A Critical Analysis of Wikipedia’s “Failure to Communicate”

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[1] – 1st 7 comments by
“The Skeptics™”

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34 – # of “The Skeptics™”
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29 – # Questioning “The Skeptics™”
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192 comments – “The Skeptics™”
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44 – Lynne Batik
31 – Fenwicke Bootzin (Sizzling Bacon Scent) Sizzling Burnt Bacon Scent
13 – Robert (Bobby) Blaskiewicz (@rjblaskiewicz)
13 – Adam Jacobs (@DianthusMed)
12 – Jen Abe
10 – David H. Gorski (@gorskon @oracknows @ScienceBasedMed)
7 – Edward Jenner
6 – Guy Chapman (@SkepticGuy)
6 – Fred Hamlet
6 – Rene F. Najera
6 – Darren Woodward (Sebastian Armstrong @spikesandspokes on Twitter)
4 – Angela Campagna
4 – Val Perry Rendel
3 – Amy Hochberg Beaton
3 – Susan Scotvold Goodstein
3 – Karl Mamer
2 – Scott Hurst
2 – Laura Calise Neimeyer
2 – Tsu Dho Nimh
1 – Catherina Becker
1 – Vicky Forster
1 – Jan Gosau
1 – David James (@StortSkeptic)
1 – Terry D. Johnson
1 – Jen Keane
1 – Adam Levenstein
1 – Keir Liddle (@endless_psych)
1 – Matthew Miller
1 – Paul Morgan (@DrPaulMorgan)
1 – Richard Murray
1 – Scott Myers
1 – Andy Roseborrough
1 – Footy Stuff
1 – Tom Steinberg

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239 comments – Questioning “The Skeptics™”
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112 – Didymus Thomas *
71 – Robert Davis
15 – Jon Barratt
13 – Eric Merola
7 – Bruce Scherzer
4 – Ben Hymas
2 – Bill Doucette
2 – Teresa Kennett
2 – Krassi Kostova
2 – Jessica Ressel-Doeden
2 – Jennifer Woods
1 – Angela Campagna
1 – Jessica Guillory Garza
1 – Melissa Gilbert
1 – Russell David Humphress
1 – Karl Jobst
1 – Anya Matkowski
1 – Susanne McAllister
1 – Terri Miller
1 – Mark Mord
1 – Shannon E. Peters
1 – Chris Rodriguez
1 – Pat Rozek
1 – Cindy Samora
1 – Ric Schiff
1 – Gary Susie
1 – Kevin Thurston
1 – Laura Vincent
1 – Susan Wassenhove
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* Requesting “The Skeptics™” reply when they did NOT, pointing out where they did NOT provide any citation(s), reference(s), and / or link(s) to support their claims
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38 comments with links – “The Skeptics™”
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19 – Lynne Batik
5 – Fenwicke Bootzin (Sizzling Bacon Scent) Sizzling Burnt Bacon Scent
5 – Adam Jacobs (@DianthusMed)
3 – David H. Gorski (@gorskon @oracknows @ScienceBasedMed)
2 – Fred Hamlet
2 – Rene F. Najera
1 – Robert (Bobby) Blaskiewicz (@rjblaskiewicz)
1 – Andy Roseborrough

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131 comments with links – Questioning “The Skeptics™”
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104 – Didymus Thomas *
18 – Robert Davis
8 – Eric Merola
1 – Paul Battista
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* One of “The Skeptics™” made the mistake of commenting that Burzynski, had NOT published any publications
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“The Skeptics™” LIES
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[2] – 3/5/2013 – Adam Jacobs

” … did you know that he’s recently removed all mention of antineoplastons from his website … “
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[3] – 3/5/2013 – William M. London

” … Burzynski’s anti-cancer fantasies … “
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[4] – 3/5/2013 – Paul Morgan

“As for his “gene-targeted” therapy, firstly Burzynski is simply using a cocktail of chemotherapy drugs in a random and haphazard manner with no thoughts as to the potential interactions and unpredictable toxicity of his mix of chemotherapy drugs”

“As for being “gene-targeted”, his approach could be described as “gene-targeted” in the same way as the military regard carpet bombing …”
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“The Skeptics™” who got it WRONG
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3/5/2013 – Rene F. Najera

