Stanislaw Rajmund Burzynski, Stanislaw R. Burzynski, Stanislaw Burzynski, Stan R. Burzynski, Stan Burzynski, S. R. BURZYNSKI, S. Burzynski, Arthur Burzynski, Hippocrates Hypocrite Hypocrites Critic Critics Critical HipoCritical
David H. Gorski, M.D., Ph.D., F.A.C.S. is an academic (i.e.: egg-head, paper-pusher, apparatchik) surgical oncologistspecializing in breast surgery and oncologic surgery
Gorski is no H.G. Wells
Wellscould, at least, tell a convincing lie; as he did in War of the Worlds
Gorski’d likely #fail as his evil half-brother, “H.G. #Fails”, in World War Peed, and probably didn’t think his readers would get the double-entendre’
Gorski is more famouser for pie in the sky
He’ll never be likened to Samuel Langhorne Clemens, or receive a “Mark Twain Award”
He’s an unlicensed Hackademic Quackademic who believes that bad press is good press, any press is good press
Gorski is the “Guy” who felt he was Scroogled by Google, when he and his public relations (P.R.) team; which reside in the hyperthalamus section of his brain, decided on 12/5/2012 to go pure pseudononsense pseudononscience:
Critiquing: Stanislaw Burzynski: On the arrogance of ignorance about cancer and targeted therapies [1]
wherein he quoted
Dr Burzynski:
“I published the review article in a peer-reviewed journal almost 20 years ago on the principles of personalized gene-targeted therapy”
====================================== Gorski:
“Curious as to just what the heck Burzynski was talking about here, I searched PubMed for this alleged review article”
“I couldn’t find it on PubMed”
“His only publications from the 1990s had nothing to do with cancer as a “genetic disease” or “personalized gene-targeted cancer therapy” and everything to do with antineoplastons”
“Perhaps Burzynski proposed this “revolutionary”
new idea in a peer-reviewed article that’s not indexed in PubMed, but if he did I couldn’t find it using Google and Google Scholar”
“I was in graduate school 20 years ago, and was taught back then that cancer was primarily a genetic disease.. ”
“There’s a term called “oncogene,” which describes genes that, when either mutated or too much is made, can result in cancer” ======================================
====================================== Gorski would have the reader suspend belief, and believe that he’s notsmarter than a fifth-grader; which is entirely plausible
That he could not do a search on the words:
antineoplastons
oncogenes
Burzynski
and find anything whatsoever ======================================
======================================
and that he did not have the cranial capacity to access the Burzynski Clinic web-site’s Scientific Publications page: ======================================
======================================
The United States Food and Drug Administration(FDA) did NOT have any problem finding it ======================================
====================================== Pg. 24
1997 – Burzynski. S.R. Antineoplastons. oncogenes and cancer. Anti-Aging Medical Therapeutics, Vol.1. Klatz RM.
Goldman R. (Ed). Health Quest Publication 1997; Marina del Rey, CA. USA
——————————————————————
======================================
This, from a doctor, eager to prove to the world, just how smart he is, because of:
—————————————————————— 12/.5/2011 – “positions I hold at an NCI-designated comprehensive cancer center“[2] ======================================
====================================== 12/13/2012 – “positions I hold at an NCI-designated comprehensive cancer center“[3] ======================================
====================================== 3/7/2013 – “my last two jobs have been at NCI-designated comprehensive cancer centers“[4] ======================================
====================================== 11/2/2012 – “Personally having pored over Burzynski’s publications” [5] ======================================
====================================== 2/18/2013 – “I’ve read many of Burzynski’s papers” [6] ======================================
====================================== 6/5/2013 – “I do know cancer science” [8] ======================================
====================================== 6/10/2013 – “I do know cancer science” [9] ======================================
====================================== 6/7/2013 – “Unlike Mr. Merola, I am indeed very concerned with getting my facts correct” [10] ======================================
======================================
The same “Guy” who claimed:
Burzynskinever explains which genes are targeted by antineoplastons ======================================
======================================
A statement which I showed to be incorrect, by pointing out at least 18 different Burzynskiscientific publications which did what Gorski claimed they did NOT [11-12] ======================================
======================================
When Dr. David H. Gorski said:
—————————————————————— “Personally having pored over Burzynski’s publications”–11/2/2012
“I’ve read many of Burzynski’s papers”–2/18/2013
“I’ve searched Burzynski’s publications”–5/8/2013
——————————————————————
exactly what did he mean by “pored over,” “read,” and “searched”?
Some Bill Clintonesque definition designed to try and stump anyone who’s not smarter than a fifth-grader ?
(“It depends upon what the meaning of the word ‘is,’ is”)
You don’t have to be smarter than a fifth-grader to understand that ifDr. Gorski actually did what he said he did, that he should have been able to conclude without any hint of doubt, thatBurzynskiexplains which genes are targeted by antineoplastons
Where was your head ?
Was your head in Mississippi?
Was your head like a hole ?
Or was your head so far up your “Show Me State” pal Robert J.(don’t call me “Bobby”)Bob (I’m not a doctor, I just pretend like I’m one on the otherburzynskipatientgroup (TOBPG) and houstoncancerquack) blatherskite Blatherskitewicz(known liar) Blaskiewicz’s AstroTurf campaign, that you couldn’t see what you were not doing ?
This is a guywho has been funded by:
a) the Department of Defense(DOD)
b) the NIH (National Institutes of Health)
c) the Conquer Cancer Foundation of ASCO
and
d) the Robert Wood Johnson Foundation
and this is the kind of supposed “Science-Based Medicine”(SBM)“results” he produces ?
This guy is proclaimed as:
“a prolific essayist and managing editor of Science-Based Medicine, a highly-respected blog that exposes non-scientific research and practices”
A “highly-respected blog”?
really ?
Really ??
REALLY ???
You’ve gotta be kiddin’ me !!!
“For the last ten years, he has been a major voice — as himself and pseudonymously — for science-based medicine”
You mean that “Orac”Hack ?
“Dr Gorski also runs an active research laboratory at the Barbara Ann Karmanos Cancer Institute”
Research ?
Is it similar to his “research” which I exposed here?
And yet, after showcasing such “brillianot” research skilz, Tuesday, 7/30/2013, Dr. Gorski was appointed / named program co-director of Michigan Breast Oncology Quality Initiative(MiBOQI); a state-wide initiative to improve the quality of breast cancer care using evidence-based guidelines[13]
He “will be involved in many aspects of the quality initiative”
Let’s hope that one of those aspects is NOT the “research” one
“Dr. Gorski has the breadth and depth of knowledge to effectively lead our very strong Breast Multidisciplinary Team,” said Dr. Bepler
“I have every confidence that Dr. Gorski will continue this very high standard of care.”
Perhaps Dr. Bepler is out-of-touch with reality when it comes to Gorski’s “research” and “standard of care” abilities
I wonder how long it is before his effort at infiltrating evidence-based guidelines with his Science-Based Medicine, raises its ugly hypocritical head ?
During the Holidays, maybe Dr. Gorski will have time to celebrate his promotion with his wife with an evening out, and before he pops the surprise to her about his retirement plans for Castro’s Cuba, he can take her by the hands, stare into her eyes with his big brown eyes; they have to be brown, right (?), because he’s so full of “it,” (?) and tell her these heart-warming words:
Darling, I know, that you know, that what I do brings home the bacon, and so it makes a difference in Michigan
In fact, I wanted to let you know how much of a difference I’m helping to make
1997 thru 2001, African American women breast cancer death rates per 100,000 in Michigan; as reported in the American Cancer Society Cancer Facts & Figures for African Americans, 2005-2006, listed Michigan as the state tied with the 20 most breast cancer cases per 100,000, with 36.2
I’m proud to announce that for the last 2 reporting periods (2011-2014), covering 2003 thru 2009, Michigan is no longer tied with the state with the 20 most cases of breast cancer per 100,000
Michiganis now the state with the 11th most cases of breast cancer in African American women, which rose .5 from 33.8 to 34.3 over the last 2 reporting periods
And that’s not all
African American womenbreast cancer incidences inMichigan, per 100,000, rose from 119.0, 2000 thru 2004 as reported in the 2007-2008 report, up .4 to 119.4, 2006 thru 2010, as reported 2013-2014
Additionally, African American womenbreast cancer death rates inMichigan, per 100,000, rose from 33.8 for 2003 thru 2007, as reported for 2011-2012, up .5 to 34.3 for 2006 thru 2010, reported 2013-2014
And furthermore, breast cancer incidences in Michigan, per 100,000, were 119.4 for African American women for 2006 thru 2010, reported 2013-2014, and 118.7 for 2006 thru 2010 for white women, reported 2013-2014
So African American womenhad .7 more breast cancer incidences thanwhite women
And also, the breast cancer death rates inMichigan, per 100,000, was 34.3 forAfrican American women 2006 thru 2010, reported 2013-2014, 11.5 more than the 22.8 for white women for 2006 thru 2010, as reported 2013-2014
And I thought you’d be very pleased to know that the estimated new breast cancer cases in women inMichigan, rose from 6,120 in 2008, to 8,140 in 2013
An increase of 2,010
And, Michiganwent from being the state with the 9th most cases of estimated new breast cancer cases, to the 8th
And as if that were not enough great news for you, the estimated breast cancer deaths in women inMichigan, rose from 1,350 in 2004, to an additional 10 more women, 1,360 in 2013
And just like with the estimated new women breast cancer cases, again, Michiganwent from being the state with the 9th most cases of estimated breast cancer deaths, to the 8th
And last, but certainly not least, Michigan cancer death rates dropped from 25.8 in 2008, 1.8 to 24.0 in 2013
However, Michiganwent from being the state tied with the 18th most cancer cases per 100,000, to the state tied with the 11th most
But don’t worry honey
If you’re white like me, because you’re in Michigan, the breast cancer incidence for you per 100,000, went from 133.9 for 1998 thru 2002, as reported 2005-2006, down 15.2 to 118.7 for 2006 thru 2010, as reported 2013-2014
And, even better, white death rates in Michigan per 100,000, dropped from 27.3 for 1996 thru 2000, as reported 2003-2004, 4.5 to 22.8 for 2006 thru 2010, as reported 2013-2014
And best of all, sweetie, if you do get breast cancer and you’re white, you have a 9% better 5-year overall survival rate (69% – whites / 60% – African Americans, and for each stage of diagnosis for most cancer sites)
And I’d be remiss if I didn’t point out that life expectancy is lower forAfrican Americans than whites among women (77.2 vs. 80.9 years) (2013-2014)
If that’s not job security for me, I don’t know what is
The mistake that Gorski made is that he did not take into account that this is not the age of Hitler, Stalin, Lenin, Mussolini, etc
In this day and age, people canNOT get away with adopting lying as a part of a strategy, because the NSA is watching, and so are We, the People
Remain calm
Germans subjugated themselves to Hitler, the Soviets, Stalin, Italians, Mussolini, Cubans to Castro, and none of them were worth subjugating oneself to
None of them were worth being put on a pedestal
None of them were greater than you or I
Gorski is NOT the greater good
Gorski has a degree in “B.S.” from the University of Michigan
I do not have a “B.S.” degree
I’m the one NOT full of“B.S.”
Now that sounds like a story ripe for a journalistic investigation
So, I guess that means Bob Blaskiewicz’s fave “journalist,” Liz Szabo, and USA TODAY, are out of the running for this type of “reporting”
But look on the bright side:
“In his new role, he will work with the Samuel Silver, M.D., Ph.D., who is the MiBOQI program director, as well as assistant dean for Research and professor of Internal Medicine/Hematology-Oncology at the University of Michigan Medical School”
Maybe “the Samuel Silver, M.D., Ph.D.” will be GorskGeeks“checks and balances” ====================================== “Our only goal is to promote high standards of science in medicine” ====================================== http://www.sciencebasedmedicine.org/editorial-staff/
======================================
====================================== Such risible hyperbole would induce fits of laughter in me if it weren’t such a complete lie ======================================
I’m just glad dad got outta Kellogg country while he could
—————————————————————— P.S.: Per Dr. David H. Gorski, anything which might erroneously be perceived as a lie about Burzynski, is NOT anything wrong, per Wayne State University[14] ======================================
GorskiGeekstarts off his soapbox stump speech:
—————————————————————— “I was very pleased last Friday, very pleased indeed”
——————————————————————
Of course he was
After all, it was as if USA TODAY was quoting directly from “The Skeptics™”fave Fahrvergnügen pharyngula and GorskGeeks’sjackedJulyjabberwocky at “The Amazing Meeting”2013 (TAM 2013 #TAM2013) Twitter Twaddle-fest
Given the normal subject matter of this blog, in which I face a seemingly unrelenting infiltration of pseudononsensepseudononscience and hackery into even the most hallowed halls of hacademic medicine, against which I seem to be fighting a mostly uphill battle, having an opportunity to see such an excellent non-deconstruction of science and medicine in a large badmainstream news outlet like USA TODAY, GONE TOMORROW is rare and ungratifying
GorskGeek gambits:
—————————————————————— “As you might recall, USA TODAY reporter Liz Szabo capped off a months-long investigation of Dr. Stanislaw Burzynski and his Burzynski Clinic with an excellent (and surprisingly long and detailed) report, complete with sidebars explaining why cancer experts don’t think that Burzysnki’s anecdotes are compelling evidence that his treatment, antineoplastons, has significant anticancer activity and a human interest story about patients whom Burzynski took to the cleaners”
——————————————————————
My question ?
