Tag Archives: Complete Response

Hannah Bradley – I Feel Empowered, In Control Of My Body: Four Women On Fighting Cancer With Alternative Therapies http://www.telegraph.co.uk/health/10383724/I-feel-empowered-in-control-of-my-body-four-women-on-fighting-cancer-with-alternative-therapies.html

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I will be doing some data clean-up and adding additional video transcripts
——————————————————————
What stood out to me in the first and last videos is that you could hear both sirens and birds

Unlike “The Skeptics™” (sirens) #whining, the birds were celebrating Hannah #winning
——————————————————————
Just as I did with the case of Burzynski patient Laura Hymas, so will I do with her friend, Hannah Bradley

Yes, unlike “Orac” I will let Hannah speak for herself instead of adding any bias as “Dr. Check my Facts” Hack does
——————————————————————
Team Hannah Blog

6/6/2013 – Posted by Hannah

(6:14)

Okay

Hello everyone

Hi

It’s uh Thursday the 6th of June

Yes

(laugh) And uh we’ve got some really good news

We’ve kind of been holding back a little but

we just wanted to be certain

so what were you going to say

Uh, I am finally off treatment

Finally off treatment which is great so as far as Dr. Burzynski is concerned, the treatment is now finished

Hannah is free

Free of the bag

Free of

Yes

Yes

How’s that feel

Yeah, it feels really kind of strange to be honest

Well you want to go back on it again

No

No

But I
I miss the bag, because I miss carrying around ohhh

Now you’re just being a little bit stupid

Um, but the great news is today, we went to go and see Hannah’s surgeon

Yes

Oncologist

A another surgeon another doctor um

Yeah

And that was a bit strange because the last time that we saw
surgeon he gave us
it was probably one of the worst days of our life

Yep

He gave us the results of

Your biopsy

Yep

Which was a grade 3 tumor uh I can remember that like that was yesterday

I don’t really remember

Well but I do

It was amazing uh seeing him today because he’s just basically just agreed with everything that uh that’s been said in America that Hannah’s doing really really well she as far as she’s concerned you don’t have to have any scan for another 6 months

No

Uh so you know really kind of cancer free and

Yep

Now, you know, it is incredible

It’s a bit of a miracle and

it both hasn’t hit home

really

How much

Yeah

How much is

Well we can start our life

We can start our lives, again

Again (laugh)

And um we just want to say

a massive thank you

the list is just

this isn’t the end for us

I’m sure we

boring you

(laughing)

had a very long day

We had to wait an hour and a half (laugh)

(laugh) Sorry I couldn’t help

Calm down

The the list of people that we have to thank

Need

Need to thank is so long, and obviously way up at the top of that list has to be uh Dr. Burzynski and all of the people at the Burzynski Clinic who have been just amazing, you know

Just so supportive um and I suppose really without that treatment I don’t
I don’t think

I don’t

No

I don’t think

You don’t think you’d what ?

It’s not worth thinking about

Yeah, it’s not worth thinking about

But um we have to thank every single person that contributed and helped us and supported us along the way

Everyone that helped us raise money

Um

to thank

Here we go

Who else do we need to thank

I think

Come back up

Come on

(laugh)

We have to thank uh

like I said it’s been a long day today

Uh we have to thank Jamie Lowe

Yes

We have to thank Lindley Gooden

Who else do we have to thank ?

Uh all the people that were in Team Hannah

Yeah

All of your friends

My parents

Your parents

Mhmm

Um just everyone that’s been watching these blogs

We really, really couldn’t have done it without you

And um

We are really, really thankful

You don’t want to go do you ?

Hannah and I were thinking about doing our own comedy show because a lot of people
comments like we’re so funny

Yeah

And who’s the funniest

Uh oh you

Yeah you

Me
Me
Me

Um

So, I don’t know what else to say really apart from, you know, this is really a bit of a fairy tale for us

We know how fortunate
we are and we know how
people
who we met along the way
who weren’t
haven’t been as fortunate as us

So we uh

So, are you alright down there ?

we’re talking about something serious

Very

Yeah, we know a lot of people who haven’t been as fortunate

As fortunate as we have people are forever in our hearts

You know, um, we know how lucky we are and um

We’re going to make the most of our lives the most of our lives together

Um, yeah

We really do think that

No don’t

You know, there was a time

Many, many times where I really didn’t think that Hannah would be here but, you know, we’re talking 2 1/2 years ago that she was diagnosed and she’s doing better than ever even though she is yawning

(laugh)

Um

I don’t think there’s any words that really put into a sense of how so lucky we think we are, and I really think it’s how our legacy to live with that and try and inspire other people as much as we can as well

Ok

So, we’re not going to get go anywhere we’re still we’ll still let you know from time to time how we’re getting on

Uh um I also think we need to give a massive shout out to Ben and Laura Hymas as well who, who really, we went to see them the week before we went to, out to America, and it was there, was a, was a bit of a shock

Really

Realizing what we were about to take on but um she’s

I’m very sorry

She’s someone else who’s done well and we want to give a big shout out to them because we know that they’ve got their lives ahead of them as well as we do too

So, I think without any further ado we’ll give your famous wave

(wave)

It’s not really a wave, is it

Thank you very much everyone

Thank you

Big hug

Wanna hug ?

C’mon

C’mon hug us [10]
======================================
London [1]

4/2010 – first met Hannah and we fell in love and since then our relationship has gone from strength to strength [3]

Hannah (28) has great personality and fantastic sense of humour [3]

10/5/2012 – from Elstead [12]

4/4/2013 – Hannah Bradley (28) [11]

Hannah Bradley from London, UK [15]

======================================
MOOD
======================================
Looking back now, was quite naive [1]

2/2011 – world took dramatic turn [11]

Hannah Bradley from London, UK [15]

To my complete horror [11]

whole world was turned upside down [11]

confused [11]

scared of all the unanswered questions that lay before me
why was this happening to ME? [11]

What did the future hold? [11]

Will I be okay? [11]

absolutely terrified as realised something seriously wrong [15]

Everybody else went into panic, but shock calmed [15]

Inside, scared, could see how frightened Pete was [15]

wasn’t easy decision but really wasn’t another choice [15]

Fear pulsed through me as was wheeled to theatre for operation [15]

4/2011 – thought once surgery over, tumour would be gone [1]

“Hello,” I croaked [15]

“Have I still got all my hair?” [15]

beamed as Pete nodded [15]

long blonde locks were pride and joy, and surgeons managed to operate without having to shave any [15]

Waiting for results was one of most harrowing periods for me and my partner [11]

had to wait for results of biopsy for few weeks and remained positive [3]

while trying to remain positive throughout [11]

tried to keep busy so didn’t dwell on what doctors would say [15]

it was hard [15]

sensed before they even spoke [15]

faces were so serious it had to be bad news [15]

Obviously medical professionals have to be detached when deliver news, but we completely broke down [15]

tried to bite back sobs so could hear what they were saying [15]

blinked for moment, realising meant me [15]

left hospital, in daze [15]

went to sit in park for 2 or 3 hours, working out how to tell everyone [15]

rang dad, feeling ashamed he had to deal with news [15]

didn’t want to upset him [15]

Pete and I rang close friends and family and became easier each time [15]

got chain going to spread news so didn’t have to ring everybody, which was relief [15]

gave me space to come to terms with diagnosis [15]

Once able to get head around it, felt detached from it: [15]

needed to get through next stage now [15]

needed 6 weeks of radiotherapy, did that, thinking this would make me better [1]

Hannah’s bravery and resolve once again rose up as shortly after this she started 6 week course of radiotherapy [3]

news was not good and world was rocked once more as results showed Grade III tumour [11]

whole world suddenly fell apart again and that very moment I didn’t know how to go on [11]

knew had to carry on and from somewhere I didn’t know existed within me, found some bravery and started to have next course of treatment, 6-week course of radiotherapy [11]

hope you will understand this was REALLY difficult for me as I loved my hair and without it felt horrible and ugly [11]

coped well at first, until hair came out in clumps [15]

warned could be few patches of fall, but lost it all [15]

wore headscarves but mourned my hair [15]

work in skincare sales and used to having to look my best [15]

know it was vain, but hair was part of my femininity [15]

missed it [15]

awful but kept going, knowing had to [15]

Seeking alternatives [15]

full of hope [15]

know it’s long fight ahead but feel everyone is behind me and
get so much from that [15]

have a mantra, which like to think I made up but think I read somewhere: [15]

‘You never know how strong you are until being strong is the only choice you have.’ [15]

exactly how I feel [15]

there was some hope [12]

was truly an incredible time and once again I was filled with hope as so many people came to my aid to support me by raising money and donating what they had [11]

still so thankful for all that support [1]

absolutely overjoyed [1]

wouldn’t turn my back on conventional medicine, but would advise anyone in situation like mine to look into other options – there could always be another way [1]

“If this whole thing has taught me anything, it’s that.” [1]

Thankfully along with other treatment, strategy has worked for me and I’m now trying to help others who are fighting against this horrible disease [11]

======================================
HEALTH
======================================
was salesperson when diagnosed with cancer [1]

ate on the run [1]

smoked [1]

had no real symptoms or warning signs [1]

2/2011 – out of the blue, Hannah had major seizure in middle of the night [3]

2/2011 – one night Hannah’s life changed drastically without any prior health concerns suddenly had major seizure [12]

2/2011 – had grand seizure while asleep [1]

2/2011 – major seizure in middle of night [11]

arms up in the air, body shaking [1]

2/2011 – lost consciousness and was rushed to hospital [3 + 11]

woke in hospital, had no idea what had happened, tests revealed brain tumour size of golf ball in frontal lobe [15]

didn’t know anything wrong before had massive seizure in sleep [15]

boyfriend thought was having nightmare at first, but when couldn’t wake me, realised was unconscious and called ambulance [15]

came round in hospital few days later and didn’t remember anything [15]

underwent countless tests, absolutely terrified as realised something seriously wrong [15]

2/2011 – 4/2011 – don’t remember much about 2 months that followed apart from seeing many doctors, having constant headaches and a # of seizures [11]

had constant headaches and number of seizures [3]

Eventually CT scan showed brain tumour, turned out to be very aggressive, anaplastic astrocytoma [1]

week after CAT and MRI scans told had brain tumour size of golf ball [15]

in frontal lobe and probably growing there for years [15]

doctor gave 3 options: [15]

leave it and see what happened
have biopsy to discover what type of tumour it was and how aggressive
go for surgery to try to remove as much as possible [15]

diagnosed with very serious brain tumour [3]

diagnosed with very aggressive brain tumour [11-12]

2/2011 – 4/2011 – have no memories of that time, from the night of seizure to coming around from 8-hour operation to remove tumour 2 months later [1]

had about 4 more seizures – including one 2 nights before surgery last April – after discharged because tumour growing and putting so much pressure on brain [15]

Pain throbbed through inside of skull as peeled eyes open [15]

Groggy, focused and saw Pete smiling down at me [15]

was in hospital 5 days before going home to rest and getting biopsy results [15]

2 weeks later, went back to see consultant and specialist nurse [15]

news was not good and our world was rocked once more as results showed Grade III tumour [3]

tumour was cancerous and had scary name – anaplastic astrocytoma [15]

4 grades of brain tumours with 4th being worst [15]

Mine grade 3 [15]

statistics quoted said person with grade-3 tumour lives around 5 years [15]

life expectancy for people with tumours like this was 18 months [1]

2 weeks into treatment was hit by wave of tiredness [15]

so shattered had to go to bed for week [15]

went well for 1st few weeks but followed by hair falling out and bouts of tiredness and lethargy [3]

lost hair
started having seizures and didn’t know how long she had to live [12]

was still having seizures and lost independence with losing driving licence [11]

On top of all of this, dealing with losing driving licence as had number of seizures and now has epilepsy [3]

At end of July, had another MRI scan, revealed still residue left from tumour [15]

6 weeks after radiotherapy finished, had another MRI to see what was going on with tumour, Once again more bad news, as there were still remnants of aggressive tumour [3]

Although it was hard I remained hopeful that 6 weeks after radiotherapy would help and I could go on to live a normal life but again results of next MRI were not good [11]

There were still remnants of aggressive tumour [11]

At this point treatment options where very limited and life expectancy was not very long [11]

was told only options available on National Health Service were to operate or have radiotherapy again [15]

Chemotherapy also mentioned but not strong enough for that [15]

doctors said were really uncertain of expected life span if didn’t do anything and since treatment options in UK so limited, we want to try something else [15]

didn’t know 100% whether would work, but had to believe in something; wanted to be positive [1]

Just 8 months after starting treatment had some incredible news [12]

latest scans show she is cancer free [12]

desire to beat this disease led me to make number other lifestyle changes [11]

One of biggest changes has been dietary; specifically cutting out most sugars from my diet [11]

involved learning how to cook, which in itself was huge challenge because I hated cooking with a passion [11]

Over time I started experimenting with different foods and became more and more adventurous and dare I say it, I even started to enjoy coming up with new healthy recipes [11]

quickly learned that exclusive food of cancer is sugar, so quickly embraced this and cut out almost completely starchy carbohydrates and refined sugars by incorporating sugar free/starch free food plan [11]

idea being that diet would feed my body, mind and starve cancer into submission [11]

also learnt this type of diet is good for blood sugar regulation, body composition and is consistent with the way that our ancestors ate thousands of years ago [11]

After months of experimentation and with help of couple of great cooks, have learned to make delicious and nutritious healthy meals and this is why I decided to write my own book, The Team Hannah Cookbook [11]

It’s my contribution to helping and inspiring others to eat a better diet [11]

I would hope you can enjoy these recipes and make them part of your diet [11]

This book will show you how easy it is uto cut out the carbs and still eat “normally.” [11]

I now believe that dieting and counting calories doesn’t work [11]

Low carb is the way forward [11]

You will find in my book great low carbohydrate recipes for – Breakfasts, Breads & Pastries, Starters, Salads, Mains, Desserts, Treats [11]

======================================
TREATMENT
======================================
2/2011 – partner, Pete, called ambulance, was rushed to hospital, unconscious [1]

decided to have operation, hopeful would get rid of it [15]

in hospital 2 weeks following 1st seizure and put on strong medication to stop from having fits [15]

kept awake 2 1/2 hours of 6-hour surgery – medical team wanted to make sure weren’t damaging any part of brain, where tumour was, relating to speech and language [15]

made list of what to talk about with speech therapist during operation, such as meeting Pete at conference in Croatia year before; favourite American TV series, Friends, niece who’d been staying with family week before seizure [15]

remember having to touch fingers with thumbs to check movement still there, hand or my leg would involuntarily move when surgeon touched particular part of brain and asking anaesthetist to scratch itch on nose [15]

“It’s going fine, we’re putting you back to sleep now,” voice said and everything went black [15]

4/2011 – 8-hour operation to remove tumour [1]

4/1/2011 – decided to have surgery underwent 6 1/2 hour operation [3]

4/1/2011 – surgery and underwent grueling 6 1/2 hour operation [11]

awake for nearly 3 hours of this operation [3]

nearly 3 hours of operation was awake [11]
——————————————————————
Pete Cohen chats with Dr. Juan F. Martinez-Canca, Neurosurgeon (Consultant) about Hannah Bradley:
https://stanislawrajmundburzynski.wordpress.com/2013/11/08/pete-cohen-chats-with-dr-juan-f-martinez-canca-neurosurgeon-consultant-about-hannah-bradley/
——————————————————————
operation was success and they managed to remove nearly all of tumour [3]

To my relief
results of operation were fairly successful and surgeon managed to remove uhmost of tumour [11]

diagnosed with Anaplastic Astrocytoma brain tumour and over next few months endured 6-hour operation and 6 weeks of radiotherapy [12]

started radiotherapy 8 weeks after surgery [15]

full on – 6 weeks of treatment, Monday to Friday [15]

needed 6 weeks of radiotherapy, did that, thinking this would make me better [1]

radiotherapy went well for 1st few weeks but fears were confirmed when hair started to fall out [11]

was gruelling – hair fell out, had quite a few seizures – then, at end, scan showed still had remnants of very aggressive tumour [1]

Pete started researching alternative treatments from beginning and was Dr Stanislaw Burzynski, biochemist and physician in US, who seemed right choice for me [15]

found pioneering treatment in America which could give her a chance [12]

One name kept cropping up [1]

Dr Burzynski [1]

treatment is controversial – claims to have identified peptides called antineoplastons, which act as molecular switch to turn off cancer cells without harming normal cells [15]

After reading everything we could, decided to try it [15]

At his clinic in Houston he’s developed a treatment using anti-cancer compounds he discovered and now manufactures – and is treating aggressive tumours, especially ones in the brain [1]

controversial [1]

medical community claims unscientific and unproven [1]

oncologist didn’t want me to go – he wanted to monitor tumour and maybe give more radiotherapy in future [1]

that was like containing it, not getting rid of it, and treatment hadn’t worked so far [1]

Dr Burzynski seemed to be only hope of getting rid of cancer for good [1]

In order to get it needed to raise £150,000 [12]

treatment wasn’t cheap (about £200,000) [1]

treatment very costly, and even using all savings didn’t have nearly enough [15]

