Stanislaw Rajmund Burzynski, Stanislaw R. Burzynski, Stanislaw Burzynski, Stan R. Burzynski, Stan Burzynski, S. R. BURZYNSKI, S. Burzynski, Arthur Burzynski, Hippocrates Hypocrite Hypocrites Critic Critics Critical HipoCritical
Let’s say you’re one of “The Skeptics,”(“The Burzynski Skeptics,”) don’t have a life (but doesn’t that go without saying?), enjoy associating yourself with known liars, cowards, ethically and intellectually challenged individuals, so you grab a newspaper(It’s doubtful that USA TODAY would qualify), and if you do NOT know what a “Newsie” is, go online and select an article which has a plethora of innuendo and allegations, compose a missive to your member in Congressassembled about the nothingness you just reviewed, just don’t piss yourself silly when you shoot that zinger off, because you’ve just sent something to your Congressperson, exhibiting what a whacky weed tobaccoday tripper you are, and a prime example of what “Rocky Mountain High” really will mean, starting January1st, 2014
Congratulations, Colorado
My only suggestion is that you add something like:
“Dear Congressperson Y,
I know your time is valuable, but please allow me to waste some of you and your staff’s, as well as provide you with “fodder” you can hang up on the bathroom wall and laugh about for days!
In the next weeks I will be contacting you about all of the “conspiracy theories” in Jesse Ventura’s book, including; but not limited to:
Area 51
Aliens The Denver International Airport
…
Smoke ’em if ya got ’em !
======================================
Letter to Congress
Dear CONGRESSPERSON’S NAME:
My name is _______ and I am one of your constituents
I am writing to you to request your urgent attention to a matter that involves the abuse of cancer patients, their families, and their communities
A few weeks ago, I wrote to you concerning the Houston cancer doctor Stanislaw Burzynski, and requested that you take action and look into how he was able to continue treating cancer patients for decades under the auspices of clinical trials with an unproven treatment he claims to have discovered, patented, manufactures, prescribes, and sells (at his in house pharmacy) at exorbitant prices
On Friday November 15, Dr. Burzynski was the subject of a front-page exposé in the USA Today
Additionally, since I last contacted your office, the FDA has released site inspection notes into the electronic FOIA reading room about Stanislaw Burzynski in his role as Principal Investigator (also included)
The findings were horrifying
Burzynski (as investigator, the subject of the inspection) “failed to comply with protocol requirements related to the primary outcome, therapeutic response […] for 67% of study subjects reviewed during the inspection.”
This means that several patients who were reported as “complete responses” did not meet the criteria defined in the investigational plan, as were patients who were reported as having a “partial response” and “stable disease.”
This means that his outcomes figures for these studies are inaccurate
Some patients admitted failed to meet the inclusion criteria for the study
Even though patients needed to have a physician back home to monitor their progress prior to enrolling in a trial, the FDA found a patient who began receiving treatment before a doctor had been found
The FDA told Burzynski:
“You failed to protect the rights, safety, and welfare of subjects under your care
Forty-eight (48) subjects experienced 102 investigational overdoses between January 1, 2005 and February 22, 2013, according to the [trial number redacted] List of Hospitalizations/SAE (serious adverse events) [redacted] Overdose [redacted]/Catheter Infection report
Overdose incidents have been reported to you [….]
There is no documentation to show that you have implemented corrective actions during this time period to ensure the safety and welfare of subjects.” [emphasis added]
It seems that these overdoses are related to the protocol, which requires family members to administer the drugs via programmable pump on their own
Further, patient records show that there were many more overdoses that were not included in the Hospitalization/SAE/Overdose list
The FDA reported:
“Your […] tumor measurements initially recorded on worksheets at baseline and on-study treatment […] studies for all study subjects were destroyed and are not available for FDA inspectional review.”
This is one of the most damning statements, as without any…not a single baseline measurement…there is no way to determine any actual effect of the antineoplaston treatment
This means that Burzynski’s studies–which by last account cost $30,000 to begin and $7000 a month to maintain–are unpublishable
It will be stunning if this finding alone were not investigated by legal authorities
Patients who had Grade 3 or 4 toxic effects were supposed to be removed from treatment
One patient had 3 Grade 3 events followed by 3 Grade 4 events
Another patient had 7 disqualifying toxic events before he was removed from the study
Burzynski did not report all adverse events as required by his study protocols
One patient had 12 events of hypernatremia (high sodium), none of which was reported
There are several similar patients
Some adverse events were not reported to the Burzynski Clinic IRB for years
For instance one patient had an adverse event in 1998 and the oversight board did not hear about it until 2005.)
