Critiquing “The Skeptic” Burzynski Critics: A Film Producer, A Cancer Doctor, And Their Critics (page 9)

onforb.es/11pwse9

http://t.co/vh3cgAR6hW

http://www.forbes.com/sites/peterlipson/2013/04/19/a-film-producer-a-cancer-doctor-and-their-critics
Didymus Judas Thomas, Contributor

Musings on the intersection of Articles, Bias, and Censorship

(The Big 3: A.B.C.)

4/19/2013 @ 9:43PM

A Film Producer, A Cancer Doctor, And Their Critics

guychapman 5 days ago

“Ah yes, a 1996 news story based on claims from the clinic.”

guychapman, would you like an opportunity to re-read the below and try again?

junkeeroo 1 week ago

The Washington Times, December 5, 1996:

Doctor’s lifesaving effort could land him in prison
– FDA ignores cancer drug’s success

HOUSTON – Federal prosecutors concede that a cancer doctor they will put on trial here in January for using an innovative but unapproved drug has been “saving lives.”

guychapman, that’s NOT

“…claims from the clinic”

“Bold claims, too. Since then he’s registered 61 clinical trials.”

guychapman, that’s NOT taking into consideration the 72 clinical trials listed on the Securities and Exchange (SEC) filings for

11/25/1997 – Form 10-SB

11/25/1997 – Company sponsoring 72 Phase II clinical trials conducted pursuant to INDs filed with FDA which are currently ongoing

“Where are the published results that back his claims?”

guychapman, HERE:

Burzynski Clinical Trials (The SEC filings):
https://stanislawrajmundburzynski.wordpress.com/2013/04/11/burzynski-clinical-trials-2
guychapman,

“The FDA is a large organisation made up of all kinds of people from clerks to political appointees.”

“No whistleblowers.”

guychapman, how do YOU know?

Surely YOU do NOT expect people to believe something just because you posted it?

Considering your stellar track-record

Where is your independent reliable citation(s), reference(s), and / or link(s)?

“Great conspiracy, really well controlled.”

guychapman, I posted this on your “blahg:”
http://www.chapmancentral.co.uk/blahg
and it was censored (removed)”:

Are you a coward like “Orac,” @gorskon, @oracknows, @ScienceBasedMed, Dr. David H. Gorski?
http://burzynskimovie.com/images/stories/transcript/Documents/BurzynskiTriesToExposeNCI.pdf
“Especially since it necessarily also covers MSKCC, NCI, ACS, CRUK and dozens of other organisations.”

guychapman, where are their reliable independent antineoplaston clinical studies?

“I think the number of people engaged in actively suppressing Burzynski’s miracle cure must be in the hundreds of thousands by now and includes lab technicians, scientists, doctors, regulators, politicians and charities in at least ten countries.”
http://t.co/N7ErbunCV2
guychapman, like THIS?
redd.it/1dk974
Wikipedia, what’s your motivation?
http://redd.it/1dk974
Didymus Judas Thomas’
http://www.reddit.com/tb/1dk974
Hipocritical Oath Blog
https://stanislawrajmundburzynski.wordpress.com/2013/05/02/wikipedia-whats-your-motivation/
“Conspiracies that watertight could give you the world on a plate.”

“I mean, Watergate only involved a handful of people and it was busted almost immediately.”

guychapman, you employ a favorite tactic of critics like you

It seems you are more interested in addressing form (CAPITALIZATION) over substance (the real issues)

Maybe you think that your verbosity (17 posts) will somehow lend credibility to your 3 comments re the Declaration of Helsinki; which does NOT state WHEN human clinical trial results MUST be published, and even though you have repeatedly proclaimed that Burzynski has NOT published the FINAL results of any of his phase 2 clinical trials, you have NOT provided any indication as to WHEN any of those trials were completed so that they can be compared to the 2006 study I cited whose results were published in 2013

You also commented:

“In order to claim that he can cure incurable tumours, he needs to publish high quality clinical trial evidence in peer-reviewed journals,”

yet you do NOT provide any citation, reference, or link that overrides the National Cancer Institute (NCI) at the National Institutes of Health (NIH) information re publication which I have commented on previously.

It is apropo you commented:

“Watergate only involved a handful of people and it was busted almost immediately,”

since President Nixon is credited with starting the

“War on Cancer”

and when Watergate occurred he was told that there was a cancer on the Presidency, but Watergate occurred in 1972 and Nixon didn’t resign until 2 years later, in 1974

It is also appropriate that you mention oncologist David Gorski; who disclosed on social media that Peter Lipson is his “pal”

Did you review Burzynski’s 2003-2006 phase 2 clinical trials preliminary reports to see if any of the authors listed on them is an oncologist?

No?

That’s why your observation that Burzynski (a biochemist) is NOT an oncologist, is irrelevant

Do you have any proof to back up your remarkable claim:

“Against that we have an anonymous shill who takes every word of the Burzynski clinic and its supporters as Revealed Truth”?

No?

That’s because you’re wrong about that just like the other issues I’ve listed above

Mr. Chapman, you attempts at obfuscation of the issues, does not impress

guychapman 5 days ago

You don’t really understand the scientific concept of proof do you?

guychapman, you do NOT really understand the concept of proof, do you?

“That probably explains why you are swallowing Burzynski’s PR hook line and sinker.”

guychapman, NO, unlike you, I actually reviewed things and am able to provide “citations,” “references,” and / or “links”

“In order to claim that he can cure incurable tumours, he needs to publish high quality clinical trial evidence in peer-reviewed journals.”

guychapman, where is your “citation(s),” “reference(s),” and / or “link(s)”?

“He needs to publish his science in a way that others can understand and replicate.”

guychapman, do you mean, like THIS?