£200,000 (Dh1.16 million) needed to go to US, plus ongoing shipping of drugs from States and private monthly scans will need for 12-18 months, was out of reach [15]

Family and friends offered to help, soon there was Team Hannah website [15]

Within few weeks had £35,000, enough to go to US for consultation and start treatment [15]

didn’t know 100% whether would work, but had to believe in something; wanted to be positive [1]

Treatment available in America [12]

Luckily was able to take part in phase 2 clinical trial in Texas, USA [11]

treatment isn’t available via NHS so had to raise considerable amount of money [11]

12/2011 – flew with Pete to Burzynski Clinic [1]
——————————————————————
12/10/2011 – Saturday – video blog
leaving tomorrow morning
——————————————————————
12/11/2011 – Day 1 – Sunday
flew to USA
massive headache
thought was going to faint
——————————————————————
12/12/2011 – Day 2 – Monday
Burzynski Clinic
temp check
vision test
meeting: Dr. Yi oncologist / Dr. Greg Burzynski
(Dr. Rowkowski)
——————————————————————
12/13/2011 – Day 3 – Tuesday
Burzynski Clinic
inject sugar syrup
PET scan
MRI scan review
?’s memory / spelling jumbled
fill out form
Valium
(as much local anesthetic as could give her w/o knocking her out)
catheter – Hickman line
(painful / really painful)
——————————————————————
12/14/2011 – Day 4 – Wednesday
Burzynski Clinic
(feeling wrecked / absolutely wrecked)
start treatment
6 doses of antineoplaston a day
4 hours apart
almost 24 hours continuously
(had chest x-ray)
(Dr. Barbera – talk pain medication)
lessons: clamps / hoses / pump
——————————————————————
12/15/2011 – Day 5 – Thursday
Burzynski Clinic
(Day 2 of treatment)
lessons: change pump
——————————————————————
12/20/2011 – Day 10 – Tuesday
Burzynski Clinic
Dr. Yi / Dr. SRB
enhancing – asked to stay month – next MRI to be done
——————————————————————
12/22/2011 – Day 12 – Thursday
Dr. Hilary Jones on Daybreak
(Pete’s colleague)
——————————————————————
12/24/2011 – Day 14 – Saturday
fever
bad breathing
shivering all night
——————————————————————
12/25/2011 – Day 15 – Sunday
Burzynski Clinic
flu symptoms
breathing
headache
uncontrollable chills couldn’t stop
Monica
off ANP
absolutely exhausted
in bed
little bit of swelling back of head
——————————————————————
12/27/2011 – Day 17 – Tuesday
back on ANP
temp 102
called Burzynski Clinic
off ANP
temp down / up
——————————————————————
12/28/2011 – Day 18 – Wednesday
Burzynski Clinic
on ANP much smaller dose
exhausted
close to breaking / cracking
——————————————————————
12/29/2011 – Day 19 – Thursday
hospital
“I’m at my wits end”
“I don’t feel I can take anymore”
——————————————————————
12/30/2011 – Day 20 – Friday
last week up & down
off on off on off
fever
chills
shaking
viral infection
bacterial infection
had to go to E.R.
surreal
——————————————————————
12/31/2011 – Day 21 – Saturday
fever in middle of night
temp 102
Dr. SRB thinks flu-like symptoms or tumor actually breaking down ->
——————————————————————

1/2012 – started treatment [11]

——————————————————————
1/1/2012 – Day 22 – Sunday
Burzynski Clinic
feel drunky
prob w pump – not closing
felt like completely drunk
double vision
Nurse said anti-seizure drug she hadn’t taken before
bit shaky

Gary – directions re pump equip
——————————————————————
1/17/2012 – Day 38 – Tuesday
Burzynski Clinic
temp 101.8
throat infection
If 102 take off ANP
BC 3x – blood – supplies
antibiotics 1 day

antibiotics 2 day – over 102 last night

fever
antibiotics been on 3 days
off ANP
disappointed
pointless
——————————————————————
1/20/2012 – Day 41 – Friday
fever
104 (103.9)
Friday night
——————————————————————
1/21/2012 – Day 42 – Saturday
Burzynski Clinic
temp up to 104
Dr. on-call – Ibuprofen
102.5
yesterday afternoon (blood) rash ?
off ANP
Dr. Popper
——————————————————————
1/23/2012 – Day 44 – Monday
Burzynski Clinic
Dr. SRB
gave name from pic
some itch
MRI – was to have Wed (12/29/2011 prev MRI)
less tumor
less enhancement
shrunk by at least 10%
call Dad

Been 1 month
Discharge
take Ashley
Rick
Fri – leave
——————————————————————
1/26/2012 – Day 47 – Thursday
Burzynski Clinic
Stable Disease
stabilization
——————————————————————
1/27/2012 – Friday – leave
——————————————————————
medication is administered directly into your body through Hickman line 24 hours a day [1]

not an easy option [1]

Pete and I learnt how to prepare and administer treatment ourselves and carried on in Britain for another 18 months (1 year 6 months) [1]

were there for 7 weeks, and scans showed in that time tumour reduced by 11% [1]

Thankfully has been successful in shrinking tumour [11]

blood was checked twice a week, was scanned every 6 weeks at private hospital [1]

Most importantly, seemed to be working [1]
——————————————————————
6/2012 – back 6 months
3 scans

6/13/2011
12/7/2011

3/21/2012 – 1
5/2/2012 – 2
7/29/2012 – 3

7 weeks at Burzynski Clinic

Complete Response
——————————————————————
tumour kept getting smaller, in January this year it was all gone [1]

started treatment and after 9 months had complete response and will continue on treatment until 4/2013 / 5/2013 [3]

now off treatment but still being monitored [1]

Dr Burzynski isn’t miracle worker [1]

There are well-publicised cases of families raising money for children to be treated at the clinic but children still tragically dying [1]

People have posted on our website that it doesn’t work, but I’m convinced that, if we hadn’t found him, I wouldn’t be here today [1]

======================================
SUPPORT
======================================
Pete Cohen: Team Hannah set up to save life of my partner, Hannah Bradley, who’s 28 years old and has brain cancer [3]

All this time, without knowing, Pete had been looking into things, searching, talking to anyone and everyone who could possibly help [1]

needed to raise around £200,000 to give her opportunity to have life-saving treatment at The Burzynski Clinic in Houston, Texas [3]

Pete launched campaign – friends and family gathered around, held events, our local radio station supported us – in 2 months already had £100,000, enough to start treatment [1]

You helped her to get it… [12]

Eagle Radio wanted to help give Hannah hope by raising money towards her fund [12]

you wanted to help too [12]

Hannah came in to Eagle Radio to meet Breakfast Show presenters PG and Bev [12]

Listen to interview here: [12]

Pete (Hannah’s boyfriend) met our reporter Anthony Zahra and starts by talking about how couple met: [12]

Jeremy (Hannah’s dad) spoke to our reporter Elizabeth Williams: [12]

photos on Hope for Hannah appeal [12]
——————————————————————
Fundraising events you told us about [12]
——————————————————————
7/21 – Matthew Cank from Farnham doing sponsored bike ride with friends riding from John O’Groats to Lands End [12]
http://2theend.co.uk
——————————————————————
**
2/24 (Friday) – Pure Dance at Backline, Guildford from 8pm to 2.30am House, electro & trance music with DJs on rotation Entry £10 with all proceeds going to the appeal [12]
——————————————————————
**
2/25 (Saturday) – Dinner, Dance and Auction at The Mandolay Hotel, Guildford (6.30pm to 12.30am) evening of fantastic food & excellent entertainment [12]
——————————————————————
**
3/3 (Saturday) – special night held at Godalming Naval Club by Hannah’s best friend
£7.50 a ticket All money to the appeal Includes – food, disco, raffles, auction and more [12]
——————————————————————
**
5/19 (Saturday) – Health, Beauty & Fitness Fair at Clock Barn Hall, Godalming Free admission, free talks on health, fitness and nutrition Includes – mini treatments, fitness drop in classes, taster sessions, new health products Raffle & bucket collection to raise money for Team Hannah [12]
——————————————————————
Your generosity was astounding and Hannah surpassed her target much earlier than she could have dreamed [12]

Hannah’s Annectdote

A film about Hannah’s journey to The Burzynski Clinic

film we made called Hannah’s Anecdote [3]

made to share with world Hannah’s journey to beat cancer and live normal life [3]

you can see Team Hannah blog we started October last year as well more information about Dr. Burzynski and treatment for cancer [3]

totally aware of controversy surrounding Dr. Burzynski but have seen with our own eyes he saved Hannah’s life [3]

share this with everyone you can, so together we can raise awareness of Hannah’s success and of Dr. Burzynski [3]

cookbook by Hannah available at teamhannah.com [1]

Any help you give will be most appreciated and will keep you updated with Hannah’s journey [3]
http://www.teamhannah.com/

Thank you for donating, raising awareness and simply helping to give Hannah hope [12]
——————————————————————
Hannah’s Annectdote: (40:42)
——————————————————————
A film about Hannah’s journey to The Burzynski Clinic
——————————————————————
Look

You’ve got a spirit level in the cam, in the front of the camera for a reason

I know

Ok
——————————————————————
Hannah’s Anectdote
——————————————————————
I’m Hanna Bradley and I’m 27 years old
I have
Well, I found out I had a brain tumor in February 2011
The way I found out is, I had a seizure in, during the middle of the night
I don’t remember anything, but my partner Pete tells me that I did
Rushed to hospital and about week later I was diagnosed with a, an aggressive brain tumor
And then I had to have an operation to remove the brain tumor and I went back for the results, which weren’t that good and I had to go for a radiotherapy

And I spoke to a friend of mine, an incredible man, he’s a doctor, he, he’s retired, he said, why don’t you just look and find people in the world who still have this condition and still alive
So, that’s what I did
And I found some people, and it, and they all led to this guy Burzynski, but you mention Burzynski to uh people who work in the world of cancer, and it’s just like, they, you know, the barriers come up immediately
Chemotherapy, radiotherapy, there’s no question about the fact that these things uh, are reflective and they are, save people’s lives, but that’s not what Hannah wants to do
(If I could go there, and take myself off there, I could)
Burzynski’s work is, some people wouldn’t say it is gene-targeted therapy
Basically it’s peptides
Peptides uh form amino acids in the body, and he’s found from his research that uh, certain people do not have these types of peptides, and uh especially people with certain types of cancer
What have you got to lose, and what’s the worst thing that can happen, if it doesn’t work ?
What’s the best thing that can happens ?
It saves her life
(laughter)
(I’ll give the ass a smack)
——————————————————————
video blog 13th of November 2011 (2:00)
——————————————————————
(Come sit down)
Good morning
Good morning
Good Morning

Why this week is such a big week is we go to see Hannah’s uh GP tomorrow, and we really need him on side with the treatment that Hannah’s going to have, and, and that could pose a bit of a challenge, because this treatment with Dr. Burzynski is not peer-reviewed, and what that means is that, with the NICE guidelines in this country, people are
very unlike to promote a uh treatment that isn’t peer-reviewed in the way that they would want it to be, but, we’re hoping that he will help and support is when we come back

Yeah

We will also go and see the oncologist this

Yes

which is gonna be a very interesting conversation because again, we want their support
It’s unlikely, very unlikely that they’ll give us the support that we need
because when Hannah comes back, she’s going to need MRI’s every month, and that’s just not gonna happen
We’re going to have to pay for that, but, we’ll let the pets do that of course
We’ll let you know next week, but this week is gone, but for now this is Team Hannah saying, Team Hannah, Team Hannah saying
Goodbye
Bye
Goodbye
That the wave that you do
(laugh)
I’m getting better at the wave
I don’t know about that, darling
——————————————————————
Royal Free Hospital
London – December 2011 (3:19)
——————————————————————
You know, maybe I’ve been led down a garden path if you like, going to work with Burzynski, because you speak to any oncologist; which we have, lots of (?) specialists in this field and they say:
“No don’t do it”
“The guy’s a charlatan”
“You’re wasting your time”
“You’re wasting your money”
“It’s not going to work”
“There’s no clinical research”
But I feel in my heart that we’ve gotta do this
Not just because, you know, what is there left to do, but I actually think it’s going to work
Is it going to be a placebo effect, or is it actually going to be that what this guy does works ?
I’ve spoken to people who he, who he’s treated uh and they all can’t speak highly enough of him and of the clinic that we’re going to
So I’m going to film as much as I can of her journey, and she’s happy for me to film
And the clinic in Houston are happy for me to film whatever I want
So I’m going to
——————————————————————
video blog 10th of December 2011 (4:10)
——————————————————————
I don’t know how many blog videos we’ve done but we’ve done quite, quite a few and I think it’s amazing that we’ve got to this point
It doesn’t seem very long ago that we were sitting and talking about doing this, and within a few months we’ve raised all this money and we’re, my bags are packed
Your bags is almost packed

My bag is packed

And your bag is packed and we’re leaving tomorrow morning
I know there’s been a little bit of controversy

Yeah

about what we’re doing, but please, whatever you hear about it, we have done a lot of research into this
and we feel very confident about what we’re doing, were going to get very well looked after and we’ll be able to share all of that with you
So, next time you see us we’re going to be in

Houston

Texas
——————————————————————
Day One (4:52)
——————————————————————
Good morning Hannah

Good morning

And where are we ?

At the airport

So, you ready for this ?

I’m ready

Ready to start this next phase of our journey ?

Yeah

Ok

I’m really ready
I hurt, like I’ve got a massive headache

Yeah
That was pretty traumatic for you, wasn’t it ?

Yep
Pressure
Um, and getting through customs and everything like that
I felt like I was going to faint
Um, yeah, apart from that all good

Yeah ?

Yeah

And how’s it feel to be in Texas

It doesn’t feel any different at the moment

(laughing) (?) that’s a (?) Avis rent-a-car thing-a-ma-bob
——————————————————————
Day Two (5:37)
——————————————————————
(?) there you go
Right-o

Hello everyone

Hi

I’ve

Ok

I’ve got less hair than Pete

Are you looking in the camera or are you looking in here ?

I’m looking in here

Uh what are you looking there ?

(laughing)

Hello
Everyone
Today is going to be a very interesting day
We’re going to film, all that we can
We’re not going to meet Dr. Burzynski
We won’t be meeting him until the 19th, but we feel more than happy to be meeting his fellow doctors
What’d you reckon ?

You’re going to kill me in the car before you, we get there ?

Why

Because you’re trying to film and drive, and you don’t know where we’re going

Well spotted
Look
There it is
We’ve finally made it

So how’d you feel, that we’re finally here ?

Yeah
I feel good

Do you ?

Yeah

You ready ?

What are your expectations ?

I have no idea

Well, lets go and find out

Don’t have any expectations although I sure don’t want to be disappointed
——————————————————————
[Temperature]
(Close your lips please)
——————————————————————
[Eyesight]
(Ok
How about this one ?)

D

(Ok. We’ll have to go )

(laughing)

(I’m sorry)

Should I actually be able to ?

(#5)

Ok
P E C F D

(Ok. Good)
——————————————————————
So, was that bad ?

Uh, can’t see any of them

Oh, ok
——————————————————————
Meeting with Dr. Yi and Dr. Greg Burzynski (7:14)
——————————————————————
(?) we’ve reviewed your scans, your MRI, and we’re very aware of your case

Yes

We have permission to start you on the antineoplastons

Mhmm

which as you know are in the final stages of drug approval

Yeah

Dr. Yi is the oncologist on this case

Yeah

Likewise Dr. Rowkowski will be involved
Likewise I’ve an I’ll, I’ll be on the case

Ok. Great

And my father as you know is aware of what we’re doing here

Yeah

So as early as Wednesday we’ll be starting treatment

Mhmm

Tomorrow we can put in the catheter, and this is an external
——————————————————————
Day Three (7:44)
——————————————————————
What else is happening today ?
Look

Don’t want to think about it right now
Gonna have some sugar syrup put into me

(?) PET scan

Yeah
Which they inject sugar
I’d rather eat some

Yeah
Inject sugar and then you’re also having a, this Hickman line fitted

Yeah

Hopefully they’re gonna let me put on a white coat and come and be by your side

You can’t put on a white coat
You’re not a doctor

Well hopefully they’ll let me film

Well I don’t care about filming
I just care about you being there
——————————————————————
Hannah’s MRI scan review (8:15)
——————————————————————
So this is the one that was done in December, right ?

Yeah
This is the one that was done in December, and it has increased

‘Cause if I look at the, it’s more intense

Yeah

There’s more weight

Yeah

upon the image
Ok

Seen change in a month, right ?

Yeah
It’s in a month
That’s why

Less than a month

Yeah
That’s why kind of it’s a little scary
’cause it has
I mean it looks like it’s more prominent now

Yeah
——————————————————————
(8:46)
——————————————————————
after (?) this MRI scan, and you can see that the tumor is enhancing
She doesn’t know that
How will I tell her ?
Probably not, but she’s probably going to ask, and if the tumor grows like it’s, then you just saw in the scan, then how long does Hannah have left
——————————————————————
(9:06)
——————————————————————
Yeah
That would mean very

That’s pretty good
Ok
That’s good
That’s good enough
So any memory problems ?
Any speaking proc, speaking problems

No
No, not really

Ok

Spelling
Spelling, yes

Ever since surgery

So, what kind of problem ?
Like when you spell you miss letters ?

