Is Dr. David H. “Orac” Gorski Down and Out in Detroit and an Ethically Bankrupt Researcher ?

After Gorski’s “research” of Burzynski’s phase I (1) clinical trials:

Critiquing: How Stanislaw Burzynski became Burzynski the Brave Maverick Doctor, part 1:
https://stanislawrajmundburzynski.wordpress.com/2013/07/22/critiquing-how-stanislaw-burzynski-became-burzynski-the-brave-maverick-doctor-part-1/
he asserts:

“For one thing, in 1976 Burzynski had no animal data to speak of”

“In fact, the question of animal studies is an interesting one”

“Both Elias and Jaffe recount a story in which ANPs didn’t work in animal tumors, and Burzynski has been quoted in multiple places as claiming that ANPs are species-specific and that ANPs derived from human blood and urine don’t work in animal tumor models”

“This is in contrast to what Null reports in his near-contemporaneous account, in which he stated that in tissue culture and animal models Burzynski’s ANPs worked “specifically against certain types of cancer,” all with “no toxic side effects”

“It makes one wonder whether the “species specificity” was an excuse developed later to explain the lack of animal data”
� � � � � � � � � � � � � � � � �
National Cancer Institute (NCI) at the National Institutes of Health (NIH)

Laboratory/Animal/Preclinical Studies:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page4
“Burzynski states that antineoplaston A is species-specific because it had no therapeutic effect when the human preparation was tested on animal tumor systems”

“Although this finding limits the usefulness of animal model testing, the developer has suggested that a “marked” therapeutic effect was produced in a xenograft bearing human tumor tissue.[1]”

“This claim is made only for antineoplaston A”

“Other formulations of antineoplastons have not been tested in animal models”

Gorski should REALLY read his own blog:
http://scienceblogs.com/insolence/2013/01/21/quoth-joe-mercola-i-love-me-some-burzynski-antineoplastons/
Comment #158 – Didymus Judas Thomas

At the Tu-Quack Center Educate Orac Oracle Phase I

February 4, 2013

.11/15/1982.- 2 Toronto physicians, Martin E. Blackstein, Head of the Division of Oncology at Mount Sinai Hospital & Daniel E. Bergsagel, Chief of Medicine at Princess Margaret Hospital, visited the Burzynski clinic & research institute
.
Both were powerful & respected physicians in the Canadian cancer establishment
.
They returned with a blistering, critical report
.
The essence of their critique was
.
(1) there was little evidence that antineoplastons had significant antitumor activity against human or animal cancers;
.
(2) SRB’s argument that antineoplastons were species-specific created a line of argument for avoiding standard animal & tissue culture screens & required testing in humans
.
SRB cooperated but was dubious
.
There were several test-tube & preventative models in which the drug had showed effectiveness, but the standard NCI pre-screen, P388 mouse leukemia, was not 1 of them. …
.
As he had predicted, these compounds were not effective against mouse leukemia
.
SRB reasonably suggested that NCI try the Antineoplastons in cell-culture assays that were similar to “human solid tumors, especially adenocarcinoma of the breast” …
.
SRB was hardly alone in voicing doubts about the P388 mouse model
.
1983 – Ironically, it was Dr. John Vendetti himself, chief of the NCI’s Drug Evaluation Branch, who coauthored an article in which he argued the limitations of this very mouse system
.
Scientists at NCI had found, for instance, that of 79 drugs which had previously been judged negative in the P388, 14 showed “significant activity” when retested in cell culture assays [1] [2]

Comment #163 – Didymus Judas Thomas

February 4, 2013

Orac’s blog hates links reformatting (www removed)
.
[1] http://www.commonweal.org/pubs/choices/21.html
[2] 9 Moss, The Cancer Ind., 14, 299-300
(Ralph Moss, The Cancer Industry)

27. Burzynski SR, Hendry LB, Mohabbat MO, et al. Purification of structure determination, synthesis and animal toxicity studies of antineoplaston A10. In: Proceedings of the 13th International Congress of Chemotherapy. Vienna, Austria; 1983:17, PS. 12.4 11-4.

34. Burzynski SR, Mohabbat MO, Burzynski B. Animal toxicology studies on oral formulation of antineoplaston A10. Drug Exptl Clin Res. 1984;10:113-118.