The FDA observed that the informed consent document did not include a statement of extra costs that might be incurred
Specifically, some informed consent documents were signed days to weeks before billing agreements, and in a couple of cases no consent form could be found
The clinic was unable to account for its stock of the investigational drug, an act that would get any other research lab shut down
Sadly, a child, Josia Cotto, had to die from apparent sodium overload before this investigation could be carried out
Despite these findings, when interviewed by USA Today, Burzynski actually said of his former cancer patients:
“As for criticism from former patients, Burzynski says, ‘We see patients from various walks of life
We see great people
We see crooks
We have prostitutes
We have thieves
We have mafia bosses
We have Secret Service agents
Many people are coming to us, OK?
Not all of them are the greatest people in the world
And many of them would like to get money from us
They pretend they got sick and they would like to extort money from us.’”
I am asking you to help me understand what happened at the FDA to allow this man to conduct clinical trials and bankrupt patients in the process despite 10 years of alarming reviews by the FDA
I also ask you to support an investigation into this betrayal of over 8,000 patients and to push for legislation to prevent the most desperate patients from such unthinkable exploitation
I will be calling your office next week to touch base with you and I look forward to your response
Gentlemen, I start your Insolence 😇
—————————————————————— (1:30) [1]
——————————————————————
The “motto” of “The Amazing (Not so Much) Meeting” is “Fighting Fakers,” which is apropos, since I doubt that “Orac” the “Check my Facts” Hack of Dr. David H. Gorski, grasps the irony, that when I read some of his blog articles, you could easily switch his name with the name of some individual he is flogging, and the proverbial shoe fits, and:
—————————————————————— (1:40)
—————————————————————— “This is a guy who sometimes fools even, you know, physicians”
—————————————————————— (I couldn’t have said it better, myself) 😊
—————————————————————— (2:47)
——————————————————————
He states:
“There is a long segment about “The Skeptics”“
(applause) 😝
—————————————————————— (4:25)
—————————————————————— “His lawyer wrote a book”
“About a half of it is about Burzynski“[4]
—————————————————————— 6:00
—————————————————————— Gorski mentions that Burzynski noticed that there were higher levels of these chemicals in healthy people, than people with cancer
——————————————————————
Whereas, Burzynski is on record as having said [5]:
” . . . healthy people have abundance of these chemicals in blood Cancer patients have varied to none“
I did NOT know before now, that GorskGeek thinks that “none” is a “level” 😶
——————————————————————
He continues:
AS2.1 – which is a chemical called phenylacetic acid, which is a byproduct of metabolism that turns into phenylacetylglutamine by the liver
A10 – soluble is basically the same thing
It breaks down to PAG
—————————————————————— WOW !
I thought it was: AS2 – 1 😊
They are “basically the same thing” ? 😳
What does Burzynski say ? [6]
Phenylacetylglutaminate (PG) and Phenylacetate (PN) are metabolites of Phenylbutyrate (PB) and are constituents of antineoplaston AS2-1
PG and PN are naturally occurring in human body as result of metabolism of phenylalanine in liver and kidneys
formulation of antineoplaston AS2-1 is 4:1 mixture of synthetic PN and PG
A10 is 4:1 mixture of PG and iso-PG
That does NOT look like “basically the same thing” to me 😛
—————————————————————— (6:50)
—————————————————————— Gorski founders on:
“And these are substances which were actually studied in the ’50’s and ’60’s and not found to be particularly, um, promising, but, he didn’t know that then”
—————————————————————— GorskGeek has #FAILED miserably to prove that on his blogs [7] 😄
—————————————————————— (8:00)
—————————————————————— Gorski comments about Burzynski’s “animal testing,” “species specific” claims:
“There are ways of getting around that”
——————————————————————
But Gorski, again, has #FAILED miserably to prove it [8] 😅
—————————————————————— (12:00)
—————————————————————— Gorski makes lame excuses about the NCI phase II clinical trial [9] 😖
—————————————————————— (12:50)
—————————————————————— Gorski claims Burzynski was indicted for insurance fraud in the 1997 case 😱
—————————————————————— GorskGeek, care to try and prove that one also ? [10] 😃
—————————————————————— (14:25)
—————————————————————— Gorski then states that out of 61 trials on clinicaltrials . gov, “most” are “closed or unknown”
—————————————————————— GorskGeek #FAILED again 😁
At the time it was:
1 – Not Yet Recruiting
(OPEN)(Phase 3) 1 – COMPLETED
2 – WITHDRAWN
(Withdrawn due to slow enrollment)
7 – WITHDRAWN
(This study has been withdrawn prior to enrollment) (9=WITHDRAWN)
10 – Recruiting (10=OPEN)
40 – Active, not recruiting – (40=CLOSED)
61 =TOTAL
—————————————————————— (15:20)
—————————————————————— Gorski attempts to go all “legal eagle”:
“Listen to Burzynski’s lawyer!”