Yeah
Her spelling

Why, yeah
It’s just I’m jumbled

Ok

Yeah
——————————————————————
(9:28)
——————————————————————
Right
So uh were just getting ready now for Hannah to go in and have her PET scan and uh catheter Hickman line fitted and she’s just filling in the form
I’m not even going to ask her how she’s feeling or anything like that ’cause she’s feeling a little emotional
——————————————————————
(9:48)
——————————————————————
(?)

(laughing) You’ve just taken some , some Valium as well, have you ?

Not helping

This is like your biggest con, fear, isn’t it ?
I just show everyone what you’ve just done to my hand as well
——————————————————————
(10:04)
——————————————————————
What I’m doing is I’m creating a little tunnel under the skin
So I have to use just a little bit of pressure
So if I hurt you, you tell me
Ok ?

How are you feeling ?

Shhh

(laugh)
Well, you’ve done so well darling

I’m feeling really cold

Hungry ?

Yep

Alright
——————————————————————
(10:30)
——————————————————————
You look like you’re some sort of Holy Woman
People are going to come in here and bow to you
Did, did, did you feel that when it was going in and stuff ?

Not really

Little bit
It’s a little bit painful now ?

Yeah
It’s quite really painful now
Yeah

Well, it’s a massive tic, of something we have to get done

Yeah, I know
——————————————————————
Day Four (10:52)
——————————————————————
I’m feeling wrecked, absolutely wrecked

(laugh)
Well you had, bit of Valium yesterday

Yeah

And you had as much um local anesthetic

Yep

as he could give you he said, without knocking you out,

Yeah

but you were very, very brave yesterday, do you not think ?

I don’t think so

Why not ?

I wasn’t brave about the (canada ?) they put in here
——————————————————————
(11:23)
——————————————————————
Yes

What’d you think of
What, now what did you think of Judith Curran ?
Talk to

Oh, she’s great

( Skype on at the same time)

She’s like a mother

Yeah

Yeah
Is she ?

Yeah

(Yeah that’s fine. Whatever)

Yeah, she really does love you

( I’ve got something)

More than most

(?) all mom’s girlfriends

Mum uh Hannah just, I said, I just asked what she thought of you and she said she thought you’re like a mother

(Pete’s Mum)

Ohhh

I really do need you here

Oh dear
Well you have to have a partner mother at the moment

Yeah

But you need cuddles you mean ?

Yeah

Ohhh lots of cuddles
Oh no, no, no don’t

I asked
I’ll go

I need something dressed there

She needs help getting dressed
——————————————————————
(12:16)
——————————————————————
It’s, it’s, you know, it’s basically it’s uh, it’s a little roadway right into your bloodstream, so yeah, it has to stay very clean, and our thing is that we have to teach you

Yeah

how to do this

Yeah
——————————————————————
(12:32)
——————————————————————
You get 6 doses of antineoplaston a day,

Mhmm

they’re 4 hours apart
So, yeah, it’s almost 24 hours continuously

Mhmm
——————————————————————
(12:41)
——————————————————————
These are your bags

Ok. Thank you

and I’m going to wait until Dr. Barbera comes and talks to you about the pain medicine

Yeah

Then we will go ahead and hook up

Yes

because she did get the chest x-ray and everything’s a go
——————————————————————
(12:51)
——————————————————————
And everything goes in with a push and a twist

Ok
Quite simple

Alright

Yep

So obviously we’re gonna, when the fluid, we need to open up the clamp

Mhmm

And I always double, triple-check, make sure all the clamps are open

Yep
——————————————————————
(13:10)
——————————————————————
I’ve been on the treatment, I don’t know
It, it’s about
I don’t know
Half day ?

How are you feeling ?

It doesn’t hurt

Yeah
And this is what you’ve got to carry around with you

Yep

Now it’s like

It’s (?) my new bike

a baby
Something you have to have with you all of the time, and me with you all of the time

Oh (laugh) Oh god
I can cope with that

Ever since this all happened it seems like it’s just been one thing after another

Yeah

of obstacles

Yep

But we’ve got this far
Who woulda believed that we’d raise the money to get out here

Mhmm

which we have done, and now we’ve started on the treatment and I am pretty impressed with them there I must admit

Yeah
They’re really nice
——————————————————————
Day Five (13:52)
——————————————————————
Yeah
This is day, it’s day 4 yeah ?
Day 2 on the job
Day 5
Day 2 on the treatment
Mmmm I need a bit of a shave
um and um yep

You need a bit of a shave
So do I

Yeah, yeah, yeah, yeah, yeah
——————————————————————
(14:08)
——————————————————————
Hi
So, can I get ya

You need a pen ?

Uh, yes please
So pull this back ?

Pull it back to undo the lock
Ok, pump is off, so your next step is to disconnect it
So push in and twist, clockwise
——————————————————————
(14:26)
——————————————————————
How’s your new friend ?

Yeah, she’s good

Yeah ?

Mmm

What have we done today ?

We’ve learnt more lessons

I’ve learnt more lessons about changing the, changing the pump
How did I do ?

Honey you did well

You think so ?

considering

Considering what ? (laughing) How challenged I am

No, considering how hard it actually is
That you did well
——————————————————————
Day Ten (14:54) Meeting with Dr. Yi and Dr. Stanislaw Burzynski and
——————————————————————
Yeah, I think so far where we are we have been very impressed with all we’ve seen

Thank you very much
It looks like (?) we should not (?)

a pretty traumatic day because uh we met with Dr. Burzynskibut he didn’t give us the sort of news that we wanted uh because he’s concerned that the treatment may be enhancing uh and he wants us to stay here until at least um Hannah’s had one month on the treatment and to do MRI and see what’s going on
We can stay here
That’s the most important thing
Just imagine if we had to go home
You know ?
I know you’re tired of all this, you know, and its hard work, and it’s, you know ?
——————————————————————
Day Twelve (15:46)
——————————————————————
So the last time we kind of filmed was when we were with Dr. Burzynski and him saying do we want to stay and that

Yep

And how, how do you feel about that now ?

Yeah, i’ve got my head ’round it

Do you have faith in him and ?

Yeah, again I know that I’m in the best hands
——————————————————————
Pete’s colleague Dr. Hilary Jones appears on ‘Daybreak’ morning TV show in the UK (16:04)
——————————————————————
Are there question marks for you with regards to going over there to this particular clinic ?

I think what we have to bare in mind is that uh the treatment that, that Dr. Burzynski is offering is, is very uh experimental
It’s pioneering research, and pioneers in medicine tend to get a rough ride to begin with, and uh he hasn’t uh uh published the numbers of people in trials that convince the established authorities that his treatment uh works
It’s very interesting treatment
We’ve known about these peptides which can switch uh tumor genes on or off, and this is a different approach to these kind of tumors, that’s uh over and above oncology, chemotherapy, radiotherapy
Um, his results um, if you look at them um, sometimes appear extraordinary in some cases um but of course not in all cases
So it’s very difficult to evaluate, how effective it is
I I researched it pretty carefully myself because I have a friend there at the moment with his partner and the reports I’m getting back are they’re getting excellent treatment, excellent support, very impressed
This is somebody who, who knows a lot about medicine
Very impressed with what’s going on there
Um, we need to keep an open mind

Yes

Um it’s unfortunate it costs so much money but pioneering treatment does, and I really hope, that if you go that route that it works out for you
I really hope

Thank you

Indeed
——————————————————————
(17:20)
——————————————————————
So, that was uh, I didn’t know uh he was doing that, and actually the weird thing was that the day before I had actually contacted him just to say that we were doing really well

Yeah

But poor old Hilary was so caught up in that yesterday
On Twitter, I mean it was just nonstop
People just saying
“Burzynski’s a fraud”
Um, but we certainly don’t feel that he’s a fraud, do we ?

No

No
I get the impression that he’s 100% genuine
——————————————————————
12/25/2011 – Christmas Day (17:50)
——————————————————————
Hello there

Hi. How are you today ?

We’re doing ok

Documenting that ?

Um yeah I’m documenting

(laughing)

everything

That’s against the rules

Really ? Oh dear

(? again)

Collecting evidence ?

Yeah, I am

We’re gonna sue
We’re gonna, we’re gonna sue a few people

(laughing)

That’s what you love to do in America, right ?
——————————————————————
(18:10)
——————————————————————
So same symptoms ?

Yeah

The flu symptoms

Mhmm

Yeah. Ok. How’s your breathing ?

The same

That was, really bad yesterday, wasn’t it ?

Yeah

Ok. Um, any headache ?

Yep

Ok. And you said you had, are they tremors or are they like shakes, like chills ?

Yeah, chills

Chills, ok

But, you know, like I couldn’t stop

Ok.

myself

It was just

Yeah

Ok. So it was un, uncontrollable ?

Yeah

Ok
——————————————————————
(18:41)
——————————————————————
This is how we spent Christmas Day, in the Burzynski Clinic

With the lovely Monica

Of course

And

How (?) would you have it any other way

And the Christmas songs

Hey (mouthing words to song)
——————————————————————
(19:04)
——————————————————————
We went to the clinic this morning, and she was shivering all night, fever
So she’s off the antineoplastons for the day, and she’s just basically in bed now, just absolutely exhausted, and now she’s got a little bit of swelling on the back of her head, which obviously is a ca, cause for concern when you’ve got a uh, a brain tumor
——————————————————————
Day Eighteen (19:04)
——————————————————————
Hannah was back on treatment yesterday, and last night her temperature went up to 102
So I phoned uh the clinic, and they said take her off the medication, the anti, antineoplastons
So I took her off
Her temperature came down
Then it went up again, and then we went back to the hospital today, back to the clinic, and they’re giving her a much smaller dose um and she’s on much smaller dose and she’s just come back, and she’s just exhausted

And she, I can see she’s just so close to breaking, which is cracking completely
(Christmas tree)
——————————————————————
(20:07)
——————————————————————
um and I’m just, got to the point where I can’t, I’m just, don’t know what to do
——————————————————————
Day Twenty (20:22)
——————————————————————
Well the last week has been very up and down
Um I have come off the dose
Gone back on it
Come

Come off it

back on
Yeah, and then come back off it again um, for several reasons: Fever, um shaking, chills, fever, and bacterial infection, um viral infection, every infection, um and then ended up with me having to go to E.R., the Emergency Room

Well at that point I was really fearing the worst

Mhmm

Because you’d a scan when we got out of here, right ?

Mhmm

and the scan definitely showed some tumor growth

Mhmm

um and I was thinking, what 2 and 1/2 weeks later from that

Yeah

That we were going back in the hospital

Mhmm

Because the tumor had gotten bigger

Yep

What has this whole experience like for you at the moment

Oh it’s just surreal
I just, I can’t explain it
It’s just surreal, to me

What, like its not happening to you ?

Yeah

You did actually said to me yesterday in the hospital, you said:
“I’m at my wits end”
“I don’t feel I can take anymore”

Yep

And what about today ? (laugh)

Well, I reckon I’ve been, I’ve just realized I’ve got to get on with it again
——————————————————————
Day Twenty-Two (21:53)
——————————————————————
So it’s, January the 1st, 2012, and we haven’t really got the,
We haven’t got off to a great start, have we ?

No

Why ?

Because I’ve had a fever

Uh you, when did you start, feeling feverish ?
In the middle of the night ?

Yeah. Yeah

And your temperature went up to 102

Yeah

What Dr. Burzynski thinks you, why you’re having a fever
you’ve either still got some flu-like symptoms or it could be the, the tumor actually breaking down

Yeah

which hopefully, that’s what it is, right ?

Yeah
——————————————————————
(22:34)
——————————————————————
Yeah, feel drunky

You know you haven’t had a drink for a year so

I haven’t had a drink for a year

(laughing)

(But I think this)

Yeah

We’ve also got some problems with our pump this morning

(So what do you think ?)

Yeah, it’s not closing again

(And then you can also see the)

Uh, there it goes

(?)

But

It ain’t gonna stay that way

I don’t think it’s going to stay closed

Huh, what’d you think about that ?

(unintelligible)
(? get it fixed)

(and this looks like it’s ?)

(? fix ?)
Love you
——————————————————————
(23:09)
——————————————————————
The last time we saw you, you felt like you were completely drunk

Yeah

And you had double vision

Mhmm

So,then what, ended up, happening ?

Well, one of the nurses, kindly, pointed out
She said: “What have you taken ?”
That is where we recognized it was an anti-seizure drug, that I hadn’t taken before

And how do you feel now ?

I feel ok
I feel a but shaky

Yeah

I just have to (?) something to eat
Um, I’m just so tired
——————————————————————
(23:50)
——————————————————————
Hi, I’m Pete Cohen
Uh you might recognize me

Oh god

from morning television in the

Yeah

U.K.

Nobody recognizes you anymore
——————————————————————
(23:58)
——————————————————————
You should keep your fingers above the little

Ok

guard thing, yeah, and try to hold this

I’ve done it

as straight as you can

Ok. I’ve done it there Gary

and put some support

Yeah

on it

In there

and then you twist them down

Easier said than done (?)

I know

You can give it much more of a whack and you can u, use the other end as well

Ok

No, like this

(laughing)

Got no chance

Use the other end
(?) better

Ok. Thank you

(laughing)

You’re welcome

There you go
There you go (?)
There you go
——————————————————————
Day Thirty-Eight (24:33)
——————————————————————
I’ve never had to take care of anyone, the way I’m kind of having to take care of Hannah, and its just constant, and I get stressed around her, which isn’t fair, you know
She’s now got another temperature
She’s got a throat infection
Her temperatures up, uh and uh if it goes up over 102, it’s 101.8
If it goes up over 102 she’s got to come off of the treatment again um, oh, just, just feels like non-stop, you know
Cooking, and changing the bags
I’ve been into this, the clinic 3 times today
Taking her blood
Taking her back, get supplies
Take her back there
——————————————————————
(25:24)
——————————————————————
I’ve got a fever
It was over 102 last night

Yep. And

I’ve got antibiotics

Which you’ve been on for how many days ?

3 days

And we’re off the treatment
So, all in all
But you feel bad because you just want to be on the treatment, and just keep coming off
It’s just
How does that make you feel ?

Just, I don’t know, angry
Disappointed
Pointless

What you mean like
The while things pointless

Yeah

because you can’t stand

I just hope one day we can look back at this and laugh

Yeah

and just think: “We beat that”
because you couldn’t be doing anymore than what you’re doing
You know ?
You really couldn’t
Should really get a few of your friends to come over

Yeah

’cause you must be a bit bored of me

(laughing). No

C’mon, I’ve been really annoying
How grumpy was I yesterday ?

(laughing)

on a scale of 1 to 10 ?

(laughing)

I don’t know

C’mon

6

Really ?

Yeah
——————————————————————
Day Forty-Two (26:54)
——————————————————————
It’s 6 o’clock in the morning, and Hannah is lying here
Her temperature went up to the highest I’ve ever seen a temperature, on the thermometer
Where is the thermometer ?
Up to 104
I’m gonna just, I’m just trying to cool her down
I just phoned the doctor on-call and she said take some ibuprofen which Hannah has, and the result is ?
It’s come down a bit
Where is it ?
There it is
102.5
Well you’d think it’d come down
My god you’re so hot
I can’t believe how hot that is, thats got
Unbelievable
——————————————————————
(27:50)
——————————————————————
Hannah
Show me what’s going on
This all came up
When did you notice this ?

Yesterday afternoon, but its got worse since then

Yeah, lift up a bit higher if you can
Just zoom in on that
Yep
So it’s just one thing after another at the moment, isn’t it ?
Aye ?

Yes

Open your hands a little bit

Yeah (?)

And obviously we’re off, treatment at the moment

Mhmm

And we’re just waiting for who ?

Dr. Popper

What do you think he’s going to have to say ?

Mmm I don’t know

Ok

Ok, bye
——————————————————————
Day Forty-Four (28:35)
——————————————————————
Who um gave it a name ?

I sent a picture of it to Dr. B and he came back and said I think that’s what it is, and I looked into it and could see that that’s exactly what it is

Well does it bother you or does it just ?

No, it does

Like

Yeah

And itch ?

In some cases

Oh I’m sorry

Especially under the dressing

(?) Hannah had a fever
104 on Friday night

104 ?

103.9 I should, if I’m being absolutely, precise
So I think it’s brought this out

I think you can, you can say 104
——————————————————————
(28:50)
——————————————————————
So, we’re now going to have the MRI that we were going to have on Wednesday
We’re going to have it today

Mhmm

so we can see what is going on

Mhmm
——————————————————————
(29:17)
——————————————————————
(?)

Why are you filming me ?

Why not ?

Please stop filming me now (laughing)

That didn’t work
I’m still filming you

(laughing)
——————————————————————
1/23/2012 MRI (29:29)
——————————————————————
This is one that was just done today ?

2012 Jan 23
Acq Tim: 12:13:09
955000
320 x 230

Today

2011 Dec 29
Acq Tim: 14:50:12
497500
256 x 192

Today
So the difference is that you can see there
How would you describe the differences between
and what you see here ?

