALL the previous BIASED opinion B.S. that his fellow-Facist forged ahead with, and which Wikipediantic history says means ABSOLUTELY NOTHING (say it again) because it is their BIASED OPINION and is ABSOLUTELY WORTHLESS, and it was as so much WikiLitter, well, he’s just facist-free speechless about that, as any Jimbroni AstroTurf Twerk should be
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To show exactly what zealots these WikiPimps are, just absorb this exchange:
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“The Burzynski Clinic Article has:

“…a Mayo Clinic study found no benefit….”

But that was not what the study concluded

See below:
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“CONCLUSION:

Although we could not confirm any tumor regression in patients in this study, the small sample size precludes definitive conclusions about treatment efficacy.”
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In the interest of Neutrality, please remove the reference to Mayo entirely or change to;
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“…a Mayo Clinic study found that “the small sample size precludes definitive conclusions about treatment efficacy.”
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Thank you very much

Didymus Judas Thomas 21:12, 12/10/2012
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“How is “found no benefit” not a a fair and pithy description of the Mayo Clinic study’s summary?”

Alexbrn 21:24, 12/10/2012
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“I feel this should be changed under WP:NPOV because not every reader is going to understand the “Fair & Pithy” reason I was provided

I feel that the average reader reading this will read it as meaning a study was done & completed with the necessary # of people for an effective study, when that was not the conclusion as pointed out in my above post

Thank you very much.”

Didymus Judas Thomas 11:02, 12/18/2012
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NO RESPONSE

That’s right !

“NO RESPONSE” from the “mini-b” (a/k/a “mini-brain”), wannabe Fascists who are so zealous about using their alleged “Fair and Pithy” “found no benefit” WikiWhOReD; which they utilize in an effort to deceive those who are NOT smarter than a fifth-grader

These WikiPimps are so certain of the righteousness of their evangelical cause, that they do NOT even have the “GRAPEFRUITS” to use what the study’s conclusions actually said, and let the chips fall where they may

There are a lot of “chips” falling at Wikipedia

“BULL CHIPS”

JIMBRONI, you’re no Maggie Thatcher

You can’t even wear her pants
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Margaret Thatcher: “The Iron Lady”

Jimbroni: “No iron in the pants”
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Jimbroni’s list of Facist, mini-Hitler, Monty Pythonesque Women’s underwear wearing Wannabes on Wikipediantic:

1. Alexbrn
2. fluffernutter
3. NE Ent
4. Choyoołʼįįhí:Seb az86556 (Seb az86556)
5. Tom Morris
6. Guerillero
7. Dave Dial
8. John
9. Nstrauss
10. Yobol
11. Drmies
12. foxj
13. Ironholds
14. Rhode Island Red
15. Anthony (AGK) BASC wikiagk@gmail.com
16. Steve Pereira (Silk Tork) silktork@gmail.com
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WikiWhOReD (Wiki + Word + Whore): Pimping a word. Attempting to deceive someone by means of misdirection with words
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The South will rise again, just not in Jimbroni’s pants
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Happy Friday the 13th, Wikipediantic
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REFERENCES:
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[1] – 6/27/2013Jimmy Wales Is Not an Internet Billionaire (By AMY CHOZICK):
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http://mobile.nytimes.com/2013/06/30/magazine/jimmy-wales-is-not-an-internet-billionaire.html
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[2] – 12/24/2012, Monday – 3:52 pm – 21:52 (UTC) – [User Talk:JzG|Guy] ([User:JzG/help|Help!])
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http://en.wikipedia.org/w/index.php?title=Talk:Burzynski_Clinic&diff=next&oldid=529537854
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[3] – 12/26/2012Lola A. Quinlan:
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http://en.wikipedia.org/w/index.php?title=Talk:Burzynski_Clinic&diff=prev&oldid=529836971
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http://en.wikipedia.org/w/index.php?title=Talk:Burzynski_Clinic&diff=next&oldid=529836971
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Houston’s KPRC News:
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http://m.click2houston.com/news/Houston-cancer-doctor-draws-new-complaints-from-patients/-/16714936/8581480/-/hmrbjk/-/index.html
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Lola A. Quinlan’s attorney’s web-site:
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http://www.jag-lawfirm.com/burzynski-suit-kprc-02012012.html
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[4] –
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http://en.wikipedia.org/w/index.php?title=User_talk:Didymus_Judas_Thomas&diff=next&oldid=528610760
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These mini-b’s went so far as to allege all sorts of sockpuppetry

Wikipediantic, why don’t you list all the dates and times I was supposedly doing all of these activities; and don’t forget to include all the time I spent blogging, on Twitter, making comments on articles, etc., and once you have all that data compiled, explain how one individual could do all that in a 24-hour day

That’s right Wikipediantic

I’m challenging you to put up or shut up your cornholio

Critiquing the Critics on Orac’s Respectful Insolence blog: Part III

Burzynski: Cancer is Serious Business, Part II
http://scienceblogs.com/insolence/2013/03/14/five-things-i-learned-second-hand-from-the-recent-screening-of-burzynski-cancer-is-serious-business-part-2

#37 – Denice Walter – March 14

“Milk kills”

Yes, it does:
https://www.google.com/search?q=%22Milk+kills%22&hl=en&client=safari&tbm=isch&tbo=u&source=univ&sa=X&ei=gXFIUZOHOvi04APZ24DoCQ&ved=0CDIQsAQ&biw=320&bih=416

#38 – Sirhcton – March 14

“. . .he’s never, despite having had over 60 phase II trials, published a complete phase II trial. . .