GorskGeek, how do you know it was a:
“months-long investigation” ?
The article does NOT indicate HOW LONG the USA TODAY“investigation” took
From this, I can only conclude, as I did after 1st reading the article, that based on the comments of Dr. David H. Gorski“Orac”, that there must have been collusion between “The Skeptics™” and USA TODAY
Most of this, of course, is no news to my readers, as I’ve been writing about Dr. Burzynski on a fairly regular basis for over 8 months now
—————————————————————— GorskGeek goofs:
—————————————————————— “It’s just amazing to see it all boiled down into three articles and ten short videos in the way that Szabo and USA TODAY did, to be read by millions, instead of the thousands who read this blog“
—————————————————————— Thousands read his blog ?
Does he mean over the 2 year period he’s been writing about Burzynski ?
GorskGeekInspector Gadgets:
—————————————————————— “Szabo also found out who the child was who died of hypernatremia due to antineoplastons in June 2012, a death that precipitated the partial clinical hold on Burzynski’s bogus clinical trials, about which both Liz Szabo and I have quoted Burzynski’s own lawyer, Richard Jaffe, from his memoir, first about Burzynski’s “wastebasket” trial, CAN-1“
—————————————————————— GorskGeek and USA TODAY both hashtag Failed to point out that a boy, the same age as Josia Cotto, survived a serum sodium (Na+) level of 234 mEq/L
If GorskGeek actually knew how to do real “science-based medicine” research, and if Liz Szabo and Jerry Mosemak had really actually done a “months-long investigation”, maybe USA TODAY and “Orac” could have had enough time to have figured the above out, as well as the clinical trialBurzynski’sattorney, Rick Jaffe, was referring to, was the CAN-1, which even you did NOT display any knowledge of in the July TAMmany Twaddle [3], and your 11/15/2013article[4]
——————————————————————
Naturally, upon reading Liz Szabo’s “ story,” I wondered how long it would be before there would be a response from GorskGeek or his minions
Both responses contain the same sorts of tropes, misinformation, and pseudononscience that I’ve come to expect from GorskGeek[1-2+4]
USA TODAY is biased and in the pocket of “The Skeptics™”
It was a “Shite Muslim Militia” piece
—————————————————————— GorskGeekdreamsicles:
—————————————————————— “I’ve deconstructed these, and many more, of Merola’s nonsense over the last two years”
“Odd how @BurzynskiMovie pretends I haven’t deconstructed his “evidence” in depth before”?
Really ?
GorskGeek is so much a monumental myopic Mythomaniac
GorskGeek all you did was “cherry-pick” what you wanted to blather about, and selectively ignored everything else
——————————————————————
What actually surprised me was the viscousness of the counterhackattack
For example, in counterhackattackingEric Merola’s letter to Liz Szabo, GorskGeek tries unsuccessfully to claim that Merola actually hopes that her child will get cancer, so that Burzynski supporters can gloat about it and Szabo will have to apologize to her children for her “perfidy” (in GorskGeek’s eyes, at least):
—————————————————————— GorskGeek gesticulates:
—————————————————————— “He denies that he hopes Szabo’s children will develop brain cancer, but then gloats gleefully over the possibility that she would have to face them after having—again in his mind—”helped to destroy the only thing that could have helped” them”
——————————————————————
In the dictionary, under the definition of “spin bowel movement (SBM),” there should be a picture of “Dr.” (and I use that term very “loosely”) David Gorski
GorskGeek would have fit in holistically as the propagandist for Hitler, Lenin, Mussolini, Pol Pot, Stalin, etc.
Then, just when I thought GorskGeek couldn’t go any lower, he does, this time in his longer response on his blog
—————————————————————— “Eric Merola and Stanislaw Burzynski respond to the FDA findings and the USA TODAY story. Hilarity ensues”
——————————————————————
Obviously, to “Orac” asking GorskGeek to follow normal rules regulating medical ethics and human subject protections in critical trolls’ blog trials is exactly like murdering millions of people’s brain cells, carrying out horrible medical experimentation on common sense and sensibility, making untold numbers of Africans, slaves to his stupendousmess, and harassing, gratuitously, families of soldiers “killed” by his word salad battle
Didn’t anyone ever teach GorskGeek that you need to build up to that sort of climax ?
Of course, the big difference between Hitler’s propaganda chief Joseph Goebbels, unfortunately, is that compared to “Orac,” he had talent, and David GorskGeek does NOT
GorskGeek is a hack and is only funny by accident because he has no filters that tell him when he’s going way under the top
To him, Burzynski is an infidel
I do not share his belief, but, even worse, I have the temerity to criticize his god“Orac,” or, to mix metaphors shamelessly, to point out that GorskGeekhas no clothes
Since I’ve dealt with so many of the tropes included in GorskGeek’snot-so-little rant, I hardly see the need to repeat myself
However, as a breast cancer surgeon’s skeptic, I find one of GorskGeek’slies to be as despicable, or perhaps more so, than his ad hominem comparisons
—————————————————————— GorskGeek, the Hitler of hipocracy, came up with this hit parade of paranoia and “conspiracy theory”:
—————————————————————— “I don’t know what sort of attacks on the UK bloggers who produce the bulk of the skeptical blog posts about Burzynski are coming in Burzynski II, but when it comes to me no doubt Merola is referring to this bit of yellow journalism in 2010 from an antivaccine propagandist named Jake Crosby, entitled David Gorski’s Financial Pharma Ties: What He Didn’t Tell You” [5]
—————————————————————— GorskGeek then ad hocs ad nauseum about ad hominem fallacy
“In this fallacy, rather than addressing the actual evidence and science that demonstrate their favorite brand of woo to be nothing more than fairy dust, the idea is to preemptively attack and discredit the person“
“The ad hominem is not just insults or concluding that someone is ignorant because, well, they say ignorant things and make stupid arguments (in which case calling someone stupid or ignorant might just be drawing a valid, albeit impolitic, conclusion from observations of that person’s behavior), but rather arguing or insinuating that you shouldn’t accept someone’s arguments not because their arguments are weak but because they have this personal characteristic or that or belong to this group or that“[6]
—————————————————————— GorskGeek, the huckster of hackery laments that “The Skeptics™” are subject to character assassination, NOT because of their “science-based medicine”, but, alas, for being biased, lying, cowards
So, he must justify that as to why he then ad hominems those who he harangues:
—————————————————————— “In Burzynski The Movie, Dr. Whitaker has his nose embedded so far up Dr. Burzynski’s rectum that Dr. Burzynski wouldn’t need a colonoscopy if Merola just strapped a light to Dr. Whitaker’s face“[7]
——————————————————————
—————————————————————— “In the meantime, I realized that seeing Josh Duhamel stick his proboscis firmly up Burzynski’s posterior was not enough to explain the disturbance that I was feeling“[8]
——————————————————————
—————————————————————— GorskiGeek seems to have an unhealthy infatuation with ASS
My suppositorsition is that GorskiGeek, the highfalutin’ He-Man of hypocrisy, does wax on, wax off, waxes phonetic about ASS, because he is the apex of ASSmuchness
——————————————————————
In essence, he denies the toxicity of water in terms I’ve never seen anyone try to downplay before:
Water… is toxic?
This was perhaps the most stunningly malicious use of emotion to manipulate the reader in any of the propaganda pieces against H2O in history
—————————————————————— GorskGeekclaims:
—————————————————————— “Josia, as readers of Liz Szabo’s report will know, was the six year old boy with an inoperable brain tumor who died of hypernatremia (elevated sodium levels in the blood) as a result of Burzynski’s therapy“
—————————————————————— GorskGeek gassticulates:
—————————————————————— “As I pointed out last Friday and Szabo reported in her story, before his death Josia’s serum sodium was measured at 205 mEq/L, way above the normal range of 136-145 mEq/L and well into the lethal range”
“As I pointed out then, I’ve never seen a sodium level anywhere near that high“
“During my residency, the highest I recall ever seeing was maybe around 180 mEq/L”
——————————————————————
As I already pointed out previously in this article:
GorskGeek and USA TODAY both hashtag Failed to point out that a boy, the same age as Josia Cotto, survived a serum sodium (Na+) level of 234 mEq/L
GorskGeekclaims that Josiadied of hypernatremia (elevated sodium levels in the blood) as a result of Burzynski’s therapy
GorskGeek does NOT provide ANY citation(s), reference(s), and / or link(s) in support of his claim, and does NOT provide a copy of the autopsy
GorskGeek’s brain cells must be “sleeping in excess”, hence the symptoms of lethargy progressing ignorance of adverse events which approach critical black hole levels
Of course, none of this is new information
—————————————————————— GorskGeek hacks:
—————————————————————— “I also note that one of Burzynski’s most famous patients, Hannah Bradley, who with her partner Pete Cohen proclaims herself cured of her brain cancer, thanks to Burzynski, suffered some pretty serious toxicities from antineoplastons herself, including high fevers to 103.9° F, shaking chills, and severe rashes“
“Pete even documented how badly Hannah reacted to antineoplastons in his YouTube documentary Hannah’s Anecdote”
—————————————————————— GorskGeekflummoxes in that he erred to elucidate that the “rash” which Hannah experienced, even entailed epilepsy anti-seizure medication [4]
GorskGeekgambols the gabroni gambit by giving nothing but glib reasons for his genetically challenged gestation of Hannah’svlogs after gears up for Great Britain
Yes, GorskGeek is gabless about Hannah’sprogress in the G.B. as a germinating gerbil, as far as flu or fever, perhaps fearing his failure to feature any fact-checking facilitation a fanboy of Fanectdotes should fittingly fictionalize
——————————————————————
The rest of GorskGeek’srant reads like a greatest hits compilation from cancer hacks
You get the picture
That’s the whack-n-hack counterhackfensive trying to shore up Liz Szabo’ssorryarticle
—————————————————————— GorskGeekblowshard and long about the FDA Form 483′s findings, but does NOT heed his massive failure to be persuaded that:
“The FDA has not yet issued final conclusions”
——————————————————————
Who would doubt that if GorskGeek were to blog about Burzynski’s1997 criminal trial, that he would NOT list each and every one of the 34 counts of mail fraud, 40 counts of violating Food and Drug Administration regulations, and the 1 contempt-of-court charge; all “allegations”, which netted the U.S. Gubment absolutely NOTHING ? [9]
—————————————————————— GorskGeekidolizes the Burzynski Research Institute(BRI)IRB, because of Burzynski’sscientific publications, which indicate:
—————————————————————— 2003 – Membership of the Institutional Review Board(IRB) was in agreement with the Food and Drug Administration(FDA) [10]
—————————————————————— 3/2004 – Membership of the Institutional Review Board(IRB) was in agreement with the Food and Drug Administration(FDA) [10]
—————————————————————— 9/2004 – Membership of the Institutional Review Board(IRB) was in agreement with the Food and Drug Administration(FDA) [10]
—————————————————————— 2004 – Membership of Institutional Review Board(IRB) was in compliance with FDA guidelines [10]
—————————————————————— 6/2005 – Membership of the Institutional Review Board(IRB) was in agreement with the Food and Drug Administration(FDA) [10]
—————————————————————— GorskGeek then does a piss-poor“slight of hand job”, jerking the reader off about Pseudoprogression, pseudoresponse, so-called pseudoprogression, and “One phenomena, termed Pseudo-Progression (psPD)”
GorskGeekfalls flat face first for failing to show this phenomenon has factually happened [11]
I’ve made no secret of how much I dispute David H. Gorski, a la “Orac”, the “self-proclaimed”brain cancer doctor and brain cancer researcher who has been treating readers with an unproven, unapproved, NOT ordinarychemotherapeutic agent since Jesus just left Chicago, bound for Nawlins, seemingly Elaphe longissimaslithering around, under, over, and past all attempts to intestate him and shut him up
Along the way, GorskGeek has become a hero to the cancer hackery industry, touted as the man who can cure incurable insomnia that science-based medicine can’t, even though his treatment, insolence, allegedly pop tarts isolated from bloopers and Uranus that normally keep insomnia in check in healthy people, are by any reasonable definition NOT ordinary chemotherapy
Indeed, they are toxic, with a number of side effects reported, the most common and dangerous of which being life-threatening hyperactivity (elevated sugar levels in the blood)