Stanislaw Rajmund Burzynski Publications:
https://stanislawrajmundburzynski.wordpress.com/2013/03/16/stanislaw-rajmund-burzynski-publications
Burzynski updates Scientific Publications page:
https://stanislawrajmundburzynski.wordpress.com/2013/03/12/burzynski-updates-scientific-publications-page
Antineoplastons, which were first described by Burzynski:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/antineoplastons-which-were-first-described-by-burzynski
Burzynski: Poland antineoplaston publications:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-poland-antineoplaston-publications
Burzynski: South Korea antineoplaston publications:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-south-korea-antineoplaston-publications
Burzynski: Russia antineoplaston publications:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-russia-antineoplaston-publications
Burzynski: Egypt antineoplaston publications:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-egypt-antineoplaston-publication
Burzynski: Japan antineoplaston publications:
https://stanislawrajmundburzynski.wordpress.com/2013/02/19/burzynski-japan
Burzynski: China antineoplaston publications:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-china-antineoplaston-publications
Burzynski and China / Taiwan, ROC:
https://stanislawrajmundburzynski.wordpress.com/2013/02/18/burzynski-china-taiwan-roc
Burzynski and Taiwan, ROC
https://stanislawrajmundburzynski.wordpress.com/2013/02/20/burzynski-taiwan-roc
Burzynski, China, and Dvorit D. Samid:
https://stanislawrajmundburzynski.wordpress.com/2013/02/21/burzynski-china-dvorit-d-samid
Burzynski, Ming-Cheng Liau, and Gi-Ming Lai:
https://stanislawrajmundburzynski.wordpress.com/2013/02/24/burzynski-ming-cheng-liau-gi-ming-lai
Review Article: Antineoplastons:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/review-article-antineoplastons
Burzynski – The Antineoplaston Randomized Japan Phase II Clinical Trial Study:
https://stanislawrajmundburzynski.wordpress.com/2013/03/28/burzynski-the-antineoplaston-randomized-japan-phase-ii-clinical-trial-study
“The people who need to understand and replicate his work in order to validate it, have been complaining for two decades and more that he has failed to do this.”

guychapman, WHO are “The people”?

“The appeal to conspiracy as an excuse for failure to publish any compelling results is a stable feature of quackery.”

guychapman, YOU ARE part of the “conspiracy” as long as you remain silent and play “dumb” about things like “censorship” and “bias” by Wikipedia; who you are the “apologist” for, and Forbes

“It is not a feature of science as such.”

And neither is your ignorance and inability to provide any citation(s), reference(s), and / or link(s)

guychapman 5 days ago

“That was 1996. Since then he’s registered 60 phase II and eon phase III clinical trials.”

guychapman, “eon”?

“Of these he has completed only one, and has failed to publish any meaningful data from any”

guychapman, where is your in-depth review of these publications?

Drugs in R and D (Drugs in Research and Development)

Drugs R D. 2003;4(2):91-101
http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
Drugs R D. 2004;5(6):315-26
http://www.ncbi.nlm.nih.gov/m/pubmed/15563234
Integrative Cancer Therapies

Integr Cancer Ther. 2005 Jun;4(2):168-77
http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Integr Cancer Ther. 2006 Mar;5(1):40-7
http://www.ncbi.nlm.nih.gov/m/pubmed/16484713
2007
http://www.cancer-therapy.org/CT/v5/B/HTML/42._Burzynski,_379-390.html

http://www.burzynskiclinic.com/images/stories/Publications/1252.pdf
Critiquing “The Skeptic” Burzynski
redd.it/1dld1j
Critics: A Film Producer, A Cancer
http://redd.it11dld1j
Doctor, And Their Critics (page 8)
http://www.reddit.com/tb/1dld1j

https://stanislawrajmundburzynski.wordpress.com/2013/05/03/critiquing-the-skeptic-burzynski-critics-a-film-producer-a-cancer-doctor-and-their-critics-page-8/
“(which is in contravention of the Helsinki Protocol governing human trials).”

guychapman, exactly WHERE does the Declaration of Helsinki indicate THAT?

Burzynski: Declaration of Helsinki
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-declaration-of-helsinki
“There’s only so much cherry picking you can do.”

guychapman, YOU are the “cherry-picking” King

“The scientific consensus is based on the totality of evidence, or rather in this case the totality of lack of credible evidence.”

guychapman, YOU have NOT provided “credible evidence” of anything, other than your own ignorance:

The dishonesty of Guy Chapman, “The Skeptics” shill
https://stanislawrajmundburzynski.wordpress.com/2013/04/12/the-dishonesty-of-guy-chapman-the-skeptics-shill
guychapman 5 days ago

“PDJT aka “Astroturfwatch” – the irony of a contributor to an astroturfing campaign of the magnitude of Burzynski’s calling skeptics for non-existent astroturfing is amusing.”

guychapman, are you related to, or know this “lilady”?

Orac, a lilady, the
redd.it/1dgqa1
Oracolytes: “The Skeptic” Burzynski Critics: A
http://redd.it/1dgqa1
Film Producer, A Cancer Doctor, And
http://www.reddit.com/tb/1dgqa1
Their Critics:
https://stanislawrajmundburzynski.wordpress.com/2013/05/01/orac-a-lilady-the-oracolytes-the-skeptic-burzynski-critics-a-film-producer-a-cancer-doctor-and-their-critics/
because you sound similar to lilady with your ASSumptions
“You say:”

“Find just one, any single cure for this tumor type and you can’t, outside of Antineoplastons”

guychapman, NO, “you” did NOT say that, since I am NOT “you”

(Forbes)

Didymus Thomas 5 days ago

As former President Ronald Reagan used to say: “Well, there you go again.”

Let me make this perfectly clear and unambiguous as I can.

1. I am NOT Dr. Stanislaw R. Burzynski, I have never worked for him, I have never met him.

2. I am NOT AstroTurfWatch.

3. I am NOT Eric Merola, I have never worked for him, I have never met him.

4. I am NOT Randy Hinton, I have never met him, this article is the first place I have seen his name.

“What you mean is:”

“Find just one, any single cure for this tumor type and you can’t, including Antineoplastons”.

guychapman, when are you going to show whether you are just a coward or not, and PROVE IT?

“Because the point about which you are in denial is that there is no credible evidence that antineoplastons cure anything.”

guychapman, WHAT does this indicate?