“I predict this poll and subsequent comments will be taken down by the end of the day”
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This “Skeptics™” must have had
CPT12
confused with “The Skeptics™” like Robert (Bobby) Blaskiewicz (@rjblaskiewicz), David H. Gorski (@gorskon @oracknows @ScienceBasedMed), Adam Jacobs (@DianthusMed), and Keir Liddle (@endless_psych), who block people on their blogs
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“The Skeptics™” who did NOT provide any citation(s), reference(s), and / or link(s) to support their claims
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3/6/2013 – Lynne Batik

“Dr. B is a scam artist who has found a few people he can claim to have cured, and uses those to sucker in far more people who he will bankrupt without curing”
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3/4/2013 – Amy Hochberg Beaton

“I think Burzynski has proved multiple times over that his $*&% doesn’t work and he is not running a legitimate trial”
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3/5/2013 – Catherina Becker

“To prey on desperate, dying people, encouraging them to fund raise, risk hundreds of thousands of dollars of debts, for life threatening humbug must be the vilest phenomenon in Medicine”

“To support such behaviour by running adverts for these vultures is equally vile”
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3/4/2013 – Robert Blaskiewicz

“ANP is toxic as anything!”

“most of Burzynski’s patients never qualify for his trials”

“They all end up taking tons of chemo used off label”
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3/5/2013 – Susan Scotvold Goodstein

“Airing a film that is nothing more than an advertisement / informercial for Burzynski’s 30 year medical scam is not presenting a fair and balanced program”
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3/5/2013 – David H. Gorski

“Antineoplastons, however, are neither nontoxic nor an effective treatment”

“In fact, they’re definitely toxic”

“People have developed a dangeros condition called hypernatremia (too high a sodium level) as a result of antineoplaston treatment”
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3/5/2013 – Adam Jacobs

“Burzynski absolutely does not research “non-toxic” treatments”

“Mostly, he uses conventional chemotherapy, but in a rather amateurish way, using unproven combinations of drugs”

“The treatment that has made him famous, antineoplastons, is highly toxic and has been known to kill people”
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3/5/2013 – David James

“You run the risk of genuinely endangering people’s lives by exposing them to unproven and ridiculously expensive treatment modalities”
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3/5/2013 – Adam Levenstein

“do I think that the fraud Burzynski should be promoted with an infomercial on a taxpayer-funded TV station … “
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3/5/2013 – William M. London

“Colorado Public Television functions as an infomercial broadcast service for false medical prophets (who profit from Colorado Public Television’s irresponsibility)”
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3/5/2013 – Paul Morgan

“Antineoplaston chemotherapy – despite the claims of Burzynski and his shills – are far from being non-toxic”

“They contain vast quantities of sodium, which results in patients having to ingest vast quantities of water to counteract the overpowering thirst generated by taking in so much sodium”

“Some patients have become grossly hypernatraemic (high serum sodium), others profoundly hypokalaemic (low serum potassium)”

“Others have developed renal failure”

“All these TOXIC SIDE EFFECTS are extremely hazardous and life-threatening”

“If you consider antineoplastons to be non-toxic, you are seriously deluded”

“If you think antineoplastons are not chemotherapy, you are also wrong”
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3/5/2013 – Tsu Dho Nimh

“You are being co-opted to slather a layer of respectability over Burzynski’s quackery”

“You seem to fit the definition of a media whore … will sell out for ratings”
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3/4/2013 – Val Perry Rendel

“Do I think magic voodoo bullshit should be used to profiteer from human suffering and desperation?”
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3/6/2013 – Andy Roseborrough

“Burzynski not only sells
bullcrap
for profit at the expense of people’s health, but he tries to silence legitimate criticism via his lawyers”

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3/4/2013 – Darren Woodward

” … the completely unproven, very expensive treatments sold to vulnerable people … “

” … rather than informing your audience it looks like you are trying to misinform them”

“by what measure are antineoplastines non-toxic, certainly medically they are toxic”
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REFERENCES:
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[1] – Critiquing Wikipedia: Burzynski Clinic, Colorado Public Television (CPT12), and Public Broadcasting System (PBS):
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https://stanislawrajmundburzynski.wordpress.com/2013/09/12/critiquing-wikipedia-burzynski-clinic-colorado-public-television-cpt12-and-public-broadcasting-system-pbs/
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[2] – Burzynski updates Scientific Publications page:
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https://stanislawrajmundburzynski.wordpress.com/2013/03/12/burzynski-updates-scientific-publications-page/
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[3] – Critiquing: American Cancer Society – Antineoplaston Therapy:
——————————————————————
https://stanislawrajmundburzynski.wordpress.com/2013/09/09/critiquing-american-cancer-society-antineoplaston-therapy/
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[4] – University of Michigan, where is alum Dr. David H. “Orac” Gorski’s Grapefruits ?:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/04/university-of-michigan-where-is-alum-dr-david-h-orac-gorskis-grapefruits/
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“The Skeptics™” Colorado Public Television (CPT12) – PBS Facebook comment links:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/14/the-skeptics-colorado-public-television-cpt12-pbs-facebook-comment-links/
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Questioning “The Skeptics™” Colorado Public Television (CPT12) PBS Facebook comments with links:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/14/questioning-the-skeptics-colorado-public-television-cpt12-pbs-facebook-comments-with-links/
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Antineoplastons: Phenylacetylglutaminate (PG or PAG), Phenylacetate (PN), and Phenylbutyrate (PB)