All you have to do is to type GorsGeek’s name into the search box of this blog, and you’ll find copious documentation of the abuses of patience, science, and critical trials perpetrated by “Orac” and the cult of impersonality that has evolved around him
He’s even acquired his very own film perpougendist, a credulous fellow named Bob Blaskiewicz, who has made 2 astoundingly bad hackumentaries that are nothing more than unabashed hagiographies of the brave maverick doctor curing insolence where no one else can
They’re chock full of misinformation, pseudononsense, spin, and obvious emotional manipulation, and the 2nd one, at least, was very popular
For the longest time, I’ve been hoping that major mainstream news organizations would take this story on
—————————————————————— GorskGeekclaims:
“Now, thanks to Liz Szabo at USA Today, we know from her article Doctor accused of selling false hope to families [1]:
“Yet hypernatremia is one of antineoplastons’ most common side effects, known to doctors for two decades”
—————————————————————— GorskGeek, of course, does NOT care to mention the 2 hypernatremia studies that I listed in the 2nd of my 3 critiques on USA TODAY’s“hatchet job” of Burzynski[2], because, as he accuses others:
THEY DO NOT FIT HIS NARRATIVE
—————————————————————— GorskGeek continues:
—————————————————————— “showed a blood sodium level of 205 millimoles per liter, a level that is typically fatal“
“I was astounded to see that number“
“I’ve never, ever seen a sodium level that high“
“Typically, normal is typically between 135 and 145 mEq/L, with slight variations of that range depending on the lab”
“Burzynski’s excuse, which I’ve heard at various times as being due to an “improper blood draw” or as described above, is purest nonsense”
“Unless the technician spiked Josia’s sample with 3% saline or something like that, there’s no way to get the leve that high”
“Josia almost certainly died because of hypernatremia from antineoplaston therapy“
“To me, this is the biggest revelation of the story:”
“The story and identity of the child who was killed by Burzynski’s treatments“
——————————————————————
I did NOT know that GorskGeek was the Medical Examiner for the United States Food and Drug Administration
—————————————————————— GorskGeek is mistaken, as the “purest nonsense” is his nonsensical claim:
“I’ve never, ever seen a sodium level that high“
The reasonGorskGeek has:
“never, ever seen a sodium level that high”
is because he’s a “hack”, who’s more interested in churning out as many blogsplats as he can, rather than doing real“science-based medicine”research
As evidence of MY claim, I submit:
—————————————————————— 9/2004 – A Non-Fatal Case of Sodium Toxicity (Hypernatremia)
—————————————————————— “6 year old boy who was taken to the hospital following a seizure attack, and lab analyses revealed a serum sodium (Na+) levels of 234 mEq/L”
“A search of the boy’s house led to the discovery of rock salt in the cabinet and a container of table salt”
“Extrapolating from the serum sodium (Na+) level, it was estimated that the child had ingested approximately 4 tablespoons of rock salt, leading to the acute toxicity“
“A literature search revealed that the serum sodium (Na+) concentration in the present report was the highest documented level of sodium in a living person“
Non-Fatal 193-209 mEq/L have been reported previously [3]
——————————————————————
We also learn that—surprise! surprise!—GorskGeek is an enormous tool
(as opposed to having “an enormous tool” His cranium is too small to have “enormous tool”)
—————————————————————— GorskGeek then hacks:
—————————————————————— “Look at him dismiss his critics, particularly former patients, many of whom, let’s recall, have terminal cancer, many of whom are dead:”
“Burzynski dismisses criticism of his work, referring to his detractors as “hooligans” and “hired assassins.””
—————————————————————— GorskGeek, you are a “hooligan”, liar, lame, loser, et al.
—————————————————————— GorskGeek proceeds:
—————————————————————— “You know, whenever I hear Burzynski fans like Eric Merola accuse skeptics of attacking cancer patients, of accusing them of horrible things”
“I think I will throw this quote right back in their faces”
“Here’s Burzynski calling his patients prostitutes, thieves, and mafia bosses, and “not the greatest people in the world,” while accusing them of wanting to “extort money from us.””
—————————————————————— GorskGeek, LAME attempt at another LIE
Burzynski did NOT CALL his patients what YOU claim he called them
Let me repeat it for YOU, because I have the sneaking suspicion that YOU are “intellectually challenged”
BurzynskiSAID:
“We see patients from various walks of life”
“We see great people”
“We see crooks”
“We have prostitutes”
“We have thieves”
“We have mafia bosses”
“We have Secret Service agents”
“Many people are coming to us, OK?”
“Not all of them are the greatest people in the world”
—————————————————————— GorskGeek, just in case you did NOT learn this at the University of Michigan, there is a difference between SAYING“WE SEE” and / or “WE HAVE”, and CALLING someone something
Allow me to provide you with a great example
If I SAY that YOU are the BIGGEST POMPOUS ASS I’ve ever seen, and YOU are NOT a BIG POMPOUS ASS, then THAT is derogatory
However, if I CALL YOU the BIGGEST POMPOUS ASS that I have ever seen, because you really and truly are a BIG POMPOUS ASS; as you are, then THAT is NOT derogatory
—————————————————————— GorskGeek tries again:
—————————————————————— “Not surprisingly, he also liberally uses the Galileo gambit, but that’s not surprising, as he’s repeatedly made the hilariously arrogant and scientifically ignorant claim that he is a pioneer in genomic and personalized cancer therapy and that M.D. Anderson Cancer Center and other world-class cancer centers are “following his lead.””
“Indeed, he claimed to have invented the field 20 years ago”
“Sadly, his publication record does not support such grandiose claims“
—————————————————————— GorskGeek, how would you know ?
You proved that you weren’t smarter than a 5th grader when you could NOT find Burzynski’s1997 Antineoplastons, oncogenes and cancer [4]
—————————————————————— “Curious as to just what the heck Burzynski was talking about here, I searched PubMed for this alleged review article”
“I couldn’t find it on PubMed“
“Perhaps Burzynski proposed this “revolutionary” new idea in a peer-reviewed article that’s not indexed in PubMed, but if he did I couldn’t find it using Google and Google Scholar“[5]
So why should ANYONE believe that you were able to locate the rest of his publications
and review all of them?
Now THAT would be a “grandiose claim”
—————————————————————— GorskGeek was also the village “idiot savant” (minus the “savant”) who face planted:
“how Burzynski never explains which genes are targeted by antineoplastons … “[6]
GorskGeek must have fumed for days when he found I “fact-checked” his fluff and found it false: [7-8]
—————————————————————— GorskGeekhopes to wreak havoc when he harrumphs:
—————————————————————— “For instance, experts are saying the same things I’ve been saying for a couple of years now about Burzynski’s anecdotes of “miracle cures,” such as Hannah Bradley and Laura Hymas”
“The reasons for these anecdotes include:”
“Burzynski often relies on anecdotes, which don’t tell the full story”
“Burzynski’s therapies are unproven“
“Burzynski’s patients may have been misdiagnosed“
“Burzynski’s patients may have been cured by previous therapy“
“There’s a reason why I’ve spent so much time deconstructing Burzynski anecdotes, and it’s for all of those reasons plus that anecdotes are often interpreted incorrectly by patients without medical training”
“Even doctors who are not oncologists sometimes interpret such anecdotes incorrectly to indicate that the cancer therapy chosen is the therapy that cured the patient“
“It’s not just Burzynski patient anecdotes, but it’s any cancer cure anecdote“
“That’s why clinical trials are necessary to differentiate all these confounding effects from actual effects due to the treatment”
—————————————————————— GorskiGeek displays what an abject #FAIL he is, as the question he should be asking is:
Why is the Food and Drug Administration FORCING patients to #FAIL conventional treatments; such as surgery, chemotherapy, and radiation therapy, before being allowed to utilize antineoplaston therapy ?
If the FDA was NOT doing this, then GorskGeek and the “so-called experts” would NOT have this crutch to fall back on
GorskGeek, please list all the other phase II clinical trials where the F.D.A. has done this, and please also explain what would you do if the FDA did this to YOUR clinical trials ?
I know this might require some “Grapefruits” on your part, but do try and see if you can find yours in order to pull this off, if you’re NOT the coward I think you are
And when you’re done with that, please try to explain away the case of Jessica Ressel-Doeden
GorskGeekwinds up for the pitch of bullshit
He ratchets back his right arm and rockets it right into his rectum, reaches ’round and pulls out this righteousness:
—————————————————————— “Not coincidentally, Hannah Bradley had surgery, chemotherapy, and radiation, and Laura Hymas had radiation and chemotherapy”
GorskGeek, Hannah Bradley NEVER had chemotherapy, unless you are now going to claim that by “chemotherapy” you meant antineoplastons [9]
Hannah specifically mentioned:
“Chemotherapy also mentioned but not strong enough for that” [10]
—————————————————————— GorskGeek:
“Even doctors who are not oncologists sometimes interpret such anecdotes incorrectly” ?
I think you meant, even breast cancer oncologist specialists who are NOT brain cancer oncology specialists interpret incorrectly, you JackASS
====================================== [4] – 1997 – Burzynski. S.R. Antineoplastons. oncogenes and cancer. Anti-Aging Medical Therapeutics, Vol.1. Klatz RM.
Goldman R. (Ed). Health Quest Publication 1997; Marina del Rey, CA. USA
Pg. 24
——————————————————————
Gorski wants to play in the kitchen, but he can’t take the heat
2/18/2013, Gorski posted his 1st book report on Hannah Bradley
Dr. Stanislaw Burzynski’s cancer “success” stories [1]
The year 2012 was rung out and the year 2013 was rung in by news that “Orac” Check-My-Facts-Hack, propagandist for “brave maverick doctor” Dr. David H. Gorski, who claims that sugar doesn’t feed cancer [2], is releasing a sequel to his wildly successful hackumentary (in “The Skeptics™” underground, that is) “How Stanislaw Burzynski became Burzynski the Brave Maverick Doctor, part 1” [3] 😃
In fact, the sequel is coming out on BFD (Blogs For Dummies) on …, well …, just any day now ! 😳
I somehow doubt that GorsKon will send me a screenerBFD to review, but I did review the 4blogettes he posted on Science Based Medicine; home of: “Our only goal is to promote high standards of science in medicine” [4], and National Geographic’s(#NatGeo)Science blogs, because it easily falls into a genre that I like to refer to as medical propaganda posts, which are almost always made in support of dubious blogs re medical treatments 😊
Gorhac’s mostly lame jokes about proposed titles aside (e.g., Burzynski II:”“Pathetic Googleloo, Burzynski II:”This Time It’s Pee-Reviewed, or even Burzynski II: FAQ Harder), it’s very clear that in the wake of his decision to drop his “[I]f I had screwed up, I would have admitted it” [5]claim re Burzynski on a technicality, and his very own spin doctor named “BOrac, are planning on a huge publicity blitz, in which @gorskon will be portrayed as, yes, a “brave maverick doctor” whom “They” (as in the BPG (Burzynski Patient Group), 3’s company, and the Don’t Mess with Texas Board of Education, a.k.a “DJT”) tried to keep down but failed because he has The Natural Cure For Rancor“Two Turntables and a Mr. Microphone” 😝
I come back to this again because Gorac’s strategy for Burzynski II, as I pointed out, is going to involve “conversion stories” of “The Skeptics™” who didn’t believe in @oracknows magic “[I]f I had screwed up, I would have admitted it”, but do now, after Bob ‘n Weave Blaskiewicz proclaimed during the 9/28/2013 “Burzynski Discussion” Google+ Hangout:“I think that professionally he would make, he he he would follow-up on these things” (2:01:00)[6], claims that he’s 75% sure of the identity of someone who has been critical of his work (like me) [7], and, of course, sucky stories 😜
“DOHrac’s” 4 posts consists of four elements:
Bias, MisDisInformation, (anecdotes), including “EOrac’s” “sucky stories”, contrasted with a rehash of “conspiracy theories” from his “review” of the first movie about the “cancer destablishment” trying to suppress common sense with pseudononsense 😄
Never mind that, even if he were FDA-approved, he would be in the same class as “The Skeptics™” that are disdained on social media as being more for hyper-“bull” than anything else because they have been giving B.S. for a long time ☺
He states: “One notes that Burzynski’s protocol requires at least 18 months of near-continuous infusion of high doses of his antineoplastons“
Does Gorski provide any citation(s), reference(s), and / or link(s) to support his claim ?