To abuse a meme: “I don’t have to show you any stinkin’ data!”

Just continue to do what you do best … ignore the information that is already out there:

2/24/2013
http://www.skeptical.gb.net/blog/?p=1442

2/27/2013
http://www.skeptical.gb.net/blog/?p=1798

3/9/2013
http://www.thetwentyfirstfloor.com/?p=8001

#41 – Krebiozen – March 14

“Denice,
to Mikey, ‘guns don’t kill people, processed milk kills people’”

You should really enjoy THIS, then:

#42 – Bob G Los Angeles – March 14

To Herr Doktor:

“The next time they do one of these B2 shows, where they screen the film and take questions, why doesn’t somebody just ask for the data right then and there — How many patients over the course of the years, including the fraction who are still alive, the fraction who died, and the fraction whose survival is unknown?

They will get used to hearing that question and do their best to adapt, but just making stuff up will have consequences of its own”

Why not just ask Dolcefino ?

#43 – Mark Thorson – March 14

“I have never heard of ANTINEOPLASTONS,” said Yu Xiong, deputy president of the Shanghai Institute of Pharmaceutical Industry”
http://usa.chinadaily.com.cn/china/2012-02/02/content_14528005.htm

Why should we care what Yu Xiong knows or does NOT know?
http://www.zoominfo.com/#!search/profile/person?personId=596114575&targetid=profile

With a population of 1,344,130,000 – 2011, I guess he does NOT keep up with:

10/29/2010 – ANTINEOPLASTONS:

New Perspectives on Innovative Drug Discovery: An Overview

CHINA:
Beijing University of Chinese Medicine

Hong Kong Baptist University

Chinese Academy of Medical Science & Peking Union Medical College

Hong Kong Polytechnic University

Hong Kong University of Science & Technology

9/1/2010 Received
9/22/2010 Revised
10/28/2010 Accepted
10/29/2010

(pg. 8 of 22 – actual pg. 457)
Human-derived compounds – ANTINEOPLASTONS and CDA-2

Urine and urine extracts have been used for therapeutic purposes for centuries, and the first identified active componentis 3 – phenylacetylamino – 2, 6 – piperidinedione (also called ANTINEOPLASTON A10)
http://ejournals.library.ualberta.ca/index.php/JPPS/article/download/9147/7453

10/1/2010 – ANTINEOPLASTON A10 – CHINA
http://www.springerlink.com/content/tj0177485773007t

(S)-2-((S)-2-(4-(3-[18F]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with 18F
http://link.springer.com/article/10.1007%2Fs10967-010-0633-2?LI=true

Journal of Radioanalytical and Nuclear Chemistry
October 2010, Volume 286, Issue 1, pp 135-140
DOI 10.1007/s10967-010-0633-2

CHINA:
Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing

PET Center of Xuan Wu Hospital, Beijing

Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing

#Burzynski References: 5. – 6.

As degradation product of ANTINEOPLASTON A10 in vivo, phenylacetyl glutamine (PG) showed antitumor activities

According to literatures, we designed and radiosynthesized a phenylacetyl glutamine (PG) derivative, which was achieved under a mild reaction condition

Evaluations in vitro and in vivo were performed on tumor bearing mice

Excitingly, the radiochemical purity was 98%, and besides the best radiochemical yield was up to 46%

it showed satisfied stability in vitro and in vivo

the results revealed it might become a potential PET imaging agent for detecting tumors

4/15/2009 – ANTINEOPLASTON AS2-5 – CHINA
3/14/2008 – Epub

http://www.ncbi.nlm.nih.gov/m/pubmed/19339187

Bioorg Med Chem. 2009 Apr 15;17(8):3061-71. doi: 10.1016/j.bmc.2009.03.017. Epub 2009 Mar 14
Bioorganic & Medicinal Chemistry
Volume 17, Issue 8, 15 April 2009, Pages 3061–3071

School of Pharmaceutical Sciences, Shandong University, No. 44 WenhuaXi Road, Ji’nan, Shandong Province, PR CHINA

Novel aminopeptidase N inhibitors derived from ANTINEOPLASTON AS2-5 (Part II)
http://www.sciencedirect.com/science/article/pii/S0968089609002478