The FDA’s Drug Review Process:

Ensuring Drugs Are Safe and Effective

“[T]he emphasis in Phase 2 is on EFFECTIVENESS”

“This phase aims to obtain PRELIMINARY DATA on whether the drug works in people who have a certain disease or condition”

“Phase 3 studies begin if EVIDENCE of EFFECTIVENESS is shown in Phase 2″

“These studies gather more information about safety and EFFECTIVENESS, studying different populations and different dosages and using the drug in combination with other drugs”
http://www.fda.gov/drugs/resourcesforyou/consumers/ucm143534.htm
“The endlessly repeated list of low quality publication does not come anywhere close to filling in the gap which ought to be filled by the sixty-one human trials he never published – and all the available evidence indicates he never had any intention of doing so.”

guychapman, WHAT does this indicate?

The “FACT” one should know is that clinicaltrials . gov does NOT contain the same data as the National Cancer Institute (NCI) at the National Institutes of Health (NIH) cancer . gov web-site:

61 TOTAL
1 – Not Yet Recruiting (Open)(Phase 3)
1 – Closed
2 – Terminated (Withdrawn due to slow enrollment)
7 – Withdrawn (This study has been withdrawn prior to enrollment)
10 – Recruiting (Open)
11 – Open (1 Not Yet Recruiting / 10 Recruiting)
40 – Active, not recruiting (Closed)

The below 1st link: 10 Active (Open):
http://cancer.gov/clinicaltrials/search/results?protocolsearchid=11475951
The below 2nd link: 25 Closed-1st screen / 15 Closed-1 Completed-2nd screen:
http://cancer.gov/clinicaltrials/search/results?protocolsearchid=11476036
NONE of the above are “UNKNOWN” per the above 2 National Cancer Institute (NCI) at the National Institutes of Health (NIH) links:

10 – Recruiting (Open)
11 – Open (1 Not Yet Recruiting / 10 Recruiting)
40 – Active, not recruiting (Closed)

10=Open
11=1 Not Yet Recruiting / 10 Recruiting
40=Closed
61-TOTAL

“I don’t think he cares any more about the Helsinki Declaration than he does about any other area of medical ethics.”

guychapman, have you even read the Declaration of Helsinki?

Because if you had, you should be able to indicate which section supports your comment

WHAT was that you were saying about “ethics”?

guychapman 5 days ago

“There’s an interesting parallel with Burzynski here.”

guychapman, there’s an interesting parallel with guychapman, Guy Chapman, @SceptiGuy, @vGuyUK, and the Wikipedia Guys: JzG|Guy and Guy (Help!)
http://t.co/N7ErbunCV2
Wikipedia, what’s your motivation?
redd.it/1dk974
Didymus Judas Thomas’
http://redd.it/1dk974
Hipocritical Oath Blog
http://www.reddit.com/tb/1dk974

https://stanislawrajmundburzynski.wordpress.com/2013/05/02/wikipedia-whats-your-motivation/
“Hoxsey, too, used patient anecdotes and conspiracy theories to sustain his business in the absence of credible evidence for a cure;”

guychapman, thank you for bringing up the issue of:

“absence of credible evidence”

THAT describes you to a “T”

If the shoe fits, wear it

“How do you recommend we should tell the difference between Burzynski and his shill Merola, and the palpable fraud and quack Hoxsey?”

guychapman,

“How do you recommend we should tell the difference between guychapman and his shill Guy Chapman, and the palpable fraud and quack @SceptiGuy / @vGuyUK?”

Guy (Help!)

User:JzG/help|Help!

Trust me, Guy, nothing can help YOU

Boris Ogon 6 days ago

“One interesting element is that Merola himself hasn’t shown up to defend his vexatious DMCA claim, which he has effectively admitted to be meritless by offering to drop it if c0nc0rdance can somehow get the after-the-fact third-party mirrors to not include his E-mail address.”

Boris Ogon, did you entirely ignore the Forbes article?

"A well-known “vlogger” who goes by the handle “C0nc0rdance” reports receiving a DMCA take-down notice from Eric Merola after posting a video critical of Burzynski."

"According to C0nc0rdance:
He objected to my “Fair Use” of a small low-res image of his movie poster.”

“Instead, he drops a post on his Facebook page complaining about this article and mischaracterizing the situation, and 10 minutes later, his adherents appear and start babbling incoherently.”

Boris Ogon, are you referring to THIS?

My review of C0nc0rdance:
redd.it/1dm31j

http://redd.it/1dm31j

http://www.reddit.com/tb/1dm31j

https://stanislawrajmundburzynski.wordpress.com/2013/03/23/my-review-of-c0nc0rdance
Mr. Ogon, I guess you were too lazy to type it, sort of like your “research”?

Burzynski, The Movie shared a link.
about an hour ago

“Wow, and people say the “Skeptics” (aka Astroturf campaign) aren’t powerful and with the system behind them.”

“This is what happens when I take down a YouTube video making false claims against my film and Burzynski as well as illegally using copyrighted images of me without permission within (not to mention publishing my personal emails in which I received countless profanity filled threats also in their YouTube post, and they claim “we” threaten – this is the system fighting back, hard):

“Again, Eric: Section 512(f) isn’t entirely toothless.”

Mr. Ogon, though your “research,” IS

"Send some more bogus takedowns and see what happens."

Mr. Ogon, do you mean THIS?

Dr. Peter A. Lipson (and / or his Censor(s)) is a Coward: Critiquing

“A Film Producer, A Cancer Doctor, And Their Critics:”
https://stanislawrajmundburzynski.wordpress.com/2013/04/26/dr-peter-a-lipson-and-or-his-censors-is-a-coward-critiquing-a-film-producer-a-cancer-doctor-and-their-critics
Dr. Lipson does not opine about the manufactured “hysteria” activities by the Burzynski “Critics,” that occurred on Twitter, YouTube, and other social media sites, which entailed this “fact-challenged” video being “mirrored” (duplicated), a ridiculous amount of times

Boris Ogon 5 days ago

For anyone unfamiliar with the tiresome tactic of “Didymus [Judas] Thomas” of trying to drive signal-to-noise ratio into the ground while being completely unable to respond coherently, this is not a bad place to start:
http://goo.gl/f59kT
He was eventually blocked under the “Competence is Required” policy and started shooting off typically garbled E-mails to Jimmy Wales demanding personal attention.