no
“mOResmACk” reminds me of Pink
That would be the Pink in Pink Floyd, singing: “We don’t need no edumacation”, because he’s like the churlish schoolboy so intent on getting on to make his 2nd mud pie, that he pulls a wanker on the 1st one
Maybe he should learn how to do real “cancer research” like I posted 8/21/2013 [8]
——————————————————————
10/2004 (Pg. 384) 4.3 months – median duration of administration
——————————————————————
11/2010 (Pg. iv72) 4.4 months – median duration of treatment
——————————————————————
10/2006 (Pg. 466) 4 1/2 months – median duration of i.v. ANP
——————————————————————
3/2006 (Pg. 40) 5 months – median duration of antineoplaston administration
——————————————————————
10/2004 (Pg. 428) 5.2 months – administered median
——————————————————————
12/2009 (Pg. 951) 5.4 months – median duration of treatment (ST)
——————————————————————
12/2009 (Pg. 951) 5.6 months – median duration of treatment (SE)
——————————————————————
10/2004 (Pg. 427) 5.7 months – average duration of ANP
——————————————————————
10/2008 (Pg. 821) 5.7 months – median duration of treatment
—————————————————————— 2003 (Pgs. 91 + 96) 6 months – median duration of treatment
——————————————————————
12/2008 (Pg. 1067) 6.5 months – median duration of treatment
——————————————————————
10/2003 (Pg. 358) 9.5 months – median duration of IV ANP
——————————————————————
7/2005 (Pg. 300) 9 1/2 months – median duration of administration
—————————————————————— 2004 (Pgs. 315 + 320) 16 months (1 year 4 months) average duration of intravenous ANP
——————————————————————
6/2008 (Pg. 450) 16.5 months (1 year 4.5 months) – median
——————————————————————
2004 (Pg. 320)
19 months – average duration of oral ANP
——————————————————————
6/2005 (Pgs. 168 + 170)
20 months (1 year 8 months) administered average duration
——————————————————————
10/2003 (Pg. 358)
28.6 months (2 years 4.6 months) – median duration of po ANP
After obtaining at least minor response (SD), the treatment continued with po ANP
——————————————————————
9/2004 (Pg. 257)
655 consecutive days – administration of antineoplastons A10 and AS2-1 with the exception of a few short interruptions
—————————————————————— Gorski continues:
“Attacks on skeptics and critics of Burzynski“
“If you don’t believe me, just read question #12 in Merola’s FAQ, in which he states,
“You will notice the ‘anti-Burzynski’ bloggers refuse to do that or adhere to reputable sources”
—————————————————————— Gorski, you did NOT even provide any “source” for your “claim” that:
” … Burzynski’s protocol requires at least 18 months of near-continuous infusion of high doses of his antineoplastons“
—————————————————————— Gorski adds:
“You might say, they are preying on desperate cancer patients and families of cancer patients by carelessly misleading their readers about Burzynski and his invention.””
—————————————————————— Gorski, let’s check and see where else YOU are “carelessly misleading” your “readers”
One marvels at your amazing level of protestation ッ
However, every movie needs a villain, and it doesn’t take “sidekick” abilities to guess why “The Skeptics™” are portrayed as villains
—————————————————————— Gorski gratuitously gabs on:
“Merola also direly accuses and threatens,
“In the worst case scenarios, some bloggers intentionally publish fabricated information to their readers in an attempt to curb new patients from going to the Burzynski Clinic“
“I can hardly wait”
—————————————————————— Gorski, did you mean to “intentionally publish fabricated information” ? 😮
—————————————————————— “Neither can, I bet, a fair number of lawyers“
—————————————————————— Gorski, who’s your lawyer ?
—————————————————————— Gorski plods onward:
“An attempt to reframe Burzynski’s enormous bills for his antineoplaston therapy and criticism that he’s making clinical trial subjects pay to be in his clinical trials”
—————————————————————— Gorski, BITE ME 🙂
Does Gorski provide any citation(s), reference(s), and / or link(s) to support his claim ?
——————————————————————
CHEMOTHERAPY: 9/24/2012 – hospitals routinely marking up prices on cancer drugs 2 to 10 times over cost
Some markups far higher
nearly $4,500 for 240-milligram dose of irinotecan to treat colon or rectal cancer average sales price: less than $60
about $19,000 1-gram dose of rituximab to treat lymphoma and leukemia roughly 3 times average sales price
about $680 50 milligrams of cisplatin markup: more than 50 times average sales price
Avastin, about $90,000 a year http://www.charlotteobserver.com/2012/09/24/3549634/prices-soar-as-hospitals-dominate.html
——————————————————————
5/14/2012 – Oral anti-cancer medications generally considered pharmacy benefit
Instead of co-payment plan members often pay % of cost — up to 50% in some cases — with no annual out-of-pocket limit
drugs expensive often costing 10s of 1,000s of $s a year http://articles.washingtonpost.com/2012-05-14/national/35457286_1_lung-cancer-drug-drugs-work-multiple-myeloma-patients
——————————————————————
RADIATION: 1/4/2013 – new study most comprehensive cost analysis ever, compared costs and outcomes associated with various types of treatment for all forms of disease, ranged from $19,901 for robot-assisted prostatectomy to treat low-risk disease, $50,276 for combined radiation therapy for high-risk disease http://www.ucsf.edu/news/2013/01/13370/how-prostate-cancer-therapies-compare-cost-and-effectiveness
——————————————————————
3/15/2012 – Using Surveillance, Epidemiology and End Results (SEER)-Medicare data, 26,163 women with localized breast cancer had undergone surgery and radiation 2001 to 2005
found Medicare billing for IMRT increased 0.9% diagnosed 2001 to 11.2% diagnosed 2005
average cost radiation treatment during 1st year $7,179 for non-IMRT $15,230 with IMRT
billing for IMRT more than 5 times higher in regions across nation where local Medicare coverage determinations favorable to IMRT compared to regions where unfavorable
“The new claim is that Burzynski isn’t making patients pay for his antineoplastons (see question #13 in Merola’s FAQ), just for “clinical management” (as if that weren’t incredibly transparent) Vindication”
—————————————————————— Gorski, “NEW CLAIM” ?
2/4/2013 my post #180 on YOUR blog addressed this “new claim” by referencing a 3/12/1996 note before you posted your article 2/18/2013 [9]
—————————————————————— 3/12/1996: 2nd – 4th paragraphs (2/4/2013 post #180)
——————————————————————
—————————————————————— Gorski, makes an excuse:
“The last time I discussed Merola’s forthcoming movie, I mentioned that he had contacted me in December and asked me to appear as a Burzynski critic“
“After consultation with skeptics with more media savvy than I, not to mention the PR department at the Barbara Ann Karmanos Cancer Institute (whom I thought it wise to give fair warning that one of their faculty might be featured as evil incarnate in a new documentary and to give the background on what it’s all about, in case there were press inquiries), I politely declined“
—————————————————————— Gorski is like fetid HOT AIR, all words and NO action
—————————————————————— Gorski fumes:
“While going on and on about how he thinks most of us have “good motives” and how we want to be the white knight riding in to save patients from quackery (a desire he somehow manages to convey with clear dismissiveness and contempt), Merola turns immediately around to claim that we don’t know what we’re talking about and we don’t read the literature“
—————————————————————— Gorski, YOU really “don’t know what” you’re “talking about” and I’m just getting warmed up 🙂
—————————————————————— Gorski has smoke coming out his ears:
“This, of course, is complete nonsense, as I’ve read many of Burzynski’s papers (such as they are), delved into ClinicalTrials.gov to look at his clinical trials, examined the plausibility of his claims from a scientific standpoint, and examined the literature from others, both on antineoplastons and related topics”
“I’ve dissected Burzynski’s claims for antineoplastons based on science, assessed his “personalized, gene-targeted cancer therapy” claims and found them wanting, and pointed out how what he is peddling isn’t really anything new at all (more on that later), all based on my knowledge, skills, and understanding of cancer as a breast cancer surgeon and researcher”
“No doubt that’s why Merola needs to discredit me“
—————————————————————— Gorski, Eric Merola does NOT need “to discredit” you
YOU have already done a yeoman’s job of discrediting yourself [10] 🙂
—————————————————————— Gorski posits:
“Other bloggers who have been critical of Burzynski might or might not have my scientific background, but they’ve delved just as deeply into his claims and the evidence for them, and, as I have, they’ve found them highly overinflated and largely not based in science”
—————————————————————— Gorski, unfortunately, is NOT able to name these “[o]ther bloggers”
—————————————————————— Gorski deposits:
“They’ve also taken on aspects of the Burzynski phenomenon, such what I consider to be his questionable ethics and finding out what happened to a lot of patients who trusted Burzynski, far better than I have”
“Merola’s dismissal of Burzynski’s critics is, quite frankly, insulting to them and to me.”
—————————————————————— Gorski fails to mention the very “questionable ethics” of his intrepid research bud Bob [11]
—————————————————————— Gorski rants:
“I don’t know what sort of attacks on the UK bloggers who produce the bulk of the skeptical blog posts about Burzynski are coming in Burzynski II, but when it comes to me no doubt Merola is referring to this bit of yellow journalism in 2010 from an antivaccine propagandist named Jake Crosby, entitled David Gorski’s Financial Pharma Ties:”
“What He Didn’t Tell You”
——————————————————————
Does Gorski provide any citation(s), reference(s), and / or link(s) to support his claim that it’s:
“UK bloggers who produce the bulk of the skeptical blog posts about Burzynski” ?
“What He Didn’t Tell You” ?
NO
—————————————————————— Gorski blots:
“Predictable and tiresome attacks aside, Pete and Hannah’s video made me curious about the specific success stories that Merola will focus on as “proof” that Burzynski is on to something; so I decided I should look into their stories”
“On the surface to those not familiar with cancer they do look like success stories”
“If one digs deeper, the true story is a lot murkier”
—————————————————————— Doctor “G” omits, that once “one digs deeper”, HIS“story is a lot murkier”
—————————————————————— Gorski A.D.D.s:
“More importantly, as I will show, even if they really are success stories—which is not at all clear—they do not constitute convincing evidence of the general efficacy of Burzynski’s antineoplastons, nor do they justify what I consider to be Burzynski’s highly unethical behavior.”
—————————————————————— More importantly, as I will show, is what I consider to be Gorski’s highly unethical behavior
—————————————————————— Gorski flails away:
“I will start with Hannah Bradley’s story because I’ve watched the entire 40 minute video Hannah’s Anecdote (whose title is even more appropriate than perhaps Pete Cohen imagined when he made it)”
“The documentary ends triumphantly several months after the events portrayed during the bulk of the film with Hannah apparently having had a complete response to Burzynski’s antineoplaston therapy:”
——————————————————————
Let me just first say something before I begin my usual analysis
I love these reviews 😘
I really do
Yes, it’s true that GorsGeek can be a bit annoying with his seeming desire to validate everything he flogs about some perceived “offender,”as being applicable to him, but I want GorskGeek and “HOrac” to be able to live a long and full life together, growing old in each other’s company
I really do
In fact, I’d love to hang with these two and maybe buy them a pint or two at their local pub (except that it’s pointed out multiple times that GOrackGeek should no longer drink alcohol)
“Such is not my intent, but what are skeptics supposed to do?”
“Shy away from undertaking a dispassionate analysis of patient anecdotes used to promote dubious cancer therapies for fear of what patients will say?”
—————————————————————— Gorski, it might actually help IF you knew how to do a proper “dispassionate analysis” 😐
—————————————————————— Gorski cites from the Team Hannah blog
“Hannah’s treatment options are very limited and her life expectancy is for this type of tumour is normally around 18 months and this is why I started a mission to find people who had the same condition and are still alive today”
“I managed to track down a number of these people to speak to them.”