4/15/2009 – ANTINEOPLASTON AS2-5 – CHINA
3/6/2009 – ePub

http://www.ncbi.nlm.nih.gov/m/pubmed/19329328
Bioorg Med Chem. 2009 Apr 15;17(8):3053-60. doi: 10.1016/j.bmc.2009.02.063. Epub 2009 Mar 6
Bioorganic & Medicinal Chemistry
Volume 17, Issue 8, 15 April 2009, Pages 3053–3060

School of Pharmaceutical Sciences, Shandong University, No. 44 WenhuaXi Road, Ji’nan, Shandong Province, PR CHINA

Novel aminopeptidase N inhibitors derived from ANTINEOPLASTON AS2-5 (Part I)
http://www.sciencedirect.com/science/article/pii/S0968089609002041

2007- ANTINEOPLASTON A10 – CHINA
http://ar.iiarjournals.org/content/27/4B/2427.short

Induction of apoptosis in human hepatocellular carcinoma cells by synthetic ANTINEOPLASTON A10

ANTICANCER RESEARCH 27: 2427-2432 (2007)

1/24/2007 Received
3/27/2007 Accepted

School of Pharmaceutical Sciences, Shandong University, Jinan

Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, CHINA

Department of Applied Biochemistry, Tokai University, Kanagawa

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery,
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

http://ar.iiarjournals.org/content/27/4B/2427.full.pdf

Burzynski References: 1, 3, 5, 13 and 15
Egypt ANTINEOPLASTON A-10 References: 2 and 20

1990 – ANTINEOPLASTON A10 – CHINA
http://www.ncbi.nlm.nih.gov/m/pubmed/2092962

Studies of the release rate and bioavailability of ANTINEOPLASTON A10 capsule

Shandong Medical University, Department of Pharmacy, Jinan, CHINA

Drugs Exp Clin Res 16 (7): 357-9 (1990), PMID .2092962
Drugs Exp Clin Res. 1990;16(7):357-9

1990 – ANTINEOPLASTON A10 – CHINA
http://www.ncbi.nlm.nih.gov/m/pubmed/2092961

Pharmacokinetic study of radioactive ANTINEOPLASTON A10 in rats and mice

Shandong Medical University, Department of Pharmacy, Jinan, CHINA

Drugs Exp Clin Res 16 (7): 351-5 (1990), PMID .2092961
Drugs Exp Clin Research
Drugs Exp Clin Res. 1990;16(7):351-5

#45 – Narad – March 14

““I have never heard of antineoplastons,” said Yu Xiong, deputy president of the Shanghai Institute of Pharmaceutical Industry

“Finally, barking up the right squirrel””

Another EPIC Burzynski Critic FAIL

#46 – herr doktor bimler – March 15

“From Mark Thorson’s link:

Li Qingchen, a doctor and member of Scientific Squirrels, a Chinese organization dedicated to the dissemination of scientific knowledge, said Thursday that the American Academy of Anti-Aging Medicine (A4M) has been using an unapproved cancer therapy to swindle Chinese patients

[…]

The Chinese representative office of A4M claimed on its website that it could offer a “breakthrough cancer therapy” developed by Dr. Stanislaw Burzynski, who asserts that cancer can be treated with ANTINEOPLASTONS, a group of amino acids and petides normally found in urine and blood

The organization also posted dozens of promotional videos and blogs on Sina Weibo, a popular Chinese microblogging site

Sounds like the international trade in snake oil has run into CITES regulations

What’s the story with AAAAM?

On first glance it’s a umbrella organisation for a heterogeneous mixture of shysters and charlatans, including Burzynski’s “Aminocare” sideline”

You mean ANTINEOPLASTONS which have the same main ingredient as CDA-2 (CDA-H or CDA-II) ?

“Phase I/II/III clinical trials of CDA-2 have been completed in China in 2003

In August 2004, the State Drug Administration (SDA) of China approved the use of CDA-2 as an anticancer drug in solid tumors.”
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117

“CDA-2 had been approved as a first class new anti-cancer drug by the SFDA of mainland China in 2004 through the effort of both side of Taiwan Strait.”
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

8/17/2005 – New anti-cancer medicine invented in east China

8/15/2005 – Professor Ming C. Liau, laboratory in Everlife Pharmaceutical Co,. Ltd. in Hefei, capital of east China’s Anhui Province

Professor Liau began his research on cancer since 1962

In 1975, he found out that methylation enzymes play a central role in the regulation of cell replication and differentiation, and by controlling these enzymes, cancer could be healed
http://english.people.com.cn/200508/17/eng20050817_202981.html

1986-1992 he worked and published with Burzynski

1992

LIAU. M.C.• Liau. C.P.• Burzynski. S.R.
Potentiation of induced terminal differentiation by phenylacetic acid and related chemicals
lnternat J Exptl Clin Chemother 1992;S:9-17

