Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate

Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate
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http://www.ncbi.nlm.nih.gov/pubmed/12241121/
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J Neurooncol. 2002 Sep;59(3):239-42
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http://www.ncbi.nlm.nih.gov/m/pubmed/12241121/
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Journal of Neuro-Oncology
Volume 59, Issue 3 , pp 239-242
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http://link.springer.com/article/10.1023%2FA%3A1019905127442
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DOI
10.1023/A:1019905127442
Journal of Neuro-Oncology 59: 239–242, 2002
2002 Kluwer Academic Publishers. Printed in the Netherlands
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http://ketonutrition.net/wp-content/uploads/2013/01/Baker_Complete_response_of_GBM_with_Phenylbutyrate_2002.pdf
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Neuro-Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
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REFERENCES:
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6. Gore SD, SAMID D, Weng LJ: Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells. Clin Cancer Res 3(10): 1755–1762, 1997
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7. Ram Z, SAMID D, Walbridge S, Oshiro EM, Viola JJ, Tao-Cheng JH, Shack S, Thibault A, Myers CE, Oldfield EH: Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate. Cancer Res 54: 2923–2927, 1994
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8. Thibault A, SAMID D, Cooper MR, Figg WD, Tompkins AC, Patronas N, Headlee DJ, Kohler DR, Venzon DJ, Myers CE: Phase I study of phenylacetate administration twice daily to patients with cancer. Cancer 75: 2932–2938, 1995
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9. SAMID D, Hudgins WR, Shack S, Liu L, Prasanna P, Myers CE: Phenylacetate and phenylbutyrate as novel, non-toxic differentiation inducers. Adv Exp Med Biol 400A: 501–505, 1997
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10. Chang SM, Kuhn JG, Robins HI, Schold SC, Spence AM, Berger MS, Mehta MP, Bozik ME, Pollack I, Schiff D, Gilbert M, Rankin C, Prados MD: Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report. J Clin Oncol 17(3): 984–990, 1999
http://m.jco.ascopubs.org/content/17/3/984.full.pdf
SAMID D References
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11. Buckner JC, Malkin MG, Reed E, Cascino TL, Reid JM, Ames MM, Tong WP, Lim S, Figg WD: Phase II study of antineoplastons A10 (NSC 648539) and AS2-1 (NSC 620261) in patients with recurrent glioma. Mayo Clin Proc 74(6): 641–642, 1999
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12. SAMID D, Ram Z, Hudgins WR, Shack S, Liu L, Walbridge S, Oldfield EH, Myers CE: Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. Cancer Res 54: 891–895, 1994
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Antineoplastons: Phenylacetylglutaminate (PG or PAG), Phenylacetate (PN), and Phenylbutyrate (PB):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/17/phenylacetylglutaminate-pg-or-pag-phenylacetate-pn-and-phenylbutyrate-pb/
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Phenylbutyrate (PB):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/18/phenylbutyrate-pb/
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Phenylacetate (PN):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/18/phenylacetate-pn/
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Phenylacetylglutamine (PG or PAG):
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https://stanislawrajmundburzynski.wordpress.com/2013/06/18/phenylacetylglutamine-pg-or-pag/
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Burzynski, China, and Dvorit D. Samid:
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https://stanislawrajmundburzynski.wordpress.com/2013/02/21/burzynski-china-dvorit-d-samid/
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Critiquing: Dr. David H. “Orac” Gorski and The Skeptics™ http://www.scienceblogs.com/Insolence
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https://stanislawrajmundburzynski.wordpress.com/2013/08/08/critiquing-dr-david-h-orac-gorski-and-the-skeptics/
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A Critical Analysis of Wikipedia’s “Failure to Communicate”

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[1] – 1st 7 comments by
“The Skeptics™”

