L.I.A.R.
Lacking
Integrity
And
Respect
Respect is EARNED
Dr. David H. “Orac” Gorski has NOT earned respect
Neither does he deserve it
6/4/2013 Gorski made an amazing admission:
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http://scienceblogs.com/insolence/2013/06/04/stanislaw-burzynski-versus-the-bbc/
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“Dr. Elloise Garside, a research scientists, echoes a lot of the questions I have, such as”
“how Burzynski never explains which genes are targeted by antineoplastons … “
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Gorski has claimed:
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6/7/2013 “Unlike Mr. Merola, I am indeed very concerned with getting my facts correct”
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http://scienceblogs.com/insolence/2013/06/07/i-want-my-anp/
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6/5/2013 “ … I do know cancer science”
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http://scienceblogs.com/insolence/2013/06/05/odds-and-ends-about-burzynski-clinic/
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11/2/2012 “Personally, having pored over Burzynski’s publications … “
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http://scienceblogs.com/insolence/2012/11/02/stanislaw-burzynski-fails-to-save-another-patient/
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5/8/2013 “I’ve searched Burzynski’s publications … “
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http://scienceblogs.com/insolence/2013/05/08/eric-merola-and-stanislaw-burzynskis-secret-weapon-against-the-skeptics-fabio-lanzoni-part-2/
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7/22/2013 I published the below article on my blog:
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Critiquing: In which Orac does Stanislaw Burzynski propagandist Eric Merola a favor…:
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Critiquing: In which Orac does Stanislaw Burzynski propagandist Eric Merola a favor…
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“… because Gorski and others do NOT seem to understand how antineoplastons (ANP) A10 (Atengenal) and AS2-1 (Astugenal) work, I provide the relevant Burzynski publications and page #’s for them to review:
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Gorski, here’s
” … how Burzynski never explains which genes are targeted by antineoplastons … “
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[1] Pg. 98
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ras oncogenes
tumor suppressor gene p53
ras oncogene protein p21ras
p21 gene
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[2] Pg. 47
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oncogenes
tumor suppressor genes
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Pg. 48
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gene p53
WRN gene
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Mechanism of Action of Antineoplaston
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tumor suppressor genes
oncogenes
p21 protein
p53 gene
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Pg. 49
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tumor suppressor gene p53
tumor suppressor gene p21
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[3] Pg. 257
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tumor suppressor genes
oncogenes
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Pg. 260 Discussion
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oncogene AKT2
oncogene RAS
oncogene MYCC
tumor suppressor p53
tumor suppressor p21
tumor suppressor PTEN
tumor suppressor INI1
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[4] Pg. 385
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AKT2 pathway
TGFB1 pathway
RAS
TP53
p21
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[5] Pg. 386
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RAS pathway
AKT2 pathway
TGFB1 pathway
p53 tumor suppressor gene
p21 tumor suppressor gene
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[6] Pg. 323 Discussion
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TP53 gene
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Pgs. 323-324
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RAS oncogene
TP53 tumor suppressor gene
p21 tumor suppressor gene
NF1 tumor suppressor gene
p21 RAS protein
RNAi
dsRNA
siRNA
RAS oncogene pathway (GF-RTK-RAS)
oncogenes
oncogene AKT2
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[7] Pg. 173 Discussion
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proto-oncogene MYCC, ERBB2
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Pg. 174
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sonic hedgehog (SHH) receptor patched (PTCH)
MYCC
MYC-MAX dimers
G1-S
gene CCD2 (encoding cyclin D2)
gene CDK4 (which encodes cyclin dependent kinase 4)
KIP1
(or p27)
CUL-1
CKS
MYC
cyclin E-CDK2
INK4B
(or p15)
p21
cyclin E/CDK2
MIZ1 (MYC-interacting zinc finger protein 1)
CDKN1A
CDKN2B
MAD protein
MEFD2D (MADS box transcription enhancer factor
17p
tumor-suppressor gene HIC-1 (hypermethylated in cancer-1)
RAS/MAPK
RAS pathway
RAS protein
AKT2
BCL2
BCL-X
BAX
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Pgs. 175-176 Charts
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[8] Pg. 40
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RAS
AKT
TP53
PTEN
INI1
p21
MYCC
apoptosis pathway
DNA
p21 protein
RAS oncogene
INI1 protein
BCL-X
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Pg. 41 Targeted Therapy with Antineoplastons chart
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protein p21
RAS oncogene
RAS
BCL-2
tumor suppressor gene TP53
tumor suppressor gene p21
DNA
oncogene AKT2
oncogene MYCC
tumor suppressor gene PTEN
tumor suppressor gene MAD
INI1 protein
BCL-X protein
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Pg. 46 Discussion / Conclusion
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AKT/PTEN
RAS
p53
p21
MYCC
apoptosis pathways
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[9] Pg. 384 E. Multitargeted therapy
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RAS pathway
AKT2 pathway
TP53 pathway
PTEN
INI1
p21 pathway
MYCC
apoptosis pathways
TGFB1 pathway
MAD
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[10] Pg. 1068
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AKT2 pathway
MYCC pathway
TGFB1
PTEN tumor suppressor gene
MAD tumor suppressor gene
RANBP1
INI protein
RAS pathway
BCL2 pathway
tumor suppressor TP53
tumor suppressor p21
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[11] Pg. 923
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AKT pathway
RAS pathway
TP53 pathway
p21 pathway
PTEN pathway
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Burzynski, Hideaki Tsuda (Japan), and the p53 gene:
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� � � � � � � � � � � � � � � �
References:
� � � � � � � � � � � � � � � �
http://www.burzynskiclinic.com/scientific-publications.html
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[1] 2003
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Interim Reports on Clinial Trials
16. 2003 (BT-11)
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report
DRUGS IN R&D
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http://www.ncbi.nlm.nih.gov/pubmed/12718563
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Drugs in R and D
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http://www.ncbi.nlm.nih.gov/m/pubmed/12718563
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(Drugs in Research and Development)
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Drugs R D. 2003;4(2):91-101
Drugs in R&D 2003;4:91-101
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[2] 3/2004
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Review Articles on Clinical Trials:
1. 3/2004
The Present State of Antineoplaston Research
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Integrative Cancer Therapies 2004;3:47-58
Volume 3, No. 1, March 2004
DOI: 10.1177/1534735-403261964
Volume 3 Number 1 March 2004
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[3] 9/2004
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Case Reports:
4. 9/2004 (Special Exception (SE) to BT-11 Study (ST))
Long-term survival and complete response of a patient with recurrent diffuse intrinsic brain stem glioblastoma multiforme
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Integrative Cancer Therapies 2004;3:257-261
Volume 3, Number 3 September 2004
DOI: 10.1177/1534735404267748
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[4] 10/2004
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Interim Reports on Clinial Trials:
2. 10/2004
Phase II study of Antineoplastons A10 and AS2-1 (ANP) in recurrent glioblastoma multiforme
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Neuro-Oncology. 2004; 6: 384
Volume 6 Issue 4 October 2004
Abstracts from the Society for Neuro-Oncology Ninth Annual Meeting, Toronto, Ontario, Canada, November 18-21, 2004
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[5] 10/2004
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Interim Reports on Clinial Trials:
3. 10/2004 (Study (ST) and Special Exception (SE))
Long-term survivals in phase II studies of Antineoplastons A10 and AS2-1 (ANP) in patients with diffuse intrinsic brain stem glioma
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Neuro-Oncology. 2004; 6: 386
Volume 6 Issue 4 October 2004
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[6] 2004
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Interim Reports on Clinial Trials:
17. 2004 (BT-13 and BT-23)
Phase II study of antineoplaston A10 and AS2-1 in children with recurrent and progressive multicentric glioma :
a preliminary report
DRUGS IN R&D
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http://www.ncbi.nlm.nih.gov/pubmed/15563234
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Drugs in R and D
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http://www.ncbi.nlm.nih.gov/m/pubmed/15563234
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(Drugs in Research and Development)
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Drugs R D. 2004;5(6):315-26
Drugs R&D 2004;5(6):315-326.
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[7] 6/2005
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Interim Reports on Clinial Trials:
18. 6/2005 (CAN-01 and BT-12)
Burzynski, S.R., Weaver, R.A., Janicki, T., Szymkowski, B., Jurida, G., Khan, M., Dolgopolov, V.
Long-term survival of high-risk pediatric patients with primitive neuroectodermal tumors treated with Antineoplastons A10 and AS2-1
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http://www.ncbi.nlm.nih.gov/pubmed/15911929
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Integr Cancer Ther. 2005 Jun;4(2):168-77
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http://www.ncbi.nlm.nih.gov/m/pubmed/15911929
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Integrative Cancer Therapies 2005;4(2):168-177
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DOI: 10.1177/1534735405276835
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http://m.ict.sagepub.com/content/4/2/168.long?view=long&pmid=15911929
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Volume 4 Number 2 June 2005
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[8] 3/2006
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Interim Reports on Clinial Trials:
19. 3/2006 (BT-03, BT-11, BT-18, and CAN-01)
Targeted therapy with Antineoplastons A10 and AS2-1 of high grade, recurrent, and progressive brainstem glioma.
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http://www.ncbi.nlm.nih.gov/pubmed/16484713
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Integr Cancer Ther. 2006 Mar;5(1):40-7
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http://www.ncbi.nlm.nih.gov/m/pubmed/16484713
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Integrative Cancer Therapies 2006;5(1):40-47
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DOI: 10.1177/1534735405285380
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http://m.ict.sagepub.com/content/5/1/40.long?view=long&pmid=16484713
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[9] 12/2007
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Review Articles on Clinical Trials:
3. 12/2007
Recent clinical trials in diffuse intrinsic brainstem glioma. Cancer Therapy 2007; 5, 379-390.
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Review Article
Cancer Therapy Vol 5, 379-390, 2007
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http://www.cancer-therapy.org/CT/v5/B/HTML/42._Burzynski,_379-390.html
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Volume 5 Number 2 December, 2007
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[10] 12/2008
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Interim Reports on Clinical Trials:
12. 12/2008
(BT-8 – PATIENTS WITH ANAPLASTIC ASTROCYTOMA)
(BT-15 – ADULT PATIENTS WITH ANAPLASTIC ASTROCYTOMA)
Phase II study of antineoplastons A10 and AS2-1 infusions (ANP) in patients with recurrent anaplastic astrocytoma
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Neuro-Oncology 2008; 10:1067
Volume 10 Issue 6 December 2008
Abstracts for the Eighth Congress of the European Association for Neuro-Oncology (EANO), Sept. 12-14, 2008, Barcelona, Spain
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[11] 12/2009
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Case Reports:
1. 12/2009 (BT-11 Special Exception (SE))
Over a 10-year survival and complete response of a patient with diffuse intrinsic brainstem glioma (DBSG) treated with antineoplastons (ANP).
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Neuro-Oncology 2009; 11:923.
Volume 11 Issue 6 December 2009
Abstracts from the Third Quadrennial Meeting of the World Federation of Neuro-Oncology (WFNO) and the Sixth Meeting of the Asian Society for Neuro-Oncology (ASNO), May 11-14, 2009, Yokohama, Japan
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