1992

LIAU, M.C., Luong, Y., Liau, C.P., Burzynski, S.R.
Prevention of drug induced DNA hypermethylation by antineoplaston components
Internal J Exptl Clin Chemother 1992;S:19-27

1992

LIAU, M.C., Luong, Y., Liau, C.P., Burzynski, S.R.
Prevention of drug-induced DNA hypermethylation by antineoplastons
Recent Advances in Chemotherapy
Adam D. (Ed), Futuramed Publishers. 1992; Munich, Germany

1990

Kampalath, B.N., LIAU, M.C., Burzynski, B., Burzynski, S.R.
Protective effect ofantineoplaston A10 in hepatocarcinogenesis induced by aflatoxin 81
Internal J Tissue Reactions 1990;12 (supp1):43-SO

1990

LIAU, M.C., Lee, S.S., Burzynski, S.R
Modulation of cancer methylation complex isoenzymes as a decisive factor in the induction of terminal differentiation mediated by antineoplaston A5
Internat J Tissue Reactions 1990; 12 (suppl): 27-36

1990

LIAU, M.C.• Ashraf. A.a.. Lee. S.S.• Hendry, L.B., Burzynski. S.R.
Riboflavin as a minor active anticancer component of antineoplaston A2 and A5
Internal J Tissue Reactions 1990;12:19-26

1990

LIAU, M.C., Lee, S.S., Burzynski, S.R.
Separation of active anticancer components of antineoplaston A2, A3, and A5
Internat J Tissue Reactions 1990; 12 (suppl): 1-17

1989

LIAU, M.C., Lee, S.S., Burzynski, S.R
Hypomethylation of nucleic acids:
A key to the induction of terminal
differentiation
Internal J Exptl Clin Chemother 1989;2:187-199

1988

LIAU, M.C., Lee, S.S, Burzynski, S.R
Differentiation inducing components of antineoplaston A5
Adv Exptl Clin Chemother. 1988; 6: 9-2S

1987

Kampalath, B.N., LIAU, M.C., Burzynski, B., Burzynski, S.R.
Chemoprevention by antineoplastonA10 ofbenzo (a) pyrene-induced pulmonary neoplasia
Drugs Exptl Clin Res 1987;13 (suppl 1):S1-SS_

1987

LIAU, M.C., Szopa, M., Burzynski, B., Burzynski, S.R
Chemoswveillance:
A novel concept of the natural defense mechanism against cancer
Drugs Exptl Cline Res 1987;13 (suppl 1):71-76

1987

LIAU, M.C., Szopa, M., Burzynski, B., Burzynski, S.R_
Quantitative assay of plasma and urinary peptides as an aid for the evaluation ofcancer patients undergoing antineoplaston therapy.
Drugs Exptl Clin Res 1987;13 (suppl 1) :6 1-7 0

1987

Ashraf, A Q., LIAU, M.C., Kampalath, B.N., Burzynski, S.R
Pharmacokinetic study of radioactive antineoplaston A10followingoraladministrationinrats_
DrugsExptlClinRes 1987;13(suppi1):4S-SO_

1986

Ashraf, AQ., LIAU, M.C., Mohabbat, M.O., Burzynski, S.R_
Preclinical studies ofantineoplastonA10 injections_
Drugs Exptl Clin Res 1986;12 (suppl 1):37-4S

1986

LIAU, M.C., Burzynski, S R
Altered methylation complex isoenzymes as selective targets for cancer chemotherapy
Drugs Exptl. Clin. Res. 12 (Suppl. 1):77-86
Drugs Exptl Clin Res 1986:12 (Suppl. 1):77-86

Burzynski, Ming-Cheng Liau, and Gi-Ming Lai

Ming C. Liau (Ming-Cheng Liau or M.C. Liau)
worked and published with Burzynski from 1986 – 1994 and worked on CDA-2 (CDA-II or CDA- H) in Taiwan, Republic of China
http://english.people.com.cn/200508/17/eng20050817_202981.html
Ming-Cheng Liau Patents
http://www.patentmaps.com/inventor/Ming-Cheng_Liau_1.html
Gi-Ming Lai, M.D. (GM Lai) also worked on CDA-2
http://faculty.nhri.org.tw/list_new2.php?indx=154
“Phase I/II/III clinical trials of CDA-2 have been completed in China in 2003
In August 2004, the State Drug Administration (SDA) of China approved the use of CDA-2 as an anticancer drug in solid tumors”
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117
“CDA-2 had been approved as a first class new anti-cancer drug by the SFDA of mainland China in 2004 through the effort of both side of Taiwan Strait.” http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
CDA-2 (cell differentiation agent 2) is a urinary preparation that isolated from healthy human urine in China
J Pharm Pharmaceut Sci (www.cspsCanada.org) 13(3) 450 – 471, 2010
New Perspectives on Innovative Drug Discovery: An Overview
(pg. 8 of 22: Human-derived compounds – Antineoplastons and CDA-2) Starting at middle of left page:
http://ejournals.library.ualberta.ca/index.php/JPPS/article/download/9147/7453