Mr. Ogon, do you have a relationship with Wikipedia?

Mr. Ogon, did you research THIS on Wikipedia?

[“Remedies may be appealed to, and amended by, Jimbo Wales, …”

([[WP:AP]] Wikipedia:Arbitration/Policy 2.9 Appeal of decisions)]

Mr. Ogon, are you referring to THIS?
http://t.co/N7ErbunCV2
Wikipedia, what’s your motivation?
redd.it/1dk974
Didymus Judas Thomas’
http://redd.it/1dk974

http://www.reddit.com/tb/1dk974
Hipocritical Oath Blog
https://stanislawrajmundburzynski.wordpress.com/2013/05/02/wikipedia-whats-your-motivation/
Mr. Ogon, why don’t you bring your coward self over to my blog where I do NOT censor comments, and let’s find out how you do under Sunshine and Blue Sky?

Boris Ogon

“You are right now having a live “debate” in front of more than 10,000 people, … “

3,907 views

Not so much

Waiting for the 10,000

4/19/2013 @ 9:43PM

Peter Lipson: “Speech is best countered by more speech”

Critiquing “The Skeptic” Burzynski Critics: A Film Producer, A Cancer Doctor, And Their Critics (page 8)

onforb.es/11pwse9

http://t.co/vh3cgAR6hW

http://www.forbes.com/sites/peterlipson/2013/04/19/a-film-producer-a-cancer-doctor-and-their-critics
Didymus Judas Thomas, Contributor

Musings on the intersection of Articles, Bias, and Censorship

(The Big 3: A.B.C.)

4/19/2013 @ 9:43PM

A Film Producer, A Cancer Doctor, And Their Critics

FW 1 week ago

“Erm, what conflict of interest?”

FW (also known as @frozenwarning), your “conflict of interest” with “facts”

Do you know how utterly, completely, fruit looping bonkers that is?

Seriously, get a grip.

FW 1 week ago

“Sadly Burzynski isn’t following FDA standards, as their warning letters and current inspection shut down proves.”

FW, being from the United Kingdom, are you even knowledgeable about the FDA warning letter process?

“He’s been doing his “research” for 40 years.”

“How long do you think he should be allowed to continue without showing his data?”

FW, what do you call THIS ?

Burzynski Clinical Trials (The SEC filings)
https://stanislawrajmundburzynski.wordpress.com/2013/04/11/burzynski-clinical-trials-2
“As I said earlier, the Phase 3 trial has been registered since 2010 and Burzynski shows no inclination to start it, having NOT A SINGLE PATIENT RECRUITED.”

FW, as I said earlier, did you pay attention to this?

Burzynski: Not every cancer clinical trial taking place in the United States is listed on our NCI clinical trials database
https://stanislawrajmundburzynski.wordpress.com/2013/04/26/burzynski-not-every-cancer-clinical-trial-taking-place-in-the-united-states-is-listed-on-our-nci-clinical-trials-database
Burzynski’s Securities and Exchange Commission (SEC) Form 10-Q for the quarterly period ended 5/31/2010 states:

1/13/2009 Company announced Company had reached an agreement with FDA for Company to move forward with pivotal Phase III clinical trial of combination Antineoplaston therapy plus radiation therapy in patients with newly diagnosed, diffuse, intrinsic brainstem gliomas (DBSG)

Agreement was made under FDA’s Special Protocol Assessment procedure, meaning design and planned analysis of Phase III study is acceptable to support regulatory submission seeking new drug approval

2/1/2010 Company entered into agreement with Cycle Solutions, Inc., dba ResearchPoint to initiate and manage pivotal Phase III clinical trial of combination Antineoplastons A10 and AS2-1 plus radiation therapy (RT) in patients with newly-diagnosed, diffuse, intrinsic brainstem glioma

ResearchPoint is currently conducting feasibility assessment

ResearchPoint has secured interest and commitment from number of sites selected

Upon completion of assessment, randomized, international phase III study will commence

Study’s objective is to compare overall survival of children with newly-diagnosed DBSG who receive combination Antineoplastons A10 and AS2-1 plus RT versus RT alone

” … only obstacles now are $300 million $s needed to pay for final phase of clinical testing-and FDA requiring children with inoperable brainstem glioma to also undergo radiation
treatment in Phase 3 trials, claiming it would be “unethical” not to do so”

why was the FDA requiring “radiation
” in the phase 3 clinical trial?

“I’ll tell you what these patients lose, they lose time, and quality of life, and hundreds of thousands of dollars on an unproven therapy that they are being misled about, and no-one in that situation deserves that.”

FW, isn’t EVERY drug in the clinical trial process “unproven therapy,” until such time as the FDA approves it?

Are you saying that because EVERY drug in the clinical trial process is “unproven therapy,” there should be NO clinical trials AT ALL?

FW 1 week ago

“Hah, if the FDA took any notice of the criticism, then I’m glad to hear it, though if Burzynski had not conducted his trials in an unethical and unscientific way, which was obvious merely from what his patients reported, they would have had no reason to shut his operation down.”

FW, what information do you have from the FDA that supports your comments?

“Why continue?”

“Well, there’s the so called gene targeted therapy that he still peddles for vast amounts of money, which isn’t gene targeted at all, merely a way of selling random scattergun, often off label chemotherapy.”

FW, where are your reliable independent sources (citation(s), reference(s), and / or link(s)?

“There are no retainers, that’s another of your usual batshit theories, used instead of answering the questions.”

FW, I’m still waiting for you to answer my questions

“Classy of you to use my family bereavements in such a way though.”

“I can assure you, they got the best care available and luckily no quack ever tried to con them. If they had, they would have got short shrift.”