“You listen to Burzynski’s lawyer; and, and I swear I don’t understand, like why Burzynski would let him, let his lawyer say stuff this damning in his own book, but he does”
“So, get a load of some of these quotes, referring to one of the clinical trials, he says:”
“It was a joke”
“. . . there could not be any possibility of meaningful data coming out of the so-called clinical trial, it was all an artifice, that, you know, designed so that they could continue giving the treatment“
“The FDA wanted all of his patients to be on an IND, so, that’s what we did”
—————————————————————— Gorski, attorney Rick Jaffe is an American, living in America NOT the formerly communist Poland
He can say whatever he wants
GorskGeek is NOT a lawyer 😓
And there’s an excellent reason why
Nor is he schooled in the proper usage of the English language
FACT:
” . . . the so-called clinical trial . . .”
Anyhuman being with a modicum of intelligence about the English language, understands that the term “clinical trial” is singular, i.e. one
Burzynski’s lawyer is obviously referring to the CAN-1 clinical trial mentioned in Burzynski’s 11/25/1997 Securities and Exchange Commission (SEC) filing [11]
One trial that is retrospective is CAN-1 Clinical Trial
—————————————————————— CAN-1 PHASE II STUDY OF ANTINEOPLASTONS A10 AND AS2-1 IN
PATIENTS WITH REFRACTORY MALIGNANCIES
133 patients
—————————————————————— Clinical trial of patients treated by Dr. Burzynski through 2/23/1996
FDA has indicated it will not accept data generated by this trial since it was not a wholly prospective one
—————————————————————— Gorski continues his trend of #FAILURES when he mentions the additional types of treatments that Burzynski was offering, but he #FAILED to mention [12] 😂
—————————————————————— ” … in 1997, his medical practice was expanded to include traditional cancer treatment options such as chemotherapy, gene targeted therapy, immunotherapy and hormonal therapy in response to FDA requirements that cancer patients utilize more traditional cancer treatment options in order to be eligible to participate in the Company’s Antineoplaston clinical trials”
—————————————————————— (18:20)
—————————————————————— Gorski addresses the case of Tori Moreno
—————————————————————— Kim Moreno states:
“We originally were at Miller’s Children at Long Beach Memorial and then went to City of Hope“
“We also sent her MRI’s to Dr. Fred Epstein in New York to be looked at”
Gorski suggests that 3 different opinions could have misdiagnosed Tori Moreno
You can read an interview with Tori’s mother [13]
—————————————————————— (19:45)
—————————————————————— Gorski goes on to mention Burzynski patients going to Texas Children’s Hospital with hypernatremia issues
—————————————————————— Gorski, do you mean this ? [14]
The changing pattern of hypernatremia in hospitalized children
Department of Pediatrics, Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas, USA
—————————————————————— (20:00)
—————————————————————— Gorski mangles the case of Hannah Bradley, who had a grade 3 anaplastic astrocytoma brain tumor
GorskGeek makes excuses like “spontaneous remission”, but then provides no citation, reference, or link to a case of such a tumor having spontaneously exhibited remission [15]
—————————————————————— (20:40)
—————————————————————— Gorski states that antineoplastons are chemotherapy
—————————————————————— No, Gorski, antineoplaston are:
“…an unapproved drug, not ordinary “chemotherapy“[16] 😣
—————————————————————— (21:53)
—————————————————————— Gorski claims in regard to Burzynski’s personalized gene-targeted therapy:
” . . . gives to the patient without regard for synergistic toxicity“
“Boom, there you go”
—————————————————————— Gorski’s #FAIL rate continues, as Burzynski has stated that phase 2 and 3 publications are reviewed as part of this process [17]
Gorski, “BOOM, THERE YOU GO” ッ
—————————————————————— Gorski, you should hire out to the Democratic Party as their mascot, because you must be the biggest pompous ASS I’ve ever seen 😜
Gorski, my advice: don’t quit your day job, HACK 😷
——————————————————————
The #TAM2013 audience then has to suffer through 22:36 of the blatherskite of Robert J. (don’t call me Bobby) “Bob” Blaskiewicz Blatherskitewicz [2]
He blathers about the “dozen,” “17,” “16 dead,” “pancreatic cancer,” “Joseph, who was alive but died well within the life expectancy given his diagnosis,” “Joann, who was alive but died within a year of starting therapy,” “Irene S., who was dead within month,” “Maxine, who was already dead,” the “103 in 2011,” “63 in mid-June,” “17 on original 1999 site,” “about 3 added a year,” the “about 50 stories,” “1/10th of patient names gathered,” “Amelia S. – 7, tumor breaking up,” “Chase,” “Cody – 1994, 20 years ago, 2 visits, 6 weeks treatment breaking up,” “David,” “Janet, 3 – 5 yrs., oncologist, now dead, ovarian cancer,” “Pete took video down,” “8,000 patients,” “probable ischemic necrosis,” “13 yr. old, getting worse getting better, vomited – Marlene, nurse,” “Rory died 2005,” “Supatra, swelling, last wed., brain tumor,” “Side-effect, 2%, sodium load,” “Andrea, U.S. News and World Report, 30% chance recovery, glioblastoma, ANP in luggage, died on plane,” “Cathy wanted to be on ANP, Greg Burzynski, found out only brain tumor,” “Denise D. breast cancer,” and finally:
—————————————————————— (18:45)
—————————————————————— ” … and light as many fires under his butt as we can“
——————————————————————
Mentions Rick Jaffe’s book Galileo’s Lawyer
IT’S ALL ABOUT THE PATIENTS [4]
——————————————————————
All you need to know about Blaskiewicz is:
“White man speak with forked tongue” [18]
——————————————————————
The 3rd video is a panel discussion, which includes “man-crush” tag-team [3]
Robert Blaskiewicz and David Gorski
—————————————————————— (8:00)
—————————————————————— Bob says:
“Yeah, I’m not that type of doctor“
—————————————————————— Bob, the correct answer for you, is:
“I’m NOT a doctor” QUACK
—————————————————————— (13:05)
—————————————————————— Gorski gabs that he’s a:
“Game of Thrones Geek”
——————————————————————
I just knew I was right, GorskGeek [19]
—————————————————————— (14:00)
——————————————————————
The only female panelist mentions “bureaucrats”, “wimps”, and “people without balls”
—————————————————————— 2 out of 3 ain’t bad
She describes the Bob and David show to a T
—————————————————————— (15:00)
——————————————————————
The claim is made that a Burzynski physician appeared on the Burzynski Facebook page announcing results
—————————————————————— (16:00)
—————————————————————— Gorski #whines that the Texas Medical Board wasn’t successful in shutting Burzynski down because of “politics”
—————————————————————— LAUGHABLE
—————————————————————— (20:55)
—————————————————————— Gorski gives his usual excuse:
“He’s not an oncologist”
—————————————————————— GorskiGeek, that claim is as dead as apparently, quite a number of your brain cells [15]
—————————————————————— (34:40)
——————————————————————
Audience members are given the opportunity to speak, and this is the garbage served up:
—————————————————————— “Hi, this is Susan
Ah, don’t forget to mention that Wikipedia has been a major battlefield
We’ve had 23,000 views to the clinic’s page this last month, also rebutr . . .”