Burzynski and Taiwan, ROC

M.C. Liau published with Burzynski from 1986 – 1992 and 1994

2001 – Effect of CDA-II, urinary preparation, on lipofuscin, lipid peroxidation and antioxidant systems in young and middle-aged rat brain
http://www.ncbi.nlm.nih.gov/m/pubmed/11321484
CDA-II, a preparation of HUMAN URINE
– …, LIAU MC, …
Department of Pharmacology, China Medical College, Taichung, Taiwan, ROC
Am J Chin Med. 2001;29(1):91-9
American Journal of Chinese Medicine, Vol. 29, No. 1, pp. 91–99
2001 Institute for Advanced Research in Asian Science and Medicine
Burzynski Reference: 3.
Samid Reference: 29. (who learned from Burzynski re Phenylacetate)
http://www.worldscientific.com/doi/abs/10.1142/S0192415X01000101
PDF
http://www.worldscientific.com/doi/pdf/10.1142/S0192415X01000101
PDF+
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X01000101
PDF+
References:
1988 – 3. BURZYNSKI, S.R. – … antineoplastons
1992 – 29. SAMID, D., S. … – Phenylacetate: …
Cited by:
1/2009 – China – 1. CDA-II, a URINARY …
2008 – China – 2. HUMAN URINE extract CDA-2 …
10/2005 – Taiwan, ROC – 3. … HUMAN URINE Extract
6/2005 – China – 4. Anti-tumor effect of CDA-II …
2003 – China / Taiwan, ROC – 5. …, Ming-Cheng LIAU, … Effect of CDA-II …
2002 – CHEN CH, … – CDA-Ⅱ … The 7th Taiwan Joint Cancer Conference ([ Conference Abstracts] Reference 5.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2002 – … HUMAN URINE extract CDA-Ⅱ … The 7th Taiwan Joint Cancer Conference ([Conference Abstracts] Reference 6. and 7.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – … , CHEN CH, … – CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] Reference 4.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – HUMAN URINE Extract CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] References 2. and 3.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – CHEN CH, – … CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] Reference 1.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid
1/2003 – Effect of CDA-II on cell viability, lipid peroxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes
http://www.ncbi.nlm.nih.gov/m/pubmed/12943172
Effect of CDA-II on Cell Viability, Lipid Peroxidation, Glutathione Concentration and Its Related Enzyme Activities in Primary Rat Hepatocyte
CDA-II (cell differentiation agent: a preparation of HUMAN URINE)
MC LIAU et al
Department of Pharmacology, China Medical College, Taichung, Taiwan, ROC
Am J Chin Med. 2003;31(3):415-23
The American Journal of Chinese Medicine, January 2003, Vol. 31, No. 03 : pp. 415-423
The American Journal of Chinese Medicine, Vol. 31, No. 3, 415–423
2003 World Scientific Publishing Company and Institute for Advanced Research in Asian Science and Medicine
doi: 10.1142/S0192415X0300103X
References (pg. 9 of PDF):
1988 – LIAU, M.C., … and S.R. BURZYNSKI – … antineoplaston A5
1990 – LIAU, M.C. and S.R. BURZYNSKI – … anticancer components of antineoplaston A2, A3 and A5
Cited by (pg. 10 of PDF):
2012 – 2. Zirong CHEN, … – … CDA- II …
2006 – 3. … , M.C. LIAU, … – Inhibitory effect of CDA-II, a urinary preparation, …
http://www.worldscientific.com/doi/abs/10.1142/S0192415X0300103X
PDF
http://www.worldscientific.com/doi/pdf/10.1142/S0192415X0300103X
PDF+
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X
PDF+
Burzynski References: 12 – 13
http://www.worldscientific.com/doi/ref/10.1142/S0192415X0300103X
10/1/2005 – Differentiation of pheochromocytoma PC12 cells induced by human urine extract and the involvement of the extracellular signal-regulated kinase signaling pathway
http://www.ncbi.nlm.nih.gov/m/pubmed/16296925
… HUMAN URINE extract …
HUMAN URINE preparation, CDA-2
Everlife Biotechnology Ltd./Incubator of
Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC
J Altern Complement Med. 2005 Oct;11(5):903-8
The Journal of Alternative and Complementary Medicine
Vol. 11: 903-908 (Volume publication date: October 2005)
DOI: 10.1089/acm.2005.11.903
http://online.liebertpub.com/doi/abs/10.1089/acm.2005.11.903