FW, so, unfortunately, even though your family “got the best care available,” they still passed?

Which also happens to Burzynski

rjblaskiewicz 1 week ago

“Damn it, Eric. Wouldn’t your time be better spent recutting your movie so it didn’t suck?”

rjblatherskiewicz, I don’t see you on here with your lame comments:

Have you heard of Anthony Jeselnik’s “Defend Your Tweet?”

I’d like to find out how you’d “Defend Your Comments”

My Critique of Bob Blaskiewicz (Colorado Public Television – PBS CPT12)
https://stanislawrajmundburzynski.wordpress.com/2013/03/26/my-critique-of-bob-blaskiewicz-colorado-public-television-pbs-cpt12
Critiquing Bob Blaskiewicz (#Burzynski Cancer is Serious Business, Part II)
https://stanislawrajmundburzynski.wordpress.com/2013/03/26/critiquing-bob-blaskiewicz-burzynski-cancer-is-serious-business-part-ii
Boris Ogon 1 week ago

(citing Astroturfwatch’s comments):

“They refuse to fact check anything. Namely Phase 2 results showing a 25% cure rate for brainstem glioma, never accomplished in medical history—ever.”

“Published plan as day in a ‘internationally peer-reviewed’ article.”

(Boris Ogon)

“You mean PMIDs 12718563 and 16484713? (These, at least, are the ones that Merola cites, which I assume is the sum total of your “fact checking.”)”

Mr. Ogon, I don’t see any comments from “Merola” on the Forbes comments, but maybe you are referring to Astroturfwatch’s comments:

“Namely Phase 2 results showing a 25% cure rate for brainstem glioma, never accomplished in medical history—ever”

“Notice the chart on page 172 (page 8 of PDF).”

“Find just one, any single cure for this tumor type and you can’t, outside of Antineoplastons FDA sanctioned clinical trials:”
http://www.burzynskiclinic.com/images/stories/Publications/1252.pdf
(Boris Ogon)

“Let’s take them in turn, noting first that

“(1) neither represents the results of a completed Phase 2 trial and”

“(2) it’s essentially the same group in both.””

“We know the following about the ultimate group of 13:”

““Medulloblastoma was diagnosed in 8 patients, pineoblastoma in 3 patients, and other PNET in 2 patients.”

“Prior therapies included surgery in 12 patients (1 had biopsy only, suboccipital craniotomy), chemotherapy in 6 patients, and radiation therapy in 6 patients.”

“Six patients had not received chemotherapy or radiation.”

“The first reference is to Drugs in R&D 4:91 (2003).”

“This is a pharmacy journal, which immediately calls into question the adequacy of the available peer review.”

“It also appears to have briefly gone out of business, with no articles published in 2010.”

“Its JCR IF for 2009 was 1.354, which represented an increase of “more than 35%” of 2008; it did not even have an IF in 2011, but in this year, it was ranked 114 out of 221 in its SCImago category, *after* it had switched to “Gold OA,” which may well lead one to wonder whether it was even a third-tier journal earlier on.”

“The side effects included anemia, hypernatremia, agranulocytosis, and granulocytopenia.”

“End result?”

“The results of this study compared favourably with the responses of patients treated with radiation therapy and chemotherapy.”

“Color me unimpressed.”

“This gets better with the next one, though.”

“The second reference is to Integrative Cancer Therapies 4:168 (2005).”

“One may suspect from the title that we may have a problem here.”

“A look at the current editorial board leaves one distinctly unimpressed.”

“In particular, it includes *Ralph Moss.*”

“If this name doesn’t immediately set of a warning klaxon in your head, you’re not familiar with cancer crankery.”

“With a 2011 IF of 2.136, it currently ranks 118 of 196 in the JCR oncology category.”

“It shared this number with papers about acupuncture and green tea, but let’s cut to the chase:”

“The percentage of patients’ response is lower than for standard treatment of favorable PNET.”

“That’s right, “antineoplastons” did *worse* than standard treatment.”

“He tries to salvage something from this mess by suggesting that “antineoplastons” might someday prove useful for some categories of PNETs.”

“*Neither* paper claims superiority over conventional treatment.”

Mr. Ogon, where did you get your data from?

The “chart on page 172 (page 8 of PDF):”
http://www.burzynskiclinic.com/images/stories/Publications/1252.pdf
refers to:

2006 Adis – Pediatr Drugs 2006; 8 (3)

pg 172

Treatments for Astrocytic Tumors

Table II. Treatment of diffuse, intrinsic brainstem glioma in children

Burzynski et al. [88] – Reference
Phase II – Study Type
(no. of pts) – pts = patients
RP (30) – RP = recurrent and progressive tumor – Tumor type
ANP – ANP = antineoplastons A10 and AS2-1 – Treatment – ANP
OS (%) – OS = overall survival
[2y; 5y]
46.7; 30 – Efficacy
MST (mo)
19.9 – MST = median survival time
[% (no. )]
27 (8) – CR – CR = complete response
[% (no. )]
20% (6) – PR – PR = partial response
[% (no. )]
23% (7) – SD – SD = stabile disease
30% (9) – PD = progressive disease

pg 177

88. Burzynski SR, Weaver RA, Janicki T. Long-term survival in phase II studies of antineoplastons A10 and AS2-1 (ANP) in patients with diffuse intrinsic brain stem glioma [abstract]. Neuro-oncol 2004; 6: 386

This is the 2004 publication, NOT 2003

Phase II study of antineoplaston A10 and AS2-1 in children with recurrent and progressive multicentric glioma : a preliminary report.
http://www.ncbi.nlm.nih.gov/m/pubmed/15563234
Drugs R D. 2004;5(6):315-26

pg 172

Burzynski et al. [89] – Reference
Phase II – Study Type
(no. of pts) – pts = patients
RPS (10) – RPS = recurrent and progressive tumors in children aged <4y – Tumor type {(66) = most in a study}
ANP – ANP = antineoplastons A10 and AS2-1 – Treatment – ANP
OS (%) – OS = overall survival
[2y; 5y] – Efficacy
60; 20 {46.7 (30) = next best study}
MST (mo)
26.3 – MST = median survival time – {19.9 = next best study}
[% (no. )]
30% (3) – CR = complete response – {27% (8) = next best study}
[% (no. )]
0% (0) – PR = partial response – {56% (1) = next best}
[% (no. )]
40% (4) – SD = stable disease – {44% (25) = best}
[% (no. )]
30% (3) – PD = progressive disease – {23% (13) = best}