40. Ashraf AQ, Liau MC, Kampalath BN, et al. Pharmacokinetic study of radioactive antineoplaston A10 following oral administration in rats. Drugs Exptl Clin Res. 1987;13(suppl 1):45-50.
http://www.ncbi.nlm.nih.gov/pubmed/3569015/

http://www.ncbi.nlm.nih.gov/m/pubmed/3569015/
43. Ashraf AQ, Kampalath BN, Burzynski SR. Pharmacokinetic analysis of antineoplaston A10 injections following intravenous administration in rats. Adv Exptl Clin Chemother. 1988;6:33-39.

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Critiquing: How Stanislaw Burzynski became Burzynski the Brave Maverick Doctor, part 1

“Orac” / Dr. David H. Gorski decided that since he can NOT seem to grasp how to do REAL “research,” that he would read something from years ago, and blog about it, whilst his Twitter twit compadres have whined like little bitches when anyone tweets anything remotely pro-Burzynski, re anything from the 1990’s or before

So Gorski digs to see if he can find any dirt worthy of making into one of his specialty Detroit, Michigan Mud Pies

How Stanislaw Burzynski became Burzynski the Brave Maverick Doctor, part 1
http://scienceblogs.com/insolence/2013/07/22/how-stanislaw-burzynski-became-burzynski-the-brave-maverick-doctor-part-1/
Gorski quotes Burzynski:

“The idea of fighting people in authority became natural to me”

“I learned that you must never let them defeat you in your own core”

Gorski blurts:

“In some ways, these can be most admirable traits”

“Virtually all highly successful people who make a difference in the world possess some measure of this sort of determination and willingness to fight for what one believes”

“If only Burzynski had found a good cause to which he could yoke such them

(“Yoke such them”? Is that a Polish saying?)

“Unfortunately, he found antineoplastons”

Unfortunately for the world, Gorski has nothing better to do

Maybe he should get to work in the Detroit salt mines, trying to get Detroit out of bankruptcy!

Gorski splats:

“… I’ll discuss some of Burzynski’s legal battles, up to and including his epic battle in the 1990s that led to his indictment in late 1995 … and his ultimate acquittal based on a hung jury in early 1997, …”

Gorski obviously is desperate as I have already commented extensively on his blogsplat before he BLOCKED me; like the truculent child he is, regarding the 1997 case

3/3/1997 – Associated Press (A.P.) News:
http://www.apnewsarchive.com/1997/Jury-deadlocks-retrial-planned-for-Dr-Stanislaw-Burzynski/id-58e7ec089bfad6697d138d7bfe26c011
5/19/1997 – Associated Press (AP)
http://www.texnews.com/texas97/doc051997.html
5/19/1997 – New York Times:
http://www.nytimes.com/1997/05/19/us/all-charges-but-one-dropped-against-doctor.html
5/21/1997 – New York Times:
http://www.nytimes.com/1997/05/21/us/unorthodox-doctor-goes-on-trial-again-on-contempt-charge.html
5/28/1997 – New York Times:
http://www.nytimes.com/1997/05/28/us/doctor-cleared-in-trial-on-unapproved-drugs.html
8/1/1997 – Reason
http://reason.com/archives/1997/08/01/balance-sheet
Gorski utters:

The question becomes:

“Does Burzynski still believe himself to be the man who has cured several forms of cancer, or does he now know that ANPs almost certainly don’t work and are definitely not some sort of “miracle cure”?”

Well, it’s NOT likely Gorski is going to figure that out any time soon, seeing as how he is stuck in the 90’s

One of his “Oracolytes” spurts:

#12 – AdamG – 7/22/2013

“Out of morbid curiosity I just checked out DJT’s current cesspool of residence…it’s still going full steam ahead with the crazy

“Poor DJT seems to have definitely lost a few more screws since it posted here”

This person apparently has nothing anywhere close to the intelligence of the original Adam, as “it” is unable to formulate a coherent sentence regarding any subject on my blog

This is the class of individuals that “Orac” likes to associate himself with

The lowest common denominator

The Adam G’s, “I have Absolutely NOTHING (say it again) worthwhile to say,” of the world