PHENYLACETYLGLUTAMINATE (PAG or PG) and PHENYLACETATE (PN) are metabolites of PHENYLBUTYRATE (PB) and are constituents of antineoplaston AS2-1
� � � � � � � � � � � � � � � �
Antineoplastons AS2-1 and AS2-5 are DERIVED FROM A10
� � � � � � � � � � � � � � � �
AS2-1 = 4:1 mixture of PHENYLACETIC ACID (PA) and PHENYLACETYLGLUTAMINE (PAG or PG)
� � � � � � � � � � � � � � � �
Antineoplaston AS2-5 = PHENYLACETYLGLUTAMINE (PAG or PG)
� � � � � � � � � � � � � � � �
National Cancer Institute (NCI) at the National Institutes of Health (NIH)
Antineoplastons
General Information: http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page2
� � � � � � � � � � � � � � � �
http://www.burzynskiclinic.com/scientific-publications.html
Review Articles on Clinical Trials:

1. 3/2004

Burzynski, S.R. The Present State of Antineoplaston Research. Integrative Cancer Therapies 2004;3:47-58.
http://www.burzynskiclinic.com/images/stories/Publications/994.pdf
Volume 3 Number 1 March 2004
DOI: 10.1177/1534735403261964

Pg. 48

Antineoplaston A2, which contributed to the highest number of complete responses in phase I clinical studies, was elected for final purification, isolation of active components, and structure determination.
Active ingredient identified as:
3-phenylacetylamino-2, 6-piperidinedione
and was named
antineoplaston A10. [27]

27. Burzynski SR, Hendry LB, Mohabbat MO, et al. Purification of structure determination, synthesis and animal toxicity studies of antineoplaston A10. In: Proceedings of the 13th International Congress of Chemotherapy. Vienna, Austria; 1983:17, PS. 12.4 11-4.

A10 has been reproduced by synthesis involving condensation of:
1-glutamine
with
phenylacetyl chloride
and subsequent cyclization of
phenylacetylglutamine (PG). [28]

28. Burzynski SR, Hai TT. Antineoplaston A10. Drugs of the Future. 1985;10:103-105.

Metabolism of A10 in human body yields:
phenylacetylglutamine (PG)
phenylacetylisoglutamine (isoPG)
phenylacetate (PN)
which were reproduced synthetically and formulated into:
antineoplaston
A10 injections (A10-I)
AS2-1
AS5
AS-25
[29-33]

29. Burzynski SR. Synthetic antineoplastons and analogs. Drugs of the Future. 1986;11:679-688.

30. Burzynski SR, Mohabbat MO, Lee SS. Preclinical studies of antineoplaston AS1-1 and antineoplaston AS2-5. Drugs Exptl Clin Res. 1986;12(suppl 1):11-16.
http://www.ncbi.nlm.nih.gov/pubmed/3743376/

http://www.ncbi.nlm.nih.gov/m/pubmed/3743376/
31. Burzynski SR, Khalid M. Antineoplaston A10 injections. Drugs of the Future. 1986;11:364-365.

32. Burzynski SR, Khalid M. Antineoplaston AS2-1. Drugs of the Future. 1986;11:361-363.

33. Burzynski SR. Antineoplaston AS2-5.. Annual Drug Data Report. 1986;8-319.

These formulations were submitted for basic research and phase I clinical studies. [34-44]

34. Burzynski SR, Mohabbat MO, Burzynski B. Animal toxicology studies on oral formulation of antineoplaston A10. Drug Exptl Clin Res. 1984;10:113-118.

35. Burzynski SR. Phase I clinical studies of antineoplaston AS2-5 injections. In: Ishigami J, ed. Recent Advances in Chemotherapy. Tokyo, Japan: University of Tokyo Press; 1985.