(Above, I also provide the best next case to compare to)

pg 177

89. Burzynski SR, Weaver RA, Janicki TJ, et al. Targeted therapy with ANP in children less than 4 years old with inoperable brain stem gliomas [abstract]. Neuro-oncol 2005; 7: 300

Long-term survival of high-risk pediatric patients with primitive neuroectodermal tumors treated with antineoplastons A10 and AS2-1.
http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Integr Cancer Ther. 2005 Jun;4(2):168-77

pg 173

1.4.3 Targeted Therapy

“…multi-targeted therapy with ANP has shown promising results [12;88-91]”

pg 176

90. Burzynski SR, Lewy RI, Weaver RA, et al. Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. Drugs R D 2003; 4: 91-101

Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report.
http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
Drugs R D. 2003;4(2):91-101

91. Burzynski SR, Weaver RA, Janicki T. et al. Targeted therapy with antineoplastons A10 and AS2-1 (ANP) of high-grade, recurrent and progressive brain stem glioma. Integr Cancer Ther 2006 Mar; 5 (1): 40-7

Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma.
http://www.ncbi.nlm.nih.gov/m/pubmed/16484713

Integr Cancer Ther. 2006 Mar;5(1):40-7

30 evaluable patients with recurrent and progressive DBSG

“>40% of patients survived for more than 2 years
30% more than 5 years.”

27% – CR – Complete Response
20% – PR – Partial Response
23% – SD – Stable Disease
30% – PD – Progressive Disease
[12,88]

pg 175

12. Burzynski SR Targeted therapy for brain tumors In: Columbus, F editor. Brain cancer research progress. New York: Nova Science Publishers Inc 2005

pg 173

10 evaluable children
aged <4 years diagnosed with DBSG treated with ANP
youngest 3-month-old infant
[89]

60% – 2-year survival rate
20% – 5-year survival rate
maximum survival more than 7 years

30% – CR – Complete Response
40% – SD – Stable Disease
30% – PD – Progressive Disease
[89]

“The results are compiled in table II.”

pg 174

2.3. Targeted Therapy

Multi-targeted ANP therapy is free from chronic toxicity in children and adults based on the results of numerous clinical studies involving

1652 adults
335 children
[147]

pg 178

147. Burzynski SR. Annual report to the FDA, IND 43,742, 2006

pg 174

Long-term follow-up of children treated with ANP for astrocytomas revealed:
normal development
no cognitive or endocrine deficiencies
normal fertility

>5 years – substantial number of patients tumor free
>17 years – follow-up period for some patients

pg 169

1.1.4. Targeted Therapy

Clinical trials with agents affecting single targets are in progress and the preliminary results of multi-targeted therapy with
antineoplastons (ANP) A10
and
AS2-1 have been reported
[39]

small group of patients with progressive LGA, ANP
60% – CR rate – Complete Response
10% – PR rate – Partial Response
median survival 7 years 9 months
maximum survival of more than 15 years
[39]

LGA = Low-Grade Astrocytomas
Table I. Selected chemotherapy regimens for the treatment of low- grade astrocytoma in children

Burzynski [39] – Reference
Phase II d – d = Preliminary results – Study type
P – P = progressive tumor – Tumor type
(no. of pts) – pts = patients
ANP (10) – ANP = antineoplastons A10 and AS2-1 – Treatment {(78) = most in a study}
OS [%] – OS = overall survival
100% (1 yr) – 90% (3 yr) – Efficacy
93 mo – MST = MST = median survival time – {96 (1 y) next closest}
CR [% (no.)]
60% (6) – CR = complete response {24 (11) next closest}
PR [% (no.)]
10% (1) – PR = partial response {60% (9) best other study}
[% (no.)]
30% (3) – SD = stable disease + MR = minor response {70% (14) best other study}
[% (no.)]
0% (0) – PD = progressive disease {4% (2) next closest}
PFS (%)
90 (1 y) – 90 (3 y) – PFS = progression-free survival {100 (1 y) – 68 (3 y) best other study}

(Above, I also provide the best next case to compare to)

pg 176

39. Burzynski SR Clinical application of body epigenetic system: multi-targeted therapy for primary brain tumors. World and Ehrlich Conference on Dosing of Magic Bullets; 2004 Sep 9-11 Nurnberg

“One further has to take into account the fact that Scamley has been known to employ idiosyncratic definitions, such as classifying tumor *growth* as “stable disease” for “less than 50% reduction in size but no more than 50% increase in size of the tumor mass, lasting for at least twelve weeks.””

Mr. Ogon, did you read THIS ?

Burzynski: STABLE DISEASE
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-stable-disease
5/2007 – Guidance for Industry – Food and Drug Administration
Guidance for Industry

Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics

U.S. Department of Health and Human Services Food and Drug Administration

Center for Drug Evaluation and Research (CDER)

Center for Biologics Evaluation and Research (CBER)

May 2007 Clinical/Medical

“STABLE DISEASE should not be a component of ORR

STABLE DISEASE can reflect the natural history of disease”

(Pg. 10 of 22 = actual pg. 7 of PDF)
“…STABLE DISEASE can be more accurately assessed by TTP or PFS analysis (see below)”
(Pg. 11 of 22 = actual pg. 8 of PDF)

Time to Progression and Progression-Free Survival

TTP – Time to Progression

PFS – Progression-Free Survival

Time to Progression and Progression-Free Survival

TTP and PFS have served as primary endpoints for drug approval

TTP and PFS have served as primary endpoints for drug approval
(Pg. 11 of 22 = actual pg. 8 of PDF)

http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071590.pdf
And in addition, the below 2005 non-Burzynski study also uses “STABLE DISEASE:”

Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children
Results of a multiinstitutional study (SJHG-98)

http://www.ncbi.nlm.nih.gov/m/pubmed/15565574
St. Jude Children’s Research Hospital (Memphis, TN)
29 (88)
Texas Children’s Medical Center (Houston, TX)
2 (6)
Children’s Medical Center (Dallas, TX)
2 (6)
Cancer. 2005 Jan 1;103(1):133-9
Cancer 103, 133-139
Cancer Volume 103, Issue 1, pages 133–139, 1 January 2005
DOI: 10.1002/cncr.20741
Article first published online: 24 NOV 2004
American Cancer Society

http://onlinelibrary.wiley.com/doi/10.1002/cncr.20741/full
“Protip:”

“Before you start crying about how “‘fact-checking’ is no longer even on the table,” you might want to try figuring out what it actually is first.”