Well 1st of all the size of the tumor is less, and um, if you see the actual, the solid enhancing part of the tumor
This is how it looks now

So from that you can see that it’s definitely, something definitely is going on
It’s changing

Yes

There’s no question about that

The size is less
The intensity of the enhancement is less

So wha, whe, whe, when you see something like this, wha, what does that show you ?

Well, certainly the, we see that the tumor’s most likely working, as the tumor is showing less enhancement, meaning less activity

Yeah

And the tumor’s by effect smaller

Yeah

So, ideally the next scan should be better
So we, we’re definitely going in the right direction

That’s, great

That’s for sure, and it’s brilliant that uh we’re going home on, on

On a high note

On a high note
Especially after our trials and tribulations
So

Certainly
——————————————————————
(30:47)
——————————————————————
Hannah’s tumor has started to shrink, and she doesn’t know
She doesn’t know that
So I’m going to go in the house
I think she’s still asleep, and give her the good news

(?)

Hannah

Can we go home ?
Can we go home ?

Guess what ?

We can go home ?

Yeah

Yea !

And guess what ?

Guess what

Your tumor started shrinking

Yea !

It shrunk by at least 10%

Let me just give you a kiss

Thank you

It’s ok
It’s ok
——————————————————————
(31:30)
——————————————————————
Hi Daddy

Hello, how are you ?

Yeah, I’m sorry for ringing so late

That’s alright

Um but I’m ringing with really, really good news

Good, that’s what I wanna hear

Go on you tell

No, you tell him

I don’t think I can

(Go on ?)

(? tell me ?)

Um

C’mon

my tumor

Yeah

has already shrunk by 10%

You’re f’n ‘ell man

F’

(?)

That is absolute, amazing

And considering I haven’t been on the treatment for

You’ve been on the dose, off the dose, and on it
F’n ‘ell
What
When you get started on the
F’n ‘ell man

(laughing)

I’m glad you phoned me

Yeah, you’re the 1st person I called, obviously
——————————————————————
(32:22)
——————————————————————
So what can you believe we’ve now been here for one month

Yes

And we’re going now
What are we going in to have done ?

Hopefully, be discharged

And are you pleased with the progress you’ve made ?

Yeah

It’s been up and down

Yeah it’s been up and down

(Trip, trip ?)

You look like a Hollywood star

(laughing)
Not many Hollywood stars have a backpack like this though

Yeah but it was also a week ago
I don’t know how long ago that was where you couldn’t even

What ?

What ?
In you go

In I go

Hi

We can’t stay away

(laugh)

We’re getting discharged now

Oh really ?

I think so

Well that’s wonderful

Yeah

Well yeah, oh we, we don’t wanna go
Right turn mate
Which floor ?
2nd floor

Oh, you’re still filming

Yeah, I just, you know, I mean, you know, why not ?
I haven’t filmed all of this
We’re going up

This was great when I was feeling really sick, ’cause it

Seems like we’ve spent a lifetime together, we used to go to the 4th floor

(laugh)

(Ok)

Hi

Ohhh

Hello

Hello

Hi

Hi

Hi everyone

Hello

Hello

Um Hannah and I are leaving on Friday
What’s going to be your overriding memory of us ?

No

What are we gonna do ?

Hey

Are you going to miss us ?

What are we gonna do ?

Of course

Peace and love

(Remind me, is Hannah ?)

Why don’t you stay

(?) who’s your favorite, because you remember we said we were gonna say

(laughing)

‘Cause, ’cause we can o, we can only take one of ’em home, and who’s it gonna be ?

(? the rash (?) dude)

(laughing)

Well you can only take one attribute from each person, what would it be ?

I’m going to take Ashley home

(laughing)

Really ? Why ?

Yes, I like that

Because she’s, because she has the same condition ?

Yep

(laughing)

Because she can look after

Very good

(laughing)

So Rick you were told I was a big shot

Yes, going to film everything so

(Who knows ?)

you have to watch out

So, c’mon, what, what point in your head did you think: “My god this guy’s an absolute idiot”

(laughing)
——————————————————————
Day Forty-Seven (34:55)
——————————————————————
This, this December 29
This is January 27
Here we have the tumor, visible previously
And we have now
Certainly, outside diameters have decreased

Mhmm

So to some extent, but also the, the intensity of the enhancement, has decreased

Mhmm

As you can see this was much brighter before, now is less
Which means that the tumor is decreasing and it’s uh losing its activity at the same time

Mhmm

Which is a good news

But, again, we are not at the remission
This is called Stable Disease
Stabilization

Mhmm

Probably next time we see this is shrinking more and this wide band is getting thinner, and thinner, and finally

Mhmm

it should disappear
So that’s what you should be looking for

Ok
——————————————————————
(35:43)
——————————————————————
There’s some hair on the camera

Well it’s not mine

It’s definitely not mine

Hmmm

Um

No
I’m gonna start

Ok

(laughing)

Go on then

Ok
So it’s June 2012, and we have been back for approximately 6 months from the, America, and generally it’s all going well

I’ve had about 3 scans since I have been back, and they’ve all looked fairly positive

I think they’ve looked more than positive but yeah, go on
Carry on

(laughing)

Um, yeah, so the tumor, well the enhancing part of the tumor is getting smaller

Basically there’s such a small little part left that I’m sure when you watch this you’ll be able to see some images so people can see your scans

December 7th 2011 scan

Yeah, mhmm

March 21st 2012 scan

and we know that if Hannah hadn’t had this treatment, with the type of tumor that she had

May 2nd 2012 scan

she might already be dead, or she probably wouldn’t be here

June 13th 2011 scan

Yeah

much longer

July 29 2012 scan

She is very much alive at this point in time

Yeah

And what’d you think about all this controversy, because the controversy around what we’re doing, and it’s just, just
I can’t believe it personally
I find it very, very hard the, the hatred and the skepticism, of, um, what Hannah’s doing
What, what, what’s that like for you ?

Well, as I, as I’ve always said along the way, you know, any of the skeptics, what would they do, if they were in my position ?
Would they want to die in 3 to 5 years or ?

Probably less than that

Uh (both)

And that’s a horrible thought

Um

Yeah, uh everyone has a, has a right to be sceptic and everyone has a right to their own opinion

Yeah, they do

Um, and, but the funny thing about people’s opinions is, opinions are often based on, what they’ve heard

Yeah

or what someone hasn’t done, whereas uh, we spent 7 weeks at the Burzynski Clinic uh

And we saw everything

We saw everything
We spent time with this man um, and I tell you from my, from, from, I think from both, I can maybe speak for you hey ?, but uh

(laughing)

he’s one of the most honest, kindest people

Yeah, he is

‘Cause I, I said to you, the other day, about making this film, and you said: “Even if I was going to die tomorrow, I would still want this to be made”

Yeah

You remember saying that ?

Yeah

What, what, why did you say that ?
Why ?

Because, it might give other people a shake up

Mhmm

Yeah

Yeah, because uh, yeah
Why did we make this ?
Well I made this because I thought it was a journey that was well worth documenting

(?)

and maybe could help other people, and maybe help people realize there are other options, apart from the conventional treatment for cancer, and to inspire people
I hope you’re inspired by Hannah’s story because she’s an amazing, she’s a, honestly she’s annoying sometimes

(laugh)

but not very often

So are you. Yep

She has such a desire to live, uh and to enjoy her life, and I think
I don’t know, if there’s anything else that we

Ok, that’s enough for now

Hannah’s most recent scan confirmed she has now had a complete response to the treatment
——————————————————————
(39:35)
——————————————————————
Special thanks to

Bacon, Lesley
Bradley, Jeremy and Irene
Cank, Elizabeth
Cohen, Judith and David
Gooden, Lindley
Jones, Dr. Hilary
Levitt, Chris and Gina
Martinez, Dr. Juan
Merola, Eric
Newman, Ofir
Norouzi, Minou
Ramsey, Anna
Rowkowski, Dr. Bob
White, Gemma

Hannah Bradley’s GP
The Eagle radio station
——————————————————————
(39:40)
——————————————————————
Dr. Stanislaw Burzynski
and all the staff at the Burzynski Clinic
——————————————————————
(39:48)
——————————————————————
camera
Pete Cohen

additional camera
Lindley Gooden

editor
Jamie Lowe
——————————————————————
(39:54)
——————————————————————
A film by
Jamie Lowe & Pete Cohen
——————————————————————
(40:00)
——————————————————————
This film is dedicated to all the people who donated their time and energy to raise funds to save Hannah’s life
——————————————————————
(40:08)
——————————————————————
To follow the progress of Hannah’s recovery and find out more about the treatment she received please visit:
http://www.teamhannah.com/blog


======================================
Extra clips from Hannah and Pete’s trip to Texas
======================================
Pete Cohen chats with Dr. Stanislaw Burzynski:
——————————————————————
https://stanislawrajmundburzynski.wordpress.com/
======================================
======================================
REFERENCES:
======================================
[1] – I Feel Empowered, In Control Of My Body: Four Women On Fighting Cancer With Alternative Therapies
——————————————————————
http://www.telegraph.co.uk/health/10383724/I-feel-empowered-in-control-of-my-body-four-women-on-fighting-cancer-with-alternative-therapies.html
======================================
[2] –

——————————————————————
http://www.teamhannah.com/the-film/
======================================
[3] – Team Hannah: Hannah’s Annectdote:
——————————————————————
http://www.teamhannah.com/
======================================
[4] –

——————————————————————
http://www.teamhannah.com/blog/page/5/
======================================
[5] –

——————————————————————

======================================
[6] –

——————————————————————
http://www.teamhannah.com/blog/page/4/
======================================
[7] –

——————————————————————

======================================
[8] –

——————————————————————
http://www.teamhannah.com/blog/page/3/
======================================
[9] –

——————————————————————
http://www.teamhannah.com/blog/page/2/
======================================
[10] –

——————————————————————
http://www.teamhannah.com/blog/
======================================
[11] –

——————————————————————
http://m.huffpost.com/uk/entry/3012836
======================================
[12] – Last Updated (Friday, 10/5/2012 03:32)

——————————————————————
http://www.964eagle.co.uk/hopeforhannah/
======================================
[13] –

——————————————————————
http://scienceblogs.com/insolence/2013/10/22/four-misleading-cancer-testimonials-and-reverse-balance/
======================================
[14] –

——————————————————————

======================================
[15] – 2/17/2012 – Friday – REAL LIFE – ‘I’ll try anything to beat brain cancer’
——————————————————————
http://m.gulfnews.com/i-ll-try-anything-to-beat-brain-cancer-1.981203
======================================
Team Hannah Blog (2:46)
4/1/2013 – Posted by Hannah
======================================
(laughing) Don’t
‘Cause you’ll put this bit in
Promise ?

Yeah

Ok

(laugh) Ok, so, it’s April the 1st and it’s 2 years on since I had my operation and but ? obviously is out

So, I just wanted to (laugh)

Start again
Start again
Start again
Start again

Ok
Ok

I don’t believe you

I have
Start today again

(laugh) I don’t believe you
It didn’t go “beep beep”

Because it’s on silent

(laugh) Do you think that I’m an idiot ?

No

(laugh)

Ok
3 2 1 go

Hi there um it’s (laugh) the, the 1st of April and it’s 2 years on since I had my operation and I’m pleased to tell you that I’m obviously still here, and um that’s thanks to you guys and thanks to me I suppose from, for fighting so hard for my life

And what, and what have you been up to then ?

I have been up to um just resting a lot and uh making up new recipes uh

Your next book

Yeah, for my next book and
Yeah, that’s pretty much it

And when are you thinking you might be able to come off the treatment ?

June
End of May
June

I have a scan in a couple of weeks and we’ll update you after that

And what will that be like, coming off the treatment ?

Oh, it’ll be amazing
Yeah, amazing

So you won’t be walking around with

No

this fellow here ?

No

Ok
Is there anything else you’d like to say ?

Um, just love to you all

Oh
The wave
——————————————————————
Team Hannah Blog (3:34)
3/2/2013 – Posted by Hannah
======================================
Hi
This is the Team Hannah blog and it is the 3rd of March and Peter is actually filming me today

He’s not there, where he normally is

Yeah
Exactly
So I’m on my own
Flying solo

Um I’d just like to say how well I’m doing and my last
Ohhh went a bit northern then
My last scan um was mid-February and it showed no enhancing tumor

So that’s really good

Um I’ve just got um a really cystic area in my head

So it looks like they’ve predicted June me me to be off the treatment
So, fingers crossed for June

What will that be like to, to come off the treatment ?

Um, yeah, it will be
The treatment is so uh, restricting I would say
Yeah, it would be good to come off

And what else have you been up to ?

I have been (holding up Team Hannah Cookbook) selling lots of copies,

Yeah

and, and,

the other book a little bit
I know that you mentioned in the last blog, but just
What, what’s the book about ?

Well it’s low-carb recipes and I’ve
Been on the radio
I did a radio
promoting it and um it’s great for anyone who wants to cut out sugar
to lose weight and decrease their, and what, decrease their

Risk

Yeah, risk of getting disease

Yeah, ’cause we saw a doctor in America, Dr. Rowkowski
and he, and one of the things he said to you was you really need to cut sugar out of your diet
to
sugar is what he said

Yeah

Um, and you’ve been getting a lot of people that
trying your recipes and taking photos

Yeah
picking up
on Facebook on Pete’s favorite page
to cook something from the book

put them up on the
page as well

And um where can people find out about your book

Um just slide over to, to Hannah Cookbook and you will find it there

And your blog as well, yeah ?

Yeah

So, I think we’re done

I just want to say there’s an airplane going overhead
Thank you to everyone whose supported us
it seems a lot of, a lot of film

And why are you laughing

Pajamas

pajamas

I didn’t quite
yep

What are those

(laughing)

This bench has seen a lot of action

Yeah, it has
Video action, that is

(laughing)

And we’re very thankful to everyone

Yeah
Thank you, yeah, again

Yeah

We try and do one after next scan

Big wave, please

Bye bye

Bye
======================================
Sapphire Sings For Team Hannah
1/3/2012 – Posted (3:00)
======================================
(Last) Christmas, I gave you my heart
The very next day, you gave it away
This year, to save me from tears
I’ll give it to someone special
Once bitten, and twice shy
I keep my distance, but you catch my eye
Tell me baby, do you recognize me ?
Well, it’s been a year, it does not surprise me
Happy Christmas, I wrapped it up and sent it
With a note saying, “I love you”, I meant it
Now I know, what a fool I’ve been
But if you kiss me now, I know you’d fool me again
Last Christmas, I gave you my heart
The very next day, you
——————————————————————
(1:04)
——————————————————————
Ok
Sapphire, all I have to say is
“Thank you, thank you, thank you
You have compiled a CD, um, in aid of Help for Hannah, and you have had quite a lot of sales so far, and you have got a beautiful voice, and I’m sure you’ll go very, very, very far, but “Thank you”, and this is just a little “Thank you” for you, but obviously other people are going to hear it
Thank you
Love you
Bye

Did you
Sorry
Did she also, sing this yesterday, uh, somewhere?

Yeah, she sung it at Aldershot uh Football Club

Again, so Aldershot was playing football against another team

Plymouth, yeah

Plymouth
And she sang it for everyone ?

Yeah

And they raised some money for you ?

Yep

Yes, so this has been a big “Thank you” from both of us (laughing)
Let’s, let’s play out a bit more of that song

Ok
‘Cause we love this song
It’s off

Uh yep, it’s my favorite Christmas song
It’s the only Christmas song
(gave it away)
we can hear when it’s not Christmas
This year, to save me from tears
I’ll give it to someone special
A crowded room, friends with tired eyes
I’m hiding from you, and your soul of ice
My god I thought you were someone to rely on
Me ? I guess I was a shoulder to cry on
A face on a lover with a fire in his heart
A man undercover but you tore me apart
Now I’ve found a real

Thank you so much
——————————————————————
An Update For You

10/21/2011 – Posted

A Message From Pete About Team Hannah (3:07)

A MESSAGE FROM PETE

Hi it’s Pete Cohen and I just wanted to share something with you

Uh in February this year my girlfriend was diagnosed with a, with a brain tumor and when this happened it really obviously rocked our world

You know, everything seemed to be ok

Everything was great in life

And then something happened, and everything changed

And I don’t know whether anything like that has ever happened to you

But these things happen don’t they

And when they happen they really test you

They really challenge you

They, it’s very easy

It made me question lots of things

It made me think to myself, well, you know, what, is life, really fair ?

You know, should this happen to such a young person ?