—————————————————————— “Control the flow of information”
—————————————————————— Gorski pipes up:
“What she said”
—————————————————————— (35:20)
—————————————————————— Blatherskitewicz chimes in:
“When it comes to Wikipedia can I just mention that is, that is, that that is so effective that Wikipedia was singled out in the most recent Burzynski movie“
—————————————————————— Gorski chirps:
“Yes”
—————————————————————— Bob yacks:
“as being controlled by evil skeptics“
—————————————————————— Gorski ejaculates:
“No, seriously”
—————————————————————— Bob bleats:
“No”
(applause)
—————————————————————— “You have to unleash the evil hoards of skeptics“
“Wahahaha” 👿
—————————————————————— Dr. Stanislaw Burzynski on Wikipedia:
“Simply don’t pay attention to it, because it, it’s not true”
“You won’t be able to, do any, clinical research which we do, without convincing evidence, especially when you have the most powerful agency in the government which is against you“
“So they would love to find something which is wrong with what we are doing”
“Ah, so the fact that they’ve, um, agreed that what we have has value, and they allow us to do phase 3 clinical trials it means that we are right”
“Because, uh, uh, nobody who didn’t have any, concrete evidence that it works, would be able to go as far”
“So whatever Wikipedia says, well, I don’t care for them“
Apparatchiks [20]
====================================== REFERENCES:
====================================== [1] – David Gorski – Why We Fight (Part I): Stanislaw Burzynski Versus Science-Based Medicine – TAM 2013 11/8/2013 (22:44)
——————————————————————
====================================== [2] – Robert Blaskiewicz – Why We Fight (Part II): It’s All About The Patients – TAM 2013 11/8/2013 (22:36)
——————————————————————
====================================== [3] – Medical Cranks And Quacks
TAM 2013 JREF
11/8/2013 (42:42)
——————————————————————
====================================== [4] – “Galileo’s Lawyer”Richard A. Jaffe, Esq.
—————————————————————— http://www.richardjaffe.com
====================================== [5] – 11/9/2013 – Pete Cohen chats with Dr. Stanislaw Burzynski:
—————————————————————— https://stanislawrajmundburzynski.wordpress.com/2013/11/09/pete-cohen-chats-with-dr-stanislaw-burzynski/
====================================== [6] – 6/2012 – Journal of Cancer Therapy, 2012, 3, 192-200 doi:10.4236/jct.2012.33028 Published Online June 2012, Pg. 192
——————————————————————
Volume 3 Number 1 March 2004
DOI: 10.1177/1534735403261964
�
Pg. 48
� Antineoplaston A2, which contributed to the highest number of complete responses in phase I clinical studies, was elected for final purification, isolation of active components, and structure determination.
Active ingredient identified as: 3-phenylacetylamino-2, 6-piperidinedione
and was named antineoplaston A10. [27]
�
27. Burzynski SR, Hendry LB, Mohabbat MO, et al. Purification of structure determination, synthesis and animal toxicity studies of antineoplaston A10. In: Proceedings of the 13th International Congress of Chemotherapy. Vienna, Austria; 1983:17, PS. 12.4 11-4.
� A10 has been reproduced by synthesis involving condensation of: 1-glutamine
with phenylacetyl chloride
and subsequent cyclization of phenylacetylglutamine (PG). [28]
�
28. Burzynski SR, Hai TT. Antineoplaston A10. Drugs of the Future. 1985;10:103-105.
�
Metabolism of A10 in human body yields: phenylacetylglutamine (PG) phenylacetylisoglutamine (isoPG) phenylacetate (PN)
which were reproduced synthetically and formulated into: antineoplaston A10 injections (A10-I) AS2-1 AS5 AS-25
[29-33]
�
29. Burzynski SR. Synthetic antineoplastons and analogs. Drugs of the Future. 1986;11:679-688.
30. Burzynski SR, Mohabbat MO, Lee SS. Preclinical studies of antineoplaston AS1-1 and antineoplaston AS2-5. Drugs Exptl Clin Res. 1986;12(suppl 1):11-16. http://www.ncbi.nlm.nih.gov/pubmed/3743376/
32. Burzynski SR, Khalid M. Antineoplaston AS2-1. Drugs of the Future. 1986;11:361-363.
33. Burzynski SR. Antineoplaston AS2-5.. Annual Drug Data Report. 1986;8-319.
�
These formulations were submitted for basic research and phase I clinical studies. [34-44]
�
34. Burzynski SR, Mohabbat MO, Burzynski B. Animal toxicology studies on oral formulation of antineoplaston A10. Drug Exptl Clin Res. 1984;10:113-118.
35. Burzynski SR. Phase I clinical studies of antineoplaston AS2-5 injections. In: Ishigami J, ed. Recent Advances in Chemotherapy. Tokyo, Japan: University of Tokyo Press; 1985.