36. Burzynski SR, Burzynski B, Mohabbat MO. Toxicology studies of antineoplaston AS 2-1 injections in cancer patients. Drugs Exptl Clin Res. 1986;12(suppl 1):25-35.
http://www.ncbi.nlm.nih.gov/pubmed/3743378/

http://www.ncbi.nlm.nih.gov/m/pubmed/3743378/
37. Burzynski SR, Kubove E. Toxicology studies of antineoplaston A10 injections in cancer patients. Drugs Exptl Clin Res. 1986;12(suppl 1):47-55.
http://www.ncbi.nlm.nih.gov/pubmed/3743380/

http://www.ncbi.nlm.nih.gov/m/pubmed/3743380/
38. Lehner AF, Burzynski SR, Hendry LB. 3-phenylacetylamino-2,6-piperidinedione, a naturally-occurring peptide analog with apparent antineoplastic activity may bind to DNA. Drugs Exptl Clin Res. 1986;12(suppl 1):57-72.
http://www.ncbi.nlm.nih.gov/pubmed/3743381/

http://www.ncbi.nlm.nih.gov/m/pubmed/3743381/
39. Ashraf AQ, Liau MC, Mohabbat MO, et al. Preclinical studies of antineoplaston A10 injections. Drugs Exptl Clin Res. 1986;12(suppl 1):37-45.
http://www.ncbi.nlm.nih.gov/pubmed/3743379/

http://www.ncbi.nlm.nih.gov/m/pubmed/3743379/
40. Ashraf AQ, Liau MC, Kampalath BN, et al. Pharmacokinetic study of radioactive antineoplaston A10 following oral administration in rats. Drugs Exptl Clin Res. 1987;13(suppl 1):45-50.
http://www.ncbi.nlm.nih.gov/pubmed/3569015/

http://www.ncbi.nlm.nih.gov/m/pubmed/3569015/
41. Hendry LB, Muldoon TG, Burzynski SR et al. Stereochemical modeling studies of the interaction of Antineoplaston A10 with DNA. Drugs Exptl Clin Res. 1987;13(suppl 1):77-81.
http://www.ncbi.nlm.nih.gov/pubmed/3569020/

http://www.ncbi.nlm.nih.gov/m/pubmed/3569020/
42. Ashraf AQ, Burzynski SR. Comparative study of antineoplaston A10 levels in plasma of healthy people and cancer patients. Adv Exptl Clin Chemother. 1988;2:19-28.

43. Ashraf AQ, Kampalath BN, Burzynski SR. Pharmacokinetic analysis of antineoplaston A10 injections following intravenous administration in rats. Adv Exptl Clin Chemother. 1988;6:33-39.

44. Burzynski SR, Kubove E, Burzynski B. Phase I clinical studies of oral formulation of antineoplaston AS2-1. Adv Exptl Clin Chemother. 1988;2:29-36.

A10
A10-I
AS2-1
were selected for phase II studies.
2 initial phase II studies in
ASTROCYTOMA
and
HIGH-GRADE GLIOMA
began in
1988
and
1990
and were conducted outside investigational new drug (IND) process.

Since 1994 the FDA authorized 74 phase II studies with
A10
A10-I
AS2-1
under INDs
43,742
22,029
in advanced malignancies.

Pg. 49

Phenylacetate (PN)
is active ingredient of
antineoplaston AS2-1.

Phenylglutamine (PG)
is main ingredient of
A10-I.

Phenylglutamine (PG) exhibits antineoplastic activity across wide array of cancer cell lines.

Phenylglutamine (PG)
inhibits uptake of growth-critical amino acids, such as:
1-glutamine
and
1-leucine
in neoplastic cells.

Reduction in amino acid availability may contribute to drug’s antineoplastic activity.

Human glioma (U-87) cells rapidly take up Phenylglutamine (PG) by mechanism similar to facilitated diffusion.

Upon removal of Phenylglutamine (PG) from media, PG rapidly and completely effluxes from the cell.

Phenylglutamine (PG)
enters cells via stereospecific amino acid transporters for
1-glutamine.

Formulations of
Antineoplastons:

Antineoplastons
are a class of 12 antitumor agents.

Following synthetic antineoplaston formulations used in phase II studies.

Antineoplaston A10
capsules contain 500 mg of
3-phenylacetylamino-2, 6-piperidinedione.

Antineoplaston A10 injection
is mixture of sodium salts of
Phenylglutamine (PG)
and
Phenylacetylisoglutamine (isoPG)
in 4:1 ratio.

Available in 500 mL and 1000 mL (300 mg/mL) plastic bags.