Mr. Ogon, what was that about

“fact-checking” ?

Lynne 1 week ago

“Angel of life, let me point out that there are many accounts of brain cancer survivors who were treated with conventional medicine.”

“Burzynski is not the only one.”

“A simple google search reveals that there are several cancer survivor groups and other accounts of healing via traditional scientific medicine.”

“Just one example:”

“virtualtrials.org”

“(go to the bottom of the page and click on survivor stories)”

“features 37 brain cancer patients who have survived from 5-30 years by choosing cutting edge research and clinical trials.”

“Their stories are identical to those of Burzynski patients.”

“Some people are just fortunate in their response to chemo, and make no mistake, Burzynski uses chemo.”

“There are a lot more examples out there.”

“Burzynski has not shown conclusively that he has a higher survival rate than conventional medicine, which would be so easy for him to do.”

Lynne, did you look HERE ?

Burzynski Clinical Trials (The SEC filings):
https://stanislawrajmundburzynski.wordpress.com/2013/04/11/burzynski-clinical-trials-2
“He could post it tomorrow; it doesn’t have to be in a peer reviewed journal.”

Lynne, at least you’re right about that:

Burzynski: What happens when a clinical trial is over?
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-what-happens-when-a-clinical-trial-is-over
“Instead, we are asked to just believe him because he’s such a nice guy who cares so much.”

Lynne, that’s one way to do it:

Burzynski: Declaration of Helsinki
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-declaration-of-helsinki
“To complete the equation, you have to know the denominator:”

Lynne, that’s another option:

Burzynski: FAQ: Clinical Trial Results
https://stanislawrajmundburzynski.wordpress.com/2013/04/26/burzynski-faq-clinical-trial-results/
“how many didn’t make it.”

Lynne, you could ask that too:

Antineoplastons: Has the FDA kept its promise to the American people ?
https://stanislawrajmundburzynski.wordpress.com/2013/03/22/antineoplastons-has-the-fda-kept-its-promise-to-the-american-people
“Conventional medicine is transparent and reports failures.”

Lynne, if you say so, though you provide no citation(s), reference(s), and / or link(s):

Burzynski: The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-the-fdas-drug-review-process-ensuring-drugs-are-safe-and-effective
“Burzynski doesn’t.”

Lynne, if you say so:

Burzynski – The Antineoplaston Randomized Japan Phase II Clinical Trial Study:
https://stanislawrajmundburzynski.wordpress.com/2013/03/28/burzynski-the-antineoplaston-randomized-japan-phase-ii-clinical-trial-study
“Just another reason the body of scientists don’t find him credible.”

Lynne, like THESE ?

Burzynski referenced by other Cancer researchers:
https://stanislawrajmundburzynski.wordpress.com/2013/04/24/burzynski-referenced-by-other-cancer-researchers
Boris Ogon

“You are right now having a live “debate” in front of more than 10,000 people, … “

3,799
views

Not so much

Waiting for the 10,000

4/19/2013 @ 9:43PM

Peter Lipson: “Speech is best countered by more speech”

Critiquing “The Skeptic” Burzynski Critics: A Film Producer, A Cancer Doctor, And Their Critics (page 6)

onforb.es/11pwse9

http://t.co/vh3cgAR6hW

http://www.forbes.com/sites/peterlipson/2013/04/19/a-film-producer-a-cancer-doctor-and-their-critics
Didymus Judas Thomas, Contributor

Musings on the intersection of Articles, Bias, and Censorship

(The Big 3: A.B.C.)

4/19/2013 @ 9:43PM

A Film Producer, A Cancer Doctor, And Their Critics

guychapman 5 days ago

“All we can tell from the records is that he completed *one* phase 2 trial (out of 60), with no indication of success or failure, and has not published the full results from a single one of these trials.”

Mr. guychapman (also known as Guy Chapman, @SceptiGuy, @vGuyUK), when does this say he must publish human clinical trials by?

Burzynski: Declaration of Helsinki:
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-declaration-of-helsinki
“Here’s a really simple question for you: what is Burzynski’s median five-year survival rate compared with standard of care for specific tumour types and stages?”

Mr. guychapman, have you looked here?

Burzynski Clinical Trials (The SEC filings)
https://stanislawrajmundburzynski.wordpress.com/2013/04/11/burzynski-clinical-trials-2
“You’ll need to cite a reliable independent source, of course.”

Mr. guychapman, have you looked here?

Burzynski: What happens when a clinical trial is over?
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-what-happens-when-a-clinical-trial-is-over
“You know, a peer-reviewed publication of decent quality.”

Mr. guychapman, have you looked here?

The “National Cancer Institute (NCI) at the National Institutes of Health (NIH)
Cancer Clinical Trials
15. What happens when a clinical trial is over?
http://m.cancer.gov/topics/factsheets/clinical-trials
advises:
“The results of clinical trials are OFTEN published in peer-reviewed scientific journals”
” … WHETHER OR NOT the results are published in a peer-reviewed scientific journal … “

This makes it clear that clinical trial results “are OFTEN” published, but sometimes they are “NOT” published “in a peer-reviewed scientific journal”

“He claims to have treated thousands of patients, this cohort is large enough to perform at least some basic statistical analysis.”