http://online.liebertpub.com/doi/abs/10.1089/acm.2005.11.903

http://ir.nhri.org.tw/handle/3990099045/2796
4/1/2006 (10/17/2005) – Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B(1)-induced oxidative stress and DNA damage in primary cultured rat hepatocytes
http://www.ncbi.nlm.nih.gov/m/pubmed/16229933
The effects of CDA-II (cell differentiation agent II; a URINARY preparation) …
M.C. LIAU et al
Department of Pharmacology, China Medical University, Taiwan, ROC
Food Chem Toxicol. 2006 Apr;44(4):546-51. Epub 2005 Oct 17
http://www.sciencedirect.com/science/article/pii/S0278691505002875

http://www.sciencedirect.com/science/article/pii/S0278691505002875

6/8/2012 – Taiwan, ROC
CDA-II (cell differentiation agent II), isolated from healthy HUMAN URINE
Biochem Biophys Res Commun. 2012 Jun 8;422(3):522-6. doi: 10.1016/j.bbrc.2012.05.068. Epub 2012 May 22
http://www.ncbi.nlm.nih.gov/m/pubmed/22627135

http://www.sciencedirect.com/science/article/pii/S0006291X1200945X

Burzynski and China / Taiwan, ROC

http://www.china-burzynski.com

http://www.china-burzynski.com/lczl/bingrengushi_135135.html

http://www.china-burzynski.com/lxwm
Below is information I have located re CDA-2 research in Taiwan, ROC and China

The history of CDA-2 (CDA-H or CDA-II) in Taiwan, ROC and China:

(Please note the numerous references to Liau & Burzynski)

1999 – Liao MC – A clever anticancer drug CDA-H
Taipei: ShiMao publisher
1999; 149–161

2000 – China – Antitumor effect of CDA-2 … (6. Publications Reference 8.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

2000 – China – HUMAN URINE extracts (CDA-II) as a novel anticancer agent … – NHRI Conf. New Drug Dev. Chin. Med (Abstract), p. 12, 2000 (listed as Reference on pg. 9 of PDF)
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X

2000 – Taiwan, ROC – HUMAN URINE extracts (CDA-II) as a novel anticancer agent …
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

2001 – Effect of CDA-II, urinary preparation, on lipofuscin, lipid peroxidation and antioxidant systems in young and middle-aged rat brain
http://www.ncbi.nlm.nih.gov/m/pubmed/11321484
– …, LIAU MC, …
Department of Pharmacology, China Medical College, Taichung, Taiwan, ROC
Am J Chin Med. 2001;29(1):91-9
References:
1988 – 3. BURZYNSKI, S.R. – … antineoplastons
1992 – 29. SAMID, D., S. … – Phenylacetate: …
http://www.worldscientific.com/doi/abs/10.1142/S0192415X01000101
PDF
http://www.worldscientific.com/doi/pdf/10.1142/S0192415X01000101
PDF+
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X01000101
Cited by:
1/2009 – China – 1. CDA-II, a URINARY …
2008 – China – 2. HUMAN URINE extract CDA-2 …
10/2005 – Taiwan, ROC – 3. … HUMAN URINE Extract
6/2005 – China – 4. Anti-tumor effect of CDA-II …
2003 – China / Taiwan, ROC – 5. …, Ming-Cheng LIAU, … Effect of CDA-II …
2002 – CHEN CH, … – CDA-Ⅱ … The 7th Taiwan Joint Cancer Conference ([ Conference Abstracts] Reference 5.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2002 – … HUMAN URINE extract CDA-Ⅱ … The 7th Taiwan Joint Cancer Conference ([Conference Abstracts] Reference 6. and 7.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – … , CHEN CH, … – CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] Reference 4.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – HUMAN URINE Extract CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] References 2. and 3.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21
2003 – CHEN CH, – … CDA-Ⅱ … The 10th SCBA International Symposium ([Conference Abstracts] Reference 1.)
http://share.cjfu.com/supersite/?uid-43-action-viewspace-itemid-21

1/2003 – Effect of CDA-II on Cell Viability, Lipid Peroxidation, Glutathione Concentration and Its Related Enzyme Activities in Primary Rat Hepatocytes
The American Journal of Chinese Medicine, January 2003, Vol. 31, No. 03 : pp. 415-423
doi: 10.1142/S0192415X0300103X
CDA-II (cell differentiation agent: a preparation of HUMAN URINE)
China / Taiwan, ROC
References (pg. 9 of PDF):
1988 – LIAU, M.C., … and S.R. BURZYNSKI – … antineoplaston A5
1990 – LIAU, M.C. and S.R. BURZYNSKI – … anticancer components of antineoplaston A2, A3 and A5
Cited by (pg. 10 of PDF):
2012 – 2. Zirong CHEN, … – … CDA- II …
2006 – 3. … , M.C. LIAU, … – Inhibitory effect of CDA-II, a urinary preparation, …
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X