These things do happen

And it really puts us in a position where it questions what we have

What we have to deal with such difficult circumstances

And I’ve definitely found things in myself that I didn’t know wa was there, you know, resolve, compassion, determination just to, to keep going

And this is the thing human beings we all have this kind of, we all have something else don’t we

All, we all have something more than our stress, and our worry, and our anxiety

We have a our true nature I think can overcome so much, of what life throws at us

You know, obviously we can’t overcome, everything

But what I really wanted to share with you is something that I’ve been so taken aback with, and that’s the beautiful nature of human beings, because we’re trying to take my girlfriend over to America to be treated over there, and we’re having to raise a considerable sum of money, and we’ve actually had to ask people, for help

Now that’s something that’s a bit alien to me, is to ask people and say, you know, can you help me, can you help us

Maybe that’s an insecurity that I have

Bur we’ve asked for help and it’s been amazing to see people all over the world spread the world, donate some money

And I’ve been so touched by that

It’s so life affirming

It so, it gives us such great strength

Any my girlfriend and I have been
so touched by that

So what’s my point here ?

Recognize how important it is for all of us to support each other

Recognize how important it is to affirm each other

You know, that’s one of the most important human needs we all have;
affirmation, it’s the fact that, to take the time to recognize each other

Hello

How are you

I care for you

So, thank you so much for watching this, and if you want to help us out please just uh visit the web-site we’ve put together for Hannah

It’s just called Team Hannah . com, and on there you can see a little more about Hannah and what’s happened to her, and the treatment we’re looking for her to have, in America

So, I hope you all have a great day and please, take the time to be there for other people, to care for other people, because that’s what makes this world great

Thanks for watching

Bye, bye
======================================
v=p5tAeYsNOZQ?rel=0
======================================
——————————————————————
Hannah’s message [3]
——————————————————————
(3:02)
——————————————————————
Ok
So what’s your name ?

I’m Hannah Bradley, and I’m 27 years old, and I come from North Hampton

And what happened to you ?

I had a seizure in middle of the night and my partner tells me I was rushed to hospital

That was in February 2011

And from there I had lots and lots of tests, and they decided that I had a brain tumor, and they were going to operate, and they successfully operated on the 1st of April, 2011, and they, the biopsy went off to be um checked

I found out that I had a grade 3 tumor

I then, under, underwent a, I had a 6 week course of radiotherapy, and that left me with no hair, and can’t remember what else (laugh)
And um that I went under another MRI scan 6 weeks after radiotherapy and we, that again wasn’t particularly good news, and we found out that there was still remnants of the tumor, and the future for me is very uncertain

So what, what are you looking for ?
What are you looking to do ?

Um, I, sorry

What do you want Hannah ?
What is it you’re looking for ?

Um, mainly I, um, I can’t

You just want to live, right ?

Yeah

So what are you asking for ?
What, what, what do you need ?

I um, I need people to raise money, for, uh, my treatment
I’m looking to going to America because there are things that they can offer me here on the NHS or locally (?) is very, very limited, and there’s a doctor in Houston, and he’s able to help

So you want some help in raising some money, yeah ?

Yeah, it’s completely out of our reach to raise that much money, and it’s, I’d like help to raise the money
——————————————————————
9/17/2012
Monday, 17 September 2012 07:23 | Written by Administrator

Hannah Bradley

Hannah’s amazing story, fighting and winning over her Brain tumor (Anaplastic Astrocytoma) is available on her support site

Team Hannah

There are more videos by Pete and Hannah, documenting her fight and the Burzynski Clinic
======================================

Critiquing: In which Orac does Stanislaw Burzynski propagandist Eric Merola a favor…

Posted on by
Reply

“Orac” / Dr. David H. Gorski posted his lame 6/3/2013 excuse for a review of Burzynski: Cancer Is Serious Business, Part II (2), and I critiqued it:

Critiquing: In which the latest movie about Stanislaw Burzynski “cancer cure” is reviewed…with Insolence:
https://stanislawrajmundburzynski.wordpress.com/2013/07/18/critiquing-in-which-the-latest-movie-about-stanislaw-burzynski-cancer-cure-is-reviewed-with-insolence-2/
7/17/2013 Gorski pushed out his “best” effort:

In which Orac does Stanislaw Burzynski propagandist Eric Merola a favor…
http://scienceblogs.com/insolence/2013/07/17/in-which-orac-does-stanislaw-burzynski-propagandist-eric-merola-a-favor/
After my Epic Sharknado Deconstruction of “Orac’s” “review,” I thought it only fair to continue the feeding frenzy with a Burzynski Texas Tornado

Believe it or not, I’m going to do “Dr.” Gorski (who particularly likes me, to the point of thinking, apparently, that I’m a white research supremacist) a favor

“Dr.” Gorski, as you recall, is a supposed “Doctor,” oncologist, breast cancer specialist, cancer (cough-cough) “researcher” who was responsible for two dubious propaganda reviews about documentary films which Eric Merola made re: Stanislaw Burzynski, the cancer doctor who has used “antineoplastons” to treat cancer without having published any final clinical trial evidence that they do what he claims, since his 1st completed phase II (2) clinical trial in 2009

However, no worries

M. D. Anderson did a clinical trial in 2006 and did NOT publish the final results until 6-7 years later, 2/13/2013

Based on that criteria, Burzynski has until 2016-2017 to publish

Back in 2010, Merola released the first of a dynamic duo of films, the first of which was called Burzynski The Movie: Cancer Is A Serious Business (as Gorski likes to call it, by adding an “A” in the title)

The sequel, the slightly less pretentiously titled Burzynski: Cancer Is A Serious Business, Part 2 (as Gorski again likes to call it with the “A”), was then released June 1 on various pay-per-view modes

As has been pointed out, it’s better than the first, and it features direct attacks on The Skeptics™, or SkeptiCowards©, if you will, who had the temerity to criticize Burzynski and Merola over the last couple of years with their school-yard bully attacks, NOT having the intestinal testicular fortitude to back up their claims with any citation(s), reference(s), and / or link(s) in support of their blatherskite, which they found worthy enough to defend on my blog

Merola is apparently trying to recreate the success of his previous strategy, which involved letting people watch the movie online for free for limited periods of time on websites like Mercola.com

I link directly to the Mercola.com link to the second Burzynski movie, because I want to give Mercola more Google juice than he already has

The movie was, however, on Vimeo until July 20:

BURZYNSKI: CANCER IS SERIOUS BUSINESS, PART II (2013) from BurzynskiMovie on Vimeo
http://articles.mercola.com/sites/articles/archive/2013/07/13/burzynski-cancer-film.aspx
If you want to see what the fuss was about and whether my criticisms of The Skeptics™, or SkeptiCowards©, were valid, now’s your chance

If you want to see the highlighted attack on The Skeptics™ SkeptiCowards©, it begins around 1:19 h into the movie

Yes, I’m encouraging you to watch Burzynski 2

It’s a beautiful example of all the things that Gorski tried to inculcate #TAM2013 attendees against

Indeed, dissecting this magnum opus is an excellent way to teach oneself critical thinking, much as dissecting creationist tripe is

Unfortunately, Gorski is unable to do this, because individuals like me, exist and will NOT let him get away with his disingenuous hack attacks

Other key points include:

Laura Hymas interview and the recording of her discussion with her oncologist (approximately 0:28 h in)

This section is horrifying (to Gorski, at least) to watch, as he can’t help but feel how dicey and ethical the situation that poor UK NHS oncologist found himself in with Hymas and her family demanding that he help her be part of one of Burzynski’s “clinical trials” by agreeing to be the local physician and agreeing to order various scans

The end of the story of Amelia Saunders (approximately 0:58 h in)

This is one where Merola caused Gorski true revulsion, as he basically implied that Amelia died because her parents took her off the antineoplastons

Or you can read what Eric Merola REALLY posted on Twitter:
https://stanislawrajmundburzynski.wordpress.com/2013/04/18/fact-checking-httpthehoustoncancerquack-com/
Hideaki Tsuda’s clinical trial (approximately 1:31 h in)

Gorski wonders why he hasn’t yet published, just like he wonders why Burzynski hasn’t published, but Gorski, SkeptiCoward© that he is, can NOT seem to explain why The Lancet Oncology Peer Review Team D-12-01519 refused to publish Burzynski’s 11/26/2012 (1:29:53) phase 2 clinical trial Progression-Free Survival (PFS) and Overall Survival (OS) re patients 8 – 16 years after diagnosis, results

Those of you who watch it, let Gorski know what you think

Those of you who can only watch part of it, let Gorski know what you think of that section

Remember, though, Gorski will BLOCK you if you question HIS infallibility, because he and his “Oracolytes” would rather comment on things that have NOTHING WHATSOEVER to do with Burzynski, like:

“it is possible to link without boosting google rankings through the “no-follow command”: http://en.wikipedia.org/wiki/Nofollow I learned about this from Bob Blaskiewicz, who proposed that we use this when linking to dubious websites in our posts”

Gorski makes unreliable excuses for NOT doing research re Burzynski, so I did it for him

Burzynski: Complete Response, Partial Response, Stable Disease, Progressive Disease, Objective Response, and Response:
https://stanislawrajmundburzynski.wordpress.com/2013/07/04/burzynski-complete-response-partial-response-stable-disease-progressive-disease-objective-response-and-response/
Burzynski: Progression-Free Survival (PFS):
https://stanislawrajmundburzynski.wordpress.com/2013/07/04/burzynski-progression-free-survival/
Antineoplastons: Adverse Effects:
https://stanislawrajmundburzynski.wordpress.com/2013/07/02/antineoplastons-adverse-effects/
Burzynski: Acknowledgements, Authors, and Co-Investigators:
https://stanislawrajmundburzynski.wordpress.com/2013/07/03/burzynski-acknowledgements/
Burzynski: Institutional Review Board (IRB):
https://stanislawrajmundburzynski.wordpress.com/2013/07/02/burzynski-institutional-review-board-irb/
And because Gorski and others do NOT seem to understand how antineoplastons (ANP) A10 (Atengenal) and AS2-1 (Astugenal) work, I provide the relevant Burzynski publications and page #’s for them to review:
http://www.burzynskiclinic.com/scientific-publications.html
======================================
Interim Reports on Clinial Trials
16. 2003 (BT-11)
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report.
DRUGS IN R&D
http://www.ncbi.nlm.nih.gov/pubmed/12718563
Drugs in R and D
http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
(Drugs in Research and Development)
http://www.burzynskiclinic.com/images/stories/Publications/960.pdf
Drugs R D. 2003;4(2):91-101
Drugs in R&D 2003;4:91-101
�
Pg. 92
Antineoplaston A10 and AS2-1 are synthetic derivatives of phenylacetate (PN) acid, glutamine and isoglutamine
�
A10 is sterile solution of sodium phenylacetylisoglutiminate (isoPG) in 4 : 1 ratio
�
Antineoplaston AS2-1 is sterile solution of sodium phenylacetate (PN) and phenylacetylglutaminate (PG) in 4 : 1 ratio
�
Pg. 97
Discussion
Pg. 99
======================================
Review Articles on Clinical Trials:
1. 3/2004
The Present State of Antineoplaston Research
http://www.burzynskiclinic.com/images/stories/Publications/994.pdf
Integrative Cancer Therapies 2004;3:47-58
Volume 3, No. 1, March 2004
DOI: 10.1177/1534735-403261964
Volume 3 Number 1 March 2004
�
Pg. 47
Pg. 48
Mechanism of Action of Antineoplaston
Pg. 49
Pg. 50
�
The reason for 50% Progressive Disease (PD) in studies is long dose-escalation process, which extends to more than a month’s time period, before the optimal dosage is reached
�
Pg. 56
Conclusion
======================================
Case Reports:
4. 9/2004 (Special Exception (SE) to BT-11 Study (ST))
Long-term survival and complete response of a patient with recurrent diffuse intrinsic brain stem glioblastoma multiforme
http://www.burzynskiclinic.com/images/stories/Publications/1145.pdf
Integrative Cancer Therapies 2004;3:257-261
Volume 3, Number 3 September 2004
DOI: 10.1177/1534735404267748
�
Pgs. 257-258
Pg. 260
Discussion
Pg. 261
======================================
Interim Reports on Clinial Trials:
2. 10/2004
Phase II study of Antineoplastons A10 and AS2-1 (ANP) in recurrent glioblastoma multiforme
http://www.burzynskiclinic.com/images/stories/Publications/1218.pdf
Neuro-Oncology. 2004; 6: 384
Volume 6 Issue 4 October 2004
Abstracts from the Society for Neuro-Oncology Ninth Annual Meeting, Toronto, Ontario, Canada, November 18-21, 2004
�
Pg. 385
======================================
Interim Reports on Clinial Trials:
3. 10/2004 (Study (ST) and Special Exception (SE))
Long-term survivals in phase II studies of Antineoplastons A10 and AS2-1 (ANP) in patients with diffuse intrinsic brain stem glioma
http://www.burzynskiclinic.com/images/stories/Publications/1219.pdf
Neuro-Oncology. 2004; 6: 386
Volume 6 Issue 4 October 2004
�
Antineoplastons (ANP) consist of 3 active ingredients including sodium salts of phenylacetylglutamine (PG), phenylacetylisoglutimine (isoPG), and phenylacetic acid (PN)
�
Preclinical data supports that the mechanism of antineoplastic activity in DBSG, involves interruption of signal transmission in the RAS, (PN) AKT2, and TGFB1 (PG) pathways, activation of p53 and p21 tumor suppressor genes (PN) and apoptosis (PG and isoPG)
======================================
Interim Reports on Clinial Trials:
17. 2004 (BT-13 and BT-23)
Phase II study of antineoplaston A10 and AS2-1 in children with recurrent and progressive multicentric glioma :
a preliminary report
DRUGS IN R&D
http://www.ncbi.nlm.nih.gov/pubmed/15563234
Drugs in R and D
http://www.ncbi.nlm.nih.gov/m/pubmed/15563234
(Drugs in Research and Development)
http://www.burzynskiclinic.com/images/stories/Publications/1194.pdf
Drugs R D. 2004;5(6):315-26
Drugs R&D 2004;5(6):315-326.
�
Pg. 316
Pg. 324
Discussion
======================================
Interim Reports on Clinial Trials:
18. 6/2005 (CAN-01 and BT-12)
Burzynski, S.R., Weaver, R.A., Janicki, T., Szymkowski, B., Jurida, G., Khan, M., Dolgopolov, V.
Long-term survival of high-risk pediatric patients with primitive neuroectodermal tumors treated with Antineoplastons A10 and AS2-1
http://www.ncbi.nlm.nih.gov/pubmed/15911929
Integr Cancer Ther. 2005 Jun;4(2):168-77
http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Integrative Cancer Therapies 2005;4(2):168-177
http://www.burzynskiclinic.com/images/stories/Publications/1220.pdf
DOI: 10.1177/1534735405276835
http://m.ict.sagepub.com/content/4/2/168.long?view=long&pmid=15911929
Volume 4 Number 2 June 2005
�
Pg. 168
Pg. 174
Discussion
Pgs. 175-176
======================================
Interim Reports on Clinial Trials:
19. 3/2006 (BT-03, BT-11, BT-18, and CAN-01)
Targeted therapy with Antineoplastons A10 and AS2-1 of high grade, recurrent, and progressive brainstem glioma.
http://www.ncbi.nlm.nih.gov/pubmed/16484713
Integr Cancer Ther. 2006 Mar;5(1):40-7
http://www.ncbi.nlm.nih.gov/m/pubmed/16484713
Integrative Cancer Therapies 2006;5(1):40-47
http://www.burzynskiclinic.com/images/stories/Publications/5825.pdf
DOI: 10.1177/1534735405285380
http://m.ict.sagepub.com/content/5/1/40.long?view=long&pmid=16484713
�
Pgs. 40-41
Pg. 46
Discussion
Conclusion
======================================
Interim Reports on Clinial Trials:
8. 10/2006
Treatment of multicentric brainstem gliomas with antineoplastons (ANP) A10 and AS2-1.
http://www.burzynskiclinic.com/images/stories/Publications/2105.pdf
Neuro-Oncology. 2006; 8:466.
Volume 8 Issue 4 October 2006
Abstracts for the Eleventh Annual Meeting of the Society for Neuro-Oncology (SNO)
�
Pg. 466
Antineoplastons (ANP) are synthetic analogues of naturally occurring phenylacetylglutamine (PG), phenylacetylisoglutimine (isoPG), and phenylacetate (PN)
======================================
Review Articles on Clinical Trials:
3. 12/2007
Recent clinical trials in diffuse intrinsic brainstem glioma. Cancer Therapy 2007; 5, 379-390.
http://www.burzynskiclinic.com/images/stories/Publications/5692.pdf
Review Article
Cancer Therapy Vol 5, 379-390, 2007
http://www.cancer-therapy.org/CT/v5/B/HTML/42._Burzynski,_379-390.html
Volume 5 Number 2 December, 2007
�
Pg. 381
Pg. 384
E. Multitargeted therapy
======================================
Interim Reports on Clinical Trials:
11. 10/2008
(BT-8 – PATIENTS WITH ANAPLASTIC ASTROCYTOMA)
(BT-15 – ADULT PATIENTS WITH ANAPLASTIC ASTROCYTOMA)
Phase II study of antineoplastons A10 and AS2-1 (ANP) in patients with newly diagnosed anaplastic astrocytoma:
A preliminary report
http://www.burzynskiclinic.com/images/stories/Publications/7853.pdf
Volume 10 Issue 5 October 2008
Neuro-Oncology 2008; 10:821
Abstracts for the Thirteenth Annual Meeting of the Society for Neuro-Oncology, November 20-23, 2008
�
Pg. 821
�
Antineoplastons (ANP) are synthetic analogs of naturally occurring phenylacetylglutamine (PG), phenylacetylisoglutimine (isoPG), and phenylacetate (PN)
�
Antineoplastons (ANP) is a multi-targeted therapy affecting signal transduction, the cell cycle, the TCA cycle, and apoptosis
======================================
Interim Reports on Clinical Trials:
12. 12/2008
(BT-8 – PATIENTS WITH ANAPLASTIC ASTROCYTOMA)
(BT-15 – ADULT PATIENTS WITH ANAPLASTIC ASTROCYTOMA)
Phase II study of antineoplastons A10 and AS2-1 infusions (ANP) in patients with recurrent anaplastic astrocytoma
http://www.burzynskiclinic.com/images/stories/Publications/7898.pdf
Neuro-Oncology 2008; 10:1067
Volume 10 Issue 6 December 2008
Abstracts for the Eighth Congress of the European Association for Neuro-Oncology (EANO), Sept. 12-14, 2008, Barcelona, Spain
�
Antineoplastons (ANP) affects multiple targets, and its components have different mechanisms of action
�
A10 interferes with signaling in the AKT2 and MYCC pathways, blocks expression of TGFB1, activates the PTEN and MAD tumor suppressor genes, and normalizes nuclear transport by decreasing the expression of RANBP1, which may restore the activity of the mutated INI protein
�
AS2-1 interferes with signal transmission in the RAS and BCL2 pathways and activates expression of the tumor suppressors TP53 and p21
======================================
Case Reports:
1. 12/2009 (BT-11 Special Exception (SE))
Over a 10-year survival and complete response of a patient with diffuse intrinsic brainstem glioma (DBSG) treated with antineoplastons (ANP).
http://www.burzynskiclinic.com/images/stories/Publications/8638.pdf
Neuro-Oncology 2009; 11:923.
Volume 11 Issue 6 December 2009
Abstracts from the Third Quadrennial Meeting of the World Federation of Neuro-Oncology (WFNO) and the Sixth Meeting of the Asian Society for Neuro-Oncology (ASNO), May 11-14, 2009, Yokohama, Japan
�
Antineoplastons (ANP) is a multi-targeted therapy that is well tolerated with minimal and reversible adverse events and has multiple different mechanisms of action by affecting the AKT, RAS, TP53, p21, and PTEN pathways
======================================