“In his movie, Pete points out that these people all led back to Burzynski“
Gorski interjects:
“Of course, as I’ve said before, dead patients don’t produce testimonials for alternative cancer cures“
——————————————————————
One wonders why Gorski even makes this comment as the number of patients Pete contacted re Burzynski’s “alternative cancer” cure, were obviously NOT dead 😮
—————————————————————— Gorski segues on to:
“Not long after they appear at the Burzynski Clinic, they meet with doctors there who tell them that Hannah’s most recent MRI scan showed progression of her tumor (around 8:30 in the movie)”
“Now, I’m not a radiologist, much less a neuroradiologist, but I wondered at all the enhancement on the superficial area of the brain, just under where her neurosurgeon must have raised the bone flap to remove what he could of the tumor“
“One wonders if much of the remaining enhancement could be still post-surgical and post-radiation change“
“Certainly, the tumor is cystic-appearing, and after surgery such cysts would likely shrink and be reabsorbed even if the tumor were to keep growing”
—————————————————————— Gorski, if you were NOT in a such a rush to post your blog article “ad homineming” Josh Duhamel, you could have taken the time to do proper “cancer research” and maybe listen to the 9/24/2012 @YouTube video of Pete Cohen talking with Neurosurgeon (Consultant) Juan F. Martinez-Canca (20:31)
After all, HE is an actual NEUROSURGEON
——————————————————————
——————————————————————
Or you could read the transcript I made of the video [12]
——————————————————————
Or you could have contacted him and asked questions http://www.neurokonsilia.com/About-Us.html
—————————————————————— Gorski tangents:
“Be that as it may, there were a number of things I found very interesting in this video”
“First, I notice that nowhere was there anything mentioned about enrolling Hannah on a clinical trial“
—————————————————————— Gorski, if you had let Hannah know you were going to do your article about her, she might have churned her 4/4/2013 article out faster just for you, where she advises:
“Luckily I was able to take part in a phase 2 clinical trial in Texas, USA”[13]
—————————————————————— Gorski stupefies:
“Given what a thorough videographer Pete obviously is, I find this omission very curious”
“Certainly, given how much detail he’s used in this video and in his vlogs I’d expect that if the subject of clinical trials was mentioned he would have included it”
—————————————————————— Gorski, if you were NOT so busy “getting the popcorn” as you “watched the entire 40 minute video Hannah’s Anecdote”, you might have actually noticed at (7:14):
—————————————————————— 12/12/2011 – Day 2 – Monday
Meeting with Dr. Yi and Dr. Greg Burzynski at Burzynski Clinic
—————————————————————— Dr. Greg Burzynski – “We have permission to start you on the antineoplastons”
“Mhmm”
Dr. Greg Burzynski – “which as you know are in the final stages of drug approval”
“Yeah”
Dr. Greg Burzynski – “Dr. Yi is the oncologist on this case”
—————————————————————— Gorski, did you SEE THAT ?
An ONCOLOGIST at the Burzynski Clinic, working with Burzynski
(No wonder you left that out !)
—————————————————————— Gorski ejects:
“The other thing that struck me was just how much Burzynski is full of it when he advertises antineoplastons as not being chemotherapy and, more importantly, as being nontoxic“
“At least a third of the video consisted of the difficulties that Hannah had with her treatment, including high fevers, a trip to the emergency room, and multiple times when the antineoplaston treatment was stopped“
“She routinely developed fevers to 102° F, and in one scene her fever reached 103.9° F“
“She felt miserable, nauseated and weak“
“I’ve seen chemotherapy patients suffer less”
—————————————————————— Gorski whines:
“I’ve seen chemotherapy patients suffer less”, but this is purely “anecdotal”
“At least a third of the video consisted of the difficulties that Hannah had with her treatment”
Let’s do the math, shall we ?
——————————————————————
In America (48 days)
12/11/2011 (Sunday) – 1/27/2012 (Friday)
[4:52 – 35:43]
—————————————————————— Burzynski Clinic 47 days – (7 weeks)
12/12/2011 (Monday) – 1/26/2012 (Thursday)
[5:37 – 35:43]
—————————————————————— 12/13/2011 (Tuesday) Day 3
after catheter – Hickman line surgery
(painful / really painful) [10:30]
—————————————————————— 12/14/2011 (Wednesday) Day 4
(feeling wrecked / absolutely wrecked) [10:52]
—————————————————————— 12/24/2011 (Saturday) Day 14
fever
bad breathing
uncontrollable chills couldn’t stop shivering all Saturday night [18:10]
—————————————————————— 12/25/2011 (Sunday) Day 15
fever
flu symptoms
bad breathing
headache
in bed
absolutely exhausted
little bit of swelling back of head [18:10]
—————————————————————— 12/27/2011 (Tuesday) Day 17
temp 102
temp down / up [19:04]
—————————————————————— 12/28/2011 (Wednesday) Day 18
exhausted
close to breaking / cracking [19:04]
—————————————————————— 12/29/2011 (Thursday) Day 19
hospital – E.R.
“I’m at my wits end”
“I don’t feel I can take anymore” [20:07]
—————————————————————— 12/30/2011 (Friday) Day 20
last week up & down
fever
chills
shaking
viral infection
bacterial infection
had to go to E.R. [20:22]
—————————————————————— 12/31/2011 (Saturday) Day 21
fever in middle of night
flu-like symptoms
temp 102 [21:53]
—————————————————————— 1/1/2012 (Sunday) Day 22
feel drunky
felt like completely drunk
double vision
Nurse said anti-seizure drug she hadn’t taken before
bit shaky [22:34]
—————————————————————— 1/15/2012 (Sunday) Day 36
antibiotics 1st day [24:33]
—————————————————————— 1/16/2012 (Monday) Day 37
over 102 Monday night
antibiotics 2nd day [25:24]
—————————————————————— 1/17/2012 (Tuesday) Day 38
fever
temp 101.8
throat infection
antibiotics been on 3 days [25:24]
—————————————————————— 1/20/2012 (Friday) Day 41
fever 104 (103.9) Friday night [26:54]
—————————————————————— 1/21/2012 (Saturday) Day 42
temp up to 104 (103.9)
Dr. on-call – Ibuprofen
102.5
yesterday afternoon (blood) rash ? [27:50]
—————————————————————— 1/23/2012 (Monday) Day 44
some itch [28:35] ======================================
47 days – Burzynski Clinic 31 days – treatmentNOTmentioned 16 days – treatment mentioned ====================================== 12/25/2011 (Sunday) Day 15 off ANP [18:10]
—————————————————————— 12/27/2011 (Tuesday) Day 17 back on ANP off ANP – temp 102
temp down / up [19:04]
—————————————————————— 12/28/2011 (Wednesday) Day 18 on ANP much smaller dose [19:04]
—————————————————————— 12/29/2011 (Thursday) Day 19
hospital – E.R. [20:07]
—————————————————————— 12/30/2011 (Friday) Day 20
last week up & down off on off on off ANP [20:22]
—————————————————————— 12/31/2011 (Saturday) Day 21
temp 102 [21:53]
—————————————————————— 1/15/2012 (Sunday) Day 36
antibiotics 1st day [24:33]
—————————————————————— 1/16/2012 (Monday) Day 37
over 102 Monday night
antibiotics 2nd day [25:24]
—————————————————————— 1/17/2012 (Tuesday) Day 38
temp 101.8 off ANP (If 102 take off ANP)
antibiotics been on 3 days [25:24]
—————————————————————— 1/20/2012 (Friday) Day 41
fever 104 (103.9) Friday night [26:54]
—————————————————————— 1/21/2012 (Saturday) Day 42 off ANP – temp up to 104 (103.9)
102.5 [27:50] ====================================== 5 – off ANP
May have beenoff ANP5 to 6 days out of 47? ====================================== 12/27/2011 (Tuesday) Day 17
temp 102
temp down / up [19:04]
—————————————————————— 12/29/2011 (Thursday) Day 19
hospital – E.R. [20:07]
—————————————————————— 12/31/2011 (Saturday) Day 21
temp 102 – in middle of night [21:53]
—————————————————————— 1/16/2012 (Monday) Day 37
temp over 102 Monday night
antibiotics 2nd day [25:24]
—————————————————————— 1/17/2012 (Tuesday) Day 38
temp 101.8
antibiotics been on 3 days [25:24]
—————————————————————— 1/20/2012 (Friday) Day 41
temp 104 (103.9) Friday night [26:54]
—————————————————————— 1/21/2012 (Saturday) Day 42
102.5 [27:50] ====================================== 6 days – temperature mentioned
temp 102 – temp down / up – 12/27/2011 102 in middle of night – 12/31/2011 102+ Monday night – 1/16/2012 temp 101.8 – 1/17/2012 104 (103.9) Friday night – 1/20/2012 102.5 – 1/21/2012 ====================================== Gorski scatterbrains on:
“I was also very puzzled at how the Burzynski Clinic could allow a cancer patient to linger with a fever of 102° F and sometimes higher, accompanied by shaking chills, in a temporary lodging without admitting her to the hospital“
——————————————————————
Does Gorski provide any citation(s), reference(s), and / or link(s) to support his claim ?
“It’s not clear what sort of workup was done to evaluate Hannah either, what her white blood cell count was, or what her other labs were“
“Did they draw blood cultures?”
“Did they get urinalyses and cultures?”
“Did they do chest X-rays to rule out pneumonia?”
—————————————————————— Gorski, maybe you should have asked Wayne Dolcefino
Or maybe you should have gone to the Burzynski Clinic
Oh, wait
You think you know everything and could NOT learn anything by going there 😅
—————————————————————— Gorski at least gets one thing correct:
“It’s all very unclear, other than that she apparently was given some antibiotics at some point”
—————————————————————— 1/15/2012 Monday Day 36 antibiotics 1st day
—————————————————————— 1/16/2012 Tuesday Day 37 antibiotics 2nd day
—————————————————————— 1/17/2012 (Tuesday) Day 38 antibiotics been on 3 days
—————————————————————— Gorski wonders:
“Did she have the flu, given her flu-like symptoms, or was this due to her antineoplaston therapy?“
—————————————————————— Gorski, why not “speculate” like “The Skeptics™” usually do ?
—————————————————————— 12/24/2011 (Saturday) Day 14 fever
bad breathing
shivering all night
—————————————————————— 12/25/2011 (Sunday) Day 15 flu symptoms
breathing
headache
uncontrollable chills couldn’t stop off ANP absolutely exhausted
in bed
little bit of swelling back of head
—————————————————————— 12/27/2011 (Tuesday) Day 17 back on ANP temp 102 – off ANP temp down / up
—————————————————————— 12/28/2011 (Wednesday) Day 18 on ANP much smaller dose exhausted – close to breaking / cracking
—————————————————————— 12/29/2011 (Thursday) Day 19 hospital – E.R.
—————————————————————— 12/30/2011 (Friday) Day 20 last week up & down off on off on off fever
chills
shaking
viral infection
bacterial infection
—————————————————————— 12/31/2011 (Saturday) Day 21 temp 102 – fever in middle of night
Dr. SRB thinks flu-like symptoms or tumor actually breaking down
—————————————————————— 1/16/2012 (Monday) Day 37 temp 102+ Monday night
—————————————————————— 1/17/2012 (Tuesday) Day 38 throat infection temp 101.8 – fever – off ANP antibiotics been on 3 days
—————————————————————— 1/20/2012 (Friday) Day 41 104 (103.9) – fever – Friday night
—————————————————————— 1/21/2012 (Saturday) Day 42 temp up to 104
Dr. on-call – Ibuprofen 102.5 – off ANP yesterday afternoon rash
—————————————————————— Gorski ponders:
“The reaction of the clinic staff (i.e., rather blasé, even though at one point Hannah clearly demonstrates a change in mental status, appearing “drunk” and complaining of double-vision) made me wonder if this sort of problem was a common occurrence”
—————————————————————— Gorski, what’s the matter ?
Did you grab another handful of popcorn ?
—————————————————————— 1/1/2012 (Sunday) Day 22Burzynski Clinic feel drunky
felt like completely drunk
double vision
bit shaky Nurse said anti-seizure drug she hadn’t taken before [22:34]
—————————————————————— Gorski, what are some of the side-effects of “anti-seizure” medications ?
dizziness
double-vision
drowsiness
imbalance
loss of coordination
Problems with motor skills
Problems with tasks requiring sustained performance
nausea
slurred speech
staggering
mental disturbances
serious mood changes
—————————————————————— http://umm.edu/health/medical/reports/articles/epilepsy
—————————————————————— Gorski continues his assault on the popcorn:
“At another point, Pete and Hannah come to believe that the fevers might have been due to the tumor breaking down, which strikes me as implausible”
—————————————————————— Gorski, if it “strikes” you “as implausible”, then why did you ask, above ?
