Liz Szabo’s USA TODAY “killer cancer” article as interpreted by “Orac” made 3 claims [0]:
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“Conventional cancer treatment can also cause tumors to swell temporarily,” [1]
“due to”
“inflammation,” [2]
“A patient who isn’t familiar with this”
“phenomenon” [3]
“may assume her tumor is growing”
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The issue with citing these 3 studies is that each then needs to be reviewed to determine if they have any relevance to the patients Burzynski has treated in the phase II clinical trials:
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[1] – 12/2009 – Pseudoprogression and pseudoresponse in the treatment of gliomas
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1. Has Burzynski treated patients with gliomas, brain tumours, or recurrent glioblastoma ?
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2. Has Burzynski’s patients been treated with combined chemo-irradiation with temozolomide which may induce in 20-30% ?
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[2] – 5/2008 – Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
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1. Has Burzynski treated patients with glioblastoma ?
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2. Have any of Burzynski’s patients been treated with temozolomide chemoradiotherapy ?
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3. so-called pseudoprogression
can occur in up to 20% of patients
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4. can explain about 1/2 of 20%
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[3] – In support of this “phenomenon”, the article provides a link to a Canadian web-site which
posits:
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“RT/TMZ is now widely practiced and the standard of care for appropriately selected patients, we are learning more about the consequences of RT/TMZ”
“One phenomena, termed Pseudo-Progression (psPD)…”
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The problem is that this only applies to “Glioblastoma Multiforme (GBM)”, and the article provides NO proof whatsoever, that any of Burzynski’s “Glioblastoma Multiforme (GBM)” patients have taken “RT/TMZ”
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Additionally, the site cites the reference as:
Sanghera, Perry, Sahgal, et al., “Sunnybrook Health Sciences Odette Cancer Centre” (in press, Canadian Journal of Neuroscience)
(“In press” refers to journal articles which have been accepted for publication, but have not yet been published)
However, the journal article in question was published 1/2010, so it has NOT been “in press” for over 3 years and 7 months [4]
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GorskGeek stupidly suppositories:
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“It’s very heartening to see a story like this in a major news outlet, and I must congratulate Ms. Szabo for her thorough deconstruction of the phenomenon that is Stanislaw Burzynski“
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GorskGeek, just because a great portion of Liz Szabo’s USA TODAY article quoted verbatim from The Skeptics™ play book, does
NOT mean she was anymore successful at “deconstructing” Burzynski [5], anymore than you have NOT
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GorskGeek then regurgitates:
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“Remember how I said that Bob Blaskiewicz will want your help?”
“Now’s the time to contact him, if you haven’t already”
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GorskGeek, Bob Blaskiewicz needs “HELP” in the same manner as you need “HELP”, because, as I have proved, you both act like compulsive liars
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REFERENCES:
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[0] – 11/15/2013 – Stanislaw Burzynski in USA Today: Abuse of clinical trials and patients versus the ineffectiveness of the FDA and Texas Medical Board
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http://scienceblogs.com/insolence/2013/11/15/stanislaw-burzynski-in-usa-today-abuse-of-clinical-trials-and-patients-versus-the-ineffectiveness-of-the-fda-and-texas-medical-board/
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[1] – 12/2009 – Pseudoprogression and pseudoresponse in the treatment of gliomas
pseudo-phenomenona
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http://www.ncbi.nlm.nih.gov/pubmed/19770760/
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Curr Opin Neurol. 2009 Dec;22(6):633-8. doi: 10.1097/WCO.0b013e328332363e
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http://www.ncbi.nlm.nih.gov/m/pubmed/19770760/
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Department of Neuro-Oncology, Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute, Amsterdam, The Netherlands
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[2] – 5/2008 – Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
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http://www.ncbi.nlm.nih.gov/pubmed/18452856/
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Lancet Oncol. 2008 May;9(5):453-61. doi: 10.1016/S1470-2045(08)70125-6
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http://www.ncbi.nlm.nih.gov/m/pubmed/18452856/
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Department of Neuro-oncology, Daniel den Hoed Cancer Centre, Erasmus Medical Centre, Rotterdam, Netherlands
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http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(08)70125-6/fulltext
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occurs more frequently and earlier after temozolomide chemotherapy than after radiotherapy alone
chemoradiotherapy
recurrent malignant glioma progression within 1st 3 months
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[3] – What is Pseudo-Progression Following Treatment for Glioblastoma Multiforme?
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Phenomenon – Psuedo-progression (GBM), Brain Tumour Foundation of Canada
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http://www.braintumour.ca/1649/ask-the-expert-psuedo-progression-gbm
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[4] – 1/2010 – Pseudoprogression following chemoradiotherapy for glioblastoma multiforme
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http://www.ncbi.nlm.nih.gov/pubmed/20169771/
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Can J Neurol Sci. 2010 Jan;37(1):36-42
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http://www.ncbi.nlm.nih.gov/m/pubmed/20169771/
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[5] – 11/17/2013 – Critiquing: Stanislaw Burzynski in USA Today: Abuse of clinical trials and patients versus the ineffectiveness of the FDA and Texas Medical Board (Getting Worse is Getting Better):
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https://stanislawrajmundburzynski.wordpress.com/2013/11/17/httpscienceblogs-cominsolence20131115stanislaw-burzynski-in-usa-today-abuse-of-clinical-trials-and-patients-versus-the-ineffectiveness-of-the-fda-and-texas-medical-board/
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