Burzynski: Complete Response, Partial Response, Stable Disease, Progressive Disease, Objective Response, and Response

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http://www.burzynskiclinic.com/scientific-publications.html
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
1. 10/2003
�
NEURO-ONCOLOGY
�
Phase II study of Antineoplastons A10 and AS2-1 (ANP) in children with recurrent and progressive MULTICENTRIC GLIOMA
�
A preliminary report
http://www.burzynskiclinic.com/images/stories/Publications/970.pdf
Neuro-Oncology. 2003; 5: 358
Volume 5 Issue 4 October 2003
�
Patients had 2 to 7 tumors:
11 – bilateral tumors
7 – visual pathway gliomas with involvement of the optic chiasm
5 – low-grade astrocytoma
4 – involvement of the brain stem
4 – involvement of the spinal cord
2 – leptomeningeal spread
�
10/2003 – Protocol – MULTICENTRIC GLIOMA
�
12 – Children Patients Accrued
10 – Evaluable Patients
(9 months – 17 years / 9 – median age)
�
4 / 33% – # and % of Patients Showing Complete Response
2 / 25% – # and % of Patients Showing Partial Response
4 / 33% – # and % of Patients Showing Stable Disease
0 / 0% – # and % of Patients Showing Progressive Disease
1 / 9% – # and % of Patients Nonevaluable due to only 4 weeks of treatment / lack of follow-up scans. Patient died while on treatment due to brain infarct / counted as treatment failure
6 / 58% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
1 / 9% – had stable disease discontinued treatment after SD against medical advice and died 4.5 years later
�
The study continues with accrual of additional patients
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
16. 2003
�
DRUGS IN R&D
Drugs in R and D
(Drugs in Research and Development)
�
BT-11 – BRAIN STEM GLIOMA
�
Special exception (SE) to BT-11
�
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic BRAIN STEM GLIOMA:
�
a preliminary report.
http://www.ncbi.nlm.nih.gov/pubmed/12718563
Drugs R D. 2003;4(2):91-101
http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
Drugs in R&D 2003;4:91-101
http://www.burzynskiclinic.com/images/stories/Publications/960.pdf
Pg. 95
�
10 / 83% – brain stem glioma
1 / 8% – astrocytoma
1 / 8% – glioma of brain stem and thalamus
�
Pgs. 91 and 95
�
3/1996 – Protocol – recurrent diffuse intrinsic BRAIN STEM GLIOMA (3/1996 – 5/1999 enrolled / Pg. 94)
�
12 – Patients Accrued (Pgs. 91 – 92)
(6 males / 6 females – Pg. 95)
10 – Evaluable Patients (Pg. 91)
(4 – 29 years / 10 – median age: Pg. 95)
�
2 / 20% – # and % of Patients Showing Complete Response
3 / 30% – # and % of Patients Showing Partial Response
3 / 30% – # and % of Patients Showing Stable Disease
2 / 20% – # and % of Patients Showing Progressive Disease
5 / 50% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
Pg. 100
�
3/1996 – Protocol – recurrent diffuse intrinsic BRAIN STEM GLIOMA
�
11 – Patients Accrued
11 – Evaluable Patients
(treated under special exception (SE) to BT-11 – Pg. 99)
�
1 / 9% – # and % of Patients Showing Complete Response
5 / 55% – # and % of Patients Showing Stable Disease
4 / 36% – # and % of Patients Showing Progressive Disease
1 / 9% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
======================================
COMBINED:
——————————————————————
# and % of Patients Showing Complete Response
2 / 20%
1 / 9% – special exception (SE) to BT-11
——————————————————————
# and % of Patients Showing Partial Response
3 / 30%
——————————————————————
# and % of Patients Showing Stable Disease
3 / 30%
5 / 55% – special exception (SE) to BT-11
——————————————————————
# and % of Patients Showing Progressive Disease
2 / 20%
4 / 36% – special exception (SE) to BT-11
——————————————————————
# and % of Patients Showing Objective Response
5 / 50%
1 / 9% – special exception (SE) to BT-11
�
Objective response = complete response and partial response
——————————————————————
Pg. 92
�
Owing to the long accrual process of all 40 patients necessary to complete the study, we decided to report the results of treatment of the 1st 12 patients diagnosed with recurrent diffuse intrinsic BRAIN STEM GLIOMA before completion of the study
�
Pgs. 91 and 100
�
Study continues with accrual of additional patients
�
Pg. 94
�
In all cases the responses were confirmed by radiologists not affiliated with Burzynski Clinic
�
All films of patients who obtained Complete Response (CR) and Partial Response (PR) were evaluated by radiologists and oncologists of the FDA
� � � � � � � � � � � � � � � � �
Case Reports:
�
4. 9/2004
�
INTEGRATIVE CANCER THERAPIES
�
Special exception (SE) to BT-11 – BRAIN STEM GLIOMA
�
Long-term survival and complete response of a patient with recurrent diffuse intrinsic brain stem GLIOBLASTOMA MULTIFORME
http://www.burzynskiclinic.com/images/stories/Publications/1145.pdf
Integrative Cancer Therapies 2004;3:257-261
Volume 3, Number 3 September 2004
DOI: 10.1177/1534735404267748
�
Pg. 257
�
2004 – Protocol – recurrent diffuse intrinsic BRAIN STEM GLIOMAs [5]
�
12 – Patients Accrued
10 – Evaluable Patients
�
5 / 50% – # and % of Patients Showing Objective Response
3 / 30% – # and % of Patients Showing Stable Disease
2 / 20% – # and % of Patients Showing Progressive Disease who subsequently died
�
Objective response = complete response and partial response
�
Pg. 261
�
5. Burzynski SR, Lewy RI, Weaver RA, et al. Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic BRAIN STEM GLIOMA (preliminary report). Drugs R D. 2003;4:91-101.
�
Interim Reports on Clinial Trials:
�
16. 2003
�
DRUGS IN R&D
Drugs in R and D
(Drugs in Research and Development)
�
BT-11 – BRAIN STEM GLIOMA
�
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic BRAIN STEM GLIOMA:
�
a preliminary report.
http://www.ncbi.nlm.nih.gov/pubmed/12718563
Drugs R D. 2003;4(2):91-101
http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
Drugs in R&D 2003;4:91-101
http://www.burzynskiclinic.com/images/stories/Publications/960.pdf
——————————————————————
Pg. 260
�
1992 – Protocol – ASTROCYTOMA [10]
�
30% – % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
Pg. 261
�
10. Burzynski SR, Kubove E, Burzynski B. Phase II clinical trials of antineoplastons A10 and AS2-1 infusions in ASTROCYTOMA. In: Adam D, ed. Recent Advances in Chemotherapy. Munich, Germany: Futramed; 1992:2506-2507.
——————————————————————
Pg. 260
�
1999 – Protocol – PRIMARY BRAIN TUMORS [11]
�
36 – Evaluable Patients
�
9 / 25% – # and % of Patients Showing Complete Response
7 / 19% – # and % of Patients Showing Partial Response
12 / 34% – # and % of Patients Showing Stable Disease
8 / 22% – # and % of Patients Showing Progressive Disease
16 / 44% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
Pg. 261
�
11. Burzynski SR, Conde AB, Peters A, et al. A retrospective study of antineoplastons A10 and AS2-1 in PRIMARY BRAIN TUMORS. Clin Drug Invest. 1999;18:1-10.
http://link.springer.com/article/10.2165%2F00044011-199918010-00001
Clinical Drug Investigation, July 1999, Volume 18, Issue 1, pp 1-10
http://link.springer.com/content/pdf/10.2165%2F00044011-199918010-00001.pdf
DOI
10.2165/00044011-199918010-00001
http://www.tlcdoctors.com/documents/aRetrospectiveStudyclinicalDrugInvestigation.pdf
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
2. 10/2004
�
NEURO-ONCOLOGY
�
BT-20 – Patients With GLIOBLASTOMA MULTIFORME (GBM)
�
Phase II study of Antineoplastons A10 and AS2-1 (ANP) in recurrent GLIOBLASTOMA MULTIFORME
http://www.burzynskiclinic.com/images/stories/Publications/1218.pdf
Neuro-Oncology. 2004; 6: 384
Volume 6 Issue 4 October 2004
Abstracts from the Society for Neuro-Oncology Ninth Annual Meeting, Toronto, Ontario, Canada, November 18-21, 2004
�
Pg. 384
�
5 – Multicentric tumors
�
20 – surgery:
10 – tumor resection once
8 – tumor resection twice
2 – biopsy only
�
22 – radiation therapy
10 – chemotherapy
�
Pg. 385
�
10/2004 – Protocol – GLIOBLASTOMA MULTIFORME (GBM) which recurred or progressed post surgery, radiation therapy, and / or chemotherapy
�
22 – Evaluable Patients (Pg. 384)
(6 men / 16 women / 27 – 63 years /47 – median age)
�
1 / 4.5% – # and % of Patients Showing Complete Response
1 / 4.5% – # and % of Patients Showing Partial Response
12 / 54.5% – # and % of Patients Showing Stable Disease
8 / 36.5% – # and % of Patients Showing Progressive Disease
2 / 9% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
3. 10/2004 (DBSG)
�
NEURO-ONCOLOGY
�
Long-term survivals in phase II studies of Antineoplastons A10 and AS2-1 (ANP) in patients with diffuse intrinsic BRAIN STEM GLIOMA
http://www.burzynskiclinic.com/images/stories/Publications/1219.pdf
Neuro-Oncology. 2004; 6: 386
Volume 6 Issue 4 October 2004
�
60 patients
(31 didn’t meet admission criteria to the study and were treated under Special Exception (SE))
�
46 – recurrent tumor after previous therapy
�
14 – progressive diffuse intrinsic brain stem glioma (DBSG) without prior treatment
�
10/2004 – Protocol – patients with diffuse intrinsic BRAIN STEM GLIOMA (DBSG)
�
29 – Evaluable Patients
�
7 / 24% – # and % of Patients Showing Complete Response
6 / 21% – # and % of Patients Showing Partial Response
6 / 21% – # and % of Patients Showing Stable Disease
10 / 34% – # and % of Patients Showing Progressive Disease
13 / 45% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
10/2004 – Protocol – patients with diffuse intrinsic BRAIN STEM GLIOMA (DBSG)
�
31 – Evaluable Patients: Special exception (SE)
�
5 / 16% – # and % of Patients Showing Complete Response
2 / 6% – # and % of Patients Showing Partial Response
16 / 52% – # and % of Patients Showing Stable Disease
8 / 26% – # and % of Patients Showing Progressive Disease
7 / 22% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
======================================
COMBINED:
——————————————————————
# and % of Patients Showing Complete Response
7 / 24%
5 / 16% – Special exception (SE)
——————————————————————
# and % of Patients Showing Partial Response
6 / 21%
2 / 6% – Special exception (SE)
——————————————————————
# and % of Patients Showing Stable Disease
6 / 21%
16 / 52% – Special exception (SE)
——————————————————————
# and % of Patients Showing Progressive Disease
10 / 34%
8 / 26% – Special exception (SE)
——————————————————————
# and % of Patients Showing Objective Response
13 / 45%
7 / 22% – Special exception (SE)
�
Objective response = complete response and partial response
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
5. 10/2004
�
NEURO-ONCOLOGY
�
BT-12 – Children with PRIMITIVE NEUROECTODERMAL TUMORS (PNET)
�
Treatment of PRIMITIVE NEUROECTODERMAL TUMORS (PNET) with antineoplastons A10 and AS2-1 (ANP)
�
Preliminary results of phase II studies
http://www.burzynskiclinic.com/images/stories/Publications/1147.pdf
Neuro-Oncology. 2004; 6: 428
Volume 6 Issue 4 October 2004
Abstracts from the Eleventh International Symposium on Pediatric Neuro-Oncology
�
17 – recurrent disease or high-risk
�
10 – Medulloblastoma
5 – pineoblastoma
2 – other primitive neuroectodermal tumors (PNET)
�
5 – multiple metastases
�
1 – involvement of the spinal cord
�
17 – resection
8 – chemotherapy
8 – radiation therapy
8 – high-risk didn’t receive prior chemotherapy and radiation
�
5.2 months – median antineoplaston administration
�
10/2004 – Protocol – PRIMITIVE NEUROECTODERMAL TUMORS (PNET)
�
17 – Patients Accrued
(2 – nonevaluable due to lack of follow-up scans)
15 – Evaluable Patients
(12 months – 23 years / 6 – median age)
�
3 / 20% – # and % of Patients Showing Complete Response
2 / 13.4% – # and % of Patients Showing Partial Response
5 / 33.3% – # and % of Patients Showing Stable Disease
5 / 33.3% – # and % of Patients Showing Progressive Disease
5 / 33.4% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
5 – objective response (OR) not treated earlier with radiation therapy and chemotherapy
�
The study is ongoing and accruing additional patients
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
17. 2004
�
DRUGS IN R&D
Drugs in R and D
(Drugs in Research and Development)
�
Pg. 317
�
BT-13 – children with low-grade astrocytoma
�
BT-23 – children with visual pathway gliomas
�
Phase II study of antineoplaston A10 and AS2-1 in children with recurrent and progressive MULTICENTRIC GLIOMA.
�
A Preliminary Report.
http://www.ncbi.nlm.nih.gov/pubmed/15563234
Drugs R&D 2004;5(6):315-326.
http://www.ncbi.nlm.nih.gov/m/pubmed/15563234
Drugs R D. 2004;5(6):315-26
http://www.burzynskiclinic.com/images/stories/Publications/1194.pdf
Pg. 315
�
incurable recurrent and progressive multicentric glioma
�
Pgs. 315-316 and 318-319
�
6 – pilocytic astrocytoma
4 – low-grade astrocytoma
1 – astrocytoma grade 2
1 – visual pathway glioma: biopsy not performed due to dangerous location
�
Pgs. 318-319
�
8 – visual pathway glioma
�
Pg. 315 and 320
�
16 months – average duration of intravenous antineoplastons
�
19 months – average duration of oral antineoplastons
�
1 – non-evaluable due to only 4 weeks of ANP and lack of follow-up scans and died while on treatment due to a non-hemorrhaging brain infarction and was considered a treatment failure
�
1 – had stable disease discontinued ANP against medical advice and died 4.5 years later
�
Pg. 316
�
Previous therapies:
4 – Surgery
4 – Surgery and chemotherapy
1 – Surgery, chemotherapy and radiation
1 – Chemotherapy and radiation
1 – Chemotherapy only
�
Pgs. 318-319
�
9 – Surgery (SU)
7 – Chemotherapy (CH)
2 – Radiation (RA)
2 – Biopsy only (Bx)
�
Pg. 317
�
progressive (without prior treatment) multicentric glioma (MCG)
�
Pg. 317 and 320
�
recurrent (progressive after prior treatment) multicentric glioma (MCG) previously treated with surgery, radiation therapy and / or chemotherapy
�
Pgs. 318-319
�
9 – Caucasian
1 – Asian Indian
1 – Latin American
1 – Oriental
�
Pg. 320
�
3 – treated under Special Exception (SE) granted by the US FDA
�
Pgs. 317 and 320
�
7/31/1996 – (7/31/1996 – 4/3/2002 as of 3/1/2004) Protocol – children with recurrent and progressive MULTICENTRIC GLIOMA (MCG)
�
Pg. 317
�
BT-13 – children with low-grade astrocytoma
�
BT-23 – children with visual pathway gliomas
�
Pgs. 317 and 320-321
�
12 – Children Patients Accrued (Pgs. 315-316)
(6 – male / 6 – female)
10 – Evaluable Patients (Pg. 315)
(9 months – 17 years / 9 – median age) (Pgs. 315-316)
�
4 / 33% – # and % of Patients Showing Complete Response
3 / 25% – # and % of Patients Showing Partial Response
4 / 33% – # and % of Patients Showing Stable Disease
0 / 0% – # and % of Patients Showing Progressive Disease
1 / 9% – # and % of Patients Non-evaluable
7 / 58% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
Pg. 321
�
3 – continue oral ANP
�
2 – expired
�
Pgs. 315 and 320
�
The study continues with ongoing accrual of additional new patients
�
Pg. 317
�
Responses confirmed by radiologists not affiliated with Burzynski Clinic (BC)
�
Radiologists and oncologists from FDA evaluated films and medical records of patients who obtained complete response (CR) and partial response (PR)
�
Responses confirmed by radiologists not affiliated with Burzynski Clinic (BC)
——————————————————————
Pgs. 324-325
�
COMPARE: Mamelak et al. [17]
�
8 – treated with various chemotherapy regimens
1 – radiation therapy and chemotherapy
1 – radiation therapy alone
1 – no treatment
�
1986 (1986 – 1992) – Protocol – MULTICENTRIC GLIOMA
�
11 – Patients Accrued
11 – Evaluable Patients
�
2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided)
5 / 46% – # and % of Patients Showing Stable Disease
4 / 36% – # and % of Patients Died
3 – from disease progression
1 – from chemotherapy-induced toxicity
======================================
COMPARE COMBINED:
======================================
# and % of Patients Showing Complete Response
——————————————————————
4 / 33% – Antineoplastons
�
2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided)
Mamelak et al. [17]
——————————————————————
# and % of Patients Showing Partial Response
——————————————————————
3 / 25% – Antineoplastons
�
2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided)
Mamelak et al. [17]
——————————————————————
# and % of Patients Showing Stable Disease
——————————————————————
4 / 33% – Antineoplastons
�
5 / 46% – Mamelak et al. [17]
——————————————————————
# and % of Patients Showing Progressive Disease
——————————————————————
0 / 0% – Antineoplastons
�
4 / 36% – # and % of Patients Died
Mamelak et al. [17]
——————————————————————
# and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
7 / 58% – Antineoplastons
�
2 / 18% – Mamelak et al. [17]
——————————————————————
Pg. 326
�
17. Mamelak AN, Prados MD, Obana WG, et al. Treatment options and prognosis for MULTICENTRIC juvenile pilocytic astrocytoma. J Neurosurg. 1994; 81: 24-30
http://www.ncbi.nlm.nih.gov/pubmed/8207524/
J Neurosurg. 1994 Jul;81(1):24-30.
http://www.ncbi.nlm.nih.gov/m/pubmed/8207524/
Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
http://thejns.org/doi/abs/10.3171/jns.1994.81.1.0024?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed&
Journal of Neurosurgery
Vol. 81: 24-30 (Volume publication date: July 1994)
DOI: 10.3171/jns.1994.81.1.0024
======================================
Pg. 325
�
COMPARE: Chamberlain and Grafe. [38]
�
1995 – Protocol – solitary recurrent chiasmatic hypothalamic GLIOMAS treated with oral etoposide