“Did she have the flu, given her flu-like symptoms, or was this due to her antineoplaston therapy?“
—————————————————————— 12/31/2011 (Saturday) Day 21 temp 102 – fever in middle of night Dr. SRB thinks flu-like symptoms OR tumor actually breaking down [21:53]
—————————————————————— Gorski blunders along:
“Later, she develops an extensive rash“
—————————————————————— 1/23/2012 (Monday) Day 44 Pete sent pic to Dr. SRB who gave name from pic and Pete verified [28:35]
—————————————————————— Gorski bumbles onward:
“It’s difficult to tell for sure what it is at the resolution of the video, but it looks like erythema multiforme, which is generally an allergic rash”
“What’s the most likely cause of such a rash?”
“Guess”
“Erythema multiforme is usually a drug reaction”
—————————————————————— Gorski, what can cause “Erythema multiforme” ?
“Does this mean that Burzynski’s antineoplaston treatment worked for Hannah?“
“Sadly, the answer is:”
“Not necessarily”
“It might have”
“It might not have”
“Why do I say this?”
“First, she didn’t have much residual disease after surgery and radiotherapy, and in fact it’s hard to tell how much is tumor and how much is postop and radiation effect“
—————————————————————— Gorski, I think it’s safe to say that neurosurgeon Dr. Martinez knows much better than you and your speculation
—————————————————————— Gorski
“Second, the median survival for anaplastic astrocytoma (which is a form of glioma) is around 2 to 3 years, and with different types of radiation therapy five year survival is around 15% or even higher”
—————————————————————— Gorski provides a link to a site which advises [14]:
High-grade tumors grow rapidly and can easily spread through the brain“
High-grade tumors are much more aggressive and require very intensive therapy
All patients with high-grade astrocytomas receive both radiation therapy and chemotherapy regardless of age
Prognosis is poor in this group of patients
—————————————————————— Gorski’s 2nd linked source advises [15]:
These highly aggressive tumors often occur in young adults and typically recur or progress to a grade 4 glioblastoma within several years of diagnosis, despite treatment with surgery, radiotherapy, and chemotherapy
Tumor more resistant to therapy and patients have shorter median survival of only 2 to 3 years
—————————————————————— Gorski’s 3rd link [16] showcases his lame research as one has to read through almost the entire article to find the reference, which directs the reader to yet another publication [17]:
Gorski FAILS to advise the reader that the 2002 study is titled:
“Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas“
Hannah Bradley’s WAS previously treated
Gorski also FAILS to advise the reader if this study included patients with grade 3 or 4 tumors
—————————————————————— Gorski claims:
“Thus, long term survival for patients with astrocytomas is not so rare that Hannah’s survival is so unlikely that the most reasonable assumption has to be that it was Burzynski’s treatment that saved her”
—————————————————————— Gorski, nice claim, but you did NOT really prove it
—————————————————————— Gorski suspects:
“More likely, Hannah is a fortunate outlier, although it’s hard for me to say even that because, at only two years out from her initial diagnosis, she’s only just reached the lower end of the range of reported median survival times for her disease”
—————————————————————— Gorski, the operative word is “outLIER”
Gorski then goes all “conspiracy theory” about a supposed “cryptic Facebook post”, a “vlog entry no longer exists”, “Hannah and Pete supposedly being “evasive”, “using vague terms”, a “little blip”, and “lack of new scans”
Next, little green “popcorn munchin'” men 👽
—————————————————————— 3/4/2013 Gorski drops “conspiracy theory, part II” on an unsuspecting audience [19]:
Dr. Stanislaw Burzynski’s cancer “success” stories update: Why is the release of the Burzynski sequel being delayed?
It’s no secret that I happen to NOT be on several mailing lists of “The Skeptics™”whose dedication to science is—shall we say?—questionable
As I delved deeper, I learned that Gorski’s evidence for the “questioning” of the anticancer efficacy of “antineoplaston therapy” doesn’t hold up; that his “questioning” of “personalized gene-targeted cancer therapy” is anything but; and that he’s an orphan now in what appears to me to be a strategy to bypass restrictions on his use of proper “cancer research “
The CliffsNotes version for those who don’t want to read Gorsack’s previous lengthy post is that he claims Hannah’s tumor, an astrocytoma (which is a form of glioma) did indeed appear to regress, but that regression can likely be explained by the surgery and radiation therapy that she had
Even then, however, he claims it would not be evidence that the antineoplastons saved her because there are occasional complete remissions in this tumor type, and long term survivors, although uncommon, are not so uncommon that Hannah must be evidence that antineoplastons are so miraculously effective that they saved her when conventional medicine could not
Gorski’s claims are anecdotal, as he failed miserably to provide the necessary citation(s), reference(s), and / or link(s) to support his claims
Gorski claims:
“I try very hard not to cross that line, and I think I’ve been successful, for instance, here”
But I proved again, above, how he fails and fails again with his “amateurish” attempts at proper “cancer research”
Similarly, Gorski realizes that it is very effective to appeal to emotions and cast Burzynski’s as heartless
Gorski inserts other Burzynski patients into his posts about Pete and Hannah
—————————————————————— GORSKI FAIL #1 – “One notes that Burzynski’s protocol requires at least 18 months of near-continuous infusion of high doses of his antineoplastons“
—————————————————————— GORSKI FAIL #2 – “The new claim is that Burzynski isn’t making patients pay for his antineoplastons (see question #13 in Merola’s FAQ), just for “clinical management” (as if that weren’t incredibly transparent) Vindication”
—————————————————————— GORSKI FAIL #3 – “First, I notice that nowhere was there anything mentioned about enrolling Hannah on a clinical trial“
—————————————————————— GORSKI FAIL #4 – “Certainly, given how much detail he’s used in this video and in his vlogs I’d expect that if the subject of clinical trials was mentioned he would have included it“
—————————————————————— GORSKI FAIL #5 – “The reaction of the clinic staff (i.e., rather blasé, even though at one point Hannah clearly demonstrates a change in mental status, appearing “drunk”and complaining of double-vision) made me wonder if this sort of problem was a common occurrence”
—————————————————————— GORSKI FAIL #6 – Well, I could add more … 🙂
——————————————————————
My apologies to the following co-authors if you ever had to check the “cancer research” of one: Gorski D., Gorski DH, D H Gorski,
I’ve made no secret of my opinion of a certain cancer “research” doctor named David H. Gorski, MD, PhD, of Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Center / Institute, Detroit, Michigan fame
After a couple of winks I changed my characterization to say that it would have made Penn and Teller vomit in revulsion at its sheer incompetence
Be that as it may, I view Gorski as highly unethical and pseudononsense, an incompetent purveyor of “personalized MUD-targeted medicine for dummies,” and someone who might at one time have been on to something but, like all hacks, just couldn’t let go when it became clear that his personalized MUD-targeted Skeptic therapy was far more toxic than advertised and way less efficacious, if it’s even efficacious at all, which is highly doubtful.
Gorski claimed:
“[I]f I had screwed up, I would have admitted it”
Data talks
BS walks
And there’s no doubt that Gorski, too, is pure BS
In fact, I think I’m being too kind
I have yet to see his admission that he lied when he posted:
What science based medicine publication(s) does Gorski cite in support of his “theory”?
NONE !!!
What do the science based medicine publications indicate?
====================================== [1] 4/1/1992 PHENYLACETATE-novel NONTOXIC inducer of tumor cell differentiation
—————————————————————— Sodium PHENYLACETATE found to affect growth and differentiation of tumor cells in vitro at concentrations achieved in humans WITH NO SIGNIFICANT ADVERSE EFFECTS
—————————————————————— PHENYLACETATE is effective in inducing tumor cell maturation and FREE OF CYTOTOXIC AND CARCINOGENIC EFFECTS, a combination that warrants attention to potential use in cancer intervention
—————————————————————— Sodium PHENYLACETATE is investigational new drug approved for human use by U.S. Food and Drug Administration
—————————————————————— DRUG ALREADY ESTABLISHED AS SAFE AND EFFECTIVE … we propose use may be extended to cancer preventation and therapy
====================================== [2] 8/20/1992 Difficulties may be overcome through exploitation of recent discovery of sodium PHENYLACETATE as NONTOXIC inducer of differentiation …
—————————————————————— (pro-drug) Sodium 4-PHENYLBUTYRATE can be given in oral doses of 0.3 to 0.6 g per kilogram of body weight per day with NO ADVERSE REACTIONS
——————————————————————
Drug rapidly metabolized to PHENYLACETATE and PHENYLACETYLGLUTAMINE
—————————————————————— PHENYLACETATE (but not PHENYLACETYLGLUTAMINE) … CAN POTENTIATE EFFICACY OF OTHER DIFFERENTIATING AGENTS, such as cytotoxic drugs …
====================================== [3] 9/15/1992 we explored efficacy of PHENYLACETATE, an amino acid derivative with LOW TOXICITY INDEX WHEN ADMINISTERED TO HUMANS
—————————————————————— PHENYLACETATE, used alone or in combination with other drugs, might offer safe and effective new approach to treatment …
====================================== [4] 5/1993 NONTOXIC differentiation inducer, sodium PHENYLACETATE (NaPA)
——————————————————————
In vitro antineoplastic activity was observed with drug concentrations that have been achieved in humans with NO SIGNIFICANT TOXICITIES, suggesting PA, used alone or in combination with other antitumor agents, warrants evaluation in treatment of advanced prostatic cancer
====================================== [5] 10/1/1993 Sodium PHENYLACETATE (NaPA) and its precursor, sodium 4-PHENYLBUTYRATE (NaPB), can enhance HbF production in cultured erythroid progenitor derived from normal donors and patients with SS anemia or beta-thal, when used at pharmacologic concentrations
—————————————————————— NaPA and NaPB, BOTH ALREADY PROVEN SAFE AND EFFECTIVE IN TREATMENT OF CHILDREN …
====================================== [6] 2/15/1994 sodium PHENYLACETATE can induce cytostasis and reversal of malignant properties of cultured human glioblastoma cells, when used at pharmacological concentrations that are WELL TOLERATED BY CHILDREN AND ADULTS
——————————————————————
Systemic treatment of rats bearing intracranial gliomas resulted in significant tumor suppression with NO APPARENT TOXICITY to host
====================================== [7] 4/1/1994 Pg. 1690
—————————————————————— protocol underwent several modifications over 6-month period
——————————————————————
Interest in PHENYLACETATE as anticancer agent generated by reports that ANTINEOPLASTON AS2-1, a preparation which by weight is 80% PHENYLACETATE, displayed clinical antitumor activity (13)
—————————————————————— 17 patients (16 men / 1 woman) (36-75) median age 57
—————————————————————— Pg. 1693
—————————————————————— Clinical Toxicities. NO TOXICITY associated with bolus administration of drug
——————————————————————
Drug-related TOXICITY clearly related to serum
PHENYLACETATE concentration
——————————————————————
3 episodes of Central Nervous System (CNS)
TOXICITY, limited to CONFUSION
and LETHARGY and often preceded by emesis, occurred in patients treated at dose levels 3 and 4
—————————————————————— Symptoms resolved within 18 h of terminating drug infusion in all instances
—————————————————————— Pg. 1694
—————————————————————— PHENYLACETATE serum concentrations … were typically associated with CNS toxicity
——————————————————————
While ability to cross blood-brain barrier may underlie clinical improvement seen in patient with glioblastoma, could also explain dose-limiting side-effects of drug, i.e., nausea, vomiting, sedation, and confusion
——————————————————————
Limited experience with 150-mg/kg i.v. boluses suggests serum PHENYLACETATE concentrations occurring transiently
above 500 ug/ml are well tolerated
—————————————————————— Intermittent drug infusion should permit some drug washout to occur, thereby minimizing drug accumulation
——————————————————————
Predicts wide range of peak drug concentrations will be observed
——————————————————————
Possible these would be sufficiently transient so as not to produce CNS toxicity and troughs not prolonged as to abrogate antitumor activity of drug
—————————————————————— Dosing alternatives should be explored, our study indicates PHENYLACETATE can be safely administered by CIVI and result in clinical improvement in some patients with hormone-refractory
prostatic carcinoma and glioblastoma multiforme who failed conventional therapies
====================================== [8] 6/1/1994 PHENYLACETATE is naturally occurring plasma component that suppresses growth of tumor cells and induces differentiation in vitro
——————————————————————
Treatment with PHENYLACETATE extended survival … WITHOUT ASSOCIATED ADVERSE EFFECTS
====================================== [9] 9/1994 PHENYLACETATE, NONTOXIC differentiation inducer, can suppress growth of other neuroectodermal tumors, i.e., gliomas, in laboratory models and humans
====================================== [10] 4/1995 PHENYLACETATE, an inducer of tumor cytostasis and differentiation, shows promise as RELATIVELY NONTOXIC antineoplastic agent in models and humans
====================================== [11] 6/15/1995 Growth-inhibiting and differentiating effects of sodium PHENYLACETATE against hematopoietic and solid tumor cell lines has aroused clinical interest in use as anticancer drug
——————————————————————
In Phase I trial of PHENYLACETATE … commonly resulted in drug accumulation and REVERSIBLE DOSE-LIMITING NEUROLOGIC TOXICITY
——————————————————————
18 patients
—————————————————————— DOSE-LIMITING TOXICITY, consisting of REVERSIBLE CENTRAL NERVOUS SYSTEM DEPRESSION, observed for 3 patients at 2nd dose level
====================================== [12] 10/12/1995 aromatic fatty acid PHENYLACETATE, a common metabolite of phenylalanine, shows promise as a RELATIVELY NON-TOXIC drug for cancer treatment
====================================== [13] 10/1995 investigated effects of a NONTOXIC differentiation inducer, PHENYLACETATE (PA), on neuroectodermal tumor-derived cell lines
====================================== [14] 1995 Antineoplastons, firstly described by Burzynski, are naturally occurring peptides and amino acid derivatives which control neoplastic growth
—————————————————————— toxicological study of Antineoplastons A-10 and AS2-1 in combination with other anticancer agents or radiation in 42 patients 46 tumors with terminal stage cancer
—————————————————————— Antineoplaston A-10 oral formulation
14 – patients A-10 injectable formulation
25 – patients
—————————————————————— Antineoplaston AS2-1 oral formulation
33 – patients AS2-1 injectable formulation
10 – patients
—————————————————————— Major adverse effects that may have been related to agents used in combination with other conventional chemotherapeutic agents or radiation:
liver dysfunction
myelosuppression
general weakness THESE EFFECTS WEREN’T SEEN WHEN EITHER ANTINEOPLASTON WAS ADMINISTERED ALONE
—————————————————————— MINOR ADVERSE EFFECTS OBSERVED IN SINGLE USE OF EITHER ANTINEOPLASTON A-10 OR AS2-1:
reduced albumin
increased alkaline phosphatase
increased amylase
reduced cholesterol
peripheral edema
eosinophilia
fingers rigidity
excess gas
headache
hypertension
maculopapullar rash
palpitation adverse effects didn’t limit to continuation of either agent
—————————————————————— Antineoplaston A-10 and AS2-1 LESS TOXIC THAN CONVENTIONAL CHEMOTHERAPIES and useful in maintenance therapy for cancer patients
====================================== [15] 1996 Antineoplastons, first described by Burzynski, are naturally occurring peptides and amino acid derivatives which control neoplastic growth
——————————————————————
reported cytostatic inhibitory effect of A10 on human hepatocellular carcinoma cells and differentiation inducing effect of AS2-1 on various tumor cells suggest potential benefit for treatment of human hepatocellular carcinoma since tumor recurs frequently despite initial successful treatment
——————————————————————
Clinical experience of hepatocellular carcinoma (HCC) patient whose tumor, after incomplete trancathere arterial embolization (TAE) for a 7cm 7cm HCC, has been stable for more than 15 months during which time he has been taking Antineoplaston AS2-1 continuously WITHOUT ANY SERIOUS ADVERSE EFFECTS
====================================== [16] 5/1996
——————————————————————
In pursuit of alternative treatments for chemoresistant tumor cells, tested response of multidrug-resistant (MDR) tumor cell lines to aromatic fatty acids phenylacetate (PA) and phenylbutyrate (PB), 2 differentiation inducers currently in clinical trials
—————————————————————— Both compounds induced cytostasis and maturation of multidrug-resistant breast, ovarian, and colon carcinoma cells with no significant effect on cell viability
——————————————————————
MDR cells generally more sensitive to growth arrest by PA and PB than their parental counterparts
—————————————————————— PA and PB potentiated cytotoxic activity of doxorubicin against MDR cells
—————————————————————— Taken together, in vitro data indicate PA and PB, differentiation inducers of aromatic fatty acid class, may provide alternative approach to treatment of MDR tumors
====================================== [17] 12/1996 PHENYLACETATE (PA) and related aromatic fatty acids constitute novel class of RELATIVELY NONTOXIC antineoplastic agents
====================================== [18] 8/1997 aromatic fatty acids PHENYLACETATE (PA) and PHENYLBUTYRATE (PB) are novel antitumor agents currently under clinical evaluation
————————————————————
ability to induce tumor differentiation in laboratory models and LOW CLINICAL TOXICITY PROFILE makes them promising candidates for COMBINATION WITH CONVENTIONAL THERAPIES
====================================== [19] 1997 PHENYLACETATE and analogs represent new class of pleiotropic growth regulators that alter tumor cell biology by affecting gene expression at both transcriptional and post transcriptional levels
————————————————————
Based on findings, NaPA and NaPB entered clinical trials at National Cancer Institute
————————————————————
Ongoing phase I studies with NaPA, involving adults with prostate and brain cancer, confirmed therapeutic levels can be achieved WITH NO SIGNIFICANT TOXICITIES, and provide preliminary evidence for benefit to patients with advanced disease (Thibault et al., submitted)
====================================== [20] 10/1997 Sodium PHENYLACETATE (PA) and sodium PHENYLBUTYRATE (PB) are aromatic fatty acids that can effect differentiation in a variety of cell lines at doses that may be clinically attainable
—————————————————————— Pg. 1760
—————————————————————— PB has been successfully administered to patients with urea acid cycle disorders and sickle cell anemia for extended periods of time, and NO HEMATOLOGICAL TOXICITY has been reported
—————————————————————— Significant HEMATOLOGICAL TOXICITY was not reported in a Phase I trial of PA in patients with malignancy
—————————————————————— Pg. 1761
——————————————————————
Because of its ATTRACTIVE CLINICAL TOXICITY PROFILE, PB represents an excellent candidate for clinical trials in this group of disorders
====================================== [21] 11.–.12/1997 Antineoplaston AS2-1 exhibits cytostatic growth inhibition of human hepatocellular carcinoma cells in vitro and SHOWED MINIMUM ADVERSE EFFECTS in phase I clinical trial
====================================== [22] 6/1999 Burkitt’s lymphoma (BL) is readily treated malignancy, recurrences, as well as disease arising in immunosuppressed patients, are notoriously resistant to conventional therapeutic approaches
——————————————————————
Using in vitro models of EBV-transformed lymphoblastoid as well as BL cell lines, we demonstrate increased expression of genes coding for HLA class I and EBV latent proteins by differentiation inducer PHENYLBUTYRATE (PB)
—————————————————————— Aromatic fatty acid also caused cytostasis associated with sustained declines in c-myc expression, a direct antitumor effect that was independent of EBV status
——————————————————————
Findings may have clinical relevance because in vitro activity has been observed with PB concentrations that are
WELL TOLERATED and nonimmunosuppressive in humans, a desirable feature for different patient populations afflicted with this disease
====================================== [23] 8/2001 PHENYLBUTYRATE (PB) is aromatic fatty acid with multiple mechanisms of action including histone deacetylase inhibition
—————————————————————— Overall DRUG WELL TOLERATED with most common TOXICITIES being grade 1-2 DYSPEPSIA and FATIGUE
——————————————————————
Nonoverlapping dose-limiting TOXICITIES of NAUSEA/VOMITING and HYPOCALCEMIA were seen at 36 g/day
—————————————————————— PB (p.o.) IS WELL TOLERATED and achieves concentration in vivo shown to have biological activity in vitro
====================================== [24] 10/2001 Sodium PHENYLBUTYRATE (PB) demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines
——————————————————————
Pharmacokinetics performed during and after first infusion period using validated high-performance liquid chromatographic assay and single compartmental pharmacokinetic model for PB and principal metabolite, PHENYLACETATE
—————————————————————— 24 patients with hormone refractory prostate cancer being predominant tumor type
—————————————————————— All evaluable for TOXICITY and response
——————————————————————
Dose escalated 150 to 515 mg/kg/day
——————————————————————
One patient at 515 mg/kg/day and one at 345 mg/kg/day experienced this DLT
——————————————————————
Maximum tolerated dose 410 mg/kg/day for 5 days
——————————————————————
Recommended Phase II dose 410 mg/kg/day for 120 h
—————————————————————— Dose-limiting TOXICITY (DLT) was neuro-cortical, exemplified by EXCESSIVE SOMNOLENCE and CONFUSION and accompanied by clinically significant HYPOKALEMIA, HYPONATREMIA, and HYPERURICEMIA
——————————————————————
Other TOXICITIES mild, including FATIGUE and NAUSEA
—————————————————————— DLT in Phase I study for infusional PB
given for 5 days every 21 days is neuro-cortical in nature
—————————————————————— TOXICITY resolved < or =12 h of discontinuing infusion
====================================== [25] 2003 Case of survival for nearly 8 years after treatment of unresectable multiple liver metastases from colon cancer, using microwave ablation and NONTOXIC ANTITUMOR AGENT, ANTINEOPLASTONS
——————————————————————
72-year-old man diagnosed with adenocarcinoma of ascending colon and 14 bilateral liver metastases underwent right hemicolectomy combined with microwave ablation of 6 metastatic liver tumors
—————————————————————— Antineoplaston A10 given intravenously, followed by oral antineoplaston AS2-1
——————————————————————
Patient underwent 2nd and 3rd microwave ablation of recurrent tumors, and has survived for nearly 8 years WITHOUT SUFFERING ANY SERIOUS ADVERSE EFFECTS
—————————————————————— Currently FREE FROM CANCER
——————————————————————
Demonstrates potential effectiveness of NONTOXIC ANTITUMOR AGENT, ANTINEOPLASTONS, for controlling liver metastases from colon cancer
====================================== [26] 4/2005 Determined maximum tolerated dose (MTD), TOXICITY profile of … oral sodium PHENYLBUTYRATE (PB) in patients with recurrent malignant gliomas
——————————————————————
All PB doses of 9, 18, and 27 g/day WELL TOLERATED
——————————————————————
At 36 g/day, 2 of 4 patients developed dose-limiting grade 3 FATIGUE and SOMNOLENCE
——————————————————————
At MTD of 27 g/day, one of 7 patients developed reversible grade 3 SOMNOLENCE
====================================== [27] 4/2007 PHENYLBUTYRATE (PBA), and its metabolite PHENYLACETATE (PAA), induce growth inhibition and cellular differentiation in multiple tumor models
——————————————————————
Conversion of PBA to PAA and PHENYLACETYLGLUTAMINE (PAG) documented without catabolic saturation
—————————————————————— THERAPY WELL TOLERATED OVERALL
——————————————————————
Common ADVERSE EFFECTS included grade 1 NAUSEA/VOMITING, FATIGUE, and LIGHTHEADEDNESS
—————————————————————— Dose limiting TOXICITIES were SHORT-TERM MEMORY LOSS, SEDATION, CONFUSION, NAUSEA, and VOMITING
——————————————————————
Administration of PBA twice-daily infusion schedule is SAFE
======================================
None of the above publications indicate that antineoplastons are toxic as Gorski would have people believe
12/12/2011 Gorski published his attempt at trying to explain why antineoplastons are supposedly toxic
====================================== What Dr. Stanislaw Burzynski doesn’t want you to know about antineoplastons
—————————————————————— http://scienceblogs.com/insolence/2011/12/12/what-dr-stanislaw-burzynski-doesnt-want/
====================================== Gorski posited:
“He’s also prescribing huge doses of antineoplastons (up to 25 g/kg/d for A10 and 80 mg/kg/d for AS-2.1, as we have seen). both of these are so far above the maximal tolerated dose of 300 mg/kg/d determined in the phase I trial I cited above as to be terrifying”
In support of his “theory”, Gorski provided a link to the National Cancer Institute (NCI) at the National Institutes of Health (NIH):
—————————————————————— http://www.cancer.gov/cancertopics/pdq/cam/antineoplastons/healthprofessional/Table1
——————————————————————
However, as is the case with a lot of Gorski’s lame research, he makes you search for what he is referring to:
[14]Ba Primitive neuroectodermal tumor (13)
A10/AS2-1
Max dose: A10: 25 g/kg/d; AS2-1: 0.6 g/kg/d
Does this support Gorski’s “toxic theory”?
====================================== [28] 2005
—————————————————————— 5 years 7 months (1-11) median age
—————————————————————— 13 / 100% – children with recurrent disease or high risk
—————————————————————— 5 / 38% – weren’t treated earlier with radiation therapy or chemotherapy
—————————————————————— 3 / 23% – Complete Response
1 / 8% – Partial Response
4 / 31% – Stable Disease
5 / 38% – Progressive Disease
—————————————————————— 6 / 46% – Survived 5+ years from initiation of ANP
—————————————————————— Serious side effects:
1 – anemia
1 – fever
1 – granulocytopenia
—————————————————————— average dosage of A10 was 10.3 g/kg/d and of AS2-1 was 0.38 g/kg/d
—————————————————————— REDUCED TOXICITY MAKES ANP PROMISING for very young children, patients at high risk of complication of standard therapy, and patients with recurrent tumors
======================================
The above sure does NOT support Gorski’s “toxic theory”
When science based medicine keeps saying the following:
====================================== [9] 9/1994 increasing incidence of melanoma and POOR RESPONSIVENESS OF DISSEMINATED DISEASE TO CONVENTIONAL TREATMENT CALL FOR DEVELOPMENT OF NEW THERAPEUTIC APPROACHES
====================================== [29] 9/27/1995 (7/17/2006) Alterations in expression of ras oncogenes are characteristic of wide variety of human neoplasms
—————————————————————— Accumulating evidence has linked elevated ras expression with disease progression and FAILURE OF TUMORS TO RESPOND TO CONVENTIONAL THERAPIES, INCLUDING RADIOTHERAPY AND CERTAIN CHEMOTHERAPIES
—————————————————————— observations led us to investigate response of ras-transformed cells to differentiation-inducer PHENYLACETATE (PA)
—————————————————————— Interestingly, IN CONTRAST TO THEIR RELATIVE RESISTANCE TO RADIATION and doxorubicin, ras-transformed cells were significantly more sensitive to PA than their parental cells
====================================== [30] 5/1996 CYOTOXIC CHEMOTHERAPIES OFTEN GIVE RISE TO MULTIDRUG RESISTANCE, WHICH REMAINS MAJOR PROBLEM IN CANCER MANAGEMENT
———————————————————— IN PURSUIT OF ALTERNATIVE TREATMENTS FOR CHEMORESISTANT TUMOR CELLS, we tested response of multidrug-resistant (MDR) tumor cell lines to aromatic fatty acids PHENYLACETATE (PA) and PHENYLBUTYRATE (PB), 2 differentiation inducers currently in clinical trials
====================================== [15] 1996 Antineoplastons, first described by Burzynski, are naturally occurring peptides and amino acid derivatives which control neoplastic growth
——————————————————————
reported cytostatic inhibitory effect of A10 on human hepatocellular carcinoma cells and differentiation inducing effect of AS2-1 on various tumor cells suggest potential benefit for treatment of human hepatocellular carcinoma since TUMOR RECURS FREQUENTLY DESPITE INITIAL SUCCESSFUL TREATMENT
====================================== [31] 7/1997 Children with malignant GLIOMAS THAT PROGRESSED AFTER CONVENTIONAL THERAPY
—————————————————————— 0 / 0% – EXHIBITED CLEAR-CUT TUMOR regression
====================================== [32] 2000 treatment combination PRODUCED NO SIGNIFICANT CHANGE in overall POOR prognosis of patients
—————————————————————— Most tumors responded initially to treatment but RECCURED as study progressed
—————————————————————— Based on POOR RESULTS, recommend ALTERNATIVE TREATMENTS be tested in patients with this type of tumor
====================================== [33] At time of approval, NO RESULTS were available from randomized controlled trials in refractory ANAPLASTIC ASTROCYTOMA that show clinical benefit such as improvement in disease-related symptoms or prolonged survival
====================================== [34] 12/2000 NO CLEAR PROOF OF EFFICACY
—————————————————————— NO BETTER THAN SURVIVAL BEFORE THE INTRODUCTION OF temozolomide
====================================== [35] 2002 p53 tumor suppressor gene plays important role in protecting cells from developing undesirable proliferation
—————————————————————— Mutant p53 gene or malfunctioning p53 protein found in more than 50% of cancer cells impedes DNA repair or apoptosis induction
—————————————————————— MAY BE WHY SOME CANCERS GAIN RESISTANCE TO CHEMOTHERAPY AND RADIATION AND BECOME MORE RESISTANT AFTER FREQUENT CANCER TREATMENTS
====================================== [36] 2004 outcome for patients with either type of tumor is POOR when STANDARD multimodality THERAPY IS USED
—————————————————————— children are ideal candidates for INNOVATIVE TREATMENT approaches
—————————————————————— 33 / 100% – DIED OF DISEASE PROGRESSION
—————————————————————— administration of temozolomide after RT DIDN’T ALTER POOR PROGNOSIS associated with newly diagnosed diffuse BRAINSTEM GLIOMA in children
====================================== [37] 2/2008 addition of vincristine and oral VP-16 to standard external beam radiation causes moderate toxicity and DOESN’T IMPROVE SURVIVAL OF CHILDREN WITH DIFFUSE INTRINSIC BRAIN STEM GLIOMA
====================================== [38] 5/6/2009 Currently, NO DATA available from randomized controlled trials demonstrating improvement in disease-related symptoms or increased survival with Avastin in GLIOBLASTOMA
====================================== [39] 10/12/2011 Afinitor (ubependymal giant cell ASTROCYTOMA (SEGA) brain tumor)
—————————————————————— none of their tumors went away completely
====================================== [18] 8/1997 aromatic fatty acids PHENYLACETATE (PA) and PHENYLBUTYRATE (PB) are novel antitumor agents currently under clinical evaluation
————————————————————
ability to induce tumor differentiation in laboratory models and LOW CLINICALTOXICITY PROFILE makes them promising candidates for COMBINATION WITH CONVENTIONAL THERAPIES
======================================
So what does Gorski think is going to fill the void?
His clinical trial drug ?
The potentially profitable drug Gorski is in the process of conducting a clinical trial for is the ALS drug Riluzole, made by Sanofi-Aventis and marketed as Rilutek
Apparently, David Gorski has had his eye on that drug for a long time, but as a possible treatment for breast cancer
As suggested by a 2008-2009 webpage of a breast cancer website:
“Three years ago in another cancer (melanoma), Dr. Gorski’s collaborators found that glutamate might have a role in promoting the transformation of the pigmented cells in the skin (melanocytes) into the deadly skin cancer melanoma”
“More importantly for therapy, it was found that this protein can be blocked with drugs, and, specifically, in melanoma cell lines and tumor models of melanoma using a drug originally designed to treat ALS and already FDA-approved for that indication (Riluzole) can inhibit the growth of melanoma.”
———————————————————— http://www.ageofautism.com/2010/06/david-gorskis-financial-pharma-ties-what-he-didnt-tell-you.html
———————————————————— Better luck next time with your personal MUD-targeted Skeptic therapy Gorski
Blood 82(7):2203–2209 Department of Hematology, Hadassah University Hospital, Jerusalem, Israel
Fibach E, Prasanna P, Rodgers GP, SAMID D SAMID D References: 15, 19-21 and 32
� � � � � � � � � � � � � � � � � [6] 2/15/1994
� � � � � � � � � � � � � � � � � SAMID, D., Ram, Z., Hudgins, W. R., Shack, S., Liu, L., Waibridge, S., Oldfield, E. H., and Myers, C. E. Selective activity of PHENYLACETATE against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. Cancer Res., 54: 891-895, 1993 http://www.ncbi.nlm.nih.gov/pubmed/8313377/
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Cancer Res February 15, 1994 54; 891 http://cancerres.aacrjournals.org/content/54/4/891/
Cancer Res 1994;54:891-895
Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Work supported by funds from Elan Pharmaceutical Research Corporation through Cooperative Research and Development Agreement (CACR-0139)
� � � � � � � � � � � � � � � � � [7] 4/1/1994
� � � � � � � � � � � � � � � � �
A phase I and pharmacokinetic study of intravenous PHENYLACETATE in patients with cancer http://www.ncbi.nlm.nih.gov/pubmed/8137283
Cancer Res. 1994 Apr 1;54(7):1690-4 http://www.ncbi.nlm.nih.gov/m/pubmed/8137283
Cancer Res 54(7):1690-4 (1994), PMID.8137283 http://m.cancerres.aacrjournals.org/content/54/7/1690.abstract
Clinical Pharmacology Branch, National Cancer Institute, NIH, Bethesda, Maryland
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2
Advances in Experimental Medicine and Biology Volume 400, 1997, pp 501-505
Clinical Pharmacology Branch, National Cancer Institute, Bethesda, MD USA D D SAMID, W R WR Hudgins, … C E CE Myers
� � � � � � � � � � � � � � � � [20] 10/1997
� � � � � � � � � � � � � � � �
Impact of the putative differentiating agents sodium PHENYLBUTYRATE and sodium PHENYLACETATE on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells http://www.ncbi.nlm.nih.gov/pubmed/9815560/
Clin Cancer Res. 1997 Oct;3(10):1755-62 http://www.ncbi.nlm.nih.gov/m/pubmed/9815560/
Clin Cancer Res October 1997 3; 1755 http://m.clincancerres.aacrjournals.org/content/3/10/1755.full.pd
Clin Cancer Res. 1997a;3:1755–1762 http://m.clincancerres.aacrjournals.org/content/3/10/1755.abstract The Johns Hopkins Oncology Center, Baltimore, Maryland, USA
The New Approaches to Brain Tumor Therapy CNS Consortium, Winship Cancer Institute, Emory University, Atlanta, GA, USA
Buckner Reference: 3
SAMID D References: 12, 17 and 19-21
� � � � � � � � � � � � � � � � � [27] 4/2007
� � � � � � � � � � � � � � � � �
Phase I dose escalation clinical trial of PHENYLBUTYRATE sodium administered twice daily to patients with advanced solid tumors http://www.ncbi.nlm.nih.gov/pubmed/17053987
Invest New Drugs. 2007 Apr;25(2):131-8. Epub 2006 Oct 20 http://www.ncbi.nlm.nih.gov/m/pubmed/17053987
Investigational New Drugs
April 2007, Volume 25, Issue 2, pp 131-138 http://link.springer.com/article/10.1007%2Fs10637-006-9017-4
Invest New Drugs 25(2):131-8 (2007), PMID.17053987 Department of Medicine, Memorial Sloan-Kettering Cancer Center, Joan and Sanford I. Weill Medical College of Cornell Medical Center, New York, New York, USA
Luis H LH Camacho, Jon J Olson, … Mark G MG Malkin SAMID D References: 4-5, 7, 20, 24, 30 and 32-38
� � � � � � � � � � � � � � � � � [28] 2005
� � � � � � � � � � � � � � � � �
14. Burzynski SR, Weaver RA, Janicki T, et al.: Long-term survival of high-risk pediatric patients with primitive neuroectodermal tumors treated with antineoplastons A10 and AS2-1. Integr Cancer Ther 4 (2): 168-77, 2005 http://www.ncbi.nlm.nih.gov/pubmed/15911929/
Integr Cancer Ther. 2005 Jun;4(2):168-77 http://www.ncbi.nlm.nih.gov/m/pubmed/15911929/
� � � � � � � � � � � � � � � � � [29] 9/27/1995
� � � � � � � � � � � � � � � � �
Increased susceptibility of ras-transformed cells to PHENYLACETATE is associated with inhibition of p21ras isoprenylation and phenotypic reversion. Int J Cancer 63:124-129, 1995 http://www.ncbi.nlm.nih.gov/pubmed/7558439/
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Clinical Pharmacology Branch, National Cancer Institute, Bethesda, MD, USA http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910630122/abstract
Int J Cancer 63:124-129, 1995
Int J Cancer. 1995 Sep 27;63(1):124-9. http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910630122/references
International Journal of Cancer
Volume 63, Issue 1, Article first published online: 17 JUL 2006
DOI: 10.1002/ijc.2910630122
Shack S, Chen L-C, Miller AC, et al: (SAMID D) http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910630122/abstract
Shack, S., Chen, L-C., Miller, A. C., Danesi, A., and SAMID, D. Int. J. Cancer, 63: 124-129, 1995
� � � � � � � � � � � � � � � � � [30] 5/1996
� � � � � � � � � � � � � � � � �
Shack, S., Miller, A., Liu, L., Prasanna, P., Thibault, A., and SAMID, D.. Vulnerability of MULTIDRUG-RESISTANT TUMOR CELLS to the aromatic fatty acids PHENYLACETATE and PHENYLBUTYRATE. Clin. Cancer Res., 2: 865-872, 1996 http://www.ncbi.nlm.nih.gov/pubmed/9816242/
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