Mr. guychapman, have you looked here?

Burzynski – The Antineoplaston Randomized Japan Phase II Clinical Trial Study
https://stanislawrajmundburzynski.wordpress.com/2013/03/28/burzynski-the-antineoplaston-randomized-japan-phase-ii-clinical-trial-study
JGC2013 4 days ago

“Actually, although Burzynski did submit a design for a phase III trial round about 2009, as of this date not a single patient has been enrolled in this study.”

JGC2013, did you read the Securities and Exchange Commission (SEC) filings?

Burzynski’s Securities and Exchange Commission (SEC) Form 10-Q for the quarterly period ended 5/31/2010 states:
1/13/2009 Company announced Company had reached an agreement with FDA for Company to move forward with pivotal Phase III clinical trial of combination Antineoplaston therapy plus radiation therapy in patients with newly diagnosed, diffuse, intrinsic brainstem gliomas (DBSG)
Agreement was made under FDA’s Special Protocol Assessment procedure, meaning design and planned analysis of Phase III study is acceptable to support regulatory submission seeking new drug approval
2/1/2010 Company entered into agreement with Cycle Solutions, Inc., dba ResearchPoint to initiate and manage pivotal Phase III clinical trial of combination Antineoplastons A10 and AS2-1 plus radiation therapy (RT) in patients with newly-diagnosed, diffuse, intrinsic brainstem glioma
ResearchPoint is currently conducting feasibility assessment
ResearchPoint has secured interest and commitment from number of sites selected
Upon completion of assessment, randomized, international phase III study will commence
Study’s objective is to compare overall survival of children with newly-diagnosed DBSG who receive combination Antineoplastons A10 and AS2-1 plus RT versus RT alone

JGC2013, but then again:

Burzynski: Not every cancer clinical trial taking place in the United States is listed on our NCI clinical trials database
https://stanislawrajmundburzynski.wordpress.com/2013/04/26/burzynski-not-every-cancer-clinical-trial-taking-place-in-the-united-states-is-listed-on-our-nci-clinical-trials-database
FW 6 days ago

“And yet the American Cancer Society makes exactly the same criticisms of Burzynki that all other critics do:”
http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/antineoplaston-therapy
“No credible evidence.”

FW (also known as @frozenwarning), where is their independent antineoplaston clinical study publications?

rjblaskiewicz 6 days ago

“It’s not a thread about the inherent corruption throughout all of medicine.”

“It’s about some bully/man-child trying to shut up critics.”

Mr. rjblaskiewicz (also known as Bob Blaskiewicz, so, like Forbes was?

A Film Producer, A Cancer Doctor, And Their Critics:
https://stanislawrajmundburzynski.wordpress.com/2013/04/20/a-film-producer-a-cancer-doctor-and-their-critics
Forbes censors Peter Lipson “Speech is best countered by more speech” article comments:
https://stanislawrajmundburzynski.wordpress.com/2013/04/23/forbes-censors-peter-lipson-speech-is-best-countered-by-more-speech-article-comments
Dr. Peter A. Lipson (and / or his Censor(s)) is a Coward: Critiquing “A Film Producer, A Cancer Doctor, And Their Critics:”
https://stanislawrajmundburzynski.wordpress.com/2013/04/26/dr-peter-a-lipson-and-or-his-censors-is-a-coward-critiquing-a-film-producer-a-cancer-doctor-and-their-critics
“You are wrong. But you know this.”
https://stanislawrajmundburzynski.wordpress.com/2013/03/26/critiquing-bob-blaskiewicz-burzynski-cancer-is-serious-business-part-ii
3/26/2013
https://stanislawrajmundburzynski.wordpress.com/2013/03/26/my-critique-of-bob-blaskiewicz-colorado-public-television-pbs-cpt12
Called-out comment

FW 6 days ago

“junkeroo, when you post something rational and intelligible,I will happily respond.”

FW (also known as @frozenwarning), when you post something rational and intelligible, I will happily respond.”
onforb.es/11pwse9

http://t.co/vh3cgAR6hW

http://www.forbes.com/sites/peterlipson/2013/04/19/a-film-producer-a-cancer-doctor-and-their-critics
“Instead of cherry picking 20 year old newspaper articles, can I suggest that you try and explain why Burzynski has started 60+ trials, finished one, and never reported the results in peer reviewed journals as any reputable scientist should do?”

FW, have you read these?

Burzynski: What happens when a clinical trial is over?
https://stanislawrajmundburzynski.wordpress.com/2013/04/25/burzynski-what-happens-when-a-clinical-trial-is-over
The “National Cancer Institute (NCI) at the National Institutes of Health (NIH)
Cancer Clinical Trials
15. What happens when a clinical trial is over?
http://m.cancer.gov/topics/factsheets/clinical-trials
advises:
“The results of clinical trials are OFTEN published in peer-reviewed scientific journals”
” … WHETHER OR NOT the results are published in a peer-reviewed scientific journal … “

This makes it clear that clinical trial results “are OFTEN” published, but sometimes they are “NOT” published “in a peer-reviewed scientific journal”
"As for this mythical Phase 3 trial, which was registered in 2010 and has yet to recruit a single patient, in a tumour that is relatively curable by real medicine."

"I suspect permission to do this was an attempt by the FDA to force Burzynski to do a decent RCT."

"Unfortunately it backfired, because he seems quite happy to never start this trial, instead using it as a marketing tool, in the same way as he is happy to use individual patients."

FW, why was the FDA requiring “radiation
” in the phase 3 clinical trial?

” … only obstacles now are $300 million $s needed to pay for final phase of clinical testing-and FDA requiring children with inoperable brainstem glioma to also undergo radiation
treatment in Phase 3 trials, claiming it would be “unethical” not to do so”

Boris Ogon

“You are right now having a live “debate” in front of more than 10,000 people, … “

3,791 views</strong

Not so much

Waiting for the 10,000

| 4/19/2013 @ 9:43PM

Peter Lipson: “Speech is best countered by more speech”