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34 – # of “The Skeptics™”
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29 – # Questioning “The Skeptics™”
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192 comments – “The Skeptics™”
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44 – Lynne Batik
31 – Fenwicke Bootzin (Sizzling Bacon Scent) Sizzling Burnt Bacon Scent
13 – Robert (Bobby) Blaskiewicz (@rjblaskiewicz)
13 – Adam Jacobs (@DianthusMed)
12 – Jen Abe
10 – David H. Gorski (@gorskon @oracknows @ScienceBasedMed)
7 – Edward Jenner
6 – Guy Chapman (@SkepticGuy)
6 – Fred Hamlet
6 – Rene F. Najera
6 – Darren Woodward (Sebastian Armstrong @spikesandspokes on Twitter)
4 – Angela Campagna
4 – Val Perry Rendel
3 – Amy Hochberg Beaton
3 – Susan Scotvold Goodstein
3 – Karl Mamer
2 – Scott Hurst
2 – Laura Calise Neimeyer
2 – Tsu Dho Nimh
1 – Catherina Becker
1 – Vicky Forster
1 – Jan Gosau
1 – David James (@StortSkeptic)
1 – Terry D. Johnson
1 – Jen Keane
1 – Adam Levenstein
1 – Keir Liddle (@endless_psych)
1 – Matthew Miller
1 – Paul Morgan (@DrPaulMorgan)
1 – Richard Murray
1 – Scott Myers
1 – Andy Roseborrough
1 – Footy Stuff
1 – Tom Steinberg

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239 comments – Questioning “The Skeptics™”
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112 – Didymus Thomas *
71 – Robert Davis
15 – Jon Barratt
13 – Eric Merola
7 – Bruce Scherzer
4 – Ben Hymas
2 – Bill Doucette
2 – Teresa Kennett
2 – Krassi Kostova
2 – Jessica Ressel-Doeden
2 – Jennifer Woods
1 – Angela Campagna
1 – Jessica Guillory Garza
1 – Melissa Gilbert
1 – Russell David Humphress
1 – Karl Jobst
1 – Anya Matkowski
1 – Susanne McAllister
1 – Terri Miller
1 – Mark Mord
1 – Shannon E. Peters
1 – Chris Rodriguez
1 – Pat Rozek
1 – Cindy Samora
1 – Ric Schiff
1 – Gary Susie
1 – Kevin Thurston
1 – Laura Vincent
1 – Susan Wassenhove
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* Requesting “The Skeptics™” reply when they did NOT, pointing out where they did NOT provide any citation(s), reference(s), and / or link(s) to support their claims
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38 comments with links – “The Skeptics™”
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19 – Lynne Batik
5 – Fenwicke Bootzin (Sizzling Bacon Scent) Sizzling Burnt Bacon Scent
5 – Adam Jacobs (@DianthusMed)
3 – David H. Gorski (@gorskon @oracknows @ScienceBasedMed)
2 – Fred Hamlet
2 – Rene F. Najera
1 – Robert (Bobby) Blaskiewicz (@rjblaskiewicz)
1 – Andy Roseborrough

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131 comments with links – Questioning “The Skeptics™”
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104 – Didymus Thomas *
18 – Robert Davis
8 – Eric Merola
1 – Paul Battista
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* One of “The Skeptics™” made the mistake of commenting that Burzynski, had NOT published any publications
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“The Skeptics™” LIES
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[2] – 3/5/2013 – Adam Jacobs

” … did you know that he’s recently removed all mention of antineoplastons from his website … “
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[3] – 3/5/2013 – William M. London

” … Burzynski’s anti-cancer fantasies … “
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[4] – 3/5/2013 – Paul Morgan

“As for his “gene-targeted” therapy, firstly Burzynski is simply using a cocktail of chemotherapy drugs in a random and haphazard manner with no thoughts as to the potential interactions and unpredictable toxicity of his mix of chemotherapy drugs”

“As for being “gene-targeted”, his approach could be described as “gene-targeted” in the same way as the military regard carpet bombing …”
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“The Skeptics™” who got it WRONG
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3/5/2013 – Rene F. Najera

“I predict this poll and subsequent comments will be taken down by the end of the day”
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This “Skeptics™” must have had
CPT12
confused with “The Skeptics™” like Robert (Bobby) Blaskiewicz (@rjblaskiewicz), David H. Gorski (@gorskon @oracknows @ScienceBasedMed), Adam Jacobs (@DianthusMed), and Keir Liddle (@endless_psych), who block people on their blogs
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“The Skeptics™” who did NOT provide any citation(s), reference(s), and / or link(s) to support their claims
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3/6/2013 – Lynne Batik

“Dr. B is a scam artist who has found a few people he can claim to have cured, and uses those to sucker in far more people who he will bankrupt without curing”
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3/4/2013 – Amy Hochberg Beaton

“I think Burzynski has proved multiple times over that his $*&% doesn’t work and he is not running a legitimate trial”
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3/5/2013 – Catherina Becker

“To prey on desperate, dying people, encouraging them to fund raise, risk hundreds of thousands of dollars of debts, for life threatening humbug must be the vilest phenomenon in Medicine”

“To support such behaviour by running adverts for these vultures is equally vile”
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3/4/2013 – Robert Blaskiewicz

“ANP is toxic as anything!”