�
14 – Patients Accrued
14 – Evaluable Patients
�
1 / 7% – # and % of Patients Showing Complete Response
4 / 29% – # and % of Patients Showing Partial Response
3 / 21% – # and % of Patients Showing Stable Disease
6 / 43% – # and % of Patients Showing Progressive Disease
5 / 36% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
======================================
COMPARE COMBINED:
======================================
# and % of Patients Showing Complete Response
——————————————————————
4 / 33% – Antineoplastons
�
1 / 7% – Chamberlain and Grafe. [38]
——————————————————————
# and % of Patients Showing Partial Response
——————————————————————
3 / 25% – Antineoplastons
�
4 / 29% – Chamberlain and Grafe. [38]
——————————————————————
# and % of Patients Showing Stable Disease
——————————————————————
4 / 33% – Antineoplastons
�
3 / 21% – Chamberlain and Grafe. [38]
——————————————————————
# and % of Patients Showing Progressive Disease
——————————————————————
0 / 0% – Antineoplastons
�
6 / 43% – Chamberlain and Grafe. [38]
——————————————————————
# and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
7 / 58% – Antineoplastons
�
5 / 36% – Chamberlain and Grafe. [38]
——————————————————————
Pg. 326
�
38. Chamberlain MC, Grafe MR. Recurrent chiasmatic-hypothalamic GLIOMA treated with oral etoposide. J Clin Oncol 1995; 13: 2072-6
http://www.ncbi.nlm.nih.gov/pubmed/7636550/
J Clin Oncol. 1995 Aug;13(8):2072-6.
http://www.ncbi.nlm.nih.gov/m/pubmed/7636550/
Department of Neurosciences, University of California, San Diego, La Jolla, USA.
http://m.jco.ascopubs.org/content/13/8/2072.long
Arch Neurol. 1995 May;52(5):509-13.
http://www.ncbi.nlm.nih.gov/pubmed/7733847/
Department of Neurosciences, University of California-San Diego, USA.
http://www.ncbi.nlm.nih.gov/m/pubmed/7733847/
Arch Neurol. 1995;52(5):509-513. doi:10.1001/archneur.1995.00540290099024.
http://archneur.jamanetwork.com/Mobile/article.aspx?articleid=593460
======================================
COMPARE: The Pediatric Oncology Group. [39]
�
10/2000 – Protocol – solitary progressive OPTIC PATHWAY TUMORS with carboplatin
�
50 – Patients Accrued
50 – Evaluable Patients
�
2 / 4% – # and % of Patients Showing Partial Response
37 / 74% – # and % of Patients Showing Stable Disease
11 / 22% – # and % of Patients Showing Progressive Disease
2 / 4% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
======================================
COMPARE COMBINED:
======================================
# and % of Patients Showing Partial Response
——————————————————————
3 / 25% – Antineoplastons
�
2 / 4% – The Pediatric Oncology Group. [39]
——————————————————————
# and % of Patients Showing Stable Disease
——————————————————————
4 / 33% – Antineoplastons
�
37 / 74% – The Pediatric Oncology Group. [39]
——————————————————————
# and % of Patients Showing Progressive Disease
——————————————————————
0 / 0% – Antineoplastons
�
11 / 22% – The Pediatric Oncology Group. [39]
——————————————————————
# and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
7 / 58% – Antineoplastons
�
2 / 4% – The Pediatric Oncology Group. [39]
——————————————————————
39. Mahoney DH, Cohen ME, Friedman HS, et al. Carboplatin is effective therapy for young children with progressive OPTIC PATHWAY TUMORS: a Pediatric Oncology Group phase II study. Neuro-oncol 2000; 2: 213-20
http://www.ncbi.nlm.nih.gov/pubmed/11265230/
Neuro Oncol. 2000 Oct;2(4):213-20.
http://www.ncbi.nlm.nih.gov/m/pubmed/11265230/
Baylor College of Medicine, Houston, TX, USA.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920597/
�
http://neuro-oncology.oxfordjournals.org/content/2/4/213.full.pdf
======================================
COMPARE COMBINED (4):
======================================
# and % of Patients Showing Complete Response
——————————————————————
4 / 33% – Antineoplastons
�
2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided)
Mamelak et al. [17]
�
1 / 7% – Chamberlain and Grafe. [38]
——————————————————————
# and % of Patients Showing Partial Response
——————————————————————
3 / 25% – Antineoplastons
�
2 / 18% – # and % of Patients Showing Remission (definition of remission wasn’t provided)
Mamelak et al. [17]
�
4 / 29% – Chamberlain and Grafe. [38]
�
2 / 4% – The Pediatric Oncology Group. [39]
——————————————————————
# and % of Patients Showing Stable Disease
——————————————————————
4 / 33% – Antineoplastons
�
5 / 46% – Mamelak et al. [17]
�
3 / 21% – Chamberlain and Grafe. [38]
�
37 / 74% – The Pediatric Oncology Group. [39]
——————————————————————
# and % of Patients Showing Progressive Disease
——————————————————————
0 / 0% – Antineoplastons
�
4 / 36% – # and % of Patients Died
Mamelak et al. [17]
�
6 / 43% – Chamberlain and Grafe. [38]
�
11 / 22% – The Pediatric Oncology Group. [39]
——————————————————————
# and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
7 / 58% – Antineoplastons
�
2 / 18% – Mamelak et al. [17]
�
5 / 36% – Chamberlain and Grafe. [38]
�
2 / 4% – The Pediatric Oncology Group. [39]
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
18. 6/2005
�
INTEGRATIVE CANCER THERAPIES
�
BT-12 – children with PRIMITIVE NEUROECTODERMAL TUMORS (PNET)
�
CAN-01 (CAN-1) – PATIENTS WITH REFRACTORY MALIGNANCIES
�
Long-term survival of high-risk pediatric patients with PRIMITIVE NEUROECTODERMALTUMORS treated with Antineoplastons A10 and AS2-1
http://www.ncbi.nlm.nih.gov/pubmed/15911929
Integrative Cancer Therapies 2005;4(2):168-177
http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Integr Cancer Ther. 2005 Jun;4(2):168-77
http://www.burzynskiclinic.com/images/stories/Publications/1220.pdf
DOI: 10.1177/1534735405276835
http://m.ict.sagepub.com/content/4/2/168.long?view=long&pmid=15911929
Volume 4 Number 2 June 2005
�
Pgs. 168-171
�
Previous treatments:
12 – surgery (resections)
(1 had biopsy only – suboccipital craniotomy)
6 – chemotherapy
6 – radiation therapy
�
6 – hadn’t received prior chemotherapy or radiation
�
20 months – average antineoplastons administered
�
Pgs. 168 and 170
�
8 – Medulloblastoma
3 – pineoblastoma
2 – other PRIMITIVE NEUROECTODERMALTUMORS (PNET)
(1 – PNET with neuronal and astrocytic differentiation / 1 – Supratentorial)
�
Pg. 169
�
12 – tumor progressed prior to ANP
8 – multiple cerebral metastases
1 – residual tumor after partial resection
1 – involvement of the spinal cord
�
Pgs. 169-170
�
CAN-01 study published. [2]
3 children with PNET were treated in this study – completed / closed for admission
�
Pg. 176
�
2. Burzynski SR, Conde AB, Peters A, et al. A retrospective study of antineoplastons A10 and AS2-1 in PRIMARY BRAIN TUMORS. Clin Drug Invest. 1999;18:1-10.
http://link.springer.com/article/10.2165%2F00044011-199918010-00001
Clinical Drug Investigation, July 1999, Volume 18, Issue 1, pp 1-10
http://link.springer.com/content/pdf/10.2165%2F00044011-199918010-00001.pdf
�
http://www.tlcdoctors.com/documents/aRetrospectiveStudyclinicalDrugInvestigation.pdf
Pg. 170
�
The group of long-term survivors:
6 – children (5 males / 1 female)
Diagnosed from age 1 – 9
3 – medulloblastoma
2 – other PNET
1 – pineoblastoma
3 – disseminated disease
1 – involvement of brainstem
5 – prior subtotal tumor resection
1 – biopsy only: treated with combination chemotherapy
6 – didn’t have radiation therapy
�
3 / 50% – # and % of Patients Showing Complete Response
2 / 33% – # and % of Patients Showing Stable Disease
1 /17% – # and % of Patients Showing Progressive Disease and subsequently received standard radiation therapy
3 / 50% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
——————————————————————
Pgs. 170 and 172
�
Case patient 1 – complete response (CR) passed away after 6 years, 10 months from start of ANP, 3 years after discontinuation of ANP: cause of death recurrent pneumonia, possibly due to chronic immunosuppression from chemotherapy administered prior to ANP
�
Pgs. 171- 173
�
Case patient 2 – stable disease (SD) / BT-12 / male / age 4 at admission / white / 5/28/1996 diagnosed (7/8/1996 – 3/25/1997 treatment: 256 days) / medulloblastoma / lost to follow-up after 6 years, 3 months, but believed to be alive since no confirmation of death
�
Case patient 8 – progressive disease (PD) / BT-12 / male / age 9 at admission / white / 10/16/1997 diagnosis (5/8/1998 – 11/3/1998 treatment: 157 days) / medulloblastoma / lost to follow-up after approximately 5 years, but believed to be alive since no confirmation of death
——————————————————————
3 – (7/27/2004) alive from 7+ – 10+ years from beginning of treatment
�
These 3 underwent partial tumor resection, but none were treated with chemotherapy and radiation therapy before ANP
�
Case patient 4 – complete response (CR) / BT-12 / female / age 1 at admission / white / 12/18/1996 diagnosis (2/27/1997 – 3/6/2003 treatment: 2,012 days) / pineoblastoma / off ANP / never treated with radiation therapy or chemotherapy / lives normal life for more than 7.5 years since ANP started
�
Case patient 5 – stable disease (SD) / BT-12 / male / age 9 at admission / white / 3/18/1997 admission (5/1/1997 – 1/27/1998 treatment: 163 days) / supratentorial / as a result of ANP and thereafter underwent radiation therapy
�
Case patient 11 – complete response (CR) / CAN-01 / male / age 2 at admission / white / 3/1/1994 admission (4/13/1994 – 6/16/1999 treatment: 952 days) / medulloblastoma / off ANP / never treated with radiation therapy or chemotherapy / lives normal life for more than 10 years, 4 months since ANP started
�
Pg. 172
�
479 – average days on treatment
157 – median days on treatment
�
Pgs. 168-170 and 176
�
4/13/1994 (4/13/1994 – 12/4/2001 as of 8/1/2004)
Protocol – poor-risk recurrent disease or
high risk (Pgs. 168-171)
�
10 – BT-12 (7 males / 3 females)
3 – CAN-01 (3 males)
�
13 – Caucasian Children Patients Accrued
(10 males / 3 females)
13 – Evaluable Patients
(1 – 11 years / 5 years, 7 months – median age: Pgs. 168-171)
3 – younger than 3
�
3 / 23% – # and % of Patients Showing Complete Response
1 / 8% – # and % of Patients Showing Partial Response
4 / 31% – # and % of Patients Showing Stable Disease
1 / 8% – # and % of Patients Showing Progressive Disease
4 / 31% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
Study ongoing and accruing new additional patients to BT-12 study
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
7. 7/2005
�
BT-11 – BRAIN STEM GLIOMA
�
Targeted therapy with ANP in children less than 4 years old with inoperable BRAIN STEM GLIOMAs.
Neuro-Oncology. 2005; 7:300.
http://www.burzynskiclinic.com/images/stories/Publications/1224.pdf
Volume 7 Issue 3 July 2005
Abstracts from the World Federation of Neuro-Oncology Meeting
�
2 trials (study and special exception (SE))
�
Intrinsic diffuse brain stem glioma (BSG)
�
7 – no biopsy: dangerous tumor location
2 – anaplastic astrocytoma
1 – pilocytic astrocytoma
�
4 – not treated prior to antineoplastons
3 – failed prior radiation and chemotherapy
2 – tumor resection
1 – stable disease after radiation
�
9.5 months – median duration of ANP administration
�
7/2005 – Protocol – BRAIN STEM GLIOMA (BSG)
�
10 – Evaluable assessable Patients
(Less than 4 years old – 3 months 3 years)
�
3 / 30% – # and % of Patients Showing Complete Response
4 / 40% – # and % of Patients Showing Stable Disease
3 / 30% – # and % of Patients Showing Progressive Disease
3 / 30% – # and % of Patients Showing Objective Response

Objective response = complete response and partial response
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
19. 3/2006
�
BT-03
�

�
BT-11 – BRAIN STEM GLIOMA (BSG)
�
BT-18 – 6. MIXED GLIOMA: ADULT PATIENTS WITH MIXED GLIOMA – “mixed glioma”, a type of primary malignant brain tumor (PMBT)
�
BT-22 – 8. CHILDREN WITH PRIMARY MALIGNANT BRAIN TUMORS
�
CAN-01 (CAN-1) – PATIENTS WITH REFRACTORY MALIGNANCIES
�
Targeted therapy with Antineoplastons A10 and AS2-1 of high grade, recurrent, and progressive BRAINSTEM GLIOMA.
Integrative Cancer Therapies 2006;5(1):40-47
http://www.ncbi.nlm.nih.gov/pubmed/16484713
Integr Cancer Ther. 2006 Mar;5(1):40-7
http://www.ncbi.nlm.nih.gov/m/pubmed/16484713
DOI: 10.1177/1534735405285380
http://www.burzynskiclinic.com/images/stories/Publications/5825.pdf
�
http://m.ict.sagepub.com/content/5/1/40.long?view=long&pmid=16484713
Pgs. 40-41
�
4 phase 2 trials
�
BRAINSTEM GLIOMA (BSG)
�
patients with inoperable tumor of high-grade pathology (HBSG)
glioblastoma
�
recurrent diffuse intrinsic glioblastomas and ANAPLASTIC ASTROCYTOMAs of brainstem
�
Pgs. 40-43
�
14 – anaplastic HBSG (patients with inoperable tumor of high-grade pathology (HBSG))
(13 – Anaplastic astrocytoma (AA) / 1 – Anaplastic astrocytoma (AA) / mixed glioma)
�
4 – glioblastomas (gliobastoma multiforme (GBM)) (GBM / brain stem glioma (BSG))
�
14 – diffuse intrinsic tumors
�
12 – tumor recurrence
�
Previous therapies:
5 – surgery (SU)
4 – surgery (SU) / chemotherapy (CH) / radiation therapy (RA)
4 – surgery (SU) / radiation therapy (RA)
2 – biopsy (Bx) / chemotherapy (CH) / radiation therapy (RA)
1 – chemotherapy (CH) / radiation therapy (RA)
1 – biopsy (Bx) / radiation therapy (RA)
1 – biopsy (Bx)
�
6 – didn’t have radiation therapy or chemotherapy
(5 – underwent surgical resection / 1 – underwent biopsy only)
�
Pgs. 40-44
�
5 months – mediation duration of antineoplaston administration
�
216 – Average days on antineoplastons
154 – Median days on antineoplastons
�
Pg. 43
�
13 – DBSG
2 – Exophytic
1 – DBSG / multifocal
1 – Multifocal
1 – Cervico-medullary
�
Pg. 44
�
High-grade, recurrent, and progressive brainstem gliomas
�
Pgs. 40 and 45-46
�
2+ years – Most patients with newly diagnosed High-grade brain stem gliomas (HBSG) don’t survive more than
�
2 years – Most patients with brainstem glioma fail standard radiation therapy and chemotherapy and don’t survive longer
�
6 months – patients with recurrent tumors survive no more than, despite standard treatment
�
Pg. 45
�
12 – most likely tumor related deaths
3 – alive and tumor free
2 – aspiration pneumonia possible deaths
1 – death due to pulmonary embolism
�
Pgs. 40-42 and 44-45
�
7/12/1988 (7/12/1988 – 11/13/2003 as of 6/10/2005) – Protocol – recurrent diffuse intrinsic glioblastomas and anaplastic astrocytomas of the brainstem high-grade pathology (HBSG)
�
18 – Evaluable Patients (Pgs. 40-43)
(8 males / 10 females – Pgs. 42-43)
2 – 42 years / 10 – median age: Pgs. 42-43
�
Pg. 43
�
BT-03 – 1 / female
BT-11 – 13 (8 males/5 females)
BT-18 – 1 / female
BT-22 – 2 / females
CAN-01 – 1 / female
�
2 / 11% – # and % of Patients Showing Complete Response
2 / 11% – # and % of Patients Showing Partial Response
7 / 39% – # and % of Patients Showing Stable Disease
7 / 39% – # and % of Patients Showing Progressive Disease
4 / 22% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
Pg. 42
�
BT-11 – ongoing: brain stem glioma (BSG)
BT-18 – ongoing: mixed gliomas (1 – diagnosed with mixed glioma of brainstem)
�
BT-03 – completed. [14]
CAN-01 – completed. [15]
�
Pg. 47
�
14. Burzynski SR, Kubove E, Burzynski B. Phase II clinical trials of antineoplastons A10 and AS2-1 infusions in ASTROCYTOMA. In: Adam D, ed. Recent Advances in Chemotherapy. Munich, Germany: Futuramed; 1992
�
15. Burzynski SR, Conde AB, Peters A, et al. A retrospective study of antineoplastons A10 and AS2-1 in PRIMARY BRAIN TUMORS. Clin Drug Invest. 1999;18:1-10.
http://link.springer.com/article/10.2165%2F00044011-199918010-00001
Clinical Drug Investigation, July 1999, Volume 18, Issue 1, pp 1-10
http://link.springer.com/content/pdf/10.2165%2F00044011-199918010-00001.pdf
�
http://www.tlcdoctors.com/documents/aRetrospectiveStudyclinicalDrugInvestigation.pdf
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
8. 10/2006
�
BT-11 – BRAIN STEM GLIOMA
�
Treatment of multicentric BRAINSTEM GLIOMAs with antineoplastons (ANP) A10 and AS2-1.
Neuro-Oncology. 2006; 8:466.
http://www.burzynskiclinic.com/images/stories/Publications/2105.pdf
Volume 8 Issue 4 October 2006
Abstracts for the Eleventh Annual Meeting of the Society for Neuro-Oncology (SNO)
�
Brainstem gliomas and multicentric tumors (MBSG)
�
95% – diffuse intrinsic brain stem glioma
5% – cervicomedullary tumor
�
37% – biopsy performed
4 – low-grade glioma
3 – high-grade glioma
�
60% – Tumor recurrence after previous standard treatment
�
4.5 months – median duration antineoplastons
�
10/2006 – Protocol – BRAINSTEM GLIOMAS and MULTICENTRIC TUMORS (MBSG)
�
19 – Evaluable Patients
(3.9 – 40.8 years / 9.2 – median age)
90% less than 18 years old
�
2 / 11% – # and % of Patients Showing Complete Response
1 / 5% – # and % of Patients Showing Partial Response
7 / 37% – # and % of Patients Showing Stable Disease
9 / 47% – # and % of Patients Showing Progressive Disease
3 / 16% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
� � � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
9. 4/2007 (NDBSG)
�
BT-11 – BRAIN STEM GLIOMA
�
Phase II studies of Antineoplastons A10 and AS 2-1 (ANP) in children with newly diagnosed diffuse, intrinsic BRAINSTEM GLIOMAs.
Neuro-Oncology 2007; 9:206.
http://www.burzynskiclinic.com/images/stories/Publications/4021.pdf
Volume 9 Issue 2 April 2007
Abstracts from the Twelfth International Symposium on Pediatric Neuro-Oncology
�
5 – high-grade gliomas
�
8 months – median duration of treatment
�
4/2007 – Protocol – newly diagnosed diffuse, intrinsic BRAINSTEM GLIOMAs (NDBSG)
�
20 – Evaluable Assessable Children Patients
(3 months – 20 years / age)
�
6 / 30% – # and % of Patients Showing Complete Response
2 / 10% – # and % of Patients Showing Partial Response
4 / 20% – # and % of Patients Showing Stable Disease
8 / 40% – # and % of Patients Showing Progressive Disease
8 / 40% – # and % of Patients Showing Objective Response
�
Objective response = complete response and partial response
======================================
COMPARE: standard radiation therapy in combination with chemotherapy (RAT) (Mandell et al. 1999) (6/1992 – 10/1997)
�
2% – % of Patients Showing Complete Response
31% – % of Patients Showing Partial Response
33% – % of Patients Showing Objective Response
�
Objective response = complete response and partial response
�
Mandell LR, Kadota R, Freeman C, et al. There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic BRAIN STEM TUMORS: results of pediatric oncology group phase III trial comparing conventional vs. hyperfractionated radiotherapy. Int J Radiat Oncol Biol Phys. 1999;43:959-964.
http://www.ncbi.nlm.nih.gov/pubmed/10192340/
Int J Radiat Oncol Biol Phys. 1999 Mar 15;43(5):959-64.
http://www.ncbi.nlm.nih.gov/m/pubmed/10192340/
International Journal of Radiation Oncology*Biology*Physics
Volume 43, Issue 5, 15 March 1999, Pages 959–964
http://www.sciencedirect.com/science/article/pii/S036030169800501X
Department of Radiation Oncology, Mount Sinai Medical Center, New York, NY, USA.
======================================
COMPARE COMBINED:
——————————————————————
Overall survival (OS):
——————————————————————
40% – 2 years: Antineoplastons (ANP)
�
7% – 2 years: standard radiation therapy in combination with chemotherapy (RAT)
——————————————————————
30% – 5 years: Antineoplastons (ANP)
�
0% – 5 years: standard radiation therapy in combination with chemotherapy (RAT)
——————————————————————
Median survival (MST)
——————————————————————
16.4 months – Antineoplastons (ANP)
�
8.5 months – standard radiation therapy in combination with chemotherapy (RAT)
� � � � � � � � � � � � � � � � �
2007 – Recent clinical trials in diffuse intrinsic BRAINSTEM GLIOMA
�
Review Article
http://www.cancer-therapy.org/CT/v5/B/HTML/42._Burzynski,_379-390.html
Cancer Therapy Vol 5, 379-390, 2007
�
chart on page 172 (page 8 of PDF):
http://www.burzynskiclinic.com/images/stories/Publications/1252.pdf
2006 Adis – Pediatr Drugs 2006; 8 (3)
�
Pg. 172
�
Treatments for Astrocytic Tumors
�
Table II. Treatment of diffuse, intrinsic BRAINSTEM GLIOMA in children
�
Burzynski et al. [88] – Reference
�
Phase II – Study Type
�
(no. of pts) – pts = patients
�
RP (30 pts) – RP = recurrent and progressive tumor – Tumor type
�
ANP = antineoplastons A10 and AS2-1 – Treatment
�
[% (no.)]
27% (8) – CR = complete response
20% (6) – PR = partial response
23% (7) – SD = stable disease
30% (9) – PD = progressive disease
�
Pg. 177
�
88. Burzynski SR, Weaver RA, Janicki T. Long-term survival in phase II studies of antineoplastons A10 and AS2-1 (ANP) in patients with diffuse intrinsic BRAIN STEM GLIOMA [abstract]. Neuro-oncol 2004; 6: 386
�
Phase II study of antineoplaston A10 and AS2-1 in children with recurrent and progressive MULTICENTRIC GLIOMA : a preliminary report.
http://www.ncbi.nlm.nih.gov/pubmed/15563234
Drugs R D. 2004;5(6):315-26
http://www.ncbi.nlm.nih.gov/m/pubmed/15563234
Pg. 172
�
Burzynski et al. [89] – Reference
�
Phase II – Study Type
�
(no. of pts) – pts = patients
�
RPS (10 pts) – RPS = recurrent and progressive tumors in children aged <4y – Tumor type
{(66) = most in a study}
�
ANP = antineoplastons A10 and AS2-1 – Treatment
�
[% (no.)]
30% (3) – CR = complete response
{27% (8) = next best study}
[% (no.)]
0% (0) – PR = partial response
{56% (1) = next best}
[% (no.)]
40% (4) – SD = stable disease
{44% (25) = best}
[% (no.)]
30% (3) – PD = progressive disease
{23% (13) = best}
�
(Above, I also provide the best next case to compare to)
�
Pg. 177
�
89. Burzynski SR, Weaver RA, Janicki TJ, et al. Targeted therapy with ANP in children less than 4 years old with inoperable BRAIN STEM GLIOMAS [abstract]. Neuro-oncol 2005; 7: 300
�
Long-term survival of high-risk pediatric patients with PRIMITIVE NEUROECTODERMAL TUMORS treated with antineoplastons A10 and AS2-1.
http://www.ncbi.nlm.nih.gov/pubmed/15911929
Integr Cancer Ther. 2005 Jun;4(2):168-77
http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Pg. 173
�
1.4.3 Targeted Therapy
�
“…multi-targeted therapy with ANP has shown promising results [12;88-91]”
�
Pg. 176
�
90. Burzynski SR, Lewy RI, Weaver RA, et al. Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic BRAIN STEM GLIOMA: a preliminary report. Drugs R D 2003; 4: 91-101
�
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic BRAIN STEM GLIOMA: a preliminary report.
http://www.ncbi.nlm.nih.gov/pubmed/12718563
Drugs R D. 2003;4(2):91-101
http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
91. Burzynski SR, Weaver RA, Janicki T. et al. Targeted therapy with antineoplastons A10 and AS2-1 (ANP) of high-grade, recurrent and progressive BRAIN STEM GLIOMA. Integr Cancer Ther 2006 Mar; 5 (1): 40-7
�
Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive BRAINSTEM GLIOMA.
http://www.ncbi.nlm.nih.gov/pubmed/16484713
Integr Cancer Ther. 2006 Mar;5(1):40-7
http://www.ncbi.nlm.nih.gov/m/pubmed/16484713
30 evaluable patients with recurrent and progressive DBSG
�
“>40% of patients survived for more than 2 years
30% more than 5 years.”
�
27% – CR – Complete Response
20% – PR – Partial Response
23% – SD – Stable Disease
30% – PD – Progressive Disease
[12,88]
�
Pg. 175
�
12. Burzynski SR Targeted therapy for BRAIN TUMORS In: Columbus, F editor. BRAIN CANCER research progress. New York: Nova Science Publishers Inc 2005
�
Pg. 173
�
10 evaluable children
aged <4 years diagnosed with DBSG treated with ANP
youngest 3-month-old infant
[89]
�
30% – CR – Complete Response
40% – SD – Stable Disease
30% – PD – Progressive Disease
[89]
�
“The results are compiled in table II.”
�
Pg. 174
�
2.3. Targeted Therapy
�
Multi-targeted ANP therapy is free from chronic toxicity in children and adults based on the results of numerous clinical studies involving
�
1652 adults
335 children
[147]
�
Pg. 178
�
147. Burzynski SR. Annual report to the FDA, IND 43,742, 2006
�
Pg. 174
�
Long-term follow-up of children treated with ANP for ASTROCYTOMAS revealed:
normal development
no cognitive or endocrine deficiencies
normal fertility
�
>5 years – substantial number of patients tumor free
>17 years – follow-up period for some patients
�
Pg. 169
�
1.1.4. Targeted Therapy
�
Clinical trials with agents affecting single targets are in progress and the preliminary results of multi-targeted therapy with
antineoplastons (ANP) A10
and
AS2-1 have been reported
[39]
�
small group of patients with progressive LGA, ANP
60% – CR rate – Complete Response
10% – PR rate – Partial Response
median survival 7 years 9 months
maximum survival of more than 15 years
[39]
�
LGA = Low-Grade ASTROCYTOMA
�
Table I. Selected chemotherapy regimens for the treatment of low-grade ASTROCYTOMA in children
�
Burzynski [39] – Reference
�
Phase II d – d = Preliminary results – Study type
�
P = progressive tumor – Tumor type
�
(no. of pts) – pts = patients
�
ANP (10 pts) – ANP = antineoplastons A10 and AS2-1 – Treatment
{(78) = most in a study}
�
OS [%] = overall survival
100% (1 year) – 90% (3 year) – Efficacy
�
MST = median survival time
93 months
{96 (1 year) next closest}
�
CR [% (no.)]
60% (6) – CR = complete response
{24 (11) next closest}
PR [% (no.)]
10% (1) – PR = partial response
{60% (9) best other study}
[% (no.)]
30% (3) – SD = stable disease + MR = minor response
{70% (14) best other study}
[% (no.)]
0% (0) – PD = progressive disease
{4% (2) next closest}
�
PFS (%)
90% (1 year) – 90% (3 years) – PFS = progression-free survival
{100% (1 year) – 68% (3 years) best other study}
�
(Above, I also provide the best next case to compare to)
�
Pg. 176
�
39. Burzynski SR Clinical application of body epigenetic system: multi-targeted therapy for PRIMARY BRAIN TUMORS. World and Ehrlich Conference on Dosing of Magic Bullets; 2004 Sep 9-11 Nurnberg
� � � � � � � � � � � � � � � � �
Interim Reports on Clinical Trials:
�
10. 6/2008 (OPG)
�
BT-23 – CHILDREN WITH VISUAL PATHWAY GLIOMA
�
Phase II study of antineoplastons A10 and AS2-1 (ANP) in CHILDREN WITH optic PATHWAY GLIOMA:
�
A preliminary report
http://www.burzynskiclinic.com/images/stories/Publications/7287.pdf
Neuro-Oncology 2008; 10:450
Volume 10 Issue 3 June 2008
�
7 / 58% – solitary tumors
5 / 42% – multicentric
�
5 / 42% – pilocytic astrocytoma
4 / 33% – low-grade astrocytoma
2 / 17% – neurofibromatosis 1
�
8 / 67% – failed chemotherapy alone
3 / 25% – didn’t have biopsy
2 / 17% – developed progression after surgery
2 / 17% – not treated prior but developed progressive tumors
�
16.5 months (1 year 4.5 months) – Median antineoplaston treatment
�
6/2008 – Protocol – CHILDREN WITH optic PATHWAY GLIOMA
�
12 Evaluable Children Patients
(7 months – 16 years / 6 years 3 months – Median age)
�
3 / 25% – # and % of Patients Showing Complete Response
2 / 17% – # and % of Patients Showing Partial Response
6 / 50% – # and % of Patients