36. Burzynski SR, Burzynski B, Mohabbat MO. Toxicology studies of antineoplaston AS 2-1 injections in cancer patients. Drugs Exptl Clin Res. 1986;12(suppl 1):25-35. http://www.ncbi.nlm.nih.gov/pubmed/3743378/
http://www.ncbi.nlm.nih.gov/m/pubmed/3569020/
42. Ashraf AQ, Burzynski SR. Comparative study of antineoplaston A10 levels in plasma of healthy people and cancer patients. Adv Exptl Clin Chemother. 1988;2:19-28.
43. Ashraf AQ, Kampalath BN, Burzynski SR. Pharmacokinetic analysis of antineoplaston A10 injections following intravenous administration in rats. Adv Exptl Clin Chemother. 1988;6:33-39.
44. Burzynski SR, Kubove E, Burzynski B. Phase I clinical studies of oral formulation of antineoplaston AS2-1. Adv Exptl Clin Chemother. 1988;2:29-36.
� A10 A10-I AS2-1
were selected for phase II studies.
2 initial phase II studies in ASTROCYTOMA
and HIGH-GRADE GLIOMA
began in
1988
and
1990
and were conducted outside investigational new drug (IND) process.
�
Since 1994 the FDA authorized 74 phase II studies with A10 A10-I AS2-1
under INDs
43,742
22,029
in advanced malignancies.
�
Pg. 49
� Phenylacetate (PN)
is active ingredient of antineoplaston AS2-1.
� Phenylglutamine (PG)
is main ingredient of A10-I.
� Phenylglutamine (PG) exhibits antineoplastic activity across wide array of cancer cell lines.
� Phenylglutamine (PG)
inhibits uptake of growth-critical amino acids, such as: 1-glutamine
and 1-leucine
in neoplastic cells.
�
Reduction in amino acid availability may contribute to drug’s antineoplastic activity.
�
Human glioma (U-87) cells rapidly take up Phenylglutamine (PG) by mechanism similar to facilitated diffusion.
�
Upon removal of Phenylglutamine (PG) from media, PG rapidly and completely effluxes from the cell.
� Phenylglutamine (PG)
enters cells via stereospecific amino acid transporters for 1-glutamine.
�
Formulations of Antineoplastons:
� Antineoplastons
are a class of 12 antitumor agents.
�
Following synthetic antineoplaston formulations used in phase II studies.
� Antineoplaston A10
capsules contain 500 mg of 3-phenylacetylamino-2, 6-piperidinedione.
� Antineoplaston A10 injection
is mixture of sodium salts of Phenylglutamine (PG)
and Phenylacetylisoglutamine (isoPG)
in 4:1 ratio.
�
Available in 500 mL and 1000 mL (300 mg/mL) plastic bags.
� Antineoplaston AS2-1
capsules containing 500 mg of 4:1 Phenylacetate (PN)
and Phenylglutamine (PG).
� Antineoplaston AS2-1 injection
is mixture of Phenylacetate (PN)
and Phenylglutamine (PG)
in 4:1 ratio.
�
Available in 250 mL (80 mg/mL) plastic bags.
� � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:
�
18. 6/2005
�
INTEGRATIVE CANCER THERAPIES
� BT-12
� CHILDREN WITH PRIMITIVE NEUROECTODERMAL TUMORS (PNET)
� CAN-01
�
CAN-1
� PATIENTS WITH REFRACTORY MALIGNANCIES
�
Burzynski, S.R., Weaver, R.A., Janicki, T., Szymkowski, B., Jurida, G., Khan, M., Dolgopolov, V.
�
Long-term survival of high-risk pediatric patients with PRIMITIVE NEUROECTODERMALTUMORS treated with Antineoplastons A10 and AS2-1 http://www.ncbi.nlm.nih.gov/pubmed/15911929
Integrative Cancer Therapies 2005;4(2):168-177 http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Integr Cancer Ther. 2005 Jun;4(2):168-77
DOI: 10.1177/1534735405276835 http://m.ict.sagepub.com/content/4/2/168.long?view=long&pmid=15911929
Antineoplastons (ANP) A10 and AS2-1, which are synthetic analogs of naturally occurring derivatives of glutamine, isoglutamine, and phenylacetic acid, have shown an increasing spectrum of activity in primary brain tumors. [1]
�
Review Articles on Clinical Trials:
�
1. 3/2004
�
Burzynski, S.R. The Present State of Antineoplaston Research. Integrative Cancer Therapies 2004;3:47-58.
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