Antineoplaston AS2-1
capsules containing 500 mg of 4:1
Phenylacetate (PN)
and
Phenylglutamine (PG).

Antineoplaston AS2-1 injection
is mixture of
Phenylacetate (PN)
and
Phenylglutamine (PG)
in 4:1 ratio.

Available in 250 mL (80 mg/mL) plastic bags.
� � � � � � � � � � � � � � � �
Interim Reports on Clinial Trials:

18. 6/2005

INTEGRATIVE CANCER THERAPIES

BT-12

CHILDREN WITH PRIMITIVE NEUROECTODERMAL TUMORS (PNET)

CAN-01

CAN-1

PATIENTS WITH REFRACTORY MALIGNANCIES

Burzynski, S.R., Weaver, R.A., Janicki, T., Szymkowski, B., Jurida, G., Khan, M., Dolgopolov, V.

Long-term survival of high-risk pediatric patients with PRIMITIVE NEUROECTODERMALTUMORS treated with Antineoplastons A10 and AS2-1
http://www.ncbi.nlm.nih.gov/pubmed/15911929
Integrative Cancer Therapies 2005;4(2):168-177
http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
Integr Cancer Ther. 2005 Jun;4(2):168-77
http://www.burzynskiclinic.com/images/stories/Publications/1220.pdf
DOI: 10.1177/1534735405276835
http://m.ict.sagepub.com/content/4/2/168.long?view=long&pmid=15911929
Antineoplastons (ANP) A10 and AS2-1, which are synthetic analogs of naturally occurring derivatives of glutamine, isoglutamine, and phenylacetic acid, have shown an increasing spectrum of activity in primary brain tumors. [1]

Review Articles on Clinical Trials:

1. 3/2004

Burzynski, S.R. The Present State of Antineoplaston Research. Integrative Cancer Therapies 2004;3:47-58.
http://www.burzynskiclinic.com/images/stories/Publications/994.pdf
Volume 3 Number 1 March 2004
DOI: 10.1177/1534735403261964
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IV. Aetna considers SODIUM PHENYLBUTYRATE medically necessary for the treatment of acute promyelocytic leukemia and malignant glioma
http://www.aetna.com/cpb/medical/data/200_299/0240.html
� � � � � � � � � � � � � � � �
The FDA has approved SODIUM PHENYLBUTYRATE as a treatment to remove ammonia from the bloodstream in individuals with urea cycle disorders
� � � � � � � � � � � � � � � �
SODIUM PHENYLBUTYRATE was given an orphan drug designation by the FDA for use as an adjunct to surgery, radiation therapy, and chemotherapy for treatment of individuals with primary or recurrent malignant glioma
http://www.anthem.com/medicalpolicies/policies/mp_pw_a050524.htm
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Cumulative List of all Products that have received Orphan Designation: Total active designations: 2002 Effecive: (sic – Effective:) 5/5/2009
http://www.fda.gov/downloads/forindustry/developingproductsforrarediseasesconditions/howtoapplyfororphanproductdesignation/ucm162066.xls
PHENYLBUTYRATE (PB) and SODIUM PHENYLBUTYRATE are listed alphabetically in the lower 1/4th of this document
� � � � � � � � � � � � � � � �
Sodium Phenylbutyrate (PB)
Year – Pubmed (110 entries)
1958 1st entry
1995 1st clinical trial
2001 Phase 1
2009 Phase 2
2012 Phase 3
� � � � � � � � � � � � � � � �
Phenylacetate (PN)
Year – Pubmed (29,686 entries)
1883 1st entry
1994 Phase 1
1999 Phase 2
2013 latest
� � � � � � � � � � � � � � � �
Antineoplaston(s)
Year – Pubmed (88 entries)
1976 1st entry
1986 Phase 1
1999 Phase 2
2003 Phase 2 preliminary
2004 Phase 2 preliminary
2012 latest
� � � � � � � � � � � � � � � �
National Cancer Institute (NCI) at the National Institutes of Health (NIH)
Antineoplastons (PDQ®) Overview:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page1

http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/patient
General Information:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page2
History:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page3
Laboratory/Animal/Preclinical Studies:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page4
Human/Clinical Studies:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page5
Adverse Effects:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page6
Summary of the Evidence for Antineoplastons:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page7
Changes to This Summary:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page8
About This PDQ Summary:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/page9
Questions and Answers About Antineoplastons:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/patient/page2
Current Clinical Trials:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/patient/page3
Changes to This Summary:
http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/patient/page4