“most of Burzynski’s patients never qualify for his trials”

“They all end up taking tons of chemo used off label”
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3/5/2013 – Susan Scotvold Goodstein

“Airing a film that is nothing more than an advertisement / informercial for Burzynski’s 30 year medical scam is not presenting a fair and balanced program”
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3/5/2013 – David H. Gorski

“Antineoplastons, however, are neither nontoxic nor an effective treatment”

“In fact, they’re definitely toxic”

“People have developed a dangeros condition called hypernatremia (too high a sodium level) as a result of antineoplaston treatment”
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3/5/2013 – Adam Jacobs

“Burzynski absolutely does not research “non-toxic” treatments”

“Mostly, he uses conventional chemotherapy, but in a rather amateurish way, using unproven combinations of drugs”

“The treatment that has made him famous, antineoplastons, is highly toxic and has been known to kill people”
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3/5/2013 – David James

“You run the risk of genuinely endangering people’s lives by exposing them to unproven and ridiculously expensive treatment modalities”
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3/5/2013 – Adam Levenstein

“do I think that the fraud Burzynski should be promoted with an infomercial on a taxpayer-funded TV station … “
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3/5/2013 – William M. London

“Colorado Public Television functions as an infomercial broadcast service for false medical prophets (who profit from Colorado Public Television’s irresponsibility)”
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3/5/2013 – Paul Morgan

“Antineoplaston chemotherapy – despite the claims of Burzynski and his shills – are far from being non-toxic”

“They contain vast quantities of sodium, which results in patients having to ingest vast quantities of water to counteract the overpowering thirst generated by taking in so much sodium”

“Some patients have become grossly hypernatraemic (high serum sodium), others profoundly hypokalaemic (low serum potassium)”

“Others have developed renal failure”

“All these TOXIC SIDE EFFECTS are extremely hazardous and life-threatening”

“If you consider antineoplastons to be non-toxic, you are seriously deluded”

“If you think antineoplastons are not chemotherapy, you are also wrong”
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3/5/2013 – Tsu Dho Nimh

“You are being co-opted to slather a layer of respectability over Burzynski’s quackery”

“You seem to fit the definition of a media whore … will sell out for ratings”
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3/4/2013 – Val Perry Rendel

“Do I think magic voodoo bullshit should be used to profiteer from human suffering and desperation?”
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3/6/2013 – Andy Roseborrough

“Burzynski not only sells
bullcrap
for profit at the expense of people’s health, but he tries to silence legitimate criticism via his lawyers”

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3/4/2013 – Darren Woodward

” … the completely unproven, very expensive treatments sold to vulnerable people … “

” … rather than informing your audience it looks like you are trying to misinform them”

“by what measure are antineoplastines non-toxic, certainly medically they are toxic”
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REFERENCES:
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[1] – Critiquing Wikipedia: Burzynski Clinic, Colorado Public Television (CPT12), and Public Broadcasting System (PBS):
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https://stanislawrajmundburzynski.wordpress.com/2013/09/12/critiquing-wikipedia-burzynski-clinic-colorado-public-television-cpt12-and-public-broadcasting-system-pbs/
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[2] – Burzynski updates Scientific Publications page:
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https://stanislawrajmundburzynski.wordpress.com/2013/03/12/burzynski-updates-scientific-publications-page/
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[3] – Critiquing: American Cancer Society – Antineoplaston Therapy:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/09/critiquing-american-cancer-society-antineoplaston-therapy/
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[4] – University of Michigan, where is alum Dr. David H. “Orac” Gorski’s Grapefruits ?:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/04/university-of-michigan-where-is-alum-dr-david-h-orac-gorskis-grapefruits/
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“The Skeptics™” Colorado Public Television (CPT12) – PBS Facebook comment links:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/14/the-skeptics-colorado-public-television-cpt12-pbs-facebook-comment-links/
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Questioning “The Skeptics™” Colorado Public Television (CPT12) PBS Facebook comments with links:
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https://stanislawrajmundburzynski.wordpress.com/2013/09/14/questioning-the-skeptics-colorado-public-television-cpt12-pbs-facebook-comments-with-links/
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