1/2003 – Synergistic effect of cell differential agent-II and arsenic trioxide on induction of cell cycle arrest and apoptosis in hepatoma cells
http://www.ncbi.nlm.nih.gov/m/pubmed/12508353
Department of General Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong Province, China
public.guangzhou.gd.cn
World J Gastroenterol. 2003 Jan;9(1):65-8
http://www.wjgnet.com/1007-9327/full/v9/i1/65.htm
PDF
http://www.wjgnet.com/1007-9327/9/65.pdf
1/2003
http://www.wjgnet.com/1007-9327/full/v9/i1/65.htm
PDF
http://www.wjgnet.com/1007-9327/9/65.pdf

Critics ignore CDA-2 (CDA-H or CDA-II) Phase III Clinical Trials list Burzynski as References: 7., 23., 32, and 35.
http://file.lw23.com/f/f0/f07/f074852c-64a4-4b03-8595-47a5e6609a3f.pdf
Critics should study the history of CDA-II (CDA-2 or CDA-H):
6/2005 – Burzynski References 7. and 9.
http://www.springerlink.com/content/vq43t88675366262
2003 – Burzynski References 12. and; 13.
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X0300103X
2001 – Burzynski Reference 3.
Samid Reference 29. (who learned from Burzynski)
http://www.worldscientific.com/doi/pdfplus/10.1142/S0192415X01000101
Connection between Burzynski and China under the section titled “Evaluating Antineoplaston Therapy,” there is a paragraph about 1/2 way through the article which describes this:
http://www.commonweal.org/pubs/choices/21.html
Phase I/II/III clinical trials of CDA-2 were completed in China in 2003
In August 2004, the State Drug Administration (SDA) of China approved the use of CDA-2 as an anticancer drug in solid tumors
CDA-2 had been approved as a 1st class new anti-cancer drug by the SFDA of mainland China in 2004 through the effort of both sides of the Taiwan Strait

2005 – Phase III Clinical Trials of the Cell Differentiation Agent-2(CDA2): Therapeutic Eficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma
Cell Differentiation Agent-2 (CDA-2) … – a URINARY preparation, …
CDA-2 & its main component PHENYLACETYLGLUTAMINE (PG) {Antineoplaston AS2-5} …
China / Taiwan, ROC
Chinese Journal of Clinical Oncology
2005/Volume2/Number4 PGA. 706-716
(PDF – 11 pgs.)
Burzynski / Liau References
1989 – 7. Liau MC, … , BURZYNSKI SR
(PDF-pg. 9 of 11)
1986 – 23. Liau MC, BURZYNSKI SR
(PDF-pg. 10 of 11)
1990 – Antineoplaston A5 – 32. Liau MC, … , BURZYNSKI SR
1987 – 35. Liau MC, … , BURZINSKY SR
http://file.lw23.com/f/f0/f07/f074852c-64a4-4b03-8595-47a5e6609a3f.pdf

6/2005 – Anti-tumor effect of CDA-II on a human glioma cell
China
Chinese Journal of Clinical Oncology
June 2005, Volume 2, Issue 3, pp 679-684
DOI
10.1007/BF02739731
http://link.springer.com/article/10.1007%2FBF02739731
References:
1999 – 2. Taiwan, ROC – Liao MC – A clever anticancer drug CDA-II
1986 – 7. BURZYNSKI SR – Antineoplastons: …
2002 – 8. China – … CDA-H …
2003 – 9. BURZYNSKI SR, … Phase II … antineoplaston A10 & AS2-1 …
2003 – 11. … CDA-II
2003 – 12. … cell differentiation agent II …
2001 – 13. … CDA-II, URINARY preparation, …

10/2005 – Differentiation of pheochromocytoma PC12 cells induced by human urine extract and the involvement of the extracellular signal-regulated kinase signaling pathway
http://www.ncbi.nlm.nih.gov/m/pubmed/16296925
… HUMAN URINE extract …
Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC
J Altern Complement Med. 2005 Oct;11(5):903-8
http://online.liebertpub.com/doi/abs/10.1089/acm.2005.11.903

4/2006 (10/17/2005) – Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B(1)-induced oxidative stress and DNA damage in primary cultured rat hepatocytes
http://www.ncbi.nlm.nih.gov/m/pubmed/16229933
The effects of CDA-II (cell differentiation agent II; a URINARY preparation) …
Department of Pharmacology, China Medical University, Taichung 404, Taiwan, ROC
Inhibitory effect of CDA-II, a URINARY preparation, …
… LIAU MC, …
Food Chem Toxicol. 2006 Apr;44(4):546-51. Epub 2005 Oct 17
http://www.sciencedirect.com/science/article/pii/S0278691505002875

8/1/2008 – Human urine extract CDA-2 induces apoptosis of myelodysplastic syndrome-derived MUTZ-1 cells through the PI3K/Akt signaling pathway in a caspase-3-dependent manner
http://www.ncbi.nlm.nih.gov/m/pubmed/18664328
HUMAN URINE extract CDA-2 …
Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Acta Pharmacol Sin. 2008 Aug;29(8):951-64. doi: 10.1111/j.1745-7254.2008.00826.x
References (pg. 13 of PDF):
1986 – 5. BURZYNSKI SR – Antineoplastons: …
2000 – 6. Egypt – Potential utility of antineoplaston A-10 levels in breast cancer
2001 – 7. …, LIAU MC – Effect of CDA-II, URINARY preparation, …
2006 – 8. …, LIAU MC, … – Inhibitory effect of CDA-II, a URINARY preparation, …
2005 – 9. … HUMAN URINE extract …
http://www.nature.com/aps/journal/v29/n8/full/aps2008115a.html
PDF
http://www.nature.com/aps/journal/v29/n8/pdf/aps2008115a.pdf

9/2008 – [In vitro study of the effects of CDA-II combined with cAMP on apoptosis induction in retinoic acid resistant acute promyelocytic leukemia cells]
http://www.ncbi.nlm.nih.gov/m/pubmed/19175987
Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
2008 Sep;29(9):603-6. Article in Chinese

1/2009 (8/9/2008) – CDA-II, a urinary preparation, induces growth arrest and apoptosis of human leukemia cells through inactivation of nuclear factor-kappaB in a caspase-dependent manner
http://www.ncbi.nlm.nih.gov/m/pubmed/18761050
CDA-II, a URINARY preparation, …
CDA-II (cell differentiation agent II) was a URINARY preparation, isolated from HEALTHY HUMAN URINE
We determined the anticancer activity of CDA-II …
Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Food Chem Toxicol. 2009 Jan;47(1):40-9. doi: 10.1016/j.fct.2008.08.001. Epub 2008 Aug 9
http://www.sciencedirect.com/science/article/pii/S0278691508004249

4/2009 (10/14/2008) – Comparative proteomics and molecular mechanical analysis in CDA-II induced therapy of LCI-D20 hepatocellular carcinoma model
http://www.ncbi.nlm.nih.gov/m/pubmed/18853186
… CDA-II … – (cell differentiation agent-II)
Chemistry Department of Fudan University, Shanghai, China
fudan.edu.cn
J Cancer Res Clin Oncol. 2009 Apr;135(4):591-602. doi: 10.1007/s00432-008-0493-0. Epub 2008 Oct 14
References
1987 – 18. LIAU MC, … BURZYNSKI SR – … urinary … antineoplaston therapy
2006 – 19. …, LIAU MC, … – Inhibitory effect of CDA-II, a URINARY preparation, …
http://link.springer.com/article/10.1007%2Fs00432-008-0493-0

http://www.springerlink.com/content/47t5872g67727285

6/8/2012 (5/22/2012) – DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation
http://www.ncbi.nlm.nih.gov/m/pubmed/22627135
CDA-II (cell differentiation agent II), isolated from HEALTHY HUMAN URINE
CDA-2, a URINARY Preparation
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China
Biochem Biophys Res Commun. 2012 Jun 8;422(3):522-6. doi: 10.1016/j.bbrc.2012.05.068. Epub 2012 May 22
http://www.sciencedirect.com/science/article/pii/S0006291X1200945X

http://services.elsevier.com/SDWebExport/export/figure/S0006291X1200945X/1-s2.0-S0006291X1200945X-gr1.jpg/ppt

11/2012 – CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma
Cell differentiation agent-2 (CDA-2) is an extraction from HEALTHY HUMAN URINE …
China
Journal of Neuro-Oncology
November 2012, Volume 110, Issue 2, pp 179-186
10.1007/s11060-012-0961-x
References:
2005 – 1. … HUMAN URINE extract …
2001 – 2. … (CDA-II) injection
2011 – 3. … CDA-2 …
2006 – 4. Effect of CDA-II …
2009 – 6. … CDA-2 …
2008 – 7. HUMAN URINE extract CDA-2 …
http://link.springer.com/article/10.1007%2Fs11060-012-0961-x

http://www.springerlink.com/content/w40102w0qm212g44

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117

12/17/2012 – CDA-2, a urinary preparation, inhibits lung cancer development through the suppression of NF-kappaB activation in myeloid cell.
http://www.ncbi.nlm.nih.gov/m/pubmed/23284890
CDA-2, a URINARY preparation, …
– … (cell differentiation agent 2) …
Department of Pharmacy, Putuo People’s Hospital, Shanghai, China
PLoS One. 2012;7(12):e52117. doi: 10.1371/journal.pone.0052117. Epub 2012 Dec 17
References (pg. 10 of PDF):
2009 – 3. CDA-II, a URINARY preparation, …
2006 – 4. …, LIAU MC, … – Inhibitory effect of CDA-II, a URINARY preparation, …
2005 – 5. … HUMAN URINE extract …
2008 – 6. HUMAN URINE extract CDA-2 …
2009 – 7. … CDA-2 …
(pg. 11 of PDF)
1995 – 22. …, Burzynski SR – …
antineoplaston AS21 …
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524164
PDF
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524164/pdf/pone.0052